Cellular localization and differential distribution of GABAA receptor subunit proteins and messenger RNAs within hypothalamic magnocellular neurons.

abstract：:Social play is a motivated and rewarding behavior that is displayed by nearly all mammals and peaks in the juvenile period. Moreover, social play is essential for the development of social skills and is impaired in social disorders like autism. We recently showed that the lateral septum (LS) is involved in the regulat...

journal_title：Neuroscience

authors： Bredewold R,Schiavo JK,van der Hart M,Verreij M,Veenema AH

更新日期：2015-10-29 00:00:00

abstract：:We have developed a stroke model involving middle cerebral artery occlusion in the rat which elicits changes in cardiac and autonomic variables that are similar to those observed clinically. It is likely that these neurogenic autonomic responses are mediated by changes in neurotransmitter systems subsequent to the str...

journal_title：Neuroscience

authors： Allen GV,Cheung RT,Cechetto DF

更新日期：1995-10-01 00:00:00

abstract：:L-arginine, a semi-essential amino acid, can be metabolized to form a number of bioactive molecules. Nitric oxide (NO), generated by NO synthase (NOS) from L-arginine, has been strongly implicated in the aging process. Agmatine, decarboxylated arginine, regulates the production of NO and other metabolites of L-arginin...

journal_title：Neuroscience

authors： Rushaidhi M,Collie ND,Zhang H,Liu P

更新日期：2012-08-30 00:00:00

abstract：:Microglia, the innate immune cells of the brain, regulate brain development through many processes such as synaptic pruning, supporting cell genesis and phagocytosing living and dying cells. There are sex differences in these same developmental processes throughout the brain, thus microglia may contribute to brain sex...

journal_title：Neuroscience

authors： Nelson LH,Peketi P,Lenz KM

更新日期：2021-01-15 00:00:00

abstract：BACKGROUND:depression is characterized by a stable negative bias toward emotional stimuli. This bias is associated with abnormal activities in emotion-processing regions (such as the amygdala) and cognitive-control regions (such as the dorsolateral prefrontal cortex [DLPFC]). However, it remains unclear whether the emo...

journal_title：Neuroscience

authors： Liao C,Feng Z,Zhou D,Dai Q,Xie B,Ji B,Wang X,Wang X

更新日期：2012-01-10 00:00:00

abstract：:A delayed-matching spatial working memory protocol in a 5-arm maze was used to test the hypothesis of differential roles for central nicotinic and muscarinic cholinergic receptors in mediating task performance. In experiment 1, using a within subjects-repeated design, groups of C57Bl/6 mice, previously trained to crit...

journal_title：Neuroscience

authors： Maviel T,Durkin TP

更新日期：2003-01-01 00:00:00

abstract：:A synthetic fragment 31-35 of beta-amyloid peptide was used in cultured cortical neurons to examine whether this smaller sequence could trigger apoptotic degeneration in vitro by using morphological, biochemical and flow-cytometric examinations. The results showed that: (i) neurons treated with fragment 31-35 of beta-...

journal_title：Neuroscience

authors： Yan XZ,Qiao JT,Dou Y,Qiao ZD

更新日期：1999-01-01 00:00:00

abstract：:In the present study we examined the effects of normal aging in the hippocampus and cerebellum, as well as behaviors associated with these substrates. A total of 67 CB6F1 hybrid mice were tested at one of five ages (4, 8, 12, 18 or 25 months) on the context pre-exposure facilitation effect (CPFE) modification of fear ...

journal_title：Neuroscience

authors： Kennard JA,Brown KL,Woodruff-Pak DS

更新日期：2013-09-05 00:00:00

abstract：:The host response to neural injury, which can include axonal sprouting and synaptic reorganization is likely to be under tight genetic regulatory control at the level of the genome and may be implicated in epileptogenesis. Despite its importance, however, the molecular basis of synaptic reorganization is unclear. We h...

journal_title：Neuroscience

authors： Yang J,Houk B,Shah J,Hauser KF,Luo Y,Smith G,Schauwecker E,Barnes GN

更新日期：2005-01-01 00:00:00

abstract：:Gambierol is a marine polycyclic ether toxin, first isolated from cultured Gambierdiscus toxicus dinoflagellates collected in French Polynesia. The chemical synthesis of gambierol permitted the analyses of its mode of action which includes the selective inhibition of voltage-gated K+ (KV) channels. In the present stud...

journal_title：Neuroscience

authors： Molgó J,Schlumberger S,Sasaki M,Fuwa H,Louzao MC,Botana LM,Servent D,Benoit E

