Dopamine autoreceptor regulation of release and uptake in mouse brain slices in the absence of D(3) receptors.

Abstract:

:The effects of the dopamine D(3) receptor, a putative autoreceptor, have been investigated by comparing behavioral and neurochemical properties of wild-type mice and mice with a genetic deletion of the D(3) receptor. The D(3) knock-out mice were modestly hyper-responsive to a novel environment relative to wild-type mice, and, consistent with this, quantitative in vivo microdialysis revealed elevated striatal dopamine extracellular levels. The dynamic actions of autoreceptors on electrically evoked dopamine release were examined in striatal brain slices from these animals and monitored with fast scan cyclic voltammetry at carbon-fiber microelectrodes. Quinpirole, a dopamine receptor agonist with potency at both D(2) and D(3) receptors, inhibited evoked dopamine in a dose-dependent manner with a slightly higher dose required in the knock-out animals (EC(50) of 60+/-10 nM in wild-type animals and 130+/-40 in D(3) knock-out animals; both curves had a Hill slope near 2). Dopamine synthesis inhibition with alpha-methyl-p-tyrosine caused released dopamine levels to decrease in each genotype. However, regulation of secretion by autoreceptors was still operant. Dose-response curves to quinpirole were unchanged in D(3) knock-out tissue, but secretion-regulated release exhibited a Hill slope decreased to 1 in the wild-type animals. In both genotypes, similar quinpirole-evoked increases in uptake rate were evident following synthesis inhibition. These data are consistent with the D(3) receptor having a small but significant role as a dopamine autoreceptor that partially regulates secretion, but not synthesis, in the caudate-putamen.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Joseph JD,Wang YM,Miles PR,Budygin EA,Picetti R,Gainetdinov RR,Caron MG,Wightman RM

doi

10.1016/s0306-4522(02)00067-2

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

39-49

issue

1

eissn

0306-4522

issn

1873-7544

pii

S0306452202000672

journal_volume

112

pub_type

杂志文章
  • Expression and alternate splicing of apolipoprotein E receptor 2 in brain.

    abstract::Apolipoprotein E isoforms affect the risk of developing Alzheimer's disease. Apolipoprotein E-associated risk may be related to its binding to and clearance by cell surface receptors, including members of the low-density lipoprotein receptor family. We examined the brain expression of the most recently identified memb...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(98)00489-8

    authors: Clatworthy AE,Stockinger W,Christie RH,Schneider WJ,Nimpf J,Hyman BT,Rebeck GW

    更新日期:1999-03-01 00:00:00

  • β-Catenin is required for maintaining hippocampal morphology during the perinatal period.

    abstract::In mice, the compact hippocampal primordium is formed during the prenatal stage by early-generated neurons that migrate from the lateral ventricular zone. However, despite much being understood about the formation of the hippocampus, the molecular mechanisms that maintain the morphology of the hippocampal primordium a...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2014.08.055

    authors: Wang HT,Zeng L,Chen Q,Zhang X,Liu JW,Lu TJ,Xiong ZQ,Zheng J,Hu ZL

    更新日期:2015-01-22 00:00:00

  • Dietary cholesterol increases ventricular volume and narrows cerebrovascular diameter in a rabbit model of Alzheimer's disease.

    abstract::Using structural magnetic resonance imaging in a clinical scanner at 3.0T, we describe results showing that following 12weeks on a diet of 2% cholesterol, rabbits experience a significant increase in the volume of the third ventricle compared to rabbits on a diet of 0% cholesterol. Using time-of-flight magnetic resona...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2013.09.015

    authors: Schreurs BG,Smith-Bell CA,Lemieux SK

    更新日期:2013-12-19 00:00:00

  • Cytoarchitecture of the olfactory bulb in the laggard mutant mouse.

    abstract::The laggard (lag) mutant mouse, characterized by hypomyelination and cerebellar ataxia, is a spontaneously occurring mutant mouse caused by mutation in the Kif14 gene. In this mutant mouse, the laminated structures such as the cerebral and cerebellar cortices and the dentate gyrus are cytoarchitecturally abnormal. Mac...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2014.06.011

    authors: Yunus J,Setsu T,Kikkawa S,Sakisaka T,Terashima T

    更新日期:2014-09-05 00:00:00

  • Regulation of apolipoprotein E secretion in rat primary hippocampal astrocyte cultures.

    abstract::Apolipoprotein E isoforms may have differential effects on a number of pathological processes underlying Alzheimer's disease. Recent studies suggest that the amount, rather than the type, of apolipoprotein E may also be an important determinant for Alzheimer's disease. Therefore, understanding the regulated synthesis ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(01)00224-x

    authors: Cedazo-Mínguez A,Hamker U,Meske V,Veh RW,Hellweg R,Jacobi C,Albert F,Cowburn RF,Ohm TG

