Abstract：
:The possible neuroprotective effect of physical exercise was investigated in rats after middle cerebral artery occlusion (MCAO), a focal stroke model. It was found that physical exercise in the form of a 12-week treadmill running programme reduced the volume of infarction caused by MCAO. At the molecular level, reverse transcription polymerase chain reaction revealed that the runner had increased gene expression for nerve growth factor (NGF) over the nonrunner with or without MCAO. Expression of the NGF receptors, p75, was increased only in the absence of MCAO. In addition, runners showed a significantly higher number of cholinergic neurons, which constitutively expressed p75, in the horizontal diagonal band of Broca. The present findings suggest that neuroprotection after physical exercise may be a result of an increase in an endogenous neurotrophic factor nerve growth factor and the proliferation of its receptive cholinergic neurons.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Ang ET,Wong PT,Moochhala S,Ng YKdoi
10.1016/s0306-4522(02)00989-2keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
335-45issue
2eissn
0306-4522issn
1873-7544pii
S0306452202009892journal_volume
118pub_type
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