当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Effects of local cholinesterase inhibition on acetylcholine release assessed simultaneously in prefrontal and frontoparietal cortex.

Effects of local cholinesterase inhibition on acetylcholine release assessed simultaneously in prefrontal and frontoparietal cortex.

Abstract：

:To investigate whether acetylcholine is released in a similar fashion in different regions of the cortex, in vivo microdialysis was used to measure acetylcholine efflux simultaneously in the medial prefrontal and the frontoparietal cortex, under both basal conditions and following tactile stimulation. Additionally, the effects of including two different concentrations (0.05 microM and 0.5 microM) of a cholinesterase inhibitor (neostigmine) in the perfusion fluid were assessed. Basal levels of acetylcholine (i.e. during non-stimulated sessions) were similar in medial prefrontal and frontoparietal areas. Tactile stimulation reliably increased acetylcholine efflux in a similar fashion (up to 140% increase above baseline) in both cortical areas studied. Predictably, the higher concentration of neostigmine (0.5 microM) increased basal acetylcholine efflux by about 150% from levels observed with the lower neostigmine concentration (0.05 microM), but the concentration of local neostigmine had no effect on either the magnitude or the duration of the increased acetylcholine efflux following tactile stimulation. These results suggest that the pattern of acetylcholine release may be comparable in different areas of the cortex, supporting the idea that cholinergic projections from the basal forebrain to the cortex represent a globally regulated system. Furthermore, while the inclusion of neostigmine in perfusion fluid must be taken into account when interpreting acetylcholine efflux data, it appears that concentrations of up to 0.5 microM do not interfere fundamentally with the lability of cortical acetylcholine efflux in response to behavioural stimulation.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Himmelheber AM,Fadel J,Sarter M,Bruno JP

doi

10.1016/s0306-4522(98)00097-9

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

949-57

issue

3

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(98)00097-9

journal_volume

86

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Alpha-2 adrenergic regulation of pedunculopontine nucleus neurons during development.

    abstract：:Rapid eye movement sleep decreases between 10 and 30 days postnatally in the rat. The pedunculopontine nucleus is known to modulate waking and rapid eye movement sleep, and pedunculopontine nucleus neurons are thought to be hyperpolarized by noradrenergic input from the locus coeruleus. The goal of the study was to in...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.04.045

    authors： Bay KD,Mamiya K,Good CH,Skinner RD,Garcia-Rill E

    更新日期：2006-08-25 00:00:00

  • Hindbrain 5'-Adenosine Monophosphate-activated Protein Kinase Mediates Short-term Food Deprivation Inhibition of the Gonadotropin-releasing Hormone-Luteinizing Hormone Axis: Role of Nitric Oxide.

    abstract：:Hindbrain-derived stimuli restrain the gonadotropin-releasing hormone (GnRH)-pituitary luteinizing hormone (LH) reproductive neuroendocrine axis during energy insufficiency. Interruption of food intake, planned or unplanned, is emblematic of modern life. This study investigated the premise that the hindbrain energy se...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2018.04.040

    authors： Shakya M,Shrestha PK,Briski KP

    更新日期：2018-07-15 00:00:00

  • Peptide YY: a neuropeptide in the gut. Immunocytochemical and immunochemical evidence.

    abstract：:Peptide YY immunoreactivity was detected in neuronal elements in the upper digestive tract of the rat, cat, ferret and pig by immunocytochemistry and radioimmunoassay combined with high-performance liquid chromatography. The two peptide YY antisera used do not recognize the related peptides neuropeptide Y and pancreat...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90472-r

    authors： Böttcher G,Ekblad E,Ekman R,Håkanson R,Sundler F

    更新日期：1993-07-01 00:00:00

  • Input-selective potentiation and rebalancing of primary sensory cortex afferents by endogenous acetylcholine.

    abstract：:Acetylcholine (ACh) plays important roles in the modulation of activity and plasticity of primary sensory cortices, thus influencing sensory detection and integration. We examined this in urethane-anesthetized rats, comparing cholinergic modulation of short latency, large amplitude field postsynaptic potentials (fPSPs...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.06.026

    authors： Kuo MC,Rasmusson DD,Dringenberg HC

    更新日期：2009-09-29 00:00:00

  • Novel molecular targets of the neuroprotective/neurorescue multimodal iron chelating drug M30 in the mouse brain.

    abstract：:The novel multifunctional brain permeable iron, chelator M30 [5-(N-methyl-N-propargyaminomethyl)-8-hydroxyquinoline] was shown to possess neuroprotective activities in vitro and in vivo, against several insults applicable to various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyo...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.03.040

    authors： Kupershmidt L,Weinreb O,Amit T,Mandel S,Bar-Am O,Youdim MB

    更新日期：2011-08-25 00:00:00

  • Influence of anxiety in spatial memory impairments related to the loss of vestibular function in rat.

