The effects of capsaicin pre-treatment on the responses of single neurones to sensory stimuli in the trigeminal nucleus caudalis of the rat: evidence against a role for substance P as the neurotransmitter serving thermal nociception.

abstract：:Intracellular microelectrode recordings were used to examine the effects of the potassium channel blockers: 4-aminopyridine, a selective blocker of fast potassium conductances gKf1 and gKf2,13 and tetraethylammonium, a blocker of gKf1, gKf2 and the slow conductance gKs,13 on the repetitive activity of large myelinated...

journal_title：Neuroscience

authors： Poulter MO,Padjen AL

更新日期：1995-09-01 00:00:00

abstract：:Semaphorins comprise a family of proteins involved in axon guidance during development. Semaphorin4D (Sema4D) has both neuroregenerative and neurorepressive functions, being able to stimulate both axonal outgrowth and growth cone collapse during development, and therefore could play an important role in neurological r...

journal_title：Neuroscience

authors： Peng SX,Yao L,Cui C,Zhao HD,Liu CJ,Li YH,Wang LF,Huang SB,Shen YQ

更新日期：2017-05-20 00:00:00

abstract：:High-frequency repetitive transcranial magnetic stimulation (HF-rTMS) is currently accepted as an evidence-based treatment option for treatment-resistant depression (TRD). Additionally, HF-rTMS showed beneficial effects on psychomotor retardation in patients. The classical HF-rTMS paradigms however are unlikely to rep...

journal_title：Neuroscience

authors： El Arfani A,Parthoens J,Demuyser T,Servaes S,De Coninck M,De Deyn PP,Van Dam D,Wyckhuys T,Baeken C,Smolders I,Staelens S

更新日期：2017-04-07 00:00:00

abstract：OBJECTIVE:Women are more prone to major depressive disorders (MDDs) and the incidence of MDD in women is almost twice that of men. Insular cortex abnormalities are a common finding in neuroanatomical studies of patients with MDD. However, it remains largely unclear whether female MDD patients at different clinical stag...

journal_title：Neuroscience

authors： Liu CH,Jing B,Ma X,Xu PF,Zhang Y,Li F,Wang YP,Tang LR,Wang YJ,Li HY,Wang CY

更新日期：2014-03-14 00:00:00

abstract：:Ablation of capsaicin-sensitive afferent neurons enhances experimentally induced ulceration in the rat gastric mucosa, which suggests that these neurons are involved in gastric mucosal protection. To provide direct evidence for such a function it was investigated whether stimulation of afferent nerve endings by the in...

journal_title：Neuroscience

authors： Holzer P,Lippe IT

更新日期：1988-12-01 00:00:00

abstract：:The 5-HT(2A) serotonin receptor represents an important molecular target for atypical antipsychotic drugs and for most hallucinogens. In the mammalian cerebral cortex, 5-HT(2A) receptors are enriched in pyramidal neurons, within which 5-HT(2A) receptors are preferentially sorted to the apical dendrites. In primary cor...

journal_title：Neuroscience

authors： Xia Z,Hufeisen SJ,Gray JA,Roth BL

更新日期：2003-01-01 00:00:00

abstract：:This study examines the effect of chronic alcohol consumption on the human cerebellum using operational criteria for case selection [Caine D. et al. (1997) J. Neurol. Neurosurg. Psychiat. 62, 51-60] and unbiased stereological techniques. We describe, for the first time, structural changes in different functional zones...

journal_title：Neuroscience

authors： Baker KG,Harding AJ,Halliday GM,Kril JJ,Harper CG

更新日期：1999-01-01 00:00:00

abstract：:Metabotropic glutamate receptors are a major class of excitatory amino acid receptors. Eight metabotropic glutamate receptor subtypes have been cloned, and are classified into three groups (I, II and III) based on amino acid sequence identity, effector systems and pharmacological profile. Previous results have shown t...

journal_title：Neuroscience

authors： Kearney JA,Albin RL

更新日期：2000-01-01 00:00:00

abstract：:Nitric oxide synthase is the biosynthetic enzyme for the free radical neurotransmitter nitric oxide. Using an affinity-purified antiserum, nitric oxide synthase was found to be localized to peripheral ocular nerve fibers, related cranial ganglia, and the retina of the rat. In the eye, nitric oxide synthase-like immuno...

journal_title：Neuroscience

authors： Yamamoto R,Bredt DS,Snyder SH,Stone RA

更新日期：1993-05-01 00:00:00

abstract：:The distribution of the enzyme protein-O-carboxylmethyltransferase (EC 2.1.1.24) has been investigated in the rat brain using both immunohistochemical and biochemical techniques. The enzyme, which carboxylmethylates free aspartic and glutamic acid residues of protein substrates, was localized in neurons, but not other...

journal_title：Neuroscience

authors： Billingsley ML,Kim S,Kuhn DM

更新日期：1985-05-01 00:00:00

abstract：:Two types of GABAergic interneurone are known to express cholecystokinin-related peptides in the isocortex: basket cells, which preferentially innervate the somata and proximal dendrites of pyramidal cells; and double bouquet cells, which innervate distal dendrites and dendritic spines. In the hippocampus, cholecystok...

journal_title：Neuroscience

authors： Cope DW,Maccaferri G,Márton LF,Roberts JD,Cobden PM,Somogyi P

更新日期：2002-01-01 00:00:00

abstract：:The genetically epilepsy-prone rat is an animal model of inherited generalised tonic-clonic epilepsy that shows abnormal susceptibility to audiogenic seizures and a lowered threshold to a variety of seizure-inducing stimuli. Recent studies suggest a crucial role for glutamate and GABA transporters in epileptogenesis a...

journal_title：Neuroscience

authors： Akbar MT,Rattray M,Williams RJ,Chong NW,Meldrum BS

更新日期：1998-08-01 00:00:00

abstract：:Nitric oxide is thought to play an important role in multiple forms of use-dependent synaptic plasticity, including that which follows noxious peripheral stimulation. This suggests that development of nociception-induced neuroplasticity should be impaired in transgenic animals lacking the neuronal form of nitric oxide...

journal_title：Neuroscience

authors： Crosby G,Marota JJ,Huang PL

更新日期：1995-12-01 00:00:00

abstract：:The dyslexia-associated gene DCDC2 is a member of the DCX family of genes known to play roles in neurogenesis, neuronal migration, and differentiation. Here we report the first phenotypic analysis of a Dcdc2 knockout mouse. Comparisons between Dcdc2 knockout mice and wild-type (wt) littermates revealed no significant ...

journal_title：Neuroscience

authors： Wang Y,Yin X,Rosen G,Gabel L,Guadiana SM,Sarkisian MR,Galaburda AM,Loturco JJ

更新日期：2011-09-08 00:00:00

abstract：:The release of tachykinins from isolated slice preparations of the guinea-pig spinal cord and ureter was studied in vitro. Capsaicin (10 microM) caused release of substance P, neurokinin A and an eledoisin-like component from both the spinal cord and ureter. The release of tachykinins induced by capsaicin or potassium...

journal_title：Neuroscience

authors： Hua XY,Saria A,Gamse R,Theodorsson-Norheim E,Brodin E,Lundberg JM

更新日期：1986-09-01 00:00:00

abstract：:Cocaine- and amphetamine-regulated transcript (CART) and nesfatin-1/nucleobindin 2 (NUCB2) are assumed to play a role in feeding and adaptation to stress. Both peptides are highly expressed in the midbrain non-preganglionic Edinger-Westphal nucleus (npEW), a center implicated in the regulation of stress adaptation and...

journal_title：Neuroscience

authors： Xu L,Bloem B,Gaszner B,Roubos EW,Kozicz T

更新日期：2010-10-13 00:00:00

abstract：:Nitric oxide has been proposed to act as an intercellular messenger in central brainstem circuits controlling gastrointestinal motility. In particular, a subpopulation of preganglionic vagal neurons of the dorsal motor nucleus of the vagus have been shown to be reduced nicotinamide adenine dinucleotide phosphate(NADPH...

journal_title：Neuroscience

authors： Zheng ZL,Rogers RC,Travagli RA

更新日期：1999-05-01 00:00:00

abstract：:The distribution of several neuropeptides (vasoactive intestinal polypeptide, cholecystokinin octapeptide, substance P, neurotensin, methionine-enkephalin and somatostatin) in the hippocampal formation has been studied with immunocytochemical techniques. Numerous vasoactive intestinal polypeptide, cholecystokinin-octa...

journal_title：Neuroscience

authors： Roberts GW,Woodhams PL,Polak JM,Crow TJ

更新日期：1984-01-01 00:00:00

abstract：:The globus pallidus sends a significant GABAergic projection to the thalamic reticular nucleus. Because pallidal neurons express D4-dopamine receptors, we have explored their presence on pallidoreticular terminals by studying the effect of dopamine and D4-receptor agonists on the GABAergic transmission in the thalamic...

journal_title：Neuroscience

authors： Gasca-Martinez D,Hernandez A,Sierra A,Valdiosera R,Anaya-Martinez V,Floran B,Erlij D,Aceves J

更新日期：2010-09-15 00:00:00

abstract：:Our previous studies have shown that selective inhibition of nitric oxide in the brain reduces pressor responses to activation of cardiac sympathetic afferents, thus suggesting that nitric oxide is involved in central regulation of cardiac-cardiovascular sympathoexcitatory reflexes. Central neural regions in which nit...

journal_title：Neuroscience

authors： Guo ZL,Longhurst JC

更新日期：2003-01-01 00:00:00

abstract：:Synapsins (SynI, SynII, SynIII) are a multigene family of synaptic vesicle (SV) phosphoproteins implicated in the regulation of synaptic transmission and plasticity. Synapsin I, II, I/II and I/II/III knockout mice are epileptic and SYN1/2 genes have been identified as major epilepsy susceptibility genes in humans. We ...

journal_title：Neuroscience

authors： Boido D,Farisello P,Cesca F,Ferrea E,Valtorta F,Benfenati F,Baldelli P

更新日期：2010-11-24 00:00:00

abstract：:The purpose of this study was to experimentally investigate the applicability of the equilibrium-point hypothesis to the dynamics of single-joint movements. Subjects were trained to perform relatively slow (movement time 600-1000 ms) or fast (movement time 200-300 ms) single-joint elbow flexion movements against a con...

journal_title：Neuroscience

authors： Latash ML,Gottlieb GL

更新日期：1991-01-01 00:00:00

abstract：:Locomotion involves complex combinations of translational and rotational head movements. For gaze stability, this necessitates the interplay of angular and linear vestibulo-ocular reflexes (VOR) as well as the integration of visual feedback about the desired viewing distance. Furthermore, gaze stabilizing systems must...

journal_title：Neuroscience

authors： Dietrich H,Wuehr M

更新日期：2019-06-01 00:00:00

abstract：:The presence of the acetylcholinesterase neurons and substance P-like and enkephalin-like fibers in the various nuclear columns of the ventral horns of the spinal cords was studied in the developing human by acetylcholinesterase histochemistry and substance P and enkephalin immunohistochemistry. Acetylcholinesterase-p...

journal_title：Neuroscience

authors： Luo CB,Yew DT,Zheng DR,Liu YQ

更新日期：1992-06-01 00:00:00

abstract：:Conductive hearing loss is a prevalent condition globally. It remains unclear whether conductive hearing loss that occurs during early development disrupts auditory peripheral systems. In this study, a mouse model of conductive auditory deprivation (CAD) was achieved using external auditory canal closure on postnatal ...

journal_title：Neuroscience

authors： Qi Y,Yu S,Du Z,Qu T,He L,Xiong W,Wei W,Liu K,Gong S

更新日期：2019-05-15 00:00:00

abstract：:The prairie vole (Microtus ochrogaster) is a socially monogamous rodent species that forms pair bonds after mating. Recent data have shown that amphetamine (AMPH) is rewarding to prairie voles as it induces conditioned place preferences. Further, repeated treatment with AMPH impairs social bonding in adult prairie vol...

journal_title：Neuroscience

authors： Fukushiro DF,Olivera A,Liu Y,Wang Z

更新日期：2015-10-29 00:00:00

abstract：:Previous studies have shown that when peripheral nerves in axolotl limbs are cut and surgically misdirected, regenerating axons grow back to the original pathways and innervate their correct muscles. In the present study however, we demonstrate that when given a choice between their correct nerve stump and an incorrec...

journal_title：Neuroscience

authors： Aaronson OS,Golding JP,Tonge DA

更新日期：1995-05-01 00:00:00

abstract：:The findings reported in this work show that pretreatment with polyunsaturated fatty acids, particularly linolenic acid, present in vegetable oils, can provide a potent tolerance against neurodegeneration in two models of neuronal death-generating treatments such as kainic acid injection and global ischemia. Rats were...

journal_title：Neuroscience

authors： Blondeau N,Widmann C,Lazdunski M,Heurteaux C

更新日期：2002-01-01 00:00:00

abstract：:The incidence of anxiety, mood, substance abuse disorders and schizophrenia increases during adolescence. Epidemiological evidence confirms that exposure to stress during sensitive periods of development can create vulnerabilities that put genetically predisposed individuals at increased risk for psychiatric disorders...

journal_title：Neuroscience

authors： Taylor SB,Taylor AR,Koenig JI

更新日期：2013-09-26 00:00:00

abstract：:Co-localization of neurotensin and cholecystokinin in tyrosine hydroxylase-containing neurons in the nucleus tractus solitarius of the rat was demonstrated by immunocytochemistry with fluorescent double-staining combined with the peroxidase-antiperoxidase method. Co-localization of neurotensin/tyrosine hydroxylase or ...

journal_title：Neuroscience

authors： Kawai Y,Takagi H,Tohyama M

更新日期：1988-01-01 00:00:00