Activin induces long-lasting N-methyl-D-aspartate receptor activation via scaffolding PDZ protein activin receptor interacting protein 1.

abstract：:The expression pattern of the pannexin2 protein (Px2) in healthy and ischemized brains of adult rats was investigated. A polyclonal antibody for rat Px2 was generated in chicken and purified for affinity. This antibody was used to study by Western blot, Enzyme-Linked Immunosorbent Assay, and immunohistochemistry, the ...

journal_title：Neuroscience

authors： Zappalà A,Li Volti G,Serapide MF,Pellitteri R,Falchi M,La Delia F,Cicirata V,Cicirata F

更新日期：2007-09-07 00:00:00

abstract：:2-(4-Methoxyphenyl)ethyl-2-acetamido-2-deoxy-β-d-pyranoside (salidroside analog-4g, SalA-4g), has shown neuroprotective prospects for the treatment of ischemic stroke. However, the dose-response and time window study for SalA-4g, and the mechanism of SalA-4g-mediated neuroprotection remain unclear. Here, we systematic...

journal_title：Neuroscience

authors： Yu S,Xu H,Chi X,Wei L,Cheng Q,Yang Y,Zhou C,Ding F

更新日期：2018-11-01 00:00:00

abstract：:Regret and relief are associated with counterfactual thinking and are sensitive to various social contexts. In the present fMRI study, we investigated the neural basis for regret and relief and how social context (following vs. not following advice) modulates them by employing a sequential risk-taking task. Participan...

journal_title：Neuroscience

authors： Liu Z,Li L,Zheng L,Hu Z,Roberts ID,Guo X,Yang G

更新日期：2016-07-07 00:00:00

abstract：:Ivane Beritashvili ("Beritoff" in Russian, and often in Western languages) was a major figure in 20th-century neuroscience. Mastering the string galvanometer, he founded the electrophysiology of spinal cord reflexes, showing that inhibition is a distinctly different process from excitation, contrary to the concepts of...

journal_title：Neuroscience

authors： Tsagareli MG,Doty RW

更新日期：2009-10-20 00:00:00

abstract：:Recent studies demonstrate that P2X7 receptor subunits (P2X7RS) are present at central and peripheral synapses and suggest that P2X7RS can regulate transmitter release. In brainstem slices from 15 to 26 day old pentobarbitone-anesthetized mice, we examined the effect of P2X7RS activation on excitatory postsynaptic cur...

journal_title：Neuroscience

authors： Ireland MF,Noakes PG,Bellingham MC

更新日期：2004-01-01 00:00:00

abstract：:In an attempt to evaluate the cellular organization and efferent projections of the nucleus tegmenti pedunculopontinus pars compacta, several experiments were performed in the rat. From measurements of neurons in the nucleus tegmenti pedunculopontinus pars compacta in Nissl-stained sections, the nucleus was observed t...

journal_title：Neuroscience

authors： Sugimoto T,Hattori T

更新日期：1984-04-01 00:00:00

abstract：:Plethodontid salamanders display intricate courtship behaviors. Proteinaceous courtship pheromones were recently discovered in the submandibular (mental) gland of the male Plethodon shermani, the red-legged salamander. Behavioral studies showed that these male pheromones are delivered by direct contact to the female s...

journal_title：Neuroscience

authors： Laberge F,Feldhoff RC,Feldhoff PW,Houck LD

更新日期：2008-01-24 00:00:00

abstract：:Intracellular recordings were made from neurons in a rat locus coeruleus slice preparation in vitro. A postsynaptic potential was evoked by electrical stimulation of afferents to the neurons. CI-977 ([5R-(5a,7a,8b)]-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec -8-yl[-4-benzofuranacetamide monohydrochloride) cause...

journal_title：Neuroscience

authors： Pinnock RD

更新日期：1992-01-01 00:00:00

abstract：:Light-microscope visualization in rat brain of a pattern of distribution of immunoreactivity, which included immunolabeled perikarya and beaded processes, was achieved using an immunoaffinity purified polyclonal antibody, Ab165, which recognizes the amino acid sequence, IRNLRQDRSKYY, found in the mu-opioid binding pro...

journal_title：Neuroscience

authors： Hiller JM,Zhang Y,Bing G,Gioannini TL,Stone EA,Simon EJ

更新日期：1994-10-01 00:00:00

abstract：:Brain injury can often result in the subsequent appearance of seizures, suggesting an alteration in neural excitability associated with the balance between neuronal excitation and inhibition. The process by which this occurs has yet to be fully elucidated. The specific nature of the changes in excitation and inhibitio...

