2-(4-Methoxyphenyl)ethyl-2-Acetamido-2-deoxy-β-d-pyranoside (A Salidroside Analog) Confers Neuroprotection with a Wide Therapeutic Window by Regulating Local Glucose Metabolism in a Rat Model of Cerebral Ischemic Injury.

abstract：:Pathological changes occur in areas of CNS tissue remote from inflammatory lesions in multiple sclerosis (MS) and its animal model experimental allergic encephalomyelitis (EAE). To determine if oxidative stress is a significant contributor to this non-inflammatory pathology, cortex tissues from mice with clinical sign...

journal_title：Neuroscience

authors： Castegna A,Palmieri L,Spera I,Porcelli V,Palmieri F,Fabis-Pedrini MJ,Kean RB,Barkhouse DA,Curtis MT,Hooper DC

更新日期：2011-06-30 00:00:00

abstract：:Prior research with a rat model of behavioral therapy [i.e., effort-based reward (EBR) contingency training] suggests that strengthened associations between physical effort and desired outcomes enhance neurobiological indices of resilience. In the current study, male and female Long-Evans rats were exposed to either s...

journal_title：Neuroscience

authors： Kent M,Scott S,Lambert S,Kirk E,Terhune-Cotter B,Thompson B,Neal S,Dozier B,Bardi M,Lambert K

更新日期：2018-08-21 00:00:00

abstract：:We evaluate a novel set-up for scanning functional connectivity in brain slices from the somatosensory cortex of the rat. Upright infrared video microscopy for targeted placement of electrodes is combined with rapid photolysis of bath-applied caged neurotransmitter induced by a xenon flash lamp. Flash photolysis of ca...

journal_title：Neuroscience

authors： Kötter R,Staiger JF,Zilles K,Luhmann HJ

更新日期：1998-09-01 00:00:00

abstract：:In order to investigate neural mechanisms by which the prefrontal cortex adaptively modifies its activities based on past experience, we examined whether or not sensory cortical projections to the medial prefrontal cortex support long-term potentiation (LTP) in rats. Monosynaptic projections from the secondary visual ...

journal_title：Neuroscience

authors： Kim MJ,Chun SK,Kim YB,Mook-Jung I,Jung MW

更新日期：2003-01-01 00:00:00

abstract：:In unanesthetized cats it has been found that pyramidal volleys elicited upon medullary pyramidal tract stimulation were capable of modifying the discharge of 41% of intracerebellar nuclear cells, via pontocerebellar systems impinging predominantly on the lateral cerebellar cortex. The incidence of responsive cells wa...

journal_title：Neuroscience

authors： Giuffrida R,Licata F,Li Volsi G,Perciavalle V,Urbano A

更新日期：1983-06-01 00:00:00

abstract：:Neural insult during development results in recovery outcomes that vary dependent upon the system under investigation. Nerve regeneration does not occur if the rat gustatory chorda tympani nerve is sectioned (CTX) during neonatal (≤P10) development. It is unclear how chorda tympani soma and terminal fields are affecte...

journal_title：Neuroscience

authors： Martin LJ,Lane AH,Samson KK,Sollars SI

更新日期：2019-03-15 00:00:00

abstract：:Although intrathecal administration of nociceptin, an endogenous ligand of the opioid receptor-like1 receptor, exhibits an antinociceptive effect in various pain models, cellular mechanisms underlying this action are still unknown. Here, we investigated the effects of nociceptin on excitatory and inhibitory synaptic t...

journal_title：Neuroscience

authors： Luo C,Kumamoto E,Furue H,Chen J,Yoshimura M

更新日期：2002-01-01 00:00:00

abstract：:Several lines of evidence have demonstrated the presence of three opioid receptor types in the CNS and periphery. These receptors are referred to as mu, delta and kappa, and have been implicated in a wide variety of functions. The present study examines the localization of the kappa 1 receptor, a region of the recepto...

journal_title：Neuroscience

authors： Mansour A,Burke S,Pavlic RJ,Akil H,Watson SJ

更新日期：1996-04-01 00:00:00

abstract：:Estrogen is likely involved in the gender specific differences in coping with stress. Activation of catecholamine (CA) biosynthetic enzyme gene expression in central and peripheral CA systems plays a key role in response to stress and in regulation of the cardiovascular system. Here we examined whether estradiol can m...

journal_title：Neuroscience

authors： Serova LI,Maharjan S,Sabban EL

更新日期：2005-01-01 00:00:00

abstract：:Thermal hyperalgesia was induced by UV irradiation of the glabrous skin of the hindpaw of adult female Sprague-Dawley rats. We have recorded single cell activity and studied excitability changes in wide dynamic range neurons in the lumbar spinal segments during the early phase (days 1-3) and late phase (days 5-7) of t...

