11beta-Hydroxysteroid dehydrogenase type 2 protects the neonatal cerebellum from deleterious effects of glucocorticoids.

abstract：:The presence of subgroups in vomeronasal sensory neurons has been known in various animals. To elucidate possible functional subdivisions in the guinea-pig accessory olfactory bulb, the combined studies with GTP-binding protein immunohistochemistry, electrophysiological and optical recordings were carried out. Gi2 alp...

journal_title：Neuroscience

authors： Sugai T,Sugitani M,Onoda N

更新日期：1997-08-01 00:00:00

abstract：:Explants of anterior, intermediate and posterior pituitary lobes of rats at various ages evoked an intense nerve fibre outgrowth when co-cultured with neonatal sympathetic superior cervical ganglia in a collagen gel medium. Freezing and thawing of pituitary lobes, prior to culture, did not abolish their growth-promoti...

journal_title：Neuroscience

authors： Lahtinen T,Soinila S,Lakshmanan J

更新日期：1989-01-01 00:00:00

abstract：:An increase of extracellular dopamine (DA) has been implicated in the psychostimulant properties of 3,4-methylenedioxymethamphetamine (MDMA). Although this drug has been reported to affect the DA uptake transporter (DAT), it might activate other mechanisms to regulate the outflow of DA in the brain. Our aim was to exa...

journal_title：Neuroscience

authors： Rizzo FR,Federici M,Mercuri NB

更新日期：2018-05-01 00:00:00

abstract：:Converging evidence in schizophrenia suggests prefrontal cortical neuronal deficits that correlate with exaggerated subcortical dopamine (DA) functions: Excitotoxic lesion of the ventral hippocampus (VH) in neonatal rats is widely considered a putative animal model of schizophrenia as they lead to characteristic post-...

journal_title：Neuroscience

authors： Bhardwaj SK,Beaudry G,Quirion R,Levesque D,Srivastava LK

更新日期：2003-01-01 00:00:00

abstract：:The visual word form area (VWFA) has been consistently identified as a crucial structure in visual word processing. Nevertheless, it is controversial whether the VWFA represents external visual information (e.g., case information) of visual words. To address that question, we functionally localized VWFA at the group l...

journal_title：Neuroscience

authors： Lu C,Li H,Fu R,Qu J,Yue Q,Mei L

更新日期：2021-01-01 00:00:00

abstract：:Transient global ischemia results in delayed selective neuronal death of hippocampal CA1 pyramidal cells. Glucocorticoids increase and adrenalectomy decreases the rate of neuronal death; however, they also produce changes in brain temperature, serum glucose and adrenocorticotropic hormone levels. In order to understan...

journal_title：Neuroscience

authors： Antonawich FJ,Miller G,Rigsby DC,Davis JN

更新日期：1999-01-01 00:00:00

abstract：:Expression of calcium channel alpha1 subunits in oocytes or cell lines has proven to be a powerful method in the analysis of structure-function relations, but these experimental systems are of limited value in the examination of neuron-specific functions such as transmitter release. Cell lines derived from neurons are...

journal_title：Neuroscience

authors： Gottschalk W,Kim DS,Chin H,Stanley EF

更新日期：1999-01-01 00:00:00

abstract：:Acetylcholine (ACh) plays important roles in the modulation of activity and plasticity of primary sensory cortices, thus influencing sensory detection and integration. We examined this in urethane-anesthetized rats, comparing cholinergic modulation of short latency, large amplitude field postsynaptic potentials (fPSPs...

journal_title：Neuroscience

authors： Kuo MC,Rasmusson DD,Dringenberg HC

更新日期：2009-09-29 00:00:00

abstract：:Compulsive drug abuse has been conceptualized as a behavioral state where behavioral stimuli override normal decision making. Clinical studies of methamphetamine users have detailed decision making changes and imaging studies have found altered metabolism and activation in the parietal cortex. To examine the molecular...

journal_title：Neuroscience

authors： Bowyer JF,Pogge AR,Delongchamp RR,O'Callaghan JP,Patel KM,Vrana KE,Freeman WM

更新日期：2007-01-05 00:00:00

abstract：:Inside-out patch recordings from rat acutely dissociated cerebral cortical neurons revealed time and voltage-dependent activity of a large-conductance calcium-activated potassium channel. Channel activity inactivated within minutes following a depolarizing voltage step, and was recovered from inactivation by membrane ...

