Abstract：
:Oxidative stress is believed to be a major factor for the onset of Parkinson's disease (PD). In this study, we have investigated oxidative status in transgenic Drosophila model of PD. Our results revealed elevated levels of reactive oxygen species (ROS) and lipid peroxidation (LPO) in A30P and A53T α-synuclein PD model flies compared to control. We have demonstrated for the first time the ameliorating potential of natural antioxidants characterized from the roots of Dh in A30P and A53T α-synuclein PD model flies. Feeding of transgenic flies with aqueous Dh root extract for 21 days significantly improved their climbing ability and circadian rhythm of locomotor activity which was associated with reduction in levels of ROS and LPO and enhancement in the activities of catalase (CAT) and superoxide dismutase (SOD). Dh protected against paraquat (PQ) sensitivity in α-synuclein transgenic flies and delayed the onset of PD-like symptoms which appears to be mediated by suppression of oxidative stress.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Jahromi SR,Haddadi M,Shivanandappa T,Ramesh SRdoi
10.1016/j.neuroscience.2015.02.048subject
Has Abstractpub_date
2015-05-07 00:00:00pages
136-50eissn
0306-4522issn
1873-7544pii
S0306-4522(15)00207-9journal_volume
293pub_type
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