Genetic background regulates semaphorin gene expression and epileptogenesis in mouse brain after kainic acid status epilepticus.

abstract：:Neonatal handling, an experimental model of early life experiences, is known to affect the hypothalamic-pituitary-adrenal axis function thus increasing adaptability, coping with stress, cognitive abilities and in general brain plasticity-related processes. A molecule that plays a most critical role in such processes i...

journal_title：Neuroscience

authors： Stamatakis A,Toutountzi E,Fragioudaki K,Kouvelas ED,Stylianopoulou F,Mitsacos A

更新日期：2009-12-29 00:00:00

abstract：:Studies demonstrated that chronic high-dose homocysteine administration induced learning and memory impairment in animals. Atractylenolide III (Aen-III), a neuroprotective constituent of Atractylodis macrocephalae Koidz, was isolated in our previous study. In this study, we investigated potential benefits of Aen-III i...

journal_title：Neuroscience

authors： Zhao H,Ji ZH,Liu C,Yu XY

更新日期：2015-04-02 00:00:00

abstract：:In the rat spinal cord in vitro, block of synaptic inhibition evokes persistent, regular disinhibited bursting which is a manifestation of the intrinsic network rhythmicity and is readily recorded from ventral roots. This model is advantageous to explore the network mechanisms controlling burst periodicity, and durati...

journal_title：Neuroscience

authors： Taccola G,Nistri A

更新日期：2007-06-08 00:00:00

abstract：:Intracellular microelectrode recordings were used to examine the effects of the potassium channel blockers: 4-aminopyridine, a selective blocker of fast potassium conductances gKf1 and gKf2,13 and tetraethylammonium, a blocker of gKf1, gKf2 and the slow conductance gKs,13 on the repetitive activity of large myelinated...

journal_title：Neuroscience

authors： Poulter MO,Padjen AL

更新日期：1995-09-01 00:00:00

abstract：:The responses in T3-4, T10-11 and L2-3 white rami to stimulation of different zones of the bulbar ventrolateral surface were maximal when the region of about 4 mm laterally to the midline was stimulated. A weak surface stimulation of all these zones elicited only a long latency response consisting of three waves. A sh...

journal_title：Neuroscience

authors： Lebedev VP,Krasyukov AV,Nikitin SA

更新日期：1986-01-01 00:00:00

abstract：:In the present study, we investigated whether endoplasmic reticulum (ER) stress is associated with neuronal- and astroglial-death in the hippocampus using LiCl-pilocarpine-induced status epilepticus (SE) rat model. Glucose-related protein (GRP) 78 and protein disulfide isomerase (PDI) expressions were transiently incr...

journal_title：Neuroscience

authors： Ko AR,Kim JY,Hyun HW,Kim JE

更新日期：2015-10-29 00:00:00

abstract：:A neuroprotected state can be acquired by preconditioning brain with a stimulus that is subthreshold for damage (tolerance). Acquisition of tolerance involves coordinate, bi-directional changes to gene expression levels and the re-programmed phenotype is determined by the preconditioning stimulus. While best studied i...

journal_title：Neuroscience

authors： Hatazaki S,Bellver-Estelles C,Jimenez-Mateos EM,Meller R,Bonner C,Murphy N,Matsushima S,Taki W,Prehn JH,Simon RP,Henshall DC

更新日期：2007-12-05 00:00:00

abstract：:The steroid hormone vitamin D has important biological roles in calcium transport, cell growth, and cell differentiation. Its cellular activities are mediated by high affinity interaction with the vitamin D receptor. In brain, autoradiographic, immunohistologic, and messenger RNA expression studies implicate a number ...

journal_title：Neuroscience

authors： Langub MC,Herman JP,Malluche HH,Koszewski NJ

更新日期：2001-01-01 00:00:00

abstract：:Neuronal activity associated with visual processing of an unfamiliar face gradually diminishes when it is viewed repeatedly. This process, known as repetition suppression (RS), is involved in the acquisition of familiarity. Current models suggest that RS results from interactions between visual information processing ...

journal_title：Neuroscience

authors： Lafontaine MP,Lacourse K,Lina JM,McIntosh AR,Gosselin F,Théoret H,Lippé S

更新日期：2016-06-21 00:00:00

abstract：:Increase in proton concentration [H+] or decrease in local and global extracellular pH occurs in both physiological and pathological conditions. Acid-sensing ion channels (ASICs), belonging to the ENaC/Deg superfamily, play an important role in signal transduction as proton sensor. ASICs and in particular ASIC-1a (one...

