Abstract:
:Normal adult cerebellar Purkinje cells in the rat rarely express low-affinity nerve growth factor receptor immunoreactivity. However, intense anti-low-affinity nerve growth factor receptor immunostaining was observed as early as one day after a lesion of the cerebellar cortex. Low-affinity nerve growth factor receptor immunoreactivity was confined to a selected group of Purkinje cells, the number of which reached a maximum at three days postlesion, and, in some neurons, persisted up to 10 days after damage. The intensity of Purkinje cell immunolabeling decayed abruptly with distance from the lesion site. Reactive Purkinje cells exhibited deposition of immunoreaction product in the cell soma, dendrites and axons. Characteristically, most Purkinje cell axons exhibiting intense low-affinity nerve growth factor receptor immunoreactivity had beaded, varicose morphology. Varicose fibres with the appearance of recurrent collaterals of Purkinje cell axons were also low-affinity nerve growth factor receptor-positive. Our results indicate that adult rat Purkinje cells increase low-affinity nerve growth factor receptor-immunoreactive protein in response to injury, suggesting that, in the cerebellum, low-affinity nerve growth factor receptor or low-affinity nerve growth factor receptor-like molecules may be involved in regulating neuronal plasticity during adulthood.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Martínez-Murillo R,Caro L,Nieto-Sampedro Mdoi
10.1016/0306-4522(93)90408-8subject
Has Abstractpub_date
1993-02-01 00:00:00pages
587-93issue
3eissn
0306-4522issn
1873-7544pii
0306-4522(93)90408-8journal_volume
52pub_type
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