Spinal Circuits Mediate a Stretch Reflex Between the Upper Limbs in Humans.

Abstract:

:Inter-limb reflexes play an important role in coordinating behaviors involving different limbs. Previous studies have demonstrated that human elbow muscles express an inter-limb stretch reflex at long-latency (50-100 ms), a timing consistent with a trans-cortical linkage. Here we probe for inter-limb stretch reflexes in the shoulder muscles of human participants. Unexpected torque pulses displaced one or both shoulders while participants adopted a steady posture against background torques. The results demonstrated inter-limb stretch reflexes occurring at short-latency for both shoulder extensors and flexors; the rapid timing (36-50 ms) must involve a spinal linkage for the two arms. Inter-limb stretch reflexes were also observed at long-latency yet they were opposite to the preceding short-latency; when the short-latency stretch reflex was excitatory then the long-latency stretch reflex was inhibitory and vice versa. Comparing the responses to contralateral arm displacement to those during simultaneous displacement of both arms revealed that inhibitory inter-limb stretch reflexes are independent of within-limb stretch reflexes, but that excitatory inter-limb stretch reflexes are suppressed by within-limb stretch reflexes. Our results provide the first demonstration of short-latency inter-limb stretch reflexes in the upper limb of humans and reveal interacting spinal circuits for within-limb and inter-limb stretch reflexes.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Muraoka T,Kurtzer I

doi

10.1016/j.neuroscience.2020.02.007

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

115-127

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(20)30093-2

journal_volume

431

pub_type

杂志文章
  • Basal forebrain and cerebral cortical muscarinic receptors mediate increase in cortical blood flow provoked by periaqueductal gray matter.

    abstract::The midbrain periaqueductal gray matter has been identified as a reflex centre located uppermost in the central organization of diverse defensive reactions. We recently found that when activated, the caudal third of the lateral periaqueductal gray was also capable of provoking a marked increase in cortical blood flow....

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(96)00705-1

    authors: Nakai M,Ogata J,Fukui K,Nakai Y,Maeda M

    更新日期:1997-07-01 00:00:00

  • Nuclear factor kappaB activation by muscarinic receptors in astroglial cells: effect of ethanol.

    abstract::Activation of muscarinic receptors leads to proliferation of astroglial cells and this effect is inhibited by ethanol. Among the intracellular pathways involved in the mitogenic action of muscarinic agonists, activation of the atypical protein kinase C zeta (PKC zeta) appears to be of most importance, and is also affe...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(03)00401-9

    authors: Guizzetti M,Bordi F,Dieguez-Acuña FJ,Vitalone A,Madia F,Woods JS,Costa LG

    更新日期:2003-01-01 00:00:00

  • Caffeine-induced calcium release from internal stores in cultured rat sensory neurons.

    abstract::Free intracellular calcium concentration ([Ca2+]in) was recorded at 22 degrees C by means of Indo-1 or Fura-2 single-cell microfluorometry in cultured dorsal root ganglion neurons obtained from neonatal rats. The resting [Ca2+]in in dorsal root ganglion neurons was 73 +/- 21 nM (mean +/- S.D., n = 94). Fast applicatio...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(93)90029-f

    authors: Usachev Y,Shmigol A,Pronchuk N,Kostyuk P,Verkhratsky A

    更新日期:1993-12-01 00:00:00

  • Genetic background regulates semaphorin gene expression and epileptogenesis in mouse brain after kainic acid status epilepticus.

    abstract::The host response to neural injury, which can include axonal sprouting and synaptic reorganization is likely to be under tight genetic regulatory control at the level of the genome and may be implicated in epileptogenesis. Despite its importance, however, the molecular basis of synaptic reorganization is unclear. We h...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2004.09.064

    authors: Yang J,Houk B,Shah J,Hauser KF,Luo Y,Smith G,Schauwecker E,Barnes GN

    更新日期:2005-01-01 00:00:00

  • Subthreshold membrane potential oscillations in neurons of deep layers of the entorhinal cortex.

    abstract::Neuronal oscillations are important for information processing. The entorhinal cortex is one of the structures which is involved in generation of theta rhythm. The major role of the entorhinal cortex is to feed diverse sources of information both to and from the hippocampus. Far from simply being a funnel for this inf...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(98)00113-4

    authors: Schmitz D,Gloveli T,Behr J,Dugladze T,Heinemann U

    更新日期:1998-08-01 00:00:00

  • Cerebrospinal fluid derived from progressive multiple sclerosis patients promotes neuronal and oligodendroglial differentiation of human neural precursor cells in vitro.