journal_title：Neuroscience

authors： Urban L,Perkins MN,Campbell E,Dray A

更新日期：1993-11-01 00:00:00

abstract：:Pathological narcissism is often characterized by arrogant behavior, a lack of empathy, and willingness to exploit other individuals. Generally, individuals with high levels of narcissism are more likely to suffer mental disorders. However, the brain structural basis of individual pathological narcissism trait among h...

journal_title：Neuroscience

authors： Mao Y,Sang N,Wang Y,Hou X,Huang H,Wei D,Zhang J,Qiu J

更新日期：2016-07-22 00:00:00

abstract：:When adult dorsal root ganglion cells are dissociated and maintained in vitro, both the small dark and the large light neurons show increases in the growth-associated protein GAP-43, a membrane phosphoprotein associated with neuronal development and plasticity. Immunoreactivity for GAP-43 appears in the cytoplasm of t...

journal_title：Neuroscience

authors： Woolf CJ,Reynolds ML,Molander C,O'Brien C,Lindsay RM,Benowitz LI

更新日期：1990-01-01 00:00:00

abstract：:The enkephalin-like immunoreactivity in the retina of chicks has been studied using immunohistochemical and radioimmunoassay techniques. The histochemical experiments showed that the immunoreactivity was confined to a subpopulation of amacrine cells in the inner nuclear layer which projected processes into sublaminae ...

journal_title：Neuroscience

authors： Millar TJ,Salipan N,Oliver JO,Morgan IG,Chubb IW

更新日期：1984-09-01 00:00:00

abstract：:Characteristics of atrial natriuretic peptide receptors were determined in cultured mouse spinal cord cells. Saturation and competition experiments demonstrated the presence of a single class of atrial natriuretic peptide binding sites with high affinity (KD = 0.054 nM) and a density of 1.92 fmoles/10(6) cells. A simi...

journal_title：Neuroscience

authors： Simonnet G,Allard M,Legendre P,Gabrion J,Vincent JD

更新日期：1989-01-01 00:00:00

abstract：:The neuropeptide substance P is an excitatory neurotransmitter produced by various cells including neurons and microglia that is involved in regulating inflammation and cerebral blood flow--functions that affect sleep and slow-wave activity (SWA). Substance P is the major ligand for the neurokinin-1 receptor (NK-1R), ...

journal_title：Neuroscience

authors： Zielinski MR,Karpova SA,Yang X,Gerashchenko D

更新日期：2015-01-22 00:00:00

abstract：:[3H]Glycine is actively taken up into bovine isolated adrenal medulla chromaffin cells with the subsequent catecholamine release. [3H]Glycine uptake has two interaction sites based on relative Km measurements. These sites are inherently distinct since the effects of strychnine and temperature on glycine binding are si...

journal_title：Neuroscience

authors： Yadid G,Youdim MB,Zinder O

更新日期：1993-08-01 00:00:00

abstract：:Peripheral neuropathy represents an important complication of diabetes involving a spectrum of structural, functional and biochemical alterations in peripheral nerves. Recent observations obtained in our laboratory have shown that the levels of neuroactive steroids present in the sciatic nerve of rat raised diabetic b...

journal_title：Neuroscience

authors： Giatti S,Pesaresi M,Cavaletti G,Bianchi R,Carozzi V,Lombardi R,Maschi O,Lauria G,Garcia-Segura LM,Caruso D,Melcangi RC

更新日期：2009-12-01 00:00:00

abstract：:Distribution of primary afferent fibers was studied in intact and neonatally capsaicin treated rats by the application of horseradish peroxidase to the central branch of the transected lumbar dorsal roots. Coarse primary afferent fibers entered the spinal cord through the larger medial portion of the rootlet and arbor...

journal_title：Neuroscience

authors： Réthelyi M,Salim MZ,Jancsó G

更新日期：1986-07-01 00:00:00

abstract：:Both [3H]clonidine and [3H]idazoxan bind to alpha 2 adrenoceptors. The former also labels imidazoline receptors, and the latter non-adrenergic idazoxan binding sites. In order to investigate whether the imidazoline receptors and non-adrenergic idazoxan binding sites are identical, we compared the binding characteristi...

journal_title：Neuroscience

authors： De Vos H,Bricca G,De Keyser J,De Backer JP,Bousquet P,Vauquelin G

更新日期：1994-04-01 00:00:00

abstract：:Inflammatory damage following ICH is often attributed to microglia/macrophage activation. In many diseases, IL-4 has been proven to switch microglia/macrophages from the pro-inflammatory to the anti-inflammatory subtype. However, the role and underlying mechanism of IL-4 in ICH, especially in neuroprotection, remain u...