    abstract：:It is now well established that vestibular information plays an important role in spatial memory processes. Although vestibular lesions induce anxiety in humans, this finding remains controversial in rodents. However, it is possible that anxiety-related behavior is associated with spatial memory impairments after vest...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.05.029

    authors： Machado ML,Lelong-Boulouard V,Smith PF,Freret T,Philoxene B,Denise P,Besnard S

    更新日期：2012-08-30 00:00:00

  • Cerebellar activity and connectivity during the experience of disgust and happiness.

    abstract：:Previous research indicates that distinct subregions of the cerebellum are involved in the processing of different primary emotions. How this is achieved in terms of connectional specificity with other brain areas still needs to be elucidated. We employed functional magnetic resonance imaging in order to investigate c...

    journal_title：Neuroscience

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.neuroscience.2013.04.048

    authors： Schienle A,Scharmüller W

    更新日期：2013-08-29 00:00:00

  • Cortical spreading depression reversibly disrupts convulsive motor seizure expression in amygdala-kindled rats.

    abstract：:To determine the role of the frontal cortex in the generalization of limbic seizures, we first produced unilateral cortical spreading depression to reversibly suppress neuronal activity in the motor cortex and then triggered an amygdala-kindled seizure. Three minutes following induction of unilateral spreading depress...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00656-3

    authors： Kelly ME,Battye RA,McIntyre DC

    更新日期：1999-01-01 00:00:00

  • Optogenetic activation of amygdala projections to nucleus accumbens can arrest conditioned and unconditioned alcohol consummatory behavior.

    abstract：:Following a Pavlovian pairing procedure, alcohol-paired cues come to elicit behavioral responses that lead to alcohol consumption. Here we used an optogenetic approach to activate basolateral amygdala (BLA) axonal terminals targeting the shell of nucleus accumbens (AcbSh) and investigated a possible influence over cue...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.07.044

    authors： Millan EZ,Kim HA,Janak PH

    更新日期：2017-09-30 00:00:00

  • Nucleoside triphosphate diphosphohydrolase-2 (NTPDase2/CD39L1) is the dominant ectonucleotidase expressed by rat astrocytes.

    abstract：:Inflammatory and degenerative pathophysiological processes within the CNS are important causes of human disease. Astrocytes appear to modulate these reactions and are a major source of inflammatory mediators, e.g. extracellular adenine nucleotides, in nervous tissues. Actions following extracellular nucleotides bindin...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.11.039

    authors： Wink MR,Braganhol E,Tamajusuku AS,Lenz G,Zerbini LF,Libermann TA,Sévigny J,Battastini AM,Robson SC

    更新日期：2006-01-01 00:00:00

  • Psychophysical determination of coordinate representation of human arm orientation.

    abstract：:The coordinate representation of the sense of limb orientation was investigated psychophysically by asking subjects to match the orientation of the arm or of the forearm in several different coordinate representations. Movement of all degrees of freedom of one arm was permitted while movement of the other limb was res...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(84)90252-5

    authors： Soechting JF,Ross B

    更新日期：1984-10-01 00:00:00

  • MiR-138 promotes the migration of cultured chicken embryonic hypothalamic cells by targeting reelin.

    abstract：:Neuronal network remodeling during critical periods of sensory development might be accompanied by alterations in hypothalamic cell populations. MicroRNAs play a central role in regulating neuronal function, including neural stem cell proliferation, and neuronal migration, maturation and integration into viable circui...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.02.020

    authors： Kisliouk T,Meiri N

    更新日期：2013-05-15 00:00:00

  • Hippocampal Subgranular Zone FosB Expression Is Critical for Neurogenesis and Learning.

    abstract：:Neural proliferation in the dentate gyrus (DG) is closely linked with learning and memory, but the transcriptional programming that drives adult proliferation remains incompletely understood. Our lab previously elucidated the critical role of the transcription factor ΔFosB in the dorsal hippocampus (dHPC) in learning ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.03.022

    authors： Manning CE,Eagle AL,Kwiatkowski CC,Achargui R,Woodworth H,Potter E,Ohnishi Y,Leinninger GM,Robison AJ

    更新日期：2019-05-15 00:00:00

  • Rescue and regeneration of injured peripheral nerve axons by intrathecal insulin.