    更新日期:2001-01-01 00:00:00

  • Co-localization of tyrosine hydroxylase and zebrin II immunoreactivities in Purkinje cells of the mutant mice, tottering and tottering/leaner.

    abstract::The mutant mice tottering, leaner and the compound heterozygous tottering/leaner exhibit varying degrees of several abnormal neurological phenotypes including petit mal-like epilepsy, ataxia and an intermittent myoclonus-like movement disorder. Aberrant expression of tyrosine hydroxylase in cerebellar Purkinje cells o...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(95)00444-0

    authors: Abbott LC,Isaacs KR,Heckroth JA

    更新日期:1996-03-01 00:00:00

  • Melatonin generates an outward potassium current in rat suprachiasmatic nucleus neurones in vitro independent of their circadian rhythm.

    abstract::The present study investigated the membrane mechanisms underlying the inhibitory influence of melatonin on suprachiasmatic nucleus (SCN) neurones in a hypothalamic slice preparation. Perforated-patch recordings were performed to prevent the rapid rundown of spontaneous firing rate as observed during whole cell recordi...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(01)00346-3

    authors: van den Top M,Buijs RM,Ruijter JM,Delagrange P,Spanswick D,Hermes ML

    更新日期:2001-01-01 00:00:00

  • Mechanisms of etomidate potentiation of GABAA receptor-gated currents in cultured postnatal hippocampal neurons.

    abstract::The effect of etomidate, an imidazole general anesthetic, on GABAA receptor function was studied in cultured hippocampal neurons. At a clinically relevant concentration of 4.1 microM, etomidate shifts the GABA dose response to the left (ED50 shift from 10.2 to 5.2 microM), with no change in the maximum current evoked ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(96)00018-8

    authors: Yang J,Uchida I

    更新日期:1996-07-01 00:00:00

  • A gamma34.5 mutant of herpes simplex 1 causes severe inflammation in the brain.

    abstract::A number of viral vectors are currently being evaluated as potential gene therapy vectors for gene delivery to the brain. As well as evaluating their ability to express a transgene for extended periods of time it is also essential to examine any cytotoxic immune response to such vectors as this may not only limit tran...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(97)00513-7

    authors: McMenamin MM,Byrnes AP,Charlton HM,Coffin RS,Latchman DS,Wood MJ

    更新日期:1998-04-01 00:00:00

  • Cathepsin G: localization in human cerebral cortex and generation of amyloidogenic fragments from the beta-amyloid precursor protein.

    abstract::Amyloid deposits in Alzheimer's disease, Down's syndrome and aged brain are composed largely of A beta protein, which is generated by proteolytic processing of beta-amyloid precursor protein. Proteases responsible for liberating the A beta protein from the precursor have not yet been identified. Here, we examined the ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(94)90490-1

    authors: Savage MJ,Iqbal M,Loh T,Trusko SP,Scott R,Siman R

    更新日期:1994-06-01 00:00:00

  • Expectancy for food or expectancy for chocolate reveals timing systems for metabolism and reward.

    abstract::The clock gene protein Per 1 (PER1) is expressed in several brain structures and oscillates associated with the suprachiasmatic nucleus (SCN). Restricted feeding schedules (RFS) induce anticipatory activity and impose daily oscillations of c-Fos and clock proteins in brain structures. Daily access to a palatable treat...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2008.06.001

    authors: Angeles-Castellanos M,Salgado-Delgado R,Rodríguez K,Buijs RM,Escobar C

    更新日期:2008-07-31 00:00:00

  • Synergistic activity between primary visual neurons.

    abstract::Cortical microcircuitry plays a pivotal role in encoding sensory information reaching the cortex. However, the fundamental knowledge concerning the mechanisms that govern feature-encoding by these sub-networks is still sparse. Here, we show through multi-electrode recordings in V1 of conventionally prepared anesthetiz...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2014.03.027

    authors: Bharmauria V,Bachatene L,Cattan S,Rouat J,Molotchnikoff S

    更新日期:2014-05-30 00:00:00

  • Ontogeny of cholecystokinin-8 containing neuron system of the rat: an immunohistochemical analysis--II. Lower brain stem.

    abstract::The ontogeny of the cholecystokinin-8 neuron system in the lower brain stem of the rat was investigated by means of indirect immunofluorescence. Cholecystokinin-8-like immunoreactive structures first appeared in the primordium of the ventral tegmental area, ventral tegmental nucleus of Gudden and the area lateral to t...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(83)90116-1

    authors: Kiyama H,Shiosaka S,Kubota Y,Cho HJ,Takagi H,Tateishi K,Hashimura E,Hamaoka T,Tohyama M

