Spinal Circuits Mediate a Stretch Reflex Between the Upper Limbs in Humans.

Abstract:

:Inter-limb reflexes play an important role in coordinating behaviors involving different limbs. Previous studies have demonstrated that human elbow muscles express an inter-limb stretch reflex at long-latency (50-100 ms), a timing consistent with a trans-cortical linkage. Here we probe for inter-limb stretch reflexes in the shoulder muscles of human participants. Unexpected torque pulses displaced one or both shoulders while participants adopted a steady posture against background torques. The results demonstrated inter-limb stretch reflexes occurring at short-latency for both shoulder extensors and flexors; the rapid timing (36-50 ms) must involve a spinal linkage for the two arms. Inter-limb stretch reflexes were also observed at long-latency yet they were opposite to the preceding short-latency; when the short-latency stretch reflex was excitatory then the long-latency stretch reflex was inhibitory and vice versa. Comparing the responses to contralateral arm displacement to those during simultaneous displacement of both arms revealed that inhibitory inter-limb stretch reflexes are independent of within-limb stretch reflexes, but that excitatory inter-limb stretch reflexes are suppressed by within-limb stretch reflexes. Our results provide the first demonstration of short-latency inter-limb stretch reflexes in the upper limb of humans and reveal interacting spinal circuits for within-limb and inter-limb stretch reflexes.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Muraoka T,Kurtzer I

doi

10.1016/j.neuroscience.2020.02.007

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

115-127

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(20)30093-2

journal_volume

431

pub_type

杂志文章
  • Astrocyte-mediated metaplasticity in the hippocampus: Help or hindrance?

    abstract::For over two decades it has been increasingly appreciated that synaptic plasticity mechanisms are subject to activity-dependent metaplastic regulation. In recent years it has also become apparent that astrocytes are active partners with neurons at synapses, and have the capability to powerfully regulate synaptic plast...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2015.08.035

    authors: Jones OD

    更新日期:2015-11-19 00:00:00

  • Dietary cholesterol increases ventricular volume and narrows cerebrovascular diameter in a rabbit model of Alzheimer's disease.

    abstract::Using structural magnetic resonance imaging in a clinical scanner at 3.0T, we describe results showing that following 12weeks on a diet of 2% cholesterol, rabbits experience a significant increase in the volume of the third ventricle compared to rabbits on a diet of 0% cholesterol. Using time-of-flight magnetic resona...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2013.09.015

    authors: Schreurs BG,Smith-Bell CA,Lemieux SK

    更新日期:2013-12-19 00:00:00

  • Involvement of the α7-nicotinic acetylcholine receptors in the anti-inflammatory action of the thymulin-related peptide (PAT).

    abstract:BACKGROUND AND PURPOSE:Peptide analog of thymulin (PAT) has been shown to have anti-hyperalgesic and anti-inflammatory properties in animal models of inflammation. Recent reports suggest that the peripheral cholinergic system has an anti-inflammatory role mediated by α7-nicotinic acetylcholine receptor (α7-nAChR). Our ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2013.07.031

    authors: Safieh-Garabedian B,Oz M,Bey RM,Shamaa F,Ashoor A,El-Agnaf OM,Saadé NE

    更新日期:2013-10-10 00:00:00

  • Fine structural changes in the superior cervical ganglion of adult rats after long-term administration of baclofen, a GABAB receptor agonist.

    abstract::The aim of the present study was to examine the fine structural changes in the superior cervical ganglion of adult rats following baclofen treatment. On the addition of this GABAB receptor agonist there was a transient increase in the number of coated vesicles and pits in the dendrites of principal sympathetic neurons...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(90)90365-b

    authors: Parducz A,Joó F,Siklós L,Wolff JR

    更新日期:1990-01-01 00:00:00

  • Time acts as a conditioned stimulus to control behavioral sensitization to amphetamine in rats.

    abstract::Repeated exposure to the psychostimulant drug, amphetamine, results in a persistent increase in the ability of the drug to elicit behavioral activation.(14,19) The development of sensitized responses to amphetamine involves long-lasting neuroadaptations within defined circuitry.(3,6,12,15,23) The behavioral expression...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/s0306-4522(00)00401-2

    authors: Arvanitogiannis A,Sullivan J,Amir S

    更新日期:2000-01-01 00:00:00

  • Muscarinic M(2) acetylcholine receptor distribution in the guinea-pig gastrointestinal tract.

