Abstract:
:Visually elicited activity contributes to the formation of orderly connections in the optic tectum of frogs. Glutamate receptors of the N-methyl-D-aspartate class participate in this process. Blocking those receptors interferes with activity-dependent refinement of maps in normal frogs and of ocular dominance bands in surgically produced animals with three eyes. Chronic application of N-methyl-D-aspartate sharpens the bands. The possibility that 5-amino-phosphonovaleric acid depresses tectal responsiveness was motivation for studying the effects of 5-amino-phosphonovaleric acid and N-methyl-D-aspartate applied both chronically and acutely. We evaluated tectal responsiveness to visual input by presenting flashes of light to one eye and recording responses in the ipsilateral tectal lobe. This method reveals the output of the tectal cells contralateral to the stimulated eye. These cells project via the nucleus isthmi to the opposite tectal lobe. We also mapped the receptive field dimensions of the crossed isthmotectal axons. Our results show that acute topical application of 500 microM or 1 mM N-methyl-D-aspartate dramatically increases spontaneous activity, while 100 microM N-methyl-D-aspartate causes little change. Chronic treatment with N-methyl-D-aspartate at a low dose (estimated to be in the micromolar range) shown to influence retinotectal mapping, reduces response latencies but produces no statistically significant changes in tectal cell firing rates or receptive field size. Acute application of 5-amino-phosphonovaleric acid produces complex results: 10 microM produces no changes in firing, 100 microM 5-amino-phosphonovaleric acid decreases firing, and doses of 500-100 microM increase the firing.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Udin SB,Scherer WJ,Constantine-Paton Mdoi
10.1016/0306-4522(92)90240-3keywords:
subject
Has Abstractpub_date
1992-08-01 00:00:00pages
739-47issue
3eissn
0306-4522issn
1873-7544pii
0306-4522(92)90240-3journal_volume
49pub_type
杂志文章相关文献
NEUROSCIENCE文献大全abstract::Spinal intrathecal administration of nicotine inhibits bradykinin-induced plasma extravasation, a component of the inflammatory response, in the knee joint of the rat in a dose-related fashion. Nociceptors contain nicotinic receptors and activation of a nociceptor at its peripheral terminal, by capsaicin, also produce...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2003.10.027
更新日期:2004-01-01 00:00:00
abstract::Neural activity during early development is known to alter innervation pathways in the central and peripheral nervous systems. We sought to examine how reduced sound-induced sensory activity in the cochlea affected the consolidation of glutamatergic synapses between inner hair cells (IHC) and the primary auditory neur...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2016.03.043
更新日期:2016-06-14 00:00:00
abstract::The finding that endogenous tetrahydroisoquinolines may be involved in the etiology of Parkinson's disease suggests that their administration may cause changes resembling those observed in parkinsonian brain. We tested, using a high-performance liquid chromatography method, how single and chronic administration of 1,2...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(99)00533-3
更新日期:2000-01-01 00:00:00
abstract::Recently, we reported that erythropoietin attenuates neonatal brain injury caused by focal cerebral ischemia. The long-term effects of erythropoietin on focal cerebral ischemia-induced injury to the developing brain and the potential gender differences in these long-term effects have not been studied in detail. The cu...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2006.02.057
更新日期:2006-01-01 00:00:00
abstract::The prairie vole (Microtus ochrogaster) is a socially monogamous rodent species that forms pair bonds after mating. Recent data have shown that amphetamine (AMPH) is rewarding to prairie voles as it induces conditioned place preferences. Further, repeated treatment with AMPH impairs social bonding in adult prairie vol...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2015.08.051
更新日期:2015-10-29 00:00:00
abstract::Freezing of gait (FOG) is a common, disabling symptom of Parkinson's disease (PD) that is associated with deficits in motor initiation and inhibition. Understanding of underlying neurobiological mechanisms has been limited by difficulties in eliciting and objectively characterizing such gait phenomena in the clinical ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2016.09.019
更新日期:2016-11-19 00:00:00
abstract::Significant alterations in glutamatergic neurotransmission have been reported in major depressive disorder (MDD) that could underlie psychiatric traits. Studies were mainly interested in synaptic dysfunction in the prefrontal cortex, a key structure involved in depressive-like behavior, however hippocampus has been sh...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2018.11.022
更新日期:2019-01-01 00:00:00
abstract::Repetitive transcranial magnetic stimulation (rTMS) is an established technique that can modulate excitability of the motor cortex and corticospinal tract, beyond the duration of the stimulation itself. More recently, a newer repetitive technique, known as I-wave periodicity TMS (iTMS) has been purported to show incre...