journal_title：Neuroscience

authors： Smith MA,Ashford ML

更新日期：2000-01-01 00:00:00

abstract：:Basic fibroblast growth factor is expressed in different isoforms which display tissue and species specificity and are differentially regulated during development and after experimental interventions. The differential regulation of the fibroblast growth factor-2 isoforms may indicate specific activities and functions ...

journal_title：Neuroscience

authors： Grothe C,Schulze A,Semkova I,Müller-Ostermeyer F,Rege A,Wewetzer K

更新日期：2000-01-01 00:00:00

abstract：:Neuronal differentiation is a critical developmental process that determines accurate synaptic connection and circuit wiring. A wide variety of naturally occurring compounds have been shown as promising drug leads for the generation and differentiation of neurons. Here we report that a diarylheptanoid from the plant A...

journal_title：Neuroscience

authors： Tang G,Dong X,Huang X,Huang XJ,Liu H,Wang Y,Ye WC,Shi L

更新日期：2015-09-10 00:00:00

abstract：:Acetylcholinesterase is released from both axon terminals and dendrites of nigrostriatal neurons. The relationship of this phenomenon to: (1) activation of receptors, and (2) firing rate, has been examined. In the first series of experiments, apomorphine or acetylcholine were infused into substantiae nigrae of urethan...

journal_title：Neuroscience

authors： Weston J,Greenfield SA

更新日期：1986-04-01 00:00:00

abstract：:The distribution of seven different binding sites for the transmitters L-glutamate (L-glutamate binding sites and N-methyl-D-aspartate receptor), GABA (GABAA receptor), noradrenaline (alpha 1 receptor), acetylcholine (muscarinic M1 and M2 receptors) and serotonin (5-hydroxytryptamine1 receptor) are analysed in the pri...

journal_title：Neuroscience

authors： Gebhard R,Zilles K,Schleicher A,Everitt BJ,Robbins TW,Divac I

更新日期：1993-10-01 00:00:00

abstract：:Six human fetuses of gestational ages 16-28 weeks were employed. The immunocytochemical avidin-biotin-peroxidase complex method combined with the silver Bodian technique was used to evaluate the presence of tyrosine hydroxylase and dopamine-beta-hydroxylase neurons and afferent and efferent fibres in the cerebellum du...

journal_title：Neuroscience

authors： Yew DT,Luo CB,Shen WZ,Chow PH,Zheng DR,Yu MC

更新日期：1995-03-01 00:00:00

abstract：:Migraine attacks are typically described as unilateral, throbbing pain that is usually accompanied by nausea, vomiting, and exaggerated sensitivities to light, noise and smell. The headache phase of a migraine attack is mediated by activation of the trigeminovascular pathway; a nociceptive pathway that originates in t...

journal_title：Neuroscience

authors： Kagan R,Kainz V,Burstein R,Noseda R

更新日期：2013-09-17 00:00:00

abstract：:Incubation of PC12 cells with S-100 protein induces a rapid (0.5-1.0 min) rise of intracellular Ca2+ which lasts for the whole period of incubation. This effect is abolished in a Ca(2+)-free medium or in the presence of 1.0 microM Ni2+, an inhibitor of calcium channels. The rise in intracellular Ca2+ is followed by a ...

journal_title：Neuroscience

authors： Mariggió MA,Fulle S,Calissano P,Nicoletti I,Fanó G

更新日期：1994-05-01 00:00:00

abstract：:The effects of muscarinic agonists on GABAergic synaptic transmission were examined using whole-cell patch-clamp recording in chick brain slices containing the lateral spiriform nucleus. Bath application of muscarine (10 microM) both increased the frequency of spontaneous GABAergic postsynaptic currents and reduced th...

journal_title：Neuroscience

authors： Guo J,Chiappinelli VA

更新日期：2001-01-01 00:00:00

abstract：:The main neuronal population of the striatum is composed of the medium spiny neurones (MSNs). In fact several sub-populations of MSNs can be distinguished according to the striatal compartment (striosomes and matrix) to which they belong, their afferents and their sites of projection, their biochemical markers and the...

journal_title：Neuroscience

authors： Venance L,Glowinski J

更新日期：2003-01-01 00:00:00

abstract：:Opioid binding sites were localized in cryostat sections of guinea-pig brain by in vitro autoradiography using (-)-[3H]bremazocine. Quantification of binding sites in gray matter was accomplished using standard samples of tritium mixed in brain gray matter. The binding sites in fiber tracts were quantified using stand...