journal_title：Neuroscience

authors： Natalia Gobetto M,González-Inchauspe Osvaldo D Uchitel C

更新日期：2021-01-22 00:00:00

abstract：:Sensory neurons express purinergic P2X receptors on their central and peripheral terminals as well as their cell bodies. ATP activation of these receptors drives action potential firing and glutamate release with potentially important consequences for sensory function. Here we show ATP-gated currents activated in cult...

journal_title：Neuroscience

authors： Labrakakis C,Gerstner E,MacDermott AB

更新日期：2000-01-01 00:00:00

abstract：:Cortical auditory evoked potential (CAEP) testing, a non-invasive technique, is widely employed to study auditory brain development. The aim of this study was to investigate the development of the auditory electrophysiological signal without addressing specific abilities such as speech or music discrimination. We were...

journal_title：Neuroscience

authors： Lippé S,Martinez-Montes E,Arcand C,Lassonde M

更新日期：2009-12-15 00:00:00

abstract：:The responses of non-dopamine neurons in substantia nigra and ventral tegmental area to systemic amphetamine were investigated in the behaving rat chronically implanted with multiple fine-wire electrodes. The neurons were identified with electrophysiological criteria requiring that the signals be of biphasic shape, sh...

journal_title：Neuroscience

authors： Olds ME

更新日期：1988-02-01 00:00:00

abstract：:l-3,4-Dihydroxyphenylalanine (l-DOPA) is the therapeutic gold standard in Parkinson's disease. However, most patients develop debilitating abnormal involuntary movements termed l-DOPA-induced dyskinesia (LID) as therapy-complicating side effects. The underlying mechanisms of LID pathogenesis are still not fully unders...

journal_title：Neuroscience

authors： Klietz M,Keber U,Carlsson T,Chiu WH,Höglinger GU,Weihe E,Schäfer MK,Depboylu C

更新日期：2016-09-07 00:00:00

abstract：:Analyses of scalp-recorded sleep spindles have demonstrated topographically distinct slow and fast spindle waves. In the present paper, the electrical activity in the brain corresponding to different types of sleep spindles was estimated by means of low-resolution electromagnetic tomography. In its new implementation,...

journal_title：Neuroscience

authors： Anderer P,Klösch G,Gruber G,Trenker E,Pascual-Marqui RD,Zeitlhofer J,Barbanoj MJ,Rappelsberger P,Saletu B

更新日期：2001-01-01 00:00:00

abstract：:The novel multifunctional brain permeable iron, chelator M30 [5-(N-methyl-N-propargyaminomethyl)-8-hydroxyquinoline] was shown to possess neuroprotective activities in vitro and in vivo, against several insults applicable to various neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyo...

journal_title：Neuroscience

authors： Kupershmidt L,Weinreb O,Amit T,Mandel S,Bar-Am O,Youdim MB

更新日期：2011-08-25 00:00:00

abstract：:Multiple sclerosis (MS) is a disease of the CNS in which inflammation, demyelination and neurodegeneration contribute to its initiation and progression. A frequently employed model of MS is experimental autoimmune encephalomyelitis (EAE). Here, to gain new insights into the disease process, an analysis of proteins in ...

journal_title：Neuroscience

authors： Morgan L,Shah B,Rivers LE,Barden L,Groom AJ,Chung R,Higazi D,Desmond H,Smith T,Staddon JM

更新日期：2007-07-13 00:00:00

abstract：:Mutations in the PI3K/Akt/mTOR signaling pathway or in the upstream negative regulator Pten cause human brain overgrowth disorders, such as focal cortical dysplasia and megalencephaly, and are characterized by the presence of hypertrophic neurons. These disorders often have a pediatric onset and a high comorbidity wit...

journal_title：Neuroscience

authors： Nikolaeva I,Kazdoba TM,Crowell B,D'Arcangelo G

更新日期：2017-06-23 00:00:00

abstract：:Seizures and status epilepticus induce an excessive production of reactive oxygen species leading to oxidative stress. Vitamin E, a classic antioxidant, has a neuroprotective effect on rats with seizures by regulating reactive oxygen species production. The activity of chaperone-mediated autophagy, a selective pathway...

journal_title：Neuroscience

authors： Cao L,Chen R,Xu J,Lin Y,Wang R,Chi Z

更新日期：2009-06-16 00:00:00

abstract：:We studied the distribution and cellular localization of Na(+)-coupled neutral amino acid transporter 2, a member of the system A family of amino acid transporters, in the rat and human cerebral cortex using immunocytochemical methods. Na(+)-coupled neutral amino acid transporter 2-positive neurons were pyramidal and ...

journal_title：Neuroscience

authors： Melone M,Varoqui H,Erickson JD,Conti F

更新日期：2006-06-19 00:00:00

abstract：:After experimentally inducing long term changes in transmitter release, a series of frog neuromuscular junctions were studied with intracellular recording and then semi-serially sectioned and examined in the electron microscope. Transmitter release per unit length of motor nerve terminal was well correlated with sever...

journal_title：Neuroscience

authors： Herrera AA,Grinnell AD,Wolowske B

更新日期：1985-11-01 00:00:00

abstract：:The neurochemical and behavioural recovery following unilateral and bilateral lesions of the nucleus basalis was investigated in adult male Wistar rats 20 days and 6 months after surgery. The lesions were made by stereotaxic injections of ibotenic acid. Twenty days after surgery there was a statistically significant c...

journal_title：Neuroscience

authors： Casamenti F,Di Patre PL,Bartolini L,Pepeu G

更新日期：1988-01-01 00:00:00

abstract：:The role of Orphanin-FQ/nociceptin in synaptic plasticity was assessed by its potency in modulating kindling epileptogenesis in vivo, and feed-forward inhibition in hippocampal recordings in vitro. In addition, a specific rabbit antiserum against this peptide was obtained and the immunohistochemical distribution of no...

journal_title：Neuroscience

authors： Gutiérrez R,Leff P,Romo-Parra H,Acevedo R,Antón B

更新日期：2001-01-01 00:00:00

abstract：:Membrane potential or ionic conductance of neurones of the mammalian central or peripheral nervous system maintained in vitro can be measured over periods of several hours. Drugs or transmitters which change potential or conductance can be applied repeatedly under equilibrium conditions, and pharmacological null metho...

journal_title：Neuroscience

authors： North RA

更新日期：1986-04-01 00:00:00

abstract：:The first Kavli Prize in Neuroscience recognizes a confluence of career achievements that together provide a fundamental understanding of how brain and spinal cord circuits are assembled during development and function in the adult. The members of the Kavli Neuroscience Prize Committee have decided to reward three sci...

journal_title：Neuroscience

authors： Glover JC

更新日期：2009-11-10 00:00:00

abstract：:The main neuronal population of the striatum is composed of the medium spiny neurones (MSNs). In fact several sub-populations of MSNs can be distinguished according to the striatal compartment (striosomes and matrix) to which they belong, their afferents and their sites of projection, their biochemical markers and the...

journal_title：Neuroscience

authors： Venance L,Glowinski J

更新日期：2003-01-01 00:00:00

abstract：:In IMR32 neuroblastoma cells, the two adenosine receptor agonists N6-R-phenylisopropyladenosine and 5'-N-ethylcarboxamidoadenosine dose-dependently stimulated membrane adenylate cyclase activity with potencies consistent with the presence of adenosine receptors of the A2-subtype. The S enantiomer of N6-R-phenylisoprop...

journal_title：Neuroscience

authors： Abbracchio MP,Cattabeni F,Clementi F,Sher E

更新日期：1989-01-01 00:00:00

abstract：:Inflammatory damage following ICH is often attributed to microglia/macrophage activation. In many diseases, IL-4 has been proven to switch microglia/macrophages from the pro-inflammatory to the anti-inflammatory subtype. However, the role and underlying mechanism of IL-4 in ICH, especially in neuroprotection, remain u...

journal_title：Neuroscience

authors： He Y,Gao Y,Zhang Q,Zhou G,Cao F,Yao S

更新日期：2020-06-15 00:00:00

abstract：:The mirror neuron system (MNS) is currently one of the most prominent areas of research in neuroscience. Some of the work has focused on the identification of factors that modulate its activity, but until now, no one has tried to identify the effect of motor ability on the MNS regions. The aim of the present work is t...

journal_title：Neuroscience

authors： Plata Bello J,Modroño C,Marcano F,González-Mora JL

更新日期：2014-09-05 00:00:00

abstract：:Distributions of somata and neurites of cholinergic neurons were studied after seeding dissociated cells onto organotypic slice cultures. Slice cultures were made from hippocampal formation and adjacent cortical regions from rats or mice. Dissociated cell suspensions of basal forebrain tissue from rat or mouse fetuses...

journal_title：Neuroscience

authors： Tsai ES,Haraldson SJ,Baratta J,Lander AD,Yu J,Robertson RT

更新日期：2002-01-01 00:00:00