journal_title:Neuroscience
pub_type: 杂志文章,评审
doi:10.1016/j.neuroscience.2016.02.041
更新日期:2016-05-13 00:00:00
abstract::Dopamine D2-autoreceptors play a key role in regulating the activity of dopamine neurons and control the synthesis, release and uptake of dopamine. These Gi/o-coupled inhibitory receptors play a major part in shaping dopamine transmission. Found at both somatodendritic and axonal sites, autoreceptors regulate the firi...
journal_title:Neuroscience
pub_type: 杂志文章,评审
doi:10.1016/j.neuroscience.2014.01.025
更新日期:2014-12-12 00:00:00
abstract::Spreading depolarizations are accompanied by transient changes in cerebral blood flow (CBF). In a post hoc analysis of previously studied control rats we analyzed CBF time courses after middle cerebral artery occlusion in the rat in order to test whether intra-ischemic flow, reperfusion, and different parameters of pe...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2012.08.049
更新日期:2012-12-13 00:00:00
abstract::The nicotinic receptor proteins and gene transcripts for the different nicotinic receptor subunits exist in human prenatal brain already at 4-5 weeks of gestation. The early presence of nicotinic receptors suggests an important role for these receptors in modulating dendritic outgrowth, establishment of neuronal conne...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(01)00209-3
更新日期:2001-01-01 00:00:00
abstract::The deep cerebellar nuclei (DCN) are the final integrative units of the cerebellar network. The strongest single afferent to the DCN is formed by GABAergic Purkinje neuron axons whose synapses constitute the majority of all synapses in the DCN, with their action strongly regulating the intrinsic activity of their targ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2008.07.060
更新日期:2008-10-15 00:00:00
abstract::Neurodegeneration in Alzheimer's disease is characterized by a selective loss of particular cell populations. Several recent lines of evidence suggest that beta-amyloid protein directly contributes to the disease's progression and is likely responsible for the observed pattern of neuronal death. We have previously dem...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(93)90331-9
更新日期:1993-09-01 00:00:00
abstract::Developmental or degenerative damage of the neuronal architecture in the entorhinal cortex may disintegrate a functional part of hippocampal input since the entorhinal cortex provides a major source of neocortical and subcortical input to the hippocampus. These alterations, such as seen in Alzheimer's disease, schizop...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(93)90034-d
更新日期:1993-12-01 00:00:00
abstract::Dopamine (DA), released from the lateral olivocochlear (LOC) efferent terminals, the efferent arm of the short-loop feedback in the cochlea, is considered as a protective factor in the inner ear since it inhibits auditory nerve dendrite firing in ischemia- or noise-induced excitotoxicity leading to sensorineural heari...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2005.01.023
更新日期:2005-01-01 00:00:00
abstract::Hippocampal theta oscillations are key elements in numerous behavioral and cognitive processes. Based on the dualistic theory of theta oscillations, one can differentiate between atropine-sensitive and atropine-insensitive theta subtypes. Urethane-induced atropine-sensitive theta oscillations are driven by muscarinic ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2011.12.032
更新日期:2012-03-15 00:00:00
abstract::Intracellular and whole-cell patch-clamp recordings were obtained from sympathetic preganglionic neurons in rat spinal cord slices. Perfusion of selective ionotropic and metabotropic excitatory amino acid agonists induced depolarizing responses in all neurons. In approximately 20% of neurons the application of these a...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(94)90325-5
更新日期:1994-09-01 00:00:00
abstract::The neuroanatomical distribution of nitric oxide synthase-immunoreactive neurons was investigated in post mortem hypothalami of 10 patients suffering from schizophrenia, eight patients with depression and 13 matched control cases. Neuronal nitric oxide synthase containing nerve cells were detected in several hypothala...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(97)00461-2
更新日期:1998-04-01 00:00:00
abstract::The molecular mechanisms underlying the response to injury in the central nervous system are incompletely understood. Many cell activation systems may be involved. Tyrosine kinase receptors and their ligands play key roles in cell activation throughout life. The Eph family of tyrosine kinase receptors/ ligands are dev...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(98)00568-5