    abstract::In the enteric nervous system, acetylcholine is the most common neurotransmitter to induce gastrointestinal smooth muscle contractions. Cholinergic signaling is mediated by muscarinic acetylcholine receptors on the surface of smooth muscle cells. Five different muscarinic receptor subtypes (M(1)-M(5)) have been identi...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2005.11.021

    authors: Iino S,Nojyo Y

    更新日期:2006-01-01 00:00:00

  • A functional alpha-bungarotoxin receptor is present in chick cerebellum: purification and characterization.

    abstract::It has recently been demonstrated that alpha-bungarotoxin receptors, which behave as functional nicotinic receptors, are present in chick CNS. In this paper, we report the purification and characterization of a functional alpha-bungarotoxin receptor from chick cerebellum, a nervous tissue in which a clear inhibition o...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(92)90386-g

    authors: Gotti C,Hanke W,Schlue WR,Briscini L,Moretti M,Clementi F

    更新日期:1992-09-01 00:00:00

  • OSO paradigm--A rapid behavioral screening method for acute psychosocial stress reactivity in mice.

    abstract::Chronic psychosocial stress is an important environmental risk factor for the development of psychiatric diseases. However, studying the impact of chronic psychosocial stress in mice is time consuming and thus not optimally suited to 'screen' increasing numbers of genetically manipulated mouse models for psychiatric e...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2015.11.043

    authors: Brzózka MM,Unterbarnscheidt T,Schwab MH,Rossner MJ

    更新日期:2016-02-09 00:00:00

  • Nicotine-induced alterations in the expression of nicotinic receptors in primary cultures from human prenatal brain.

    abstract::The nicotinic receptor proteins and gene transcripts for the different nicotinic receptor subunits exist in human prenatal brain already at 4-5 weeks of gestation. The early presence of nicotinic receptors suggests an important role for these receptors in modulating dendritic outgrowth, establishment of neuronal conne...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(01)00209-3

    authors: Hellström-Lindahl E,Seiger A,Kjaeldgaard A,Nordberg A

    更新日期:2001-01-01 00:00:00

  • Induction and selective accumulation of mutant ubiquitin in CA1 pyramidal neurons after transient global ischemia.

    abstract::Accumulation of mutant ubiquitin-B (UBB(+1)) in neurons is considered the hallmark of proteasomal dysfunction in neurodegenerative disorders, however no such evidence in ischemic brain has been reported. We investigated the contribution of UBB(+1) in delayed neuronal death after transient global ischemia. Transient gl...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2007.03.048

    authors: Yamashiro K,Liu R,Maeda M,Hattori N,Urabe T

    更新日期:2007-06-15 00:00:00

  • Diurnal pattern of clock gene expression in the hypothalamus of the newborn rabbit.

    abstract::In the European rabbit (Oryctolagus cuniculus) nursing acts as a strong non-photic synchronizer of circadian rhythmicity in the newborn young. Rabbits only nurse for a few minutes once every 24 h and previous studies have shown that the pups, blind at birth, display endogenous circadian rhythms in behavior and physiol...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2006.09.020

    authors: Caldelas I,Tejadilla D,González B,Montúfar R,Hudson R

    更新日期:2007-01-19 00:00:00

  • Immunolocalization of ecto-nucleoside triphosphate diphosphohydrolase 3 in rat brain: implications for modulation of multiple homeostatic systems including feeding and sleep-wake behaviors.

    abstract::Three anti-peptide antisera were raised against three distinct amino acid sequences of ecto-nucleoside triphosphate diphosphohydrolase 3 (NTPDase3), characterized by Western blot analyses, and used to determine the distribution of NTPDase3 protein in adult rat brain. The three antisera all yielded similar immunolocali...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2005.08.086

    authors: Belcher SM,Zsarnovszky A,Crawford PA,Hemani H,Spurling L,Kirley TL

    更新日期:2006-01-01 00:00:00

  • Calcineurin (protein phosphatase 2B) is involved in the mechanisms of action of antidepressants.

    abstract::Calcineurin (PP2B) is a Ca(2+)-dependent protein phosphatase enriched in the brain that takes part in intracellular signaling pathways regulating synaptic plasticity and neuronal functions. Calcineurin-dependent pathways are important for complex brain functions such as learning and memory. More recently, they have be...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2006.11.030

    authors: Crozatier C,Farley S,Mansuy IM,Dumas S,Giros B,Tzavara ET

    更新日期:2007-02-23 00:00:00

  • Polarization of primary afferent terminals of lumbosacral cord elicited by the activity of spinal locomotor generator.

    abstract::The changes of electrical polarization of primary afferent terminals in the lumbosacral spinal cord have been investigated on immobilized, decorticated and spinal cats during fictive locomotion. Fictive locomotion was spontaneous or provoked by stimulation of either dorsal root or dorsal funiculi in the lumbar segment...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(82)90253-6

    authors: Bayev KV,Kostyuk PG

    更新日期:1982-06-01 00:00:00

  • Amphetamine-induced increase in motor activity is correlated with higher firing rates of non-dopamine neurons in substantia nigra and ventral tegmental area.