journal_title：Neuroscience

authors： Ding MC,Lo EH,Stanley GB

更新日期：2008-06-23 00:00:00

abstract：:Most mammals rely on semiochemicals, such as pheromones, to mediate their social interactions. Recent studies found that semiochemicals are perceived by at least two distinct chemosensory systems: the main and accessory olfactory systems, which share many molecular, cellular, and anatomical features. Nevertheless, the...

journal_title：Neuroscience

authors： Zibman S,Shpak G,Wagner S

更新日期：2011-08-25 00:00:00

abstract：:The present study set out to assess the possible role of the medial prefrontal cortex (mPFC) cannabinoid CB1 receptors and BDNF/cFOS signaling pathways in morphine-dextromethorphan (DXM) cross state-dependent memory (SDM) using male Wistar rats. Changes on the levels of BDNF and cFOS proteins in the PFC were examined ...

journal_title：Neuroscience

authors： Ghasemzadeh Z,Rezayof A

更新日期：2018-11-21 00:00:00

abstract：:A previous study in our laboratory, involving early stage, amyloid pathology in 8-month-old transgenic mice, demonstrated a selective loss of cholinergic terminals in the cerebral and hippocampal cortices of doubly transgenic (APP(K670N,M671L)+PSl(M146L)) mice, an up-regulation in the single mutant APP(K670N,M671L) mi...

journal_title：Neuroscience

authors： Hu L,Wong TP,Côté SL,Bell KF,Cuello AC

更新日期：2003-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) belongs to a family of ligand-activated transcription factors, and its ligands are known to control many physiological and pathological conditions. The hypothesis of our study was that the PPARγ agonist (rosiglitazone) could mediate tumor necrosis factor alpha (...

journal_title：Neuroscience

authors： Chiang MC,Cheng YC,Lin KH,Yen CH

更新日期：2013-01-15 00:00:00

abstract：:The neuropeptide oxytocin (OT) has been implicated in a range of mammalian reproductive and social behaviors including parent-offspring bonding and partner preference formation between socially monogamous mates. Its role in mediating non-reproductive social relationships in rodents, however, remains largely unexplored...

journal_title：Neuroscience

authors： Beery AK,Zucker I

更新日期：2010-08-25 00:00:00

abstract：:Stroke is a leading cause of death and disability in industrialized countries. Although surviving patients exhibit a certain degree of restoration of function attributable to brain plasticity, the majority of stroke survivors has to struggle with persisting deficits. In order to potentiate post-stroke recovery, severa...

journal_title：Neuroscience

authors： Madinier A,Bertrand N,Rodier M,Quirié A,Mossiat C,Prigent-Tessier A,Marie C,Garnier P

更新日期：2013-02-12 00:00:00

abstract：:Diabetes type 1 is a common autoimmune disease manifesting by insulin deficiency and hyperglycemia, which can lead to dementia-like brain dysfunctions. The factors triggering the pathological processes in hyperglycemic brain remain unknown. We reported in this study that brain areas with different susceptibility to di...

journal_title：Neuroscience

authors： Fiedorowicz A,Prokopiuk S,Zendzian-Piotrowska M,Chabowski A,Car H

更新日期：2014-01-03 00:00:00

abstract：:Cannabinoid ligands have been shown to be anti-nociceptive in animal models of acute and chronic pain by acting at the two known cannabinoid receptors, cannabinoid-1 receptor (CB-1) and cannabinoid-2 receptor (CB-2). A major concern with the use of cannabinoids for pain relief is that they activate receptors at sites ...

journal_title：Neuroscience

authors： Palmer JA,Higuera ES,Chang L,Chaplan SR

更新日期：2008-07-17 00:00:00

abstract：:beta-Endorphin is a non-selective opioid peptide which binds mu-, delta- and putative epsilon (beta-endorphin-sensitive non-mu-, non-delta- and non-kappa(1)-)-opioid receptors. We have previously reported that beta-endorphin-produced G-protein activation is mediated by the stimulation of both mu- and putative epsilon-...

journal_title：Neuroscience

authors： Mizoguchi H,Wu HE,Narita M,Hall FS,Sora I,Uhl GR,Nagase H,Tseng LF

更新日期：2002-01-01 00:00:00

abstract：:The molecular mechanisms underlying the response to injury in the central nervous system are incompletely understood. Many cell activation systems may be involved. Tyrosine kinase receptors and their ligands play key roles in cell activation throughout life. The Eph family of tyrosine kinase receptors/ ligands are dev...