    abstract::In the adult CNS, tissue-specific germinal niches, such as the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus of the hippocampus, contain multipotent neural precursor cells (NPCs) with the capacity to self-renew and differentiate into functional brain cells (i.e. neurons, a...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2013.07.022

    authors: Cristofanilli M,Cymring B,Lu A,Rosenthal H,Sadiq SA

    更新日期:2013-10-10 00:00:00

  • Cutaneous sympathetic motor rhythms in the decerebrate rat.

    abstract::Investigation of rhythmic discharges may provide insights into integrative mechanisms underlying nervous system control of effectors. We have previously shown that, in CNS-intact, anesthetized rats, cutaneous sympathetic vasoconstrictor neurones innervating thermoregulatory circulations exhibit a robust rhythmicity in...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(02)00969-7

    authors: Collins DR,Gilbey MP

    更新日期:2003-01-01 00:00:00

  • Sympathectomy decreases size and invasiveness of tongue cancer in rats.

    abstract::The sympathetic nervous system plays a role in carcinogenesis wherein locally released sympathetic neurotransmitters affect proliferation, angiogenesis, vessel permeability, lymphocyte traffic and cytokine production. The present in vivo study was designed to investigate whether surgical sympathectomy, both unilateral...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2007.07.048

    authors: Raju B,Haug SR,Ibrahim SO,Heyeraas KJ

    更新日期:2007-11-09 00:00:00

  • Quantitation of neurokinin 1 receptor internalization and recycling in guinea-pig myenteric neurons.

    abstract::Agonist-induced endocytosis and recycling of G protein-coupled receptors contributes to desensitization and resensitization of the receptors. In this study, we have used fluorescence immunohistochemistry, confocal microscopy and digital image analysis to quantify the proportion of receptor in the cytoplasm and on the ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(98)00176-6

    authors: Southwell BR,Seybold VS,Woodman HL,Jenkinson KM,Furness JB

    更新日期:1998-12-01 00:00:00

  • C6 glioma cells differentiated by retinoic acid overexpress the glutamate transporter excitatory amino acid carrier 1 (EAAC1).

    abstract::The transport of excitatory amino acids (EAA) in CNS is performed by a family of high affinity, sodium dependent carriers. One of these transporters, excitatory amino acid carrier 1 (EAAC1), is known to be regulated by several mechanisms that modify carrier abundance on the plasma membrane. Much less is known on EAAC1...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2007.11.055

    authors: Bianchi MG,Gazzola GC,Tognazzi L,Bussolati O

    更新日期:2008-02-19 00:00:00

  • The PDZ-binding domain is essential for the dendritic targeting of 5-HT2A serotonin receptors in cortical pyramidal neurons in vitro.

    abstract::The 5-HT(2A) serotonin receptor represents an important molecular target for atypical antipsychotic drugs and for most hallucinogens. In the mammalian cerebral cortex, 5-HT(2A) receptors are enriched in pyramidal neurons, within which 5-HT(2A) receptors are preferentially sorted to the apical dendrites. In primary cor...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(03)00589-x

    authors: Xia Z,Hufeisen SJ,Gray JA,Roth BL

    更新日期:2003-01-01 00:00:00

  • Changes in lipid composition of neuroblastoma C1300 N18 cell during differentiation.

    abstract::Phospholipids and cholesterol were found to be the main lipids in mature and immature neuroblastoma cells. The ratios for the total cholesterol/phospholipids in these undifferentiated and differentiated cells were 0.33 and 0.52, respectively. The ratios of 0.45 and 0.62 were obtained with corresponding plasma membrane...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(89)90361-8

    authors: Gulaya NM,Volkov GL,Klimashevsky VM,Govseeva NN,Melnik AA

    更新日期:1989-01-01 00:00:00

  • Cortical inhibition in Parkinson's disease: new insights from early, untreated patients.

    abstract::Transcranial magnetic stimulation (TMS) has opened important perspectives on the pathophysiological bases and potential targets of treatment strategies for idiopathic Parkinson's disease (IPD). Studies have been mainly focusing on motor cortical inhibitory phenomena. However, differences in patients and methods caused...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2007.08.033

    authors: Cantello R,Tarletti R,Varrasi C,Cecchin M,Monaco F

    更新日期:2007-11-30 00:00:00

  • Ovarian steroid regulation of the midbrain corticotropin releasing factor and urocortin systems in macaques.

    abstract::A significant number of postmenopausal women report increased anxiety and vulnerability to stress, which has been linked to decreased secretion of ovarian steroids. Communication between the serotonin system and the corticotropin releasing factor (CRF) system determines stress sensitivity or resilience. This study exa...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2010.08.059

    authors: Sanchez RL,Reddy AP,Bethea CL

    更新日期:2010-12-15 00:00:00

  • A brain Na+, K+-ATPase inhibitor (endobain E) enhances norepinephrine release in rat hypothalamus.

