Maintaining stable memory engrams: new roles for Nogo-A in the CNS.

abstract：:Cocaine- and amphetamine-regulated transcript (CART) and nesfatin-1/nucleobindin 2 (NUCB2) are assumed to play a role in feeding and adaptation to stress. Both peptides are highly expressed in the midbrain non-preganglionic Edinger-Westphal nucleus (npEW), a center implicated in the regulation of stress adaptation and...

journal_title：Neuroscience

authors： Xu L,Bloem B,Gaszner B,Roubos EW,Kozicz T

更新日期：2010-10-13 00:00:00

abstract：:Drug addiction behavior that is established and maintained by psychostimulants has been shown to be associated with the expression of brain-derived neurotrophic factor (BDNF) in the mesolimbic dopamine (DA) system. Cocaine has been used for most prior studies testing this effect of psychostimulants and therefore relat...

journal_title：Neuroscience

authors： Shen YL,Chang TY,Chang YC,Tien HH,Yang FC,Wang PY,Liao RM

更新日期：2014-03-28 00:00:00

abstract：:Riluzole, an anti-amyotrophic lateral sclerosis drug, known to decrease presynaptic glutamate release, is viewed as a candidate supplementary medication for epilepsy. In the present study, we compared the effects of riluzole and valproate (VPA) in the pilocarpine-induced limbic seizure model and in the gamma-hydroxybu...

journal_title：Neuroscience

authors： Kim JE,Kim DS,Kwak SE,Choi HC,Song HK,Choi SY,Kwon OS,Kim YI,Kang TC

更新日期：2007-06-15 00:00:00

abstract：:Current theories of neuropathic hypersensitivity include an imbalance of supraspinal inhibition and facilitation. Our overall hypothesis is that the locus coeruleus (LC), classically interpreted as a source of pain inhibition, may paradoxically result in facilitation after tibial and common peroneal nerve transection ...

journal_title：Neuroscience

authors： Brightwell JJ,Taylor BK

更新日期：2009-04-21 00:00:00

abstract：:The effects of centrifugal afferents on membrane potentials of identified granule cell layer using evoked field potential profiles, and trans-synaptic activation via antidromic stimulation of output cell axon collaterals. Intracellular recordings maintained for 4-30 min showed complex spontaneous spike discharges and ...

journal_title：Neuroscience

authors： Kunze WA,Shafton AD,Kem RE,McKenzie JS

更新日期：1992-01-01 00:00:00

abstract：:The neuromodulator adenosine maintains brain homeostasis and regulates complex behaviour via activation of inhibitory and excitatory adenosine receptors (ARs) in a brain region-specific manner. AR antagonists such as caffeine have been shown to ameliorate cognitive impairments in animal disease models but their effect...

journal_title：Neuroscience

authors： Singer P,McGarrity S,Shen HY,Boison D,Yee BK

更新日期：2012-06-28 00:00:00

abstract：:An increase of extracellular dopamine (DA) has been implicated in the psychostimulant properties of 3,4-methylenedioxymethamphetamine (MDMA). Although this drug has been reported to affect the DA uptake transporter (DAT), it might activate other mechanisms to regulate the outflow of DA in the brain. Our aim was to exa...

journal_title：Neuroscience

authors： Rizzo FR,Federici M,Mercuri NB

更新日期：2018-05-01 00:00:00

abstract：:Similarities in cellular morphology, afferentation, efferentation, and neurotransmitter content between the internal and external parts of the pallidum and the substantia nigra pars reticulata have long been noted. Here we present evidence that the globus pallidus, entopedunucular nucleus and substantia nigra pars ret...

journal_title：Neuroscience

authors： Sousa R,Hrinya Tannery N,Lafer EM

更新日期：1990-01-01 00:00:00

abstract：:Most mammals rely on semiochemicals, such as pheromones, to mediate their social interactions. Recent studies found that semiochemicals are perceived by at least two distinct chemosensory systems: the main and accessory olfactory systems, which share many molecular, cellular, and anatomical features. Nevertheless, the...

journal_title：Neuroscience

authors： Zibman S,Shpak G,Wagner S

更新日期：2011-08-25 00:00:00

abstract：:Synaptic terminals of the habenulo-interpeduncular axons in rat interpeduncular nucleus are demonstrated by electron-microscopic autoradiography following [3H]leucine injection into the habenula. The endings are of two types, S and crest synapses. Previous descriptions of the S synapses based on indirect identificatio...

