Abstract：
:Despite high levels of use, the mechanism of action of effective pharmacotherapies in attention deficit hyperactivity disorder (ADHD) is unknown. It has recently been hypothesized that one site of therapeutic action is the midbrain superior colliculus, a structure traditionally associated with visual processing, but also strongly implicated in distractibility, a core symptom of ADHD. We used male juvenile Wistar rats to examine the effects of therapeutically relevant doses of methylphenidate and d-amphetamine on collicular activity in vitro. Here we report a novel shared mechanism of the two drugs whereby they enhance the signal-to-noise ratio in the superior colliculus. The effects on the signal-to-noise ratio were mediated by serotonin (5-HT) via a pre-synaptic mechanism. This modulatory action would bias the system towards salient events and lead to an overall decrease in distractibility.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Dommett EJ,Overton PG,Greenfield SAdoi
10.1016/j.neuroscience.2009.09.007subject
Has Abstractpub_date
2009-12-15 00:00:00pages
1369-76issue
3eissn
0306-4522issn
1873-7544pii
S0306-4522(09)01483-3journal_volume
164pub_type
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