    abstract::The responses of non-dopamine neurons in substantia nigra and ventral tegmental area to systemic amphetamine were investigated in the behaving rat chronically implanted with multiple fine-wire electrodes. The neurons were identified with electrophysiological criteria requiring that the signals be of biphasic shape, sh...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(88)90343-0

    authors: Olds ME

    更新日期:1988-02-01 00:00:00

  • Rostral ventromedial medulla and the control of cutaneous vasoconstrictor activity following i.c.v. prostaglandin E(1).

    abstract::Neurones within the rostral ventromedial medulla project to the intermediolateral cell column of the spinal cord where they may influence sympathetic preganglionic neuronal activity controlling cutaneous vascular beds. Here we assess whether such neurones contribute to cutaneous sympathetic vasoconstrictor activity in...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2003.12.019

    authors: Korsak A,Gilbey MP

    更新日期:2004-01-01 00:00:00

  • PI3K/Akt and NF-κB activation following intravitreal administration of 17β-estradiol: neuroprotection of the rat retina from light-induced apoptosis.

    abstract::The neuroprotective role of 17β-estradiol is well known; however, its mechanism of action remains unclear. In the present study, we applied light-induced apoptosis on the Sprague-Dawley rat retina to determine the neuroprotective effect of intravitreal administration of 17β-estradiol on retinal neurons and to demonstr...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2012.10.002

    authors: Mo MS,Li HB,Wang BY,Wang SL,Zhu ZL,Yu XR

    更新日期:2013-01-03 00:00:00

  • Synaptic excitation in the dorsal nucleus of the lateral lemniscus: whole-cell patch-clamp recordings from rat brain slice.

    abstract::The synaptic events underlying the excitation of neurons in the rat's dorsal nucleus of the lateral lemniscus were studied by whole-cell patch-clamp recordings in a brain slice preparation of the auditory midbrain. Both current-clamp and voltage-clamp data were obtained with the brain slice submerged in artificial cer...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(96)00580-5

    authors: Fu XW,Brezden BL,Kelly JB,Wu SH

    更新日期:1997-06-01 00:00:00

  • Microbial genome dynamics in CNS pathogenesis.

    abstract::The balancing act between microbes and their host in commensal and disease states needs to be deciphered in order to fully treat and combat infectious diseases. The elucidation of microbial genome dynamics in each instance is therefore required. In this context, the major bacterial meningitis pathogens are Neisseria m...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2007.01.059

    authors: Davidsen T,Koomey M,Tønjum T

    更新日期:2007-04-14 00:00:00

  • Regulation of 1,4,5-IP3, 1,3,4,5-IP4 and IP6 binding sites following entorhinal cortex lesions in rat brain.

    abstract::A lesion of the entorhinal cortex produces a loss of more than 80% of the synapses in the outer molecular layer of the hippocampus in the rat. However, this synaptic loss is transient. Beginning a few days after denervation, new synapses are formed, virtually replacing the lost inputs within two months. Synaptic remod...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(94)90434-0

    authors: Parent A,Poirier J,Baccichet A,Quirion R

    更新日期:1994-08-01 00:00:00

  • Activation of state-regulating neurochemical systems in newborn and embryonic chicks.

    abstract::Coordinated activity in different sets of widely-projecting neurochemical systems characterize waking (W) and sleep (S). How and when this coordination is achieved during development is not known. We used embryos and newborns of a precocial bird species (chickens) to assess developmental activation in different neuroc...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2016.09.048

    authors: Chan A,Li S,Lee AR,Leung J,Yip A,Bird J,Godden KE,Martinez-Gonzalez D,Rattenborg NC,Balaban E,Pompeiano M

    更新日期:2016-12-17 00:00:00

  • Normalizing dopamine D2 receptor-mediated responses in D2 null mutant mice by virus-mediated receptor restoration: comparing D2L and D2S.

    abstract::D2 receptor null mutant (Drd2(-/-)) mice have altered responses to the rewarding and locomotor effects of psychostimulant drugs, which is evidence of a necessary role for D2 receptors in these behaviors. Furthermore, work with mice that constitutively express only the D2 receptor short form (D2S), as a result of genet...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2013.06.035

    authors: Neve KA,Ford CP,Buck DC,Grandy DK,Neve RL,Phillips TJ

    更新日期:2013-09-17 00:00:00

  • Chemically defined neuron groups and their subpopulations in the glomerular layer of the rat main olfactory bulb--II. Prominent differences in the intraglomerular dendritic arborization and their relationship to olfactory nerve terminals.