    更新日期:1983-12-01 00:00:00

  • Rationale for intrastriatal grafting of striatal neuroblasts in patients with Huntington's disease.

    abstract::Huntington's disease is a genetic disease, autosomal and dominant, that induces motor disorders, an inexorable deterioration of higher brain functions and psychiatric disturbances. At present, there are no known therapeutics against Huntington's disease. The Network of European CNS Transplantation and Restoration (NEC...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/0306-4522(95)00162-c

    authors: Peschanski M,Cesaro P,Hantraye P

    更新日期:1995-09-01 00:00:00

  • Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents.

    abstract::Leptin is well known to be involved in the control of feeding, reproduction and neuroendocrine functions through its action on the hypothalamus. However, leptin receptors are found in brain regions other than the hypothalamus (including the hippocampus and cerebral cortex) suggesting extrahypothalamic functions. We in...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(02)00162-8

    authors: Li XL,Aou S,Oomura Y,Hori N,Fukunaga K,Hori T

    更新日期:2002-01-01 00:00:00

  • Effects of microdialysis on brain metabolism in normal and seizure states.

    abstract::The effect of intracranial microdialysis on brain glucose metabolism in control and kainic acid-treated rats was assessed by semi-quantitative [14C]2-deoxyglucose autoradiography. A dialysis fiber loop was implanted into the piriform cortex or a horizontal Vita fiber into the hippocampus, and 24 h later, fibers were p...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(90)90200-n

    authors: Chastain JE Jr,Samson F,Nelson SR,Pazdernik TL

    更新日期:1990-01-01 00:00:00

  • Development of a water-escape motivated version of the Stone T-maze for mice.

    abstract::Mice provide a highly valuable resource for investigating learning and memory processes; however, many of the established tasks for evaluating learning and memory were developed for rats. Behaviors of mice in these tasks appear to be driven by different motivational factors, and as a result, they often do not perform ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2009.12.029

    authors: Pistell PJ,Ingram DK

    更新日期:2010-03-10 00:00:00

  • Double orientation tuning in the cat visual cortex units.

    abstract::Orientation tuning of 271 neurons of the cat visual cortex (area 17) was studied with a light bar flashing in the receptive field. Under different conditions, 27-57% of units were found to have double-orientation tuning: they demonstrated the main preferred orientation and an additional preferred orientation. The stat...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(94)90416-2

    authors: Shevelev IA,Lazareva NA,Novikova BV,Tikhomirov AS,Sharaev GA

    更新日期:1994-08-01 00:00:00

  • Distribution of the messenger RNA for the extracellularly regulated kinases 1, 2 and 3 in rat brain: effects of excitotoxic hippocampal lesions.

    abstract::Neurofibrillary tangles in Alzheimer's disease are composed of hyperphosphorylated forms of the microtubule-associated protein tau. Based on biochemical criteria, several enzymes have emerged as potential tau protein kinases, including the extracellularly regulated kinases 1, 2 and 3. In situ hybridization was used to...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(97)00014-6

    authors: Hollister RD,Page KJ,Hyman BT

    更新日期:1997-08-01 00:00:00

  • Peri-infarct flow transients predict outcome in rat focal brain ischemia.

    abstract::Spreading depolarizations are accompanied by transient changes in cerebral blood flow (CBF). In a post hoc analysis of previously studied control rats we analyzed CBF time courses after middle cerebral artery occlusion in the rat in order to test whether intra-ischemic flow, reperfusion, and different parameters of pe...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2012.08.049

    authors: Lückl J,Dreier JP,Szabados T,Wiesenthal D,Bari F,Greenberg JH

    更新日期:2012-12-13 00:00:00

  • White matter differences between multiple system atrophy (parkinsonian type) and Parkinson's disease: A diffusion tensor image study.

    abstract::The clinical differential diagnosis between the Parkinson variant of multiple system atrophy (MSA-P) and Parkinson's disease (PD) is difficult in early stages. To identify objective markers for differential diagnosis, we combined the novel tract-based spatial statistics (TBSS) and region of interest (ROI) analyses for...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2015.07.060

    authors: Ji L,Wang Y,Zhu D,Liu W,Shi J

    更新日期:2015-10-01 00:00:00

  • Topographical organization of the tecto-olivo-cerebellar projection in the cat.