    abstract::We have shown that synaptosomal membrane Na+, K+-ATPase activity is stimulated or inhibited by norepinephrine according to the presence or absence of a brain soluble fraction. Gel filtration of such soluble fraction has allowed the separation of two fractions, peaks I and II, able to stimulate and inhibit Na+, K+-ATPa...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(98)00421-7

    authors: Vatta M,Peña C,Fernández B,Rodríguez de Lores Arnaiz G

    更新日期:1999-05-01 00:00:00

  • Voluntary Binge-like Ethanol Consumption Site-specifically Increases c-Fos Immunoexpression in Male C57BL6/J Mice.

    abstract::The assessment of binge ethanol-induced neuronal activation, using c-Fos immunoreactivity (IR) as a marker of neuronal activity, is typically accomplished via forced ethanol exposure, such as intraperitoneal injection or gavage. Neuronal activity using a voluntary binge-like drinking model, such as "drinking-in-the-da...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2017.10.027

    authors: Burnham NW,Thiele TE

    更新日期:2017-12-26 00:00:00

  • Lactate Administration Reduces Brain Injury and Ameliorates Behavioral Outcomes Following Neonatal Hypoxia-Ischemia.

    abstract::Neonatal hypoxic-ischemic encephalopathy is a major cause of mortality and disability in newborns and the only standard approach for treating this condition is therapeutic hypothermia, which shows some limitations. Thus, putative neuroprotective agents have been tested in animal models. The present study evaluated the...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2020.09.006

    authors: Tassinari ID,Andrade MKG,da Rosa LA,Hoff MLM,Nunes RR,Vogt EL,Fabres RB,Sanches EF,Netto CA,Paz AH,de Fraga LS

    更新日期:2020-11-10 00:00:00

  • Interactions of the serotonin and circadian systems: nature and nurture in rhythms and blues.

    abstract::The serotonin and circadian systems are principal regulatory networks of the brain. Each consists of a unique set of neurons that make widespread neural connections and a defined gene network of transcriptional regulators and signaling genes that subserve serotonergic and circadian function at the genetic level. These...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2011.09.036

    authors: Ciarleglio CM,Resuehr HE,McMahon DG

    更新日期:2011-12-01 00:00:00

  • Effect of rapid eye movement sleep deprivation on rat brain monoamine oxidases.

    abstract::Monoamine oxidase, monoamine oxidase-A, and monoamine oxidase-B activities were compared in free moving, rapid eye movement sleep-deprived, recovered, and control rat brains. The activities were estimated in the whole brain, cerebrum, cerebellum, whole brainstem, medulla, pons, and midbrain. The flowerpot method was u...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(93)90433-g

    authors: Thakkar M,Mallick BN

    更新日期:1993-08-01 00:00:00

  • Vanilloid receptor 1-like receptor-immunoreactive primary sensory neurons in the rat trigeminal nervous system.

    abstract::Immunohistochemistry for vanilloid receptor 1-like receptor (VRL-1), a candidate transducer for high-threshold noxious heat, was performed on rat trigeminal primary sensory neurons. The immunoreactivity was detected in 14% of the trigeminal ganglion cell bodies, while the neurons in the mesencephalic trigeminal tract ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(00)00427-9

    authors: Ichikawa H,Sugimoto T

    更新日期:2000-01-01 00:00:00

  • Polyunsaturated fatty acids induce ischemic and epileptic tolerance.

    abstract::The findings reported in this work show that pretreatment with polyunsaturated fatty acids, particularly linolenic acid, present in vegetable oils, can provide a potent tolerance against neurodegeneration in two models of neuronal death-generating treatments such as kainic acid injection and global ischemia. Rats were...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(01)00473-0

    authors: Blondeau N,Widmann C,Lazdunski M,Heurteaux C

    更新日期:2002-01-01 00:00:00

  • A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior.

    abstract::This study investigated the effect of ionotropic glutamate receptor agonist or antagonist administration into the nucleus accumbens on the maintenance of cocaine self-administration and the reinstatement of cocaine-seeking behavior. The stimulation of alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid or N-meth...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(99)00214-6

    authors: Cornish JL,Duffy P,Kalivas PW

    更新日期:1999-01-01 00:00:00

  • 3alpha-hydroxy-5alpha-pregnan-20-one in the midbrain ventral tegmental area mediates social, sexual, and affective behaviors.