更新日期：2020-07-15 00:00:00

abstract：:The extracellular matrix is a complex network of macromolecules including glycoproteins, polysaccharides and proteoglycans. Tenascin-R and chondroitin sulfate proteoglycans are essential components of hippocampal extracellular matrix co-localised in perineuronal nets on interneurons. Mutant mice deficient in expressio...

journal_title：Neuroscience

authors： Bukalo O,Schachner M,Dityatev A

更新日期：2001-01-01 00:00:00

abstract：:Stress affects brain activity and promotes long-term changes in multiple neural systems. Exposure to stressors causes substantial effects on the perception and response to pain. In several animal models, chronic stress produces lasting hyperalgesia. The insular (IC) and anterior cingulate cortices (ACC) are the region...

journal_title：Neuroscience

authors： Imbe H,Kimura A,Donishi T,Kaneoke Y

更新日期：2014-02-14 00:00:00

abstract：:To better understand the function of the Wnt pathway in the developing telencephalon, we analyzed neocortical development in low density lipoprotein receptor-related protein (LRP) 6 mutants. LRP6 mutant mice are hypomorphic for the canonical Wnt signaling pathway and have hypoplasia of the developing neocortex. While ...

journal_title：Neuroscience

authors： Zhou CJ,Borello U,Rubenstein JL,Pleasure SJ

更新日期：2006-11-03 00:00:00

abstract：:To examine changes in corticostriatal synaptic transmission in rats with ethanol withdrawal syndrome, intracellular and extracellular responses to subcortical white matter stimulation were recorded in neostriatal slice preparations. The resting membrane potential, input resistance and depolarizing postsynaptic potenti...

journal_title：Neuroscience

authors： Yamamoto Y,Nakanishi H,Takai N,Shimazoe T,Watanabe S,Kita H

更新日期：1999-01-01 00:00:00

abstract：:White matter lesions are common when global cerebral ischemia (GCI) occurs in the elderly, and cause damage to neurological and psychological functions. Remyelination often fails because of the limited recruitment of oligodendrocyte progenitor cells (OPCs) to the demyelinated site or the inefficient differentiation of...

journal_title：Neuroscience

authors： Du B,Liang M,Zheng H,Fan C,Zhang H,Lu X,Du Z,Lian Y,Zhang Y,Bi X

更新日期：2020-07-01 00:00:00

abstract：:Recent reports show that striatal dopamine D1-type receptors from one side of the normal rat brain can control brain activity (as measured by c-fos induction) on both sides of the brain. However, this phenomenon has not yet been studied in the presence of sensitized dopamine D1-type receptors. Here we address this iss...

journal_title：Neuroscience

authors： Taymans JM,Kia HK,Groenewegen HJ,Leysen JE,Langlois X

更新日期：2005-01-01 00:00:00

abstract：:Light-microscope visualization in rat brain of a pattern of distribution of immunoreactivity, which included immunolabeled perikarya and beaded processes, was achieved using an immunoaffinity purified polyclonal antibody, Ab165, which recognizes the amino acid sequence, IRNLRQDRSKYY, found in the mu-opioid binding pro...

journal_title：Neuroscience

authors： Hiller JM,Zhang Y,Bing G,Gioannini TL,Stone EA,Simon EJ

更新日期：1994-10-01 00:00:00

abstract：:Rats were systemically pre-treated with capsaicin either on the first day of life or at an age of 1 month. Both treatments were found to deplete substance P levels in the trigeminal nucleus caudalis (55.6% and 57.9% depletions, respectively). Extracellular single neurone recordings in the trigeminal nucleus caudalis r...

journal_title：Neuroscience

authors： Salt TE,Crozier CS,Hill RG

更新日期：1982-05-01 00:00:00

abstract：:The role of the oxytocin-containing projections to the autonomic nuclei of the spinal cord for lower urinary tract function has not been clarified. The hypothesis was tested that oxytocin acts as a mediator of bladder contraction at the spinal cord level. In conscious female rats undergoing continuous cystometry, intr...

journal_title：Neuroscience

authors： Pandita RK,Nylén A,Andersson KE

更新日期：1998-08-01 00:00:00

abstract：:Using antisera raised against neurofilaments and the glial fibrillary acidic protein (GFAP) we have examined the appearance and distribution of neurofilament- and GFAP-like immunoreactivity in the enteric nervous system of rat, mouse and guinea-pig. In whole mounts of the external circular and longitudinal muscle laye...

