Neural Representation in Visual Word Form Area during Word Reading.

abstract：:Multiple sclerosis (MS) is an autoimmune disease in which more than 70% of patients experience visual disturbance as the earliest symptoms. Lysolecithin (LPC)-induced focal demyelination model has been developed to evaluate the effects of different therapies on myelin repair improvement. In this study, the effects of ...

journal_title：Neuroscience

authors： Daneshdoust D,Khalili-Fomeshi M,Ghasemi-Kasman M,Ghorbanian D,Hashemian M,Gholami M,Moghadamnia A,Shojaei A

更新日期：2017-03-06 00:00:00

abstract：:In order to gain insights into the steps (binding, uptake, intracellular effect) which differ in the inhibitory actions of tetanus toxin and botulinum neurotoxins types A or B, their temperature dependencies were investigated at identified cholinergic and non-cholinergic synapses in Aplysia. Upon lowering the temperat...

journal_title：Neuroscience

authors： Poulain B,De Paiva A,Deloye F,Doussau F,Tauc L,Weller U,Dolly JO

更新日期：1996-01-01 00:00:00

abstract：:Most patients with temporal lobe epilepsy (TLE), the most common type of epilepsy, show pronounced loss of neurons in limbic brain regions, including the hippocampus. The massive neurodegeneration in the hippocampus is known as hippocampal sclerosis, and is considered one of the hallmarks of this type of difficult-to-...

journal_title：Neuroscience

authors： Brandt C,Potschka H,Löscher W,Ebert U

更新日期：2003-01-01 00:00:00

abstract：:Cultured neurons offer many advantages over a slice preparation for whole-cell patch-clamp studies, such as better control over the environment and space clamp control. However, heterogeneous cultures of neurons present problems in distinguishing the cell type from which recordings are made. The present study uses cor...

journal_title：Neuroscience

authors： Mynlieff M

更新日期：1999-01-01 00:00:00

abstract：:A plethora of studies have indicated that enriched environment (EE) paradigm provokes plastic and morphological changes in astrocytes with accompanying increments of their density and positively affects the behavior of rodents. We also previously documented that EE could be employed to preclude several behavioral abno...

journal_title：Neuroscience

authors： Rahati M,Nozari M,Eslami H,Shabani M,Basiri M

更新日期：2016-06-21 00:00:00

abstract：:Neurofibrillary tangles in Alzheimer's disease are composed of hyperphosphorylated forms of the microtubule-associated protein tau. Based on biochemical criteria, several enzymes have emerged as potential tau protein kinases, including the extracellularly regulated kinases 1, 2 and 3. In situ hybridization was used to...

journal_title：Neuroscience

authors： Hollister RD,Page KJ,Hyman BT

更新日期：1997-08-01 00:00:00

abstract：:We previously reported that the novel antidepressant-like effect of tipepidine may be produced at least partly through the activation of mesolimbic dopamine (DA) neurons via inhibiting G protein-coupled inwardly rectifying potassium (GIRK) channels. In this study, we investigated the action of tipepidine on DA D2 rece...

journal_title：Neuroscience

authors： Hamasaki R,Shirasaki T,Soeda F,Takahama K

更新日期：2013-11-12 00:00:00

abstract：:Erythropoietin (EPO) and its receptor (EPO-R), mediate neuroprotection from axonopathy and apoptosis in the peripheral nervous system (PNS). We examined the impact and potential mechanisms of local EPO signaling on regenerating PNS axons in vivo and in vitro. As a consequence of injury, peripheral nerve axons and DRG ...

journal_title：Neuroscience

authors： Toth C,Martinez JA,Liu WQ,Diggle J,Guo GF,Ramji N,Mi R,Hoke A,Zochodne DW

更新日期：2008-06-23 00:00:00

abstract：:The effects of acute application of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNFalpha) on levels of intracellular Ca(2+) ([Ca(2+)]i) and on whole-cell outward and inward K(+) currents were studied in cultured human microglia. TNFalpha elicited a linear increase in [Ca(2+)]i to a plateau level in micr...

journal_title：Neuroscience

authors： McLarnon JG,Franciosi S,Wang X,Bae JH,Choi HB,Kim SU

更新日期：2001-01-01 00:00:00

abstract：:Inflammatory damage following ICH is often attributed to microglia/macrophage activation. In many diseases, IL-4 has been proven to switch microglia/macrophages from the pro-inflammatory to the anti-inflammatory subtype. However, the role and underlying mechanism of IL-4 in ICH, especially in neuroprotection, remain u...