    abstract::In the glomerular layer of the rat main olfactory bulb, we previously reported three chemically defined interneuron groups: GABA-like immunoreactive, calretinin-immunoreactive and Calbindin-D28k-immunoreactive groups [Kosaka K. et al. (1995) Neurosci. Res. 23, 73-88]. In the present study, we analysed the structural f...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(96)00308-9

    authors: Kosaka K,Toida K,Margolis FL,Kosaka T

    更新日期:1997-02-01 00:00:00

  • Long-term changes in striatal D1 dopamine receptor distribution after dopaminergic deafferentation.

    abstract::The morphochemical disposition of the adenylate cyclase-linked dopamine receptor (D1 type) in the rat striatum has been assessed at various time points after a neurotoxic lesion of the dopaminergic afferent pathway to the caudate nucleus. D1 receptor binding sites in the caudate nucleus were determined by in vitro aut...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(89)90119-x

    authors: Ariano MA

    更新日期:1989-01-01 00:00:00

  • Trigeminal Pain Responses in Obese ob/ob Mice Are Modality-Specific.

    abstract::How obesity exacerbates migraine and other pain disorders remains unknown. Trigeminal nociceptive processing, crucial in migraine pathophysiology, is abnormal in mice with diet induced obesity. However, it is not known if this is also true in genetic models of obesity. We hypothesized that obese mice, regardless of th...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2019.06.043

    authors: Rossi HL,Raj NR,Marquez de Prado B,Kuburas A,Luu AKS,Barr GA,Recober A

    更新日期:2019-09-01 00:00:00

  • The major neurotransmitter systems in the basolateral amygdala and the ventral tegmental area mediate morphine-induced memory consolidation impairment.

    abstract::In the present study, we investigated the possible participation of the endocannabinoid system in the basolateral amygdala and N-methyl-d-aspartate (NMDA) or GABA-A receptor neurotransmission in the ventral tegmental area in the memory consolidation impairment induced by morphine administration. To measure memory form...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2017.03.036

    authors: Sharifi KA,Rezayof A,Torkaman-Boutorabi A,Zarrindast MR

    更新日期:2017-06-14 00:00:00

  • Porcine neural xenografts in the immunocompetent rat: immune response following grafting of expanded neural precursor cells.

    abstract::Intracerebral neural xenografts elicit a host immune response that results in their rapid rejection. This forms a key barrier to the therapeutic use of xenogeneic tissue transplantation for conditions such as Parkinson's disease. The current study sought to provide insight into the cellular components of donor cell su...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(01)00273-1

    authors: Armstrong RJ,Harrower TP,Hurelbrink CB,McLaughin M,Ratcliffe EL,Tyers P,Richards A,Dunnett SB,Rosser AE,Barker RA

    更新日期:2001-01-01 00:00:00

  • Interleukin-1 beta induces long-term increase of axonally transported opiate receptors and substance P.

    abstract::Interleukin-1 is known to exert pleiotropic effects in host defence mechanisms and in inflammation. Chronic pain, inflammation and interleukin-1 beta enhance the production of substance P. Recently, axonal transport of opiate receptors was found to increase in rat sciatic nerves in the model of Freund's adjuvant-induc...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(95)00106-s

    authors: Jeanjean AP,Moussaoui SM,Maloteaux JM,Laduron PM

    更新日期:1995-09-01 00:00:00

  • 5-HT(1B) receptor regulation of serotonin (5-HT) release by endogenous 5-HT in the substantia nigra.

    abstract::Axonal release of serotonin (5-hydroxytryptamine, 5-HT) in the CNS is typically regulated by presynaptic 5-HT autoreceptors. Release of 5-HT in substantia nigra pars reticulata (SNr), a principal output from the basal ganglia, has seemed an interesting exception to this rule. The SNr receives one of the highest densit...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2009.10.005

    authors: Threlfell S,Greenfield SA,Cragg SJ

    更新日期:2010-01-13 00:00:00

  • Kappa opioid binding sites in the dog cerebral cortex and spinal cord.

    abstract::In the dog cerebral cortex and spinal cord, [3H]bremazocine and [3H]U69593 both bound with high affinity to an apparent single population of binding sites under kappa-selective conditions. In the cortex similar Bmax values for both radioligands in the saturation studies and the high affinity of the kappa-selective age...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(89)90437-5

    authors: Hunter JC,Birchmore B,Woodruff R,Hughes J

    更新日期:1989-01-01 00:00:00