journal_title：Neuroscience

authors： Björklund H,Dahl D,Seiger A

更新日期：1984-05-01 00:00:00

abstract：:Estradiol-induced plasticity involves changes in dendritic spine density and in the relative proportions of the different dendritic spine types that influence neurons and neural circuits. Such events affect brain structures that control the timing of neuroendocrine and behavioral processes, influencing both reproducti...

journal_title：Neuroscience

authors： González-Burgos I,Velázquez-Zamora DA,González-Tapia D,Cervantes M

更新日期：2015-07-09 00:00:00

abstract：:The postsynaptic density is a highly dynamic structure, which is reorganized in an activity-dependent manner. An animal model for temporal lobe epilepsy, i.e. kainate-induced limbic seizures in rats, was used to study changes in postsynaptic density composition after extensive synaptic activity. Six hours after kainat...

journal_title：Neuroscience

authors： Wyneken U,Smalla KH,Marengo JJ,Soto D,de la Cerda A,Tischmeyer W,Grimm R,Boeckers TM,Wolf G,Orrego F,Gundelfinger ED

更新日期：2001-01-01 00:00:00

abstract：:Dephosphin/dynamin is a 94,000/96,000 mol. wt protein kinase C substrate from rat brain that is phosphorylated in nerve terminals and dephosphorylated upon stimulation of exocytosis and synaptic vesicle recycling. Phosphorylation activates an intrinsic GTPase activity and dephosphin may play a role in endocytosis [Rob...

journal_title：Neuroscience

authors： Powell KA,Robinson PJ

更新日期：1995-02-01 00:00:00

abstract：:There is increasing evidence that alterations in the focus of attention result in changes in neural responding at the most peripheral levels of the auditory system. To date, however, those studies have not ruled out differences in task demands or overall arousal in explaining differences in responding across intermoda...

journal_title：Neuroscience

authors： Srinivasan S,Keil A,Stratis K,Woodruff Carr KL,Smith DW

更新日期：2012-10-25 00:00:00

abstract：:Neurons lying in the white matter of the upper cervical spinal cord become transneuronally labelled following pseudorabies virus injections into the kidney or stellate ganglion, suggesting that they project directly to sympathetic preganglionic neurons. In the present study, we extend these findings and report here th...

journal_title：Neuroscience

authors： Jansen AS,Loewy AD

更新日期：1997-04-01 00:00:00

abstract：:Semaphorins comprise a family of proteins involved in axon guidance during development. Semaphorin4D (Sema4D) has both neuroregenerative and neurorepressive functions, being able to stimulate both axonal outgrowth and growth cone collapse during development, and therefore could play an important role in neurological r...

journal_title：Neuroscience

authors： Peng SX,Yao L,Cui C,Zhao HD,Liu CJ,Li YH,Wang LF,Huang SB,Shen YQ

更新日期：2017-05-20 00:00:00

abstract：:Cell surface glycoconjugates are thought to mediate cell-cell recognition and play roles in neuronal development and functions. We demonstrated here that exposure of neuronal cells to nanomolar levels of gangliosides Neu5Acalpha 8Neu5Acalpha 3Galbeta 4GlcCer, Galbeta 3GalNAcbeta 4(Neu5Acalpha 8Neu5Acalpha 3)Galbeta 4G...

journal_title：Neuroscience

authors： Chen N,Furuya S,Doi H,Hashimoto Y,Kudo Y,Higashi H

更新日期：2003-01-01 00:00:00

abstract：:Extracellular signal-regulated kinases and activator protein 1 transcription factor have been functionally linked to addiction. It has also been shown that extracellular signal-regulated kinase activation can regulate cocaine-induced expression of c-Fos and FosB, two possible components of activator protein 1. A direc...

journal_title：Neuroscience

authors： Radwanska K,Valjent E,Trzaskos J,Caboche J,Kaczmarek L

更新日期：2006-01-01 00:00:00

abstract：:The dorsal pallidal complex is made up of the external and internal segments of the globus pallidus (GPe and GPi respectively). It is part of the main axis of the basal ganglia (BG) that connects the thalamo-cortical networks to the BG input stages (striatum and subthalamic nucleus) and continues directly, and indirec...

journal_title：Neuroscience

authors： Goldberg JA,Bergman H

更新日期：2011-12-15 00:00:00

abstract：:Intracellular stimulation of single propriospinal axons evoked excitatory postsynaptic potentials (EPSPs) in lumbar motoneurons. Mean EPSP amplitudes differed by two orders of magnitude when measured in different connections. After analyzing the distribution of mean amplitudes of 47 single-fiber EPSPs, two populations...

journal_title：Neuroscience

authors： Dityatev A,Birinyi A,Puskár Z,Antal M,Clamann HP

更新日期：2001-01-01 00:00:00