Glial cell line-derived neurotrophic factor (GDNF) expression and NMJ plasticity in skeletal muscle following endurance exercise.

abstract：:Interleukin-1 (IL-1) plays a crucial role in stress responses and its mRNA is induced in the brain by stress load; however, the precise role of IL-1 in higher brain functions and their abnormalities is largely unknown. Here, we report that IL-1 receptor antagonist (IL-1Ra) knockout (KO) mice, which lack IL-1Ra molecul...

journal_title：Neuroscience

authors： Wakabayashi C,Kiyama Y,Kunugi H,Manabe T,Iwakura Y

更新日期：2011-09-29 00:00:00

abstract：:The purpose of this paper is to study the effect of smilagenin (SMI) (PYM50028), a sapogenin compound originally identified from Chinese medicinal herb, on dopamine neurons and locomotor ability in aged rats. Experiments were carried out on young and aged Sprague-Dawley rats, which were daily administered with either ...

journal_title：Neuroscience

authors： Li J,Xia Z,Sun X,Zhang R,Huang G,Hickling R,Xia Z,Hu Y,Zhang Y

更新日期：2013-08-15 00:00:00

abstract：:I.c.v. injection of L-ornithine has been shown to have sedative and hypnotic effects on neonatal chicks exposed to acute stressful conditions. To clarify the mechanism, we conducted three experiments under strengthened stressful conditions with corticotropin-releasing factor (CRF). In Experiment 1, the effect of i.c.v...

journal_title：Neuroscience

authors： Kurata K,Shigemi K,Tomonaga S,Aoki M,Morishita K,Denbow DM,Furuse M

更新日期：2011-01-13 00:00:00

abstract：:The tachykinin NK3 receptor (NK3R) is a G-protein coupled receptor that is activated, internalized, and trafficked to the nuclei of magnocellular neurons in the paraventricular nucleus of the hypothalamus (PVN) in response to acute hyperosmolarity. The lack of information on the nuclear import pathway raises concerns ...

journal_title：Neuroscience

authors： Jensen DD,Sundstrom K,Flynn FW

更新日期：2010-11-10 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by selective vulnerability of specific neuronal populations within particular brain regions. For example, hippocampal glutamatergic cell populations within the CA1/subicular pyramidal cell fields have been found to be particularly vulnerable early in AD progression. In contras...

journal_title：Neuroscience

authors： Rissman RA,Mishizen-Eberz AJ,Carter TL,Wolfe BB,De Blas AL,Miralles CP,Ikonomovic MD,Armstrong DM

更新日期：2003-01-01 00:00:00

abstract：:Transient receptor potential vanilloid 1 (TRPV1), vanilloid 2 (TRPV2) and melastatin 8 (TRPM8) are thermosensitive cation channels expressed on primary sensory neurons. In contrast to TRPV1, which is present on nociceptive primary afferents and keratinocytes in human skin, less is known about the distribution of TRPV2...

journal_title：Neuroscience

authors： Axelsson HE,Minde JK,Sonesson A,Toolanen G,Högestätt ED,Zygmunt PM

更新日期：2009-09-15 00:00:00

abstract：:Both [3H]clonidine and [3H]idazoxan bind to alpha 2 adrenoceptors. The former also labels imidazoline receptors, and the latter non-adrenergic idazoxan binding sites. In order to investigate whether the imidazoline receptors and non-adrenergic idazoxan binding sites are identical, we compared the binding characteristi...

journal_title：Neuroscience

authors： De Vos H,Bricca G,De Keyser J,De Backer JP,Bousquet P,Vauquelin G

更新日期：1994-04-01 00:00:00

abstract：:The present studies were undertaken to determine whether the major electrophysiological characteristics of neostriatal neurons are altered during aging. The passive and active membrane properties of 130 neostriatal neurons obtained from young (three to five months, N = 65) and aged (24-26 months, N = 65) Fischer 344 r...

journal_title：Neuroscience

authors： Cepeda C,Lee N,Buchwald NA,Radisavljevic Z,Levine MS

更新日期：1992-11-01 00:00:00

abstract：:Oxidative stress is believed to be a major factor for the onset of Parkinson's disease (PD). In this study, we have investigated oxidative status in transgenic Drosophila model of PD. Our results revealed elevated levels of reactive oxygen species (ROS) and lipid peroxidation (LPO) in A30P and A53T α-synuclein PD mode...

journal_title：Neuroscience

authors： Jahromi SR,Haddadi M,Shivanandappa T,Ramesh SR

更新日期：2015-05-07 00:00:00

abstract：:Intracellular microelectrode recordings were used to examine the effects of the potassium channel blockers: 4-aminopyridine, a selective blocker of fast potassium conductances gKf1 and gKf2,13 and tetraethylammonium, a blocker of gKf1, gKf2 and the slow conductance gKs,13 on the repetitive activity of large myelinated...