    abstract::Progestins mediate the onset and duration of lordosis, the mating posture of female rodents, through actions in the hypothalamus and ventral tegmental area. In the hypothalamus, progesterone has traditional, "genomic" actions via intracellular progestin receptors. In the ventral tegmental area, 3alpha-hydroxy-5alpha-p...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2005.06.015

    authors: Frye CA,Rhodes ME,Petralia SM,Walf AA,Sumida K,Edinger KL

    更新日期:2006-01-01 00:00:00

  • Central boutons of glomeruli in the spinal cord of the cat are enriched with L-glutamate-like immunoreactivity.

    abstract::Several lines of evidence indicate that L-glutamate may be a neurotransmitter of fine myelinated and unmyelinated primary afferent fibres in the spinal cord. The aim of the present study was to determine if L-glutamate was enriched in the terminals of these fibres. We performed the post-embedding immunogold technique ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(90)90353-6

    authors: Maxwell DJ,Christie WM,Short AD,Storm-Mathisen J,Ottersen OP

    更新日期:1990-01-01 00:00:00

  • Dynorphin in pro-opiomelanocortin neurons of the hypothalamic arcuate nucleus.

    abstract::Considerable evidence suggests that dynorphin participates in the regulation of energy balance. In this study, we have used immunohistochemistry to investigate in detail the cellular localization of pro-dynorphin (DYN) immunoreactive cell bodies in the mediobasal hypothalamus with special reference to neurons producin...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2008.04.011

    authors: Maolood N,Meister B

    更新日期:2008-06-26 00:00:00

  • Increase of B-50/GAP-43 immunoreactivity in uninjured muscle nerves of MDX mice.

    abstract::Lack of dystrophin in mdx mice leads to muscle fibre degeneration followed by the formation of new myofibres. This degeneration-regeneration event occurs in clusters. It is accompanied by inflammation and remodelling of the intramuscular terminal nerve fibres. Since the growth-associated protein B-50/GAP-43 has been s...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(96)83017-x

    authors: Verzè L,Buffo A,Rossi F,Oestreicher AB,Gispen WH,Strata P

    更新日期:1996-02-01 00:00:00

  • No evidence for role of extracellular choline-acetyltransferase in generation of gamma oscillations in rat hippocampal slices in vitro.

    abstract::Acetylcholine (ACh) is well known to induce persistent γ-oscillations in the hippocampus when applied together with physostigmine, an inhibitor of the ACh degrading enzyme acetylcholinesterase (AChE). Here we report that physostigmine alone can also dose-dependently induce γ-oscillations in rat hippocampal slices. We ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2014.10.016

    authors: Hollnagel JO,Ul Haq R,Behrens CJ,Maslarova A,Mody I,Heinemann U

    更新日期:2015-01-22 00:00:00

  • Glutamate-dependent translational regulation in cultured Bergmann glia cells: involvement of p70S6K.

    abstract::Glutamate, the main excitatory amino acid transmitter in the vertebrate brain is involved in the dynamic changes in protein repertoire that underlie synaptic plasticity. Activity-dependent differential expression patterns occur not only in neurons but also in glial cells. In fact, a membrane to nuclei signaling has be...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2006.04.076

    authors: González-Mejia ME,Morales M,Hernández-Kelly LC,Zepeda RC,Bernabé A,Ortega A

    更新日期:2006-09-01 00:00:00

  • Stress suppresses and learning induces plasticity in CA3 of rat hippocampus: a three-dimensional ultrastructural study of thorny excrescences and their postsynaptic densities.

    abstract::Chronic stress and spatial training have been proposed to affect hippocampal structure and function in opposite ways. Previous morphological studies that addressed structural changes after chronic restraint stress and spatial training were based on two-dimensional morphometry which does not allow a complete morphometr...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2004.10.031

    authors: Stewart MG,Davies HA,Sandi C,Kraev IV,Rogachevsky VV,Peddie CJ,Rodriguez JJ,Cordero MI,Donohue HS,Gabbott PL,Popov VI

    更新日期:2005-01-01 00:00:00

  • Specific binding of a mutated fragment of Clostridium perfringens enterotoxin to endothelial claudin-5 and its modulation of cerebral vascular permeability.

    abstract::The vertebrate blood-brain barrier (BBB) creates an obstacle for central nervous system-related drug delivery. Claudin-5 (Cldn5), expressed in large quantities in BBB, plays a vital role in restricting BBB permeability. The C-terminal domain of Clostridium perfringens enterotoxin (cCPE) has been verified as binding to...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2016.04.013

    authors: Liao Z,Yang Z,Piontek A,Eichner M,Krause G,Li L,Piontek J,Zhang J

    更新日期:2016-07-07 00:00:00