journal_title：Neuroscience

authors： He Y,Gao Y,Zhang Q,Zhou G,Cao F,Yao S

更新日期：2020-06-15 00:00:00

abstract：:l-3,4-Dihydroxyphenylalanine (l-DOPA) is the therapeutic gold standard in Parkinson's disease. However, most patients develop debilitating abnormal involuntary movements termed l-DOPA-induced dyskinesia (LID) as therapy-complicating side effects. The underlying mechanisms of LID pathogenesis are still not fully unders...

journal_title：Neuroscience

authors： Klietz M,Keber U,Carlsson T,Chiu WH,Höglinger GU,Weihe E,Schäfer MK,Depboylu C

更新日期：2016-09-07 00:00:00

abstract：:Extracellular recordings were made from serotonergic neurons of the rat dorsal raphe nucleus in a slice preparation. In the presence of phenylephrine (3 microM) to restore the pacemaker activity of otherwise silent serotonergic neurons, superfusion with the 5-hydroxytryptamine1A agonist ipsapirone depressed the firing...

journal_title：Neuroscience

authors： Haj-Dahmane S,Hamon M,Lanfumey L

更新日期：1991-01-01 00:00:00

abstract：:Hindbrain-derived stimuli restrain the gonadotropin-releasing hormone (GnRH)-pituitary luteinizing hormone (LH) reproductive neuroendocrine axis during energy insufficiency. Interruption of food intake, planned or unplanned, is emblematic of modern life. This study investigated the premise that the hindbrain energy se...

journal_title：Neuroscience

authors： Shakya M,Shrestha PK,Briski KP

更新日期：2018-07-15 00:00:00

abstract：:The ability to selectively control the differentiation of neural stem cells (NSCs) into cholinergic neurons in vivo would be an important step toward cell replacement therapy. First, green fluorescent protein (GFP)-NSCs were induced to differentiate into cholinergic neuron-like cells (CNLs) with retinoic acid (RA) pre...

journal_title：Neuroscience

authors： Gu G,Zhang W,Li M,Ni J,Wang P

更新日期：2015-04-16 00:00:00

abstract：:The distribution of CA3 hippocampal axonal terminal fields undergo a period of widespread connectivity-based changes in the early postnatal stages of life. The purpose of the current study was to examine the effect of acute phthalate exposure during this period of hippocampal development (postnatal days 16-22 (p16-p22...

journal_title：Neuroscience

authors： Smith CA,Macdonald A,Holahan MR

更新日期：2011-10-13 00:00:00

abstract：:The globus pallidus sends a significant GABAergic projection to the thalamic reticular nucleus. Because pallidal neurons express D4-dopamine receptors, we have explored their presence on pallidoreticular terminals by studying the effect of dopamine and D4-receptor agonists on the GABAergic transmission in the thalamic...

journal_title：Neuroscience

authors： Gasca-Martinez D,Hernandez A,Sierra A,Valdiosera R,Anaya-Martinez V,Floran B,Erlij D,Aceves J

更新日期：2010-09-15 00:00:00

abstract：:We tested the hypothesis that efferents from the nucleus basalis magnocellularis (NBM) play a direct role in the regulation of neuropeptide synthesis and expression by neurons of the rat suprachiasmatic nucleus (SCN). Adult male rats in which the NBM was destroyed with quinolinic acid, either unilaterally or bilateral...

journal_title：Neuroscience

authors： Madeira MD,Pereira PA,Silva SM,Cadete-Leite A,Paula-Barbosa MM

更新日期：2004-01-01 00:00:00

abstract：:The aging process is known to coincide with a decline in circulating sex hormone levels in both men and women. Due to an increase in the average lifespan, a growing number of post-menopausal women are now receiving hormone therapy for extended periods of time. Recent findings of the Women's Health Initiative, however,...

journal_title：Neuroscience

authors： Mhyre AJ,Dorsa DM

更新日期：2006-01-01 00:00:00

abstract：:Clozapine, an atypical antipsychotic agent important for the treatment of schizophrenia, has marked inhibitory effects on sympathetic outflow to the thermoregulatory cutaneous circulation. In rabbits clozapine reverses ear pinna vasoconstriction induced either by administration of MDMA (3,4-methylenedioxymethamphetami...

journal_title：Neuroscience

authors： Blessing WW,Zilm A,Ootsuka Y

更新日期：2006-09-15 00:00:00

abstract：:Using microdialysis from medial prefrontal cortex of gerbils during aversive auditory conditioning in the shuttle-box we have previously shown a transient increase of dopamine efflux correlated with the establishment of avoidance behavior. We hypothesized that the acquisition of a new behavioral strategy is generally ...

journal_title：Neuroscience

authors： Stark H,Rothe T,Wagner T,Scheich H

更新日期：2004-01-01 00:00:00