    abstract::The superior colliculus sends a climbing fiber output to cerebellar vermal lobules VI-VII through the inferior olive. The present study in cats morphologically clarified the existence of a topographical organization in the tecto-olivo-cerebellar projection. A horseradish peroxidase study on the tecto-olivary projectio...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(91)90212-7

    authors: Kyuhou S,Matsuzaki R

    更新日期:1991-01-01 00:00:00

  • Vascular Endothelial Cell-derived Exosomes Protect Neural Stem Cells Against Ischemia/reperfusion Injury.

    abstract::Vascular endothelial cells were activated during acute ischemic brain injury, which could induce neural progenitor cell proliferation and migration. However, the mechanism was still unknown. In the current study, we explored whether vascular endothelial cells promoted neural progenitor cell proliferation and whether m...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2020.05.046

    authors: Zhou S,Gao B,Sun C,Bai Y,Cheng D,Zhang Y,Li X,Zhao J,Xu D

    更新日期:2020-08-10 00:00:00

  • Modification of extracellular matrix by enzymatic removal of chondroitin sulfate and by lack of tenascin-R differentially affects several forms of synaptic plasticity in the hippocampus.

    abstract::The extracellular matrix is a complex network of macromolecules including glycoproteins, polysaccharides and proteoglycans. Tenascin-R and chondroitin sulfate proteoglycans are essential components of hippocampal extracellular matrix co-localised in perineuronal nets on interneurons. Mutant mice deficient in expressio...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(01)00082-3

    authors: Bukalo O,Schachner M,Dityatev A

    更新日期:2001-01-01 00:00:00

  • Cytochemical localization of 5'-nucleotidase activity in retinal photoreceptor cells.

    abstract::Further cytochemical studies on the ultrastructural localization of 5'-nucleotidase in the rat retina have revealed activity to be associated with the complex synapses formed by the rod spherules of the receptors and the bipolar and horizontal cell processes. Activity was also seen on the axolemma of receptor fibers. ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(84)90196-9

    authors: Kreutzberg GW,Hussain ST

    更新日期:1984-04-01 00:00:00

  • Mast cell mediators excite the afferents of cat small intestine.

    abstract::The influence of intra-arterial injections of 5-hydroxytryptamine, histamine and prostaglandin E2 on afferent impulse activity of mesenteric nerves of small intestine was studied. In anaesthetized cats 5-hydroxytryptamine (10(-5)-10(-4) M) and histamine (10(-5)-10(-3) M) were shown to increase the impulse activity in ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(95)00479-3

    authors: Akoev GN,Filippova LV,Sherman NO

    更新日期:1996-04-01 00:00:00

  • Blockade of ionotropic quisqualate receptor desensitization in rat hippocampal neurons by wheatgerm agglutinin and other lectins.

    abstract::Previous experiments with wheatgerm agglutinin, an inhibitor of ionotropic quisqualate receptor desensitization, suggest that desensitization regulates quisqualate receptor-mediated synaptic transmission and excitotoxicity. Using whole-cell recordings from cultured postnatal rat hippocampal neurons, we have examined t...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(93)90179-j

    authors: Thio LL,Clifford DB,Zorumski CF

    更新日期:1993-01-01 00:00:00

  • Substance P modifies the 6-hydroxydopamine induced alteration of postnatal development of central noradrenaline neurons.

    abstract::Systemic treatment of new-born rats with the catecholamine neurotoxin 6-hydroxydopamine leads to a permanent and selective alteration of the postnatal development of the central noradrenaline neurons, in particular of the locus coeruleus system. The changes involve a pronounced and permanent degeneration of distant ne...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(82)90113-0

    authors: Jonsson G,Hallman H

    更新日期:1982-01-01 00:00:00

  • Long-term changes in striatal D1 dopamine receptor distribution after dopaminergic deafferentation.

    abstract::The morphochemical disposition of the adenylate cyclase-linked dopamine receptor (D1 type) in the rat striatum has been assessed at various time points after a neurotoxic lesion of the dopaminergic afferent pathway to the caudate nucleus. D1 receptor binding sites in the caudate nucleus were determined by in vitro aut...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(89)90119-x

    authors: Ariano MA

    更新日期:1989-01-01 00:00:00

  • Characterization of nicotinic receptors involved in the release of noradrenaline from the hippocampus.

    abstract::The pharmacological features of putative nicotinic acetylcholine receptor sites involved in the release of [3H]noradrenaline were assessed in rat hippocampus. The effect of nicotinic agonists to induce [3H]noradrenaline release was examined in superfused slices. The nicotinic agonists (-)-epibatidine, (+)-anatoxin-a, ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(96)00425-3

    authors: Sershen H,Balla A,Lajtha A,Vizi ES

    更新日期:1997-03-01 00:00:00