journal_title：Neuroscience

authors： He Y,Gao Y,Zhang Q,Zhou G,Cao F,Yao S

更新日期：2020-06-15 00:00:00

abstract：:Excitatory amino acid carrier 1 (EAAC1) is one important subtype of the excitatory amino acid transporters (EAATs), and its absence can increase the vulnerability to oxidative stress in neural tissue. Enhanced expression of EAAC1 can provide neuroprotection in multiple disorders, including ischemia and multiple sclero...

journal_title：Neuroscience

authors： Huang C,Yuan P,Wu J,Huang J

更新日期：2016-04-05 00:00:00

abstract：:The mechanisms involved in morphine tolerance are poorly understood. It was reported by our group that calcitonin gene-related peptide (CGRP)-like immunoreactivity (IR) was increased in the spinal dorsal horn during morphine tolerance [Ménard et al. (1996) J. Neurosci. 16, 2342-2351]. More recently, we observed that i...

journal_title：Neuroscience

authors： Belanger S,Ma W,Chabot JG,Quirion R

更新日期：2002-01-01 00:00:00

abstract：:The distribution and origin of nerves with calcitonin gene-related peptide, substance P or neurokinin A immunoreactivity in the walls of the cerebral arteries were investigated in three microchiropteran species. The supply of nerves immunoreactive for substance P and neurokinin A to the bat cerebral arteries is confin...

journal_title：Neuroscience

authors： Ando K,Arai S,Kawamura K

更新日期：1990-01-01 00:00:00

abstract：:The rapid eye movement dreaming sleep stage and schizophrenia are both characterized by common intracerebral disconnections, disturbed responsiveness and sensory deafferentation processes. Moreover, in both states, there is dorsolateral prefrontal deactivation as shown by the decrease of blood flow. Finally, identical...

journal_title：Neuroscience

authors： Gottesmann C

更新日期：2006-07-21 00:00:00

abstract：:We evaluate a novel set-up for scanning functional connectivity in brain slices from the somatosensory cortex of the rat. Upright infrared video microscopy for targeted placement of electrodes is combined with rapid photolysis of bath-applied caged neurotransmitter induced by a xenon flash lamp. Flash photolysis of ca...

journal_title：Neuroscience

authors： Kötter R,Staiger JF,Zilles K,Luhmann HJ

更新日期：1998-09-01 00:00:00

abstract：:Neuronal nicotinic acetylcholine receptors are members of the ligand-gated ion channel superfamily composed of alpha and beta subunits with specific structural, functional and pharmacological properties. In this study we have used immunohistochemistry to investigate the presence of nicotinic acetylcholine receptor sub...

journal_title：Neuroscience

authors： Graham A,Court JA,Martin-Ruiz CM,Jaros E,Perry R,Volsen SG,Bose S,Evans N,Ince P,Kuryatov A,Lindstrom J,Gotti C,Perry EK

更新日期：2002-01-01 00:00:00

abstract：:Noninvasive functional imaging holds great promise for the future of translational research, due to the ability to directly compare between preclinical and clinical models of psychiatric disorders. Despite this potential, concerns have been raised regarding the necessity to anesthetize rodent and monkey subjects durin...

journal_title：Neuroscience

authors： Smith ML,Li J,Cote DM,Ryabinin AE

更新日期：2016-03-01 00:00:00

abstract：:Adrenalectomy (ADX) abolishes behavioral sensitization to cocaine in DBA/2, but not C57BL/6 inbred mice. The present study tests the hypothesis that this ADX effect on behavioral sensitization in the DBA/2 strain involves changes in midbrain dopamine systems that do not occur in the C57BL/6 strain. For that purpose, w...

journal_title：Neuroscience

authors： de Jong IE,Steenbergen PJ,de Kloet ER

更新日期：2008-05-15 00:00:00

abstract：:The prefrontal cortex is highly vulnerable to traumatic brain injury (TBI) and its structural and/or functional alterations as a result of TBI can give rise to persistent working memory (WM) dysfunction. Using a rodent model of TBI, we have described profound WM deficits following TBI that are associated with increase...

journal_title：Neuroscience

authors： Kobori N,Hu B,Dash PK

更新日期：2011-01-13 00:00:00

abstract：:Many epidemiological studies support the notion that people who drink alcohol also smoke cigarettes and vice versa thereby suggesting a possible functional interaction between these two most widely used psychoactive substances. We have earlier demonstrated that direct intracerebellar (ICB) microinfusion of nicotine do...