journal_title：Neuroscience

authors： Foote RW

更新日期：1987-01-01 00:00:00

abstract：:Repeated nonreinforced preexposure to a stimulus interferes with the establishment of conditioned responding to this stimulus when it is subsequently paired with reinforcement. This stimulus-preexposure effect is known as latent inhibition (LI). Rather remarkably, LI appears to be resistant to the effects of numerous ...

journal_title：Neuroscience

authors： Schiller D,Weiner I

更新日期：2004-01-01 00:00:00

abstract：:Neurons containing melanin-concentrating hormone (MCH) in the lateral hypothalamic area (LH) have been shown to promote rapid eye movement sleep (REMs) in mice. However, the downstream neural pathways through which MCH neurons influence REMs remained unclear. Because MCH neurons are considered to be primarily inhibito...

journal_title：Neuroscience

authors： Kroeger D,Bandaru SS,Madara JC,Vetrivelan R

更新日期：2019-05-15 00:00:00

abstract：:There is a consensus that active (REM) sleep (AS) is controlled by cholinergic projections from the laterodorsal and pedunculopontine tegmental nuclei (LDT/PPT) to neurons in the nucleus pontis oralis (NPO) that generate AS (i.e. AS-Generator neurons). The present study was designed to provide evidence that other proj...

journal_title：Neuroscience

authors： Xi M,Fung SJ,Sampogna S,Chase MH

更新日期：2011-12-01 00:00:00

abstract：:The amyloid beta precursor protein can exist as both a membrane-bound and a secreted protein, with the former having the potential to generate the amyloid beta peptide present in the neuritic plaques which are characteristic of Alzheimer's disease. In this study, we have used a clone of the AtT20 mouse pituitary cell ...

journal_title：Neuroscience

authors： McFarlane I,Georgopoulou N,Coughlan CM,Gillian AM,Breen KC

更新日期：1999-04-01 00:00:00

abstract：:The neural correlates of consciousness are largely unknown but many neural circuits are likely to be involved. Our experiments with mice that cannot synthesize dopamine suggest that dopamine signaling is a critical component necessary for the expression of consciousness. Although dopamine-deficient mice are awake and ...

journal_title：Neuroscience

authors： Palmiter RD

更新日期：2011-12-15 00:00:00

abstract：:The 5-HT(2A) serotonin receptor represents an important molecular target for atypical antipsychotic drugs and for most hallucinogens. In the mammalian cerebral cortex, 5-HT(2A) receptors are enriched in pyramidal neurons, within which 5-HT(2A) receptors are preferentially sorted to the apical dendrites. In primary cor...

journal_title：Neuroscience

authors： Xia Z,Hufeisen SJ,Gray JA,Roth BL

更新日期：2003-01-01 00:00:00

abstract：:A previously developed model of exercise-induced muscle contracture using iodoacetate to inhibit glyceraldehyde-3-phosphate dehydrogenase in rat hindlimb muscles produced selective type II myofiber damage. Utilizing a modification of the same model system, rats were given intra-aortic ortho-iodosobenzoic acid (700 nmo...

journal_title：Neuroscience

authors： Locklear I,Feeback DL,Brumback RA

更新日期：1990-01-01 00:00:00

abstract：:Inter-limb reflexes play an important role in coordinating behaviors involving different limbs. Previous studies have demonstrated that human elbow muscles express an inter-limb stretch reflex at long-latency (50-100 ms), a timing consistent with a trans-cortical linkage. Here we probe for inter-limb stretch reflexes ...

journal_title：Neuroscience

authors： Muraoka T,Kurtzer I

更新日期：2020-04-01 00:00:00

abstract：:It has recently been reported that the degeneration of retinal ganglion cells induced by transection of the optic nerve in the neonatal rat is due to an active process of apoptosis, as opposed to passive necrosis. Here we tested whether the administration of the trophic factor nerve growth factor could prevent the apo...

journal_title：Neuroscience

authors： Rabacchi SA,Ensini M,Bonfanti L,Gravina A,Maffei L

更新日期：1994-12-01 00:00:00

abstract：:In partially denervated skeletal muscle, spared motor fibres sprout, enlarging motor unit size. Neuritogenesis and sprouting are known to depend on the synaptic input to the neurons. This suggests that spared motoneuron reaction to partial muscle denervation might be controlled by primary sensory neurons which directl...

journal_title：Neuroscience

authors： Cuppini R,Ambrogini P,Sartini S

更新日期：1998-05-01 00:00:00