    abstract：:Insulin peptide, acting through tyrosine kinase receptor pathways, contributes to nerve development or repair. In this work, we examined the direction, impact and repertoire of insulin signaling in vivo during peripheral nerve regeneration in rats. First, we demonstrated that insulin receptor is expressed on lumbar do...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.11.065

    authors： Toth C,Brussee V,Martinez JA,McDonald D,Cunningham FA,Zochodne DW

    更新日期：2006-05-12 00:00:00

  • Histogenesis at the level of the basal forebrain: the entopeduncular nucleus.

    abstract：:This study shows that the neurons of the entopeduncular nucleus are derived from a longitudinal slab of isochronically generated neurons on day 11 and 15 h of gestation. Many neurons of this longitudinal slab which we have named the basal forebrain cell column, originate from an ependymal matrix closely associated wit...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(86)90032-1

    authors： Marchand R,Lajoie L,Blanchet C

    更新日期：1986-03-01 00:00:00

  • Somatostatin inhibits the excitability of rat small-diameter trigeminal ganglion neurons that innervate nasal mucosa and project to the upper cervical dorsal horn via activation of somatostatin 2a receptor.

    abstract：:This study investigated whether somatostatin (SST) modulates the excitability of nociceptive trigeminal ganglion (TRG) neurons that innervate the nasal mucosa and project to the upper cervical (C(1)) dorsal horn by using perforated-patch clamping, retrograde-labeling, and immunohistochemistry. Fluorogold (FG) retrogra...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.06.048

    authors： Takeda M,Kadoi J,Takahashi M,Nasu M,Matsumoto S

    更新日期：2007-09-07 00:00:00

  • Quantitative study of neuronal degeneration induced by Ricinus toxin and crush of postganglionic nerves in the ciliary ganglion of quail.

    abstract：:The effects of Ricinus toxin on the neurons of the ciliary ganglia were investigated in the quail. The neuronal death and the morphological alterations of the ganglionic cells were assessed following injection of the toxin in the anterior chamber of the eye or after application of the toxin on the postganglionic nerve...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(91)90052-p

    authors： Ciofi Luzzatto A,De Stefano ME,Guidolin D,Paggi P,Toschi G

    更新日期：1991-01-01 00:00:00

  • Long-term and regional specific changes in [3H]flunitrazepam binding in kindled rat hippocampus.

    abstract：:The binding of the GABAA/benzodiazepine receptor agonist [3H]flunitrazepam was studied in the hippocampus of rats kindled by daily stimulation of the Schaffer collaterals, using semi-quantitative autoradiography. Two kindled stages were investigated: (i) 24 h after the last generalized tonic-clonic seizure (fully kind...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)00158-f

    authors： Titulaer MN,Kamphuis W,Lopes da Silva FH

    更新日期：1995-09-01 00:00:00

  • Vasoactive intestinal peptide in the hamster seminal vesicle: distribution, binding sites and possible functions.

    abstract：:The presence and functional role of vasoactive intestinal peptide in the hamster seminal vesicle were studied by a combination of structural and functional approaches. The use of an immunofluorescence staining technique in both cryostat sections and whole-mount preparations revealed that vasoactive intestinal peptide-...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90307-7

    authors： Pinho MS,Sebastião AM,Rodrigues G,Barroso CP,Ribeiro JA,Mata LR,Gulbenkian S

    更新日期：1994-04-01 00:00:00

  • microRNA-124 is down regulated in nerve-injured motor neurons and it potentially targets mRNAs for KLF6 and STAT3.

    abstract：:MicroRNA (miRNA) is a small non-coding RNA that regulates gene expression by degrading target mRNAs or inhibiting translation. Although many miRNAs play important roles in various conditions, it is unclear whether miRNAs are involved in motor nerve regeneration. In this study, we identified the possible implication of...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.10.055

    authors： Nagata K,Hama I,Kiryu-Seo S,Kiyama H

    更新日期：2014-01-03 00:00:00

  • K369I Tau Mice Demonstrate a Shift Towards Striatal Neuron Burst Firing and Goal-directed Behaviour.

    abstract：:Pathological forms of the microtubule-associated protein tau are involved in a large group of neurodegenerative diseases named tauopathies, including frontotemporal lobar degeneration (FTLD-tau). K369I mutant tau transgenic mice (K3 mice) recapitulate neural and behavioural symptoms of FTLD, including tau aggregates i...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.09.023

    authors： Mo M,Jönsson ME,Mathews MA,Johnstone D,Ke YD,Ittner LM,Balleine BW,Furlong TM,Camp AJ

    更新日期：2020-11-21 00:00:00

  • Role of central cholinergic receptor sub-types in spatial working memory: a five-arm maze task in mice provides evidence for a functional role of nicotinic receptors in mediating trace access processes.

    abstract：:A delayed-matching spatial working memory protocol in a 5-arm maze was used to test the hypothesis of differential roles for central nicotinic and muscarinic cholinergic receptors in mediating task performance. In experiment 1, using a within subjects-repeated design, groups of C57Bl/6 mice, previously trained to crit...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(03)00403-2

    authors： Maviel T,Durkin TP

    更新日期：2003-01-01 00:00:00

  • Bilateral irradiation of head and neck induces an enhanced expression of substance P in the parasympathetic innervation of the submandibular gland.

    abstract：:Substance P and calcitonin gene-related peptide (CGRP) are present in nerve fibers innervating the submandibular gland. Radiotherapy of tumors in the head and neck region usually embraces the salivary glands in the irradiated field and consequently a dramatic decrease in salivary function is seen. In this study, the s...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(92)90023-u

    authors： Forsgren S,Franzén L,Funegård U,Gustafsson H,Henriksson R

    更新日期：1992-01-01 00:00:00

  • Effect of melatonin on neuronal differentiation requires CBP/p300-mediated acetylation of histone H3 lysine 14.

    abstract：:The transition from multipotent neural stem cells (NSCs) to terminally differentiated neurons is a multistep process, and the transition is finely regulated by transcription factors with basic helix-loop-helix (bHLH) motifs. Melatonin is an endogenous neurohormone with profound neurotrophic and neuroprotective effects...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.07.064

    authors： Li X,Chen X,Zhou W,Ji S,Li X,Li G,Liu G,Wang F,Hao A

    更新日期：2017-11-19 00:00:00

  • Contribution of astrocyte glycogen stores to progression of spreading depression and related events in hippocampal slices.

    abstract：:Spreading depression (SD) is a wave of coordinated cellular depolarization that propagates slowly throughout brain tissue. SD has been associated with migraine aura, and related events have been implicated in the enlargement of some brain injuries. Selective disruption of astrocyte oxidative metabolism has previously ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.05.006

    authors： Seidel JL,Shuttleworth CW

    更新日期：2011-09-29 00:00:00

  • Two new monoclonal antibodies provide immunohistochemical evidence for the unique biochemical similarity of the mouse globus pallidus, entopeduncular nucleus and substantia nigra pars reticulata.

    abstract：:Similarities in cellular morphology, afferentation, efferentation, and neurotransmitter content between the internal and external parts of the pallidum and the substantia nigra pars reticulata have long been noted. Here we present evidence that the globus pallidus, entopedunucular nucleus and substantia nigra pars ret...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(90)90149-x

    authors： Sousa R,Hrinya Tannery N,Lafer EM

    更新日期：1990-01-01 00:00:00

  • Imaging genetics and the power of combined technologies: a perspective from neuroethics.

    abstract：:Imaging genetics has emerged as a powerful and sensitive approach to the study of functional genetic variations and brain responses in psychiatric and neurologic disorders. Ethics issues in contemporary neuroscience as they apply separately to genetics and neuroimaging have been a growing focus for research but, to da...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2009.01.052

    authors： Tairyan K,Illes J

    更新日期：2009-11-24 00:00:00

  • Organotypic slice cultures of the rat striatum--I. A histochemical and immunocytochemical study of acetylcholinesterase, choline acetyltransferase, glutamate decarboxylase and GABA.

    abstract：:Slices of striatal tissue from newborn to eight-day-old rats were cultured for six to 47 days. Cholinergic neurons and fibres were then visualized by histochemical staining for acetylcholinesterase or immunocytochemical staining for choline acetyltransferase. GABA-containing neurons and fibres were visualized by immun...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90616-n

    authors： Ostergaard K

    更新日期：1993-04-01 00:00:00

  • Laminar distributions of muscarinic acetylcholine, serotonin, GABA and opioid receptors in human posterior cingulate cortex.

    abstract：:Experimental animal studies have demonstrated a number of receptor localizations on specific cortical afferents and neurons. The present study of human posterior cingulate cortex evaluates the laminar distributions of particular receptors and their likely association with components of the neuropil. Coverslip autoradi...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(90)90359-c

    authors： Vogt BA,Plager MD,Crino PB,Bird ED

    更新日期：1990-01-01 00:00:00

  • Leu27 insulin-like growth factor-II, an insulin-like growth factor-II analog, attenuates depolarization-evoked GABA release from adult rat hippocampal and cortical slices.

    abstract：:Accumulated evidence suggests that the single transmembrane domain insulin-like growth factor-II/mannose 6-phosphate receptor (IGF-II/M6P or IGF-II receptor) plays an important role in the intracellular trafficking of lysosomal enzymes and endocytosis-mediated degradation of insulin like growth factor (IGF-II). Howeve...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.07.026

    authors： Amritraj A,Rauw G,Baker GB,Kar S

    更新日期：2010-10-27 00:00:00