journal_title：Neuroscience

authors： Moreno-Flores MT,Wandosell F

更新日期：1999-01-01 00:00:00

abstract：:The afferent inputs to the rostral pole of the anterior pretectal nucleus have been examined by utilizing the retrograde axonal transport of a fluorescent dye, Fast Blue. After unilateral injection of the dye into the rostral anterior prectectal nucleus, large numbers of labelled neuronal somata were found in the soma...

journal_title：Neuroscience

authors： Foster GA,Sizer AR,Rees H,Roberts MH

更新日期：1989-01-01 00:00:00

abstract：:Hippocampal sclerosis is the most frequent pathology encountered in mesial temporal structures resected from patients with intractable temporal lobe epilepsy and it mainly involves hippocampal neuronal loss and gliosis. These alterations are accompanied by changes in the expression of a variety of molecules in the sur...

journal_title：Neuroscience

authors： Andrioli A,Alonso-Nanclares L,Arellano JI,DeFelipe J

更新日期：2007-10-12 00:00:00

abstract：:The ontogeny of substance P-containing neuron system in the forebrain and upper brain stem of the rat was investigated by means of the indirect immunofluorescence technique. Substance P-positive structures first appeared in the primordium of the epithalamus and the area which surrounded the commissura posterior of the...

journal_title：Neuroscience

authors： Inagaki S,Sakanaka M,Shiosaka S,Senba E,Takatsuki K,Takagi H,Kawai Y,Minagawa H,Tohyama M

更新日期：1982-01-01 00:00:00

abstract：:Basic fibroblast growth factor is expressed in different isoforms which display tissue and species specificity and are differentially regulated during development and after experimental interventions. The differential regulation of the fibroblast growth factor-2 isoforms may indicate specific activities and functions ...

journal_title：Neuroscience

authors： Grothe C,Schulze A,Semkova I,Müller-Ostermeyer F,Rege A,Wewetzer K

更新日期：2000-01-01 00:00:00

abstract：:The amyloid beta precursor protein can exist as both a membrane-bound and a secreted protein, with the former having the potential to generate the amyloid beta peptide present in the neuritic plaques which are characteristic of Alzheimer's disease. In this study, we have used a clone of the AtT20 mouse pituitary cell ...

journal_title：Neuroscience

authors： McFarlane I,Georgopoulou N,Coughlan CM,Gillian AM,Breen KC

更新日期：1999-04-01 00:00:00

abstract：:In the ascending auditory pathway, the central nucleus of the inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from many bilateral lower auditory nuclei, intrinsic projections within the IC, contralateral IC through the commissure of the IC and from the auditory cortex. All these presy...

journal_title：Neuroscience

authors： Wang H,Shen S,Zheng T,Bi L,Li B,Wang X,Yang Y,Jen PH

更新日期：2018-10-15 00:00:00

abstract：:Social play is a motivated and rewarding behavior that is displayed by nearly all mammals and peaks in the juvenile period. Moreover, social play is essential for the development of social skills and is impaired in social disorders like autism. We recently showed that the lateral septum (LS) is involved in the regulat...

journal_title：Neuroscience

authors： Bredewold R,Schiavo JK,van der Hart M,Verreij M,Veenema AH

更新日期：2015-10-29 00:00:00

abstract：:The role of agrin in synaptogenesis has been extensively studied. On the other hand, little is known about the function of this extracellular matrix protein during developmental processes that precede the formation of synapses. Recently, agrin was shown to regulate the rate of neurite elongation and the behavior of gr...

journal_title：Neuroscience

authors： Bergstrom RA,Sinjoanu RC,Ferreira A

更新日期：2007-11-09 00:00:00

abstract：:Monoamine oxidase, monoamine oxidase-A, and monoamine oxidase-B activities were compared in free moving, rapid eye movement sleep-deprived, recovered, and control rat brains. The activities were estimated in the whole brain, cerebrum, cerebellum, whole brainstem, medulla, pons, and midbrain. The flowerpot method was u...

journal_title：Neuroscience

authors： Thakkar M,Mallick BN

更新日期：1993-08-01 00:00:00

abstract：:The synaptic organization of terminals originating either from the spinal cord (spinothalamic) or from the dorsal column nuclei (lemniscal) was investigated in the ventrobasal complex of the rat thalamus. Wheatgerm agglutinin conjugated to horseradish peroxidase was used as an anterogradely transported axonal tracer, ...

journal_title：Neuroscience

authors： Ma W,Peschanski M,Ralston HJ 3rd

更新日期：1987-09-01 00:00:00