journal_title：Neuroscience

authors： Poulter MO,Padjen AL

更新日期：1995-09-01 00:00:00

abstract：:The histopathological sequelae of parenteral administration of kainic acid were investigated in immature rats (3-35 days of age). The brains were fixed 1-14 days after the administration of kainate and the damage evaluated by means of argyrophylic (Fink-Heimer, Gallyas or Nauta-Gygax) and Nissl stains. In animals of l...

journal_title：Neuroscience

authors： Nitecka L,Tremblay E,Charton G,Bouillot JP,Berger ML,Ben-Ari Y

更新日期：1984-12-01 00:00:00

abstract：:Neuronal apoptosis plays important roles in the early brain injury after subarachnoid hemorrhage (SAH). This study first showed that inhibition of activating transcription factor 6 (ATF6) by apelin-13 could reduce endoplasmic reticulum (ER)-stress-mediated apoptosis and blood-brain-barrier (BBB) disruption after SAH. ...

journal_title：Neuroscience

authors： Xu W,Gao L,Li T,Zheng J,Shao A,Zhang J

更新日期：2018-09-15 00:00:00

abstract：:We have reported that hypoxia affects the hypothalamic-pituitary-adrenal (HPA) axis and behavior by driving the expression of central corticotropin-releasing hormone (CRH) and its receptors in adult mammals, and this effect is modulated by other factors. Here, we address whether or not intermittent hypoxia (IH) or res...

journal_title：Neuroscience

authors： Fan JM,Chen XQ,Jin H,Du JZ

更新日期：2009-04-10 00:00:00

abstract：:Long-term changes in synaptic transmission between neurons in the brain are considered the cellular basis of learning and memory. Over the last few decades, many studies have revealed that the precise order and timing of activity between pre- and post-synaptic cells ("spike-timing-dependent plasticity; STDP") is cruci...

journal_title：Neuroscience

authors： Fuenzalida M,Chiu CQ,Chávez AE

更新日期：2020-08-20 00:00:00

abstract：:Limb somatosensory signals modify the discharge of vestibular neurons and elicit postural reflexes, which stabilize the body position. The aim of this study was to investigate the contribution of the γ-amino-butyric-acid (GABA) to the responsiveness of vestibular neurons to somatosensory inputs. The activity of 128 ve...

journal_title：Neuroscience

authors： Grasso C,Li Volsi G,Cataldo E,Manzoni D,Barresi M

更新日期：2016-10-29 00:00:00

abstract：:Activation of the adenosine A(2A) receptor (A(2A)R) at the time of reperfusion has been shown to reduce ischemia-reperfusion injury in peripheral tissues and spinal cord. In this study we show that treating mice with the A(2A)R agonist, 4-{3-[6-amino-9-(5-cyclopropylcarbamoyl-3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-pu...

journal_title：Neuroscience

authors： Li Y,Oskouian RJ,Day YJ,Rieger JM,Liu L,Kern JA,Linden J

更新日期：2006-09-15 00:00:00

abstract：:During spinal cord maturation neuronal excitability gradually differentiates to meet different functional demands. Spontaneous activity, appearing early during spinal development, is regulated by the expression pattern of ion channels in individual neurons. While emerging excitability of embryonic motoneurons has been...

journal_title：Neuroscience

authors： Furlan F,Guasti L,Avossa D,Becchetti A,Cilia E,Ballerini L,Arcangeli A

更新日期：2005-01-01 00:00:00

abstract：:Despite high levels of use, the mechanism of action of effective pharmacotherapies in attention deficit hyperactivity disorder (ADHD) is unknown. It has recently been hypothesized that one site of therapeutic action is the midbrain superior colliculus, a structure traditionally associated with visual processing, but a...

journal_title：Neuroscience

authors： Dommett EJ,Overton PG,Greenfield SA

更新日期：2009-12-15 00:00:00

abstract：:The glomeruli are the first synaptic relay on the olfactory pathway and play a basic role in smell perception. Glomerular degeneration occurs in humans with age and in Alzheimer's disease (AD). The glomeruli heavily express β-amyloid precursor protein (APP), β-secretase (BACE1) and γ-secretase complex. However, extrac...

journal_title：Neuroscience

authors： Cai Y,Xue ZQ,Zhang XM,Li MB,Wang H,Luo XG,Cai H,Yan XX

更新日期：2012-07-26 00:00:00

abstract：:The development of the catecholaminergic system in the hypothalamus and in the septal region was studied in rats from the 12th fetal day until the 9th postnatal day. Catecholaminergic structures were visualized with pre-embedding immunocytochemistry using antiserum to tyrosine hydroxylase. An intensification of diamin...

