Anti-glutamatergic effect of riluzole: comparison with valproic acid.

abstract：:Antagonists acting at the 5-hydroxytryptamine3 receptor are potent anti-emetic agents in cases of cytotoxic- and radiation-induced vomiting, and binding sites for these compounds have been described in brainstem areas known to be involved in mediation of nausea and vomiting. We have used autoradiography to examine the...

journal_title：Neuroscience

authors： Leslie RA,Reynolds DJ,Andrews PL,Grahame-Smith DG,Davis CJ,Harvey JM

更新日期：1990-01-01 00:00:00

abstract：:Vagal afferents ascending from the gastrointestinal tract synapse on neurons in the nucleus of the solitary tract. Although these neurons constitute a significant proportion of solitary tract cells their firing behaviour and synaptic properties are not documented. Since gastrointestinal tract afferent termination site...

journal_title：Neuroscience

authors： Paton JF,Li YW,Deuchars J,Kasparov S

更新日期：2000-01-01 00:00:00

abstract：:Neuroinflammation, and elevated levels of inflammatory proteins, such as tumor necrosis factor-alpha, and the deposition of beta-amyloid may interact to contribute to the pathogenesis of Alzheimer's disease. We reproduced a component of the neuroinflammatory state within the basal forebrain cholinergic system, a regio...

journal_title：Neuroscience

authors： Wenk GL,McGann-Gramling K,Hauss-Wegrzyniak B

更新日期：2004-01-01 00:00:00

abstract：:Dopamine (DA), released from the lateral olivocochlear (LOC) efferent terminals, the efferent arm of the short-loop feedback in the cochlea, is considered as a protective factor in the inner ear since it inhibits auditory nerve dendrite firing in ischemia- or noise-induced excitotoxicity leading to sensorineural heari...

journal_title：Neuroscience

authors： Halmos G,Doleviczényi Z,Répássy G,Kittel A,Vizi ES,Lendvai B,Zelles T

更新日期：2005-01-01 00:00:00

abstract：:In two experiments, we combined a semantic blocked naming paradigm with anodal transcranial direct current stimulation (tDCS) to shed light on the neural correlates of the semantic interference (SI) effect. In particular, prior to the naming task, anodal tDCS was applied over the left superior temporal gyrus (STG, Exp...

journal_title：Neuroscience

authors： Pisoni A,Papagno C,Cattaneo Z

更新日期：2012-10-25 00:00:00

abstract：:The striatum is thought to be generated from two transient swellings in the ventral telencephalon, the lateral and medial ganglionic eminences, present at mid-stages of embryonic rat development. We have studied the relative contribution of these structures to the specific generation of striatal neuronal subtypes such...

journal_title：Neuroscience

authors： Olsson M,Björklund A,Campbell K

更新日期：1998-06-01 00:00:00

abstract：:Some of the myelinated axons in rat peripheral nerves possess marked axoplasmic carbonic anhydrase activity [Riley, Ellis and Bain (1982) J. Histochem. Cytochem. 30, 1275-1288; Riley and Lang (1984) J. Hand Surg. 9A, 112-120]. A mixture of reactive and nonreactive neurons was a general observation in cervical, thoraci...

journal_title：Neuroscience

authors： Riley DA,Ellis S,Bain JL

更新日期：1984-09-01 00:00:00

abstract：:To investigate the minimum neuron and neurite densities required for synchronized bursts, we cultured rat cortical neurons on planar multi-electrode arrays (MEAs) at five plating densities (2500, 1000, 500, 250, and 100 cells/mm(2)) using two culture media: Neuron Culture Medium and Dulbecco's Modified Eagle Medium su...

journal_title：Neuroscience

authors： Ito D,Tamate H,Nagayama M,Uchida T,Kudoh SN,Gohara K

更新日期：2010-11-24 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for the human disease multiple sclerosis (MS), a demyelinating and neurodegenerative pathology of the central nervous system. Both diseases share physiopathological and clinical characteristics, mainly associated with a neuroinflammatory pro...

journal_title：Neuroscience

authors： Chanaday NL,Roth GA

更新日期：2016-02-09 00:00:00

abstract：:Golgi, Nissl, Bielschowsky and cholinesterase techniques have been used to analyze the optic tectum of the weakly electric teleost fish Eigenmannia virescens and Apteronotus leptorhynchus. Six layers are readily distinguished: a fairly thick stratum marginale, a narrow stratum opticum and stratum fibrosum et griseum s...

journal_title：Neuroscience

authors： Sas E,Maler L

更新日期：1986-05-01 00:00:00

abstract：:The distribution of adenosine A1 receptors was studied quantitatively in the brain of the rat, mouse, guinea-pig and cat, using in vitro autoradiography with [3H]N6-cyclohexyladenosine as ligand. Preliminary binding studies in brain sections from the guinea-pig and cat gave results similar to previous data from the ra...

journal_title：Neuroscience

authors： Fastbom J,Pazos A,Palacios JM

更新日期：1987-09-01 00:00:00

abstract：:Several lines of evidence suggest that integrin receptors play a pivotal role in consolidation of long-term potentiation (LTP), but which of the many integrin dimers are involved remains to be discovered. The present study used an LTP reversal paradigm to test if alpha3 integrins make an important contribution. Functi...

journal_title：Neuroscience

authors： Kramár EA,Bernard JA,Gall CM,Lynch G

更新日期：2002-01-01 00:00:00

abstract：:In the present study, in vivo voltammetry was used to monitor changes in dopamine levels in the left and right medial prefrontal cortex of rats exposed to mild physical and psychological stress. These were 2 min of tail-pinch and 15 min exposure to cat odour, respectively. Fourteen male Long Evans rats with bilateral ...

journal_title：Neuroscience

authors： Sullivan RM,Gratton A

更新日期：1998-03-01 00:00:00

abstract：:Aquaporin 4 (AQP4) is abundantly expressed in the perivascular glial endfeet in the central nervous system (CNS), where it is involved in the exchange of fluids between blood and brain. At this location, AQP4 contributes to the formation and/or the absorption of the brain edema that may arise following pathologies suc...

journal_title：Neuroscience

authors： Moeller HB,Fenton RA,Zeuthen T,Macaulay N

更新日期：2009-12-29 00:00:00

abstract：:This immunocytochemical study, using a double-staining method, showed that calcitonin gene-related peptide-like immunoreactive structures are widely distributed in the peripheral nervous system and that many of them coexist with substance P-like immunoreactive structures in single sensory ganglion cells. Neurons posit...

journal_title：Neuroscience

authors： Lee Y,Takami K,Kawai Y,Girgis S,Hillyard CJ,MacIntyre I,Emson PC,Tohyama M

更新日期：1985-08-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a major cause of morbidity and mortality world-wide and can result in persistent cognitive, sensory and behavioral dysfunