当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Transgenic mice expressing F3/contactin from the transient axonal glycoprotein promoter undergo developmentally regulated deficits of the cerebellar function.

Transgenic mice expressing F3/contactin from the transient axonal glycoprotein promoter undergo developmentally regulated deficits of the cerebellar function.

Abstract：

:We have shown that transgenic transient axonal glycoprotein (TAG)/F3 mice, in which the mouse axonal glycoprotein F3/contactin was misexpressed from a regulatory region of the gene encoding the transient axonal glycoprotein TAG-1, exhibit a transient disruption of cerebellar granule and Purkinje cell development [Development 130 (2003) 29]. In the present study we explore the neurobehavioural consequences of this mutation. We report on assays of reproductive parameters (gestation length, litter size and offspring viability) and on somatic and neurobehavioural end-points (sensorimotor development, homing performance, motor activity, motor coordination and motor learning). Compared with wild-type littermates, TAG/F3 mice display delayed sensorimotor development, reduced exploratory activity and impaired motor activity, motor coordination and motor learning. The latter parameters, in particular, were affected also in adult mice, despite the apparent recovery of cerebellar morphology, suggesting that subtle changes of neuronal circuitry persist in these animals after development is complete. These behavioural deficits indicate that the finely coordinated expression of immunoglobulin-like cell adhesion molecules such as TAG-1 and F3/contactin is of key relevance to the functional, as well as morphological maturation of the cerebellum.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Coluccia A,Tattoli M,Bizzoca A,Arbia S,Lorusso L,De Benedictis L,Buttiglione M,Cuomo V,Furley A,Gennarini G,Cagiano R

doi

10.1016/j.neuroscience.2003.08.025

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

155-66

issue

1

eissn

0306-4522

issn

1873-7544

pii

S0306452203006328

journal_volume

123

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • High Fructose Diet Induces Sex-specific Modifications in Synaptic Respiration and Affective-like Behaviors in Rats.

    abstract：:The consequences of excessive fructose intake extend beyond those of metabolic disorder to changes in emotional regulation and cognitive function. Long-term consumption of fructose, particularly common when begun in adolescence, is more likely to lead to deleterious consequences than acute consumption. These long-term...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.11.039

    authors： Kloster A,Hyer MM,Dyer S,Salome-Sanchez C,Neigh GN

    更新日期：2021-02-01 00:00:00

  • Nitric oxide alters proenkephalin and prodynorphin gene expression in hippocampal granule cells.

    abstract：:Application of N-methyl-D-aspartate on to the dendrites of hippocampal granule cells dramatically decreased prodynorphin messenger RNA levels in the affected cells while increasing proenkephalin messenger RNA levels. Sin-1 molsidomine (an agent which releases nitric oxide) and 8-bromo-cyclic GMP were similarly effecti...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90423-5

    authors： Johnston HM,Morris BJ

    更新日期：1994-08-01 00:00:00

  • Dynamic expression of secreted Frizzled-related protein 3 (sFRP3) in the developing mouse spinal cord and dorsal root ganglia.

    abstract：:Wnt proteins have been implicated in regulating a variety of developmental processes in the CNS. Secreted Frizzled-related protein 3 (sFRP3) is a member of the sFRP family that can inhibit the Wnt signaling by binding directly to Wnts via their regions of homology to the Wnt-binding domain of Frizzleds. Recent studies...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.06.044

    authors： Zhao X,Huang H,Chen Y,Liu Y,Zhang Z,Ma Q,Qiu M

    更新日期：2013-09-17 00:00:00

  • Capsaicin stimulation of the cochlea and electric stimulation of the trigeminal ganglion mediate vascular permeability in cochlear and vertebro-basilar arteries: a potential cause of inner ear dysfunction in headache.

    abstract：:Trigeminal neurogenic inflammation is one explanation for the development of vascular migraine. The triggers for this inflammation and pain are not well understood, but are probably vasoactive components acting on the blood vessel wall. Migraine-related inner ear symptoms like phonophobia, tinnitus, fluctuation in hea...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(00)00521-2

    authors： Vass Z,Steyger PS,Hordichok AJ,Trune DR,Jancsó G,Nuttall AL

    更新日期：2001-01-01 00:00:00

  • Properties of inward and outward potassium currents in cultured mouse motoneurons.

    abstract：:Inward rectifier potassium currents and calcium-dependent potassium currents have been studied in cultured embryonic mouse motoneurons. Sustained unitary inward rectifier potassium currents were recorded from cell-attached patches and the channel conductance was dependent on external K+ concentration with a value of 2...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)90396-o

    authors： McLarnon JG,Kim SU,Michikawa M,Xu R

    更新日期：1995-01-01 00:00:00

  • Effect of propentofylline on free radical generation during cerebral hypoxia in the newborn piglet.

    abstract：:The present study tests the hypothesis that propentofylline, an adenosine re-uptake inhibitor, will reduce free radical generation during cerebral hypoxia. Ten newborn piglets were pretreated with propentofylline (10 mg/kg), five of which were subjected to hypoxia, while the other five were maintained at normoxia. Fiv...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(97)00542-3

    authors： Numagami Y,Marro PJ,Mishra OP,Delivoria-Papadopoulos M

    更新日期：1998-06-01 00:00:00

  • Gray matter damage in multiple sclerosis: Impact on clinical symptoms.

    abstract：:Traditionally, multiple sclerosis (MS) is considered to be a disease primarily affecting the white matter (WM). However, the development of some clinical symptoms such as cognitive impairment cannot be fully explained by the severity of WM pathology alone. During the past decades it became clear that gray matter (GM) ...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2015.07.006

    authors： van Munster CE,Jonkman LE,Weinstein HC,Uitdehaag BM,Geurts JJ

    更新日期：2015-09-10 00:00:00

  • Tonic and stimulus-evoked nitric oxide production in the mouse olfactory bulb.

    abstract：:Nitric oxide (NO) has been long assumed to play a key role in mammalian olfaction. This was based largely on circumstantial evidence, i.e. prominent staining for nitric oxide synthase (NOS) and cyclic guanosine 3',5'-cyclic monophosphate (cGMP) or soluble guanylyl cyclase, an effector enzyme activated by NO, in local ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.03.003

    authors： Lowe G,Buerk DG,Ma J,Gelperin A

    更新日期：2008-05-15 00:00:00

  • Long noncoding RNA Malat1 is a potent autophagy inducer protecting brain microvascular endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury by sponging miR-26b and upregulating ULK2 expression.

    abstract：:Brain microvascular endothelial cell (BMEC) injury induced by ischemia-reperfusion (I/R) is the initial stage of blood-brain barrier (BBB) disruption, which results in a poor prognosis in ischemic stroke patients. Autophagy has been shown to have protective effects on BMECs against cerebral ischemic insults. However, ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.04.017

    authors： Li Z,Li J,Tang N

    更新日期：2017-06-23 00:00:00

  • Activation of the 5-HT(6) receptor attenuates long-term potentiation and facilitates GABAergic neurotransmission in rat hippocampus.

    abstract：:The 5-HT(6) receptor is predominantly expressed in the CNS and has been implicated in the regulation of cognitive function. Antagonists of the 5-HT(6) receptor improve cognitive performance in a number of preclinical models and have recently been found to be effective in Alzheimer's disease patients. Systemic administ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.07.061

    authors： West PJ,Marcy VR,Marino MJ,Schaffhauser H

    更新日期：2009-12-01 00:00:00

  • Control of rat hypothalamic pro-opiomelanocortin neurons by a circadian clock that is entrained by the daily light-off signal.

    abstract：:Previous studies have clearly demonstrated that the immediate-early gene, c-fos can regulate, through its protein product Fos, the expression of the pro-opiomelanocortin gene. In the present study, immunohistochemistry for Fos and beta-endorphin was used to assess the basal activity of hypothalamic pro-opiomelanocorti...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(99)00208-0

    authors： Jamali KA,Tramu G

    更新日期：1999-01-01 00:00:00

  • Sphingolipid profiles are altered in prefrontal cortex of rats under acute hyperglycemia.

    abstract：:Diabetes type 1 is a common autoimmune disease manifesting by insulin deficiency and hyperglycemia, which can lead to dementia-like brain dysfunctions. The factors triggering the pathological processes in hyperglycemic brain remain unknown. We reported in this study that brain areas with different susceptibility to di...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.10.022

    authors： Fiedorowicz A,Prokopiuk S,Zendzian-Piotrowska M,Chabowski A,Car H

    更新日期：2014-01-03 00:00:00

  • Role of the substantia nigra in the expression of dopamine D1 receptor-mediated and D2 receptor-mediated behaviours.

    abstract：:This study examines the proposal that striatonigral pathways support circling mediated by dopamine D1 receptors, but not D2 receptors, in unilaterally 6-hydroxydopamine-treated rats. In this model the D1/D2 agonist apomorphine, the D1 agonist 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine hydrochloride and...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(87)90175-8

    authors： Fletcher GH,Starr MS

    更新日期：1987-12-01 00:00:00

  • Termination pattern and fine structural characteristics of GABA- and [Met]enkephalin-containing nerve fibers and synapses in the superior cervical ganglion of adult rat.

    abstract：:Morphological features of nerve fibers and synapses containing GABA and [Met]enkephalin were studied at the light and electron microscopic levels in the superior cervical ganglia of rats by pre- and postembedding immunohistochemistry. Both GABA and [Met]enkephalin immunoreactivities were found in varicose nerve fibers...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(92)90372-9

    authors： Párducz A,Dobó E,Joó F,Wolff JR

    更新日期：1992-08-01 00:00:00

  • Serotonin-induced in vitro long-term facilitation exhibits differential pattern sensitivity in cervical and thoracic inspiratory motor output.

    abstract：:Intermittent hypoxia induces 5-HT-dependent, pattern-sensitive long-term facilitation (LTF) of spinal respiratory motor output. We used a split-bath in vitro neonatal rat brainstem-spinal cord preparation to test whether: 1) intermittent spinal 5-HT exposure (without hypoxia) is sufficient to induce LTF in phrenic and...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.06.036

    authors： Lovett-Barr MR,Mitchell GS,Satriotomo I,Johnson SM

    更新日期：2006-10-27 00:00:00

  • Differential expression of group I metabotropic glutamate receptors in human motoneurons at low and high risk of degeneration in amyotrophic lateral sclerosis.

    abstract：:Glutamate excitotoxicity has been suggested to play a role in amyotrophic lateral sclerosis, since overstimulation of post-synaptic glutamate receptors by accumulated extracellular glutamate leads to motoneuron cell death. It is however unclear as to why some groups of motoneurons degenerate in this disease while othe...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.07.058

    authors： Ma L,Ostrovsky H,Miles G,Lipski J,Funk GD,Nicholson LF

    更新日期：2006-11-17 00:00:00

  • Spike-Wave Discharges and Sleep-Wake States during Circadian Desynchronization: No Effects of Agomelatine upon Re-Entrainment.

    abstract：:Rapid changes in the light-dark cycle cause circadian desynchronization between rhythms of spike-wave discharges (SWDs) and motor activity in genetic epileptic rats, and this is accompanied by an increase in epileptic activity. Given the close relationship between absence seizures and sleep-wake states, the present st...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.03.062

    authors： Smyk MK,van Luijtelaar G,Huysmans H,Drinkenburg WH

    更新日期：2019-06-01 00:00:00

  • Behavioral assessment and identification of a molecular marker in a salicylate-induced tinnitus in rats.

    abstract：:Tinnitus is a non-observable phantom sensation. As such, it is a difficult condition to investigate and, to date, no effective treatment has been developed. To approach this phantom sensation, we aimed to develop a rat behavioral model of tinnitus using salicylate, an active component of aspirin known to induce tinnit...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.11.048

    authors： Kizawa K,Kitahara T,Horii A,Maekawa C,Kuramasu T,Kawashima T,Nishiike S,Doi K,Inohara H

    更新日期：2010-02-17 00:00:00

  • Estrogen-dependent MicroRNA-504 Expression and Related Baroreflex Afferent Neuroexcitation via Negative Regulation on KCNMB4 and KCa1.1 β4-subunit Expression.

    abstract：:Large conductance of Ca2+-activated K+ channel (KCa1.1) plays an inhibitory role in neuroexcitation. However, the expression of KCNMB4/β4-subunit in the nodose ganglia (NG) and nucleus tractus solitarius (NTS), and its effect and regulation on baroreflex afferent function at post-transcriptional level of female rats r...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.07.003

    authors： Feng Y,Liu Y,Cao PX,Sun X,Li KX,Li XY,Liu L,Wang HD,Cui CP,Xiong X,Zhang HC,Qiao GF,Li BY

    更新日期：2020-08-21 00:00:00

  • Nucleus accumbens core lesions enhance two-way active avoidance.

    abstract：:The majority of work examining the nucleus accumbens core (NAc) has focused on functions pertaining to behaviors guided by appetitive outcomes. These studies have pointed to the NAc as being critical for motivating behavior toward desirable outcomes. For example, we have recently shown that lesions of the NAc impaired...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.11.028

    authors： Lichtenberg NT,Kashtelyan V,Burton AC,Bissonette GB,Roesch MR

    更新日期：2014-01-31 00:00:00

  • Memory consolidation and reconsolidation of an inhibitory avoidance task in mice: effects of a new different learning task.

    abstract：:CF-1 male mice were trained in an inhibitory avoidance task using a high footshock (1.2mA, 50Hz, 1 s) in order to reduce the influence of extinction on retention performance. A single session of 5 min exposure to a hole-board (nose-poke behavior), either immediately after training or the first retention test (memory r...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.04.068

    authors： Boccia MM,Blake MG,Acosta GB,Baratti CM

    更新日期：2005-01-01 00:00:00

  • Systemic administration of leptin potentiates the response of neurons in the nucleus of the solitary tract to chemoreceptor activation in the rat.

    abstract：:Leptin microinjections into the nucleus of the solitary tract (NTS) have been shown to elicit sympathoexcitatory responses, and potentiate the cardiovascular responses to activation of the chemoreflex. In this study, experiments were done in Sprague-Dawley rats initially to provide a detailed mapping within the NTS co...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.10.065

    authors： Ciriello J,Moreau JM

    更新日期：2013-01-15 00:00:00

  • Blockade of N-methyl-D-aspartate receptors in the insular cortex disrupts taste aversion and spatial memory formation.

    abstract：:The present experiments examined the effects of direct intracortical microinjections of the N-methyl-D-aspartate receptor antagonist 2-amino-5-phosphonovaleric acid directly into the insular cortex of rats, before or immediately after training of conditioned taste aversion and the water maze spatial learning task. In ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00360-1

    authors： Gutiérrez H,Hernández-Echeagaray E,Ramírez-Amaya V,Bermúdez-Rattoni F

    更新日期：1999-03-01 00:00:00

  • The integrated ultradian organization of behavior and physiology in mice and the contribution of orexin to the ultradian patterning.

    abstract：:Our series of rat experiments have shown that locomotor activity, arousal level, body and brown adipose tissue temperatures, heart rate and arterial pressure increase episodically in an integrated manner approximately every 100min (ultradian manner). Although it has been proposed that the integrated ultradian pattern ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.07.041

    authors： Miyata K,Kuwaki T,Ootsuka Y

    更新日期：2016-10-15 00:00:00

  • Selective blockade of substance P or neurokinin A receptors reduces the expression of c-fos in trigeminal subnucleus caudalis after corneal stimulation in the rat.

    abstract：:Stimulation of the cornea activates neurons in two distinct regions of the spinal trigeminal nucleus: at the transition between trigeminal subnucleus interpolaris and subnucleus caudalis and at the transition between trigeminal subnucleus caudalis and the upper cervical spinal cord as estimated by expression of the im...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(97)00433-8

    authors： Bereiter DA,Bereiter DF,Tonnessen BH,Maclean DB

    更新日期：1998-03-01 00:00:00

  • Exercise influences hippocampal plasticity by modulating brain-derived neurotrophic factor processing.

    abstract：:Exercise has been shown to impact brain plasticity and function by involving the action of brain-derived neurotrophic factor (BDNF); however, mechanisms involved are poorly understood. Two types of BDNF coexist in the brain, the precursor (proBDNF) and its mature product (mBDNF), which preferentially bind specific rec...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.06.032

    authors： Ding Q,Ying Z,Gómez-Pinilla F

    更新日期：2011-09-29 00:00:00

  • The Secretome of Microglia Regulate Neural Stem Cell Function.

    abstract：:Brain injury is associated with neuroinflammation, and microglia are key players in this process. Microglia can acquire pro-inflammatory or anti-inflammatory properties, but how this affects neural stem cells (NSCs) remains controversial. Here, NSCs were grown in conditioned media collected from either non-stimulated ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.10.034

    authors： Osman AM,Rodhe J,Shen X,Dominguez CA,Joseph B,Blomgren K

    更新日期：2019-05-01 00:00:00

  • Nodes of Ranvier in Glaucoma.

    abstract：:Retinal ganglion cell axons of the DBA/2J mouse model of glaucoma, a model characterized by extensive neuroinflammation, preserve synaptic contacts with their subcortical targets for a time after onset of anterograde axonal transport deficits, axon terminal hypertrophy, and cytoskeletal alterations. Though retrograde ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2018.08.016

    authors： Smith MA,Plyler ES,Dengler-Crish CM,Meier J,Crish SD

    更新日期：2018-10-15 00:00:00

  • Midbrain areas required for locomotion initiated by electrical stimulation of the lateral hypothalamus in the anesthetized rat.

    abstract：:Locomotor stepping in the Nembutal-anesthetized rat was elicited by electrical stimulation of either of two sites in the right or left posterolateral hypothalamus. Essential midbrain loci were identified by reversibly blocking the elicited locomotion through local injections of the anesthetic procaine (15%, 0.5 microl...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(90)90251-x

    authors： Levy DI,Sinnamon HM

    更新日期：1990-01-01 00:00:00

  • Sex differences in behavioral, neurochemical and neuroendocrine effects induced by the forced swim test in rats.

    abstract：:The forced swim test (FST) has been considered as a pharmacologically valid test of the depressive syndrome in rodents. However, few studies have focused on neurochemical and behavioral responses during FST in both male and female rats. Thus, we investigated certain behavioral and neuroendocrine responses as well as t...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.04.044

    authors： Drossopoulou G,Antoniou K,Kitraki E,Papathanasiou G,Papalexi E,Dalla C,Papadopoulou-Daifoti Z

    更新日期：2004-01-01 00:00:00