更新日期:1999-01-01 00:00:00
abstract::Obesity may result from dysfunction of the reward system, especially in the nucleus accumbens (Acb). Based on this hypothesis, many researchers have tested the effect of high-frequency stimulation (HFS) of the Acb shell (Acb-Sh) and/or core (Acb-Co) on ingestive behaviors, but few studies have explored the possible me...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2015.06.006
更新日期:2015-08-20 00:00:00
abstract::The aim of this paper was to evaluate the cholinergic component of the septohippocampal input signals in neuronal activity of the hippocampal fields CA1 and CA3 recorded extracellularly in chronic alert rabbits. Effects of electrical stimulation of the medial septal area were analysed in the control state, on the back...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(93)90482-u
更新日期:1993-04-01 00:00:00
abstract::Status epilepticus is a major medical emergency that results in significant alteration of neuronal function. Status epilepticus involves seizure activity recurring frequently enough to induce a sustained alteration in brain function. This study was initiated to investigate how status epilepticus affects the activity o...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(99)00462-5
更新日期:2000-01-01 00:00:00
abstract::The amygdala is a temporal lobe region that is implicated in emotional information processing. The amygdala also is associated with the processing and modulation of pain sensation. Recently, we demonstrated that in nonhuman primates, the amygdala is necessary for the full expression of cannabinoid-induced antinocicept...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(03)00356-7
更新日期:2003-01-01 00:00:00
abstract::Systemic treatment of new-born rats with the catecholamine neurotoxin 6-hydroxydopamine leads to a permanent and selective alteration of the postnatal development of the central noradrenaline neurons, in particular of the locus coeruleus system. The changes involve a pronounced and permanent degeneration of distant ne...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(82)90113-0
更新日期:1982-01-01 00:00:00
abstract::GABA(A) functioning has been implicated in anxiety and depressive disorders. In this regard, we suggested that in addition to analyzing GABA(A) and the subunits that comprise the GABA(A) receptor, it might be profitable to assess the coordinated expression of subunits that comprise the GABA(A) receptor cassette. We de...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2009.11.028
更新日期:2010-02-17 00:00:00
abstract::The duration of long-term potentiation in the dentate gyrus of awake rats was examined following systematic manipulation of the number of stimulus trains delivered. This was correlated with the induction of immediate early genes in separate groups of animals given identical stimulus regimes. Following 10 trains of sti...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(93)90369-q
更新日期:1993-10-01 00:00:00
abstract::The present study examines the spatial distribution within rat locus coeruleus of neurons projecting to particular brain regions. In order to accurately recreate, in digital and pictorial formats, the spatial distribution of neurons for the entire nucleus locus coeruleus, three-dimensional reconstructions were created...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(86)90155-7
更新日期:1986-06-01 00:00:00
abstract::The reciprocal connections between the mediodorsal thalamic nucleus and the prefrontal cortex participate in a circuit that is essential to a number of higher cognitive processes. Projections from the dopamine-containing cells of the ventral mesencephalon to the prefrontal cortex are also critical for these cognitive ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(01)00021-5
更新日期:2001-01-01 00:00:00
abstract::The incidence of anxiety, mood, substance abuse disorders and schizophrenia increases during adolescence. Epidemiological evidence confirms that exposure to stress during sensitive periods of development can create vulnerabilities that put genetically predisposed individuals at increased risk for psychiatric disorders...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2012.09.045
更新日期:2013-09-26 00:00:00
abstract::Normal adult cerebellar Purkinje cells in the rat rarely express low-affinity nerve growth factor receptor immunoreactivity. However, intense anti-low-affinity nerve growth factor receptor immunostaining was observed as early as one day after a lesion of the cerebellar cortex. Low-affinity nerve growth factor receptor...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(93)90408-8
更新日期:1993-02-01 00:00:00