journal_title：Neuroscience

authors： Lenn NJ,Wong V,Hamill GS

更新日期：1983-06-01 00:00:00

abstract：:Neurosteroids are synthesized de novo in the brain and the cerebellar Purkinje cell is a major site for neurosteroid formation. We have demonstrated that the rat Purkinje cell actively produces progesterone de novo from cholesterol only during neonatal life and progesterone promotes dendritic growth, spinogenesis and ...

journal_title：Neuroscience

authors： Sakamoto H,Ukena K,Takemori H,Okamoto M,Kawata M,Tsutsui K

更新日期：2004-01-01 00:00:00

abstract：:The effects of electrical stimulation of the hypothalamus paraventricular nucleus on the spontaneous firing of mitral and granule cells in the main olfactory bulb were examined in ovariectomized female rats under urethane anaesthesia. High-frequency stimulation (0.5-1.0 mA, 10-20 pulses at 100 Hz) of the paraventricul...

journal_title：Neuroscience

authors： Yu GZ,Kaba H,Okutani F,Takahashi S,Higuchi T,Seto K

更新日期：1996-06-01 00:00:00

abstract：:The presence of mRNAs in synaptic terminals and their regulated translation are important factors in neuronal communication and plasticity. Heterogeneous nuclear ribonucleoprotein (hnRNP) complexes are involved in the translocation, stability, and subcellular localization of mRNA and the regulation of its translation....

journal_title：Neuroscience

authors： Lico DT,Lopes GS,Brusco J,Rosa JC,Gould RM,De Giorgis JA,Larson RE

更新日期：2015-08-06 00:00:00

abstract：:Scratching inhibits pruritogen-evoked responses of neurons in the superficial dorsal horn, implicating a spinal site for scratch inhibition of itch. We investigated if scratching differentially affects neurons depending on whether they are activated by itchy vs. painful stimuli, and if the degree of inhibition depends...

journal_title：Neuroscience

authors： Nishida K,Takechi K,Akiyama T,Carstens MI,Carstens E

更新日期：2013-10-10 00:00:00

abstract：:Isoflurane preconditioning improved short-term neurological outcome after focal brain ischemia in adult rats. It is not known whether desflurane induces a delayed phase of preconditioning in the brain and whether isoflurane preconditioning-induced neuroprotection is long-lasting. Two months-old Sprague-Dawley male rat...

journal_title：Neuroscience

authors： Li L,Zuo Z

更新日期：2009-12-01 00:00:00

abstract：:Tianeptine (Tian) has been widely used in treating mood and anxiety disorders, and recently as a nootropic to improve cognitive performance. However, its mechanisms of action are insufficiently clear. We used a comparative proteomic approach to identify sub-proteome changes in hippocampal cytosol and non-synaptic mito...

journal_title：Neuroscience

authors： Perić I,Costina V,Findeisen P,Gass P,Filipović D

更新日期：2020-12-15 00:00:00

abstract：:The calcium binding protein, Calbindin-D28k, is known to be localized within spiny neurons of the matrix of the dorsal striatum, caudate-putamen nuclei. This compartment is also known to contain an abundance of GABAergic neurons and to receive extensive input from excitatory limbic and cortical afferents whose activat...

journal_title：Neuroscience

authors： Pickel VM,Heras A

更新日期：1996-03-01 00:00:00

abstract：:Physiological evidence has indicated that serotonin (5-hydroxytryptamine) could be a regulator of cerebral blood flow in various regions of the brain. In the present study, tryptophan hydroxylase immunocytochemistry was used to characterize, both at the light and electron microscopic levels, serotonergic nerve termina...

journal_title：Neuroscience

authors： Cohen Z,Ehret M,Maitre M,Hamel E

更新日期：1995-06-01 00:00:00

abstract：:The electrical activity of locus coeruleus neurons was investigated during cortical spreading depression in urethane-anaesthetized rats. Cortical spreading depression was induced by a direct application of 1-3 M KCl solution to the surface of the cerebral cortex. The occurrence of cortical spreading depression was ass...

journal_title：Neuroscience

authors： Arakawa S,Nakamura S,Kawashima N,Nishiike S,Fujii Y

更新日期：1997-06-01 00:00:00

abstract：:The peripheral sympathetic and parasympathetic cholinergic innervation was investigated with antibodies directed against the C-terminus of the rat vesicular acetylcholine transporter. Immunohistochemistry for the vesicular acetylcholine transporter resulted in considerably more detailed visualization of cholinergic te...