journal_title：Neuroscience

authors： Taslim N,Al-Rejaie S,Saeed Dar M

更新日期：2008-11-11 00:00:00

abstract：:Aged rats may be behaviorally classified as either cognitively impaired or unimpaired based upon their performance in the Morris water maze task. In aged Long-Evans rats, emergence of functional deficits has been related to the increase in the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor s...

journal_title：Neuroscience

authors： Andrés N,Rodríguez MJ,Andrade C,Rowe W,Quirion R,Mahy N

更新日期：2000-01-01 00:00:00

abstract：:The effect of etomidate, an imidazole general anesthetic, on GABAA receptor function was studied in cultured hippocampal neurons. At a clinically relevant concentration of 4.1 microM, etomidate shifts the GABA dose response to the left (ED50 shift from 10.2 to 5.2 microM), with no change in the maximum current evoked ...

journal_title：Neuroscience

authors： Yang J,Uchida I

更新日期：1996-07-01 00:00:00

abstract：:The mutant mice tottering, leaner and the compound heterozygous tottering/leaner exhibit varying degrees of several abnormal neurological phenotypes including petit mal-like epilepsy, ataxia and an intermittent myoclonus-like movement disorder. Aberrant expression of tyrosine hydroxylase in cerebellar Purkinje cells o...

journal_title：Neuroscience

authors： Abbott LC,Isaacs KR,Heckroth JA

更新日期：1996-03-01 00:00:00

abstract：:In recent years, there has been a great deal of progress toward understanding the role of the striatum and dopamine in action selection. The advent of new animal models and the development of optical techniques for imaging and stimulating select neuronal populations have provided the means by which identified synapses...

journal_title：Neuroscience

authors： Surmeier DJ,Carrillo-Reid L,Bargas J

更新日期：2011-12-15 00:00:00

abstract：:Thrombin and activated protein C (aPC) bound to the endothelial protein C receptor (EPCR) both activate protease-activated receptor 1 (PAR1) generating either harmful or protective signaling respectively. In the present study we examined the localization of PAR-1 and EPCR and thrombin activity in Schwann glial cells o...

journal_title：Neuroscience

authors： Gera O,Shavit-Stein E,Bushi D,Harnof S,Shimon MB,Weiss R,Golderman V,Dori A,Maggio N,Finegold K,Chapman J

更新日期：2016-12-17 00:00:00

abstract：:The nucleus accumbens is considered to be critically involved in the control of complex motivated behaviors. By modulating its glutamatergic excitatory input, mesolimbic dopaminergic afferents have been implicated in the reinforcing properties of drugs of abuse. However, they might not represent the only path for infl...

journal_title：Neuroscience

authors： d'Alcantara P,Ledent C,Swillens S,Schiffmann SN

更新日期：2001-01-01 00:00:00

abstract：:beta-Endorphin is a non-selective opioid peptide which binds mu-, delta- and putative epsilon (beta-endorphin-sensitive non-mu-, non-delta- and non-kappa(1)-)-opioid receptors. We have previously reported that beta-endorphin-produced G-protein activation is mediated by the stimulation of both mu- and putative epsilon-...

journal_title：Neuroscience

authors： Mizoguchi H,Wu HE,Narita M,Hall FS,Sora I,Uhl GR,Nagase H,Tseng LF

更新日期：2002-01-01 00:00:00

abstract：:Neurones in the lumbosacral spinal cord are known to play a significant role in ejaculation. In these same areas neurones containing nitric oxide synthase (NOS) have been described. This raised the question as to whether there is a physiological role for nitrous oxide (NO) in the spinal cord in sexual behavior. We fir...

journal_title：Neuroscience

authors： Brack KE,Watkins N,Pyner S,Coote JH

更新日期：2007-12-05 00:00:00

abstract：:Visually elicited activity contributes to the formation of orderly connections in the optic tectum of frogs. Glutamate receptors of the N-methyl-D-aspartate class participate in this process. Blocking those receptors interferes with activity-dependent refinement of maps in normal frogs and of ocular dominance bands in...

journal_title：Neuroscience

authors： Udin SB,Scherer WJ,Constantine-Paton M

更新日期：1992-08-01 00:00:00

abstract：:The reciprocal connections between the mediodorsal thalamic nucleus and the prefrontal cortex participate in a circuit that is essential to a number of higher cognitive processes. Projections from the dopamine-containing cells of the ventral mesencephalon to the prefrontal cortex are also critical for these cognitive ...

journal_title：Neuroscience

authors： Melchitzky DS,Lewis DA

更新日期：2001-01-01 00:00:00