journal_title：Neuroscience

authors： Ugrumov MV,Taxi J,Tixier-Vidal A,Thibault J,Mitskevich MS

更新日期：1989-01-01 00:00:00

abstract：:In the present study, we used co-culture of astrocytes from one species with neurons from a different species to examine neuritic outgrowth. We include a focus on human cells. Three types of neuron were used, including rat hippocampal dentate granule cells, rat hypothalamic neurons and human cortical neurons. To visua...

journal_title：Neuroscience

authors： van den Pol AN,Spencer DD

更新日期：2000-01-01 00:00:00

abstract：:When adult dorsal root ganglion cells are dissociated and maintained in vitro, both the small dark and the large light neurons show increases in the growth-associated protein GAP-43, a membrane phosphoprotein associated with neuronal development and plasticity. Immunoreactivity for GAP-43 appears in the cytoplasm of t...

journal_title：Neuroscience

authors： Woolf CJ,Reynolds ML,Molander C,O'Brien C,Lindsay RM,Benowitz LI

更新日期：1990-01-01 00:00:00

abstract：:Changes in the distribution of muscarinic acetylcholine receptor-immunoreactive neurons were examined in the amygdaloid complex at different time-intervals following a single training session of active shock avoidance in a two-way shuttle-box. Muscarinic acetylcholine receptors were visualized using M35, a monoclonal ...

journal_title：Neuroscience

authors： Roozendaal B,van der Zee EA,Hensbroek RA,Maat H,Luiten PG,Koolhaas JM,Bohus B

更新日期：1997-01-01 00:00:00

abstract：:Extinction of drug-seeking is an integral part of addiction treatment, and can profoundly reverse or ameliorate the harmful consequences of drug use. These consequences may be the most deleterious during adolescence. The studies presented here build from recent evidence that adolescent rats are more resistant to extin...

journal_title：Neuroscience

authors： Brenhouse HC,Dumais K,Andersen SL

更新日期：2010-08-25 00:00:00

abstract：:The dorsal portion of the nucleus submedius of the rat thalamus receives spinal and trigeminal projections which may convey noxious inputs. The present study was undertaken to analyse the fine structure of the nucleus with particular reference to a possible trigemino-thalamo-prefrontal cortical pathway relaying in nuc...

journal_title：Neuroscience

authors： Ma W,Peschanski M,Ohara PT

更新日期：1988-07-01 00:00:00

abstract：:The distribution of axoplasmic organelles at consecutive nodes of Ranvier was investigated light- and electronmicroscopically in horseradish peroxidase-transporting muscle nerve fibres of the adult cat. Three main and apparently temporally interrelated distribution patterns were noted. These patterns were referred to ...

journal_title：Neuroscience

authors： Berthold CH,Mellström A

更新日期：1986-12-01 00:00:00

abstract：:It has recently been demonstrated that alpha-bungarotoxin receptors, which behave as functional nicotinic receptors, are present in chick CNS. In this paper, we report the purification and characterization of a functional alpha-bungarotoxin receptor from chick cerebellum, a nervous tissue in which a clear inhibition o...

journal_title：Neuroscience

authors： Gotti C,Hanke W,Schlue WR,Briscini L,Moretti M,Clementi F

更新日期：1992-09-01 00:00:00

abstract：:Non-synaptic transmission is pervasive throughout the nervous system. It appears especially prevalent in peripheral ganglia, where non-synaptic interactions between neighboring cell bodies have been described in both physiological and pathological conditions, a phenomenon referred to as cross-depolarization (CD) and t...

journal_title：Neuroscience

authors： Carvalho GB,Mulpuri Y,Damasio A,Spigelman I

更新日期：2019-12-15 00:00:00

abstract：:To evaluate the potential for lipofectin-mediated central nervous system gene transfer, the plasmid coding for cholecystokinin was administered intracerebroventricularly to rats, which have congenital audiogenic seizures and high responses to peripheral electric stimulation-induced analgesia. Previous studies had show...

journal_title：Neuroscience

authors： Zhang LX,Li XL,Smith MA,Post RM,Han JS

更新日期：1997-03-01 00:00:00

abstract：:Delivering effective commands in the nervous systems require a temporal integration of neural activities such as synchronous firing. Although sympathetic nerve discharges are characterized by synchronous firing, its temporal structures and how it is modulated are largely unknown. This study used a collagenase-dissocia...

journal_title：Neuroscience

authors： Su CK

更新日期：2016-01-15 00:00:00