journal_title：Neuroscience

authors： Schäfer MK,Eiden LE,Weihe E

更新日期：1998-05-01 00:00:00

abstract：:Brain injury can often result in the subsequent appearance of seizures, suggesting an alteration in neural excitability associated with the balance between neuronal excitation and inhibition. The process by which this occurs has yet to be fully elucidated. The specific nature of the changes in excitation and inhibitio...

journal_title：Neuroscience

authors： Ding MC,Lo EH,Stanley GB

更新日期：2008-06-23 00:00:00

abstract：:The balancing act between microbes and their host in commensal and disease states needs to be deciphered in order to fully treat and combat infectious diseases. The elucidation of microbial genome dynamics in each instance is therefore required. In this context, the major bacterial meningitis pathogens are Neisseria m...

journal_title：Neuroscience

authors： Davidsen T,Koomey M,Tønjum T

更新日期：2007-04-14 00:00:00

abstract：:The present studies were conducted to test the hypothesis that systemically inactive doses of cannabinoids suppress inflammation-evoked neuronal activity in vivo via a peripheral mechanism. We examined peripheral cannabinoid modulation of spinal Fos protein expression, a marker of neuronal activity, in a rat model of ...

journal_title：Neuroscience

authors： Nackley AG,Suplita RL 2nd,Hohmann AG

更新日期：2003-01-01 00:00:00

abstract：:Brain bioenergetic abnormalities in mood disorders were detected by neuroimaging in vivo studies in humans. Because of the increasing importance of mitochondrial pathogenetic hypothesis of Depression, in this study the effects of sub-chronic treatment (21days) with desipramine (15mg/kg) and fluoxetine (10mg/kg) were e...

journal_title：Neuroscience

authors： Villa RF,Ferrari F,Gorini A,Brunello N,Tascedda F

更新日期：2016-08-25 00:00:00

abstract：:7beta-Hydroxycholesterol has been previously demonstrated to inhibit astrocytosis in injured cortex or spinal cord of rats. In this study, we explored the inhibitory effects of the liposome containing 7beta-hydroxycholesterol on the reactive astrocytosis caused by the injection of iron into the hippocampus of rats and...

journal_title：Neuroscience

authors： Yao Y,Sun S,Kong Q,Tong E

更新日期：2006-01-01 00:00:00

abstract：:Sensory neurons express purinergic P2X receptors on their central and peripheral terminals as well as their cell bodies. ATP activation of these receptors drives action potential firing and glutamate release with potentially important consequences for sensory function. Here we show ATP-gated currents activated in cult...

journal_title：Neuroscience

authors： Labrakakis C,Gerstner E,MacDermott AB

更新日期：2000-01-01 00:00:00

abstract：:The cerebral peptidergic caudodorsal cells of the freshwater snail Lymnaea stagnalis control egg laying and egg-laying behaviour by releasing peptides into (1) the haemolymph, from neurohaemal axon terminals in the periphery of the cerebral commissure and (2) the intercellular space of the central nervous system, from...

journal_title：Neuroscience

authors： Schmidt ED,Roubos EW

更新日期：1988-07-01 00:00:00

abstract：:The response to iontophoretic application of acetylcholine in the mouse neuroblastoma cell line N1E-115 was composed of three phases. The initial fast depolarizing phase was blocked by 10 microM d-tubocurarine, but not by 0.1 microM atropine. This phase was followed by a transient hyperpolarization which in turn was f...

journal_title：Neuroscience

authors： Kato E,Anwyl R,Quandt FN,Narahashi T

更新日期：1983-03-01 00:00:00

abstract：:The circling rat is an autosomal recessive mutant (homozygous ci2/ci2) that displays lateralized circling behavior, locomotor hyperactivity, hyperexcitability, ataxia, and stereotypic head-movement. These abnormal behaviors are induced or intensified by stress. Heterozygous (ci2/+) littermates display normal spontaneo...

journal_title：Neuroscience

authors： Fedrowitz M,Potschka H,Richter A,Löscher W

更新日期：2000-01-01 00:00:00

abstract：:The present experiments examined the effects of direct intracortical microinjections of the N-methyl-D-aspartate receptor antagonist 2-amino-5-phosphonovaleric acid directly into the insular cortex of rats, before or immediately after training of conditioned taste aversion and the water maze spatial learning task. In ...

journal_title：Neuroscience

authors： Gutiérrez H,Hernández-Echeagaray E,Ramírez-Amaya V,Bermúdez-Rattoni F

更新日期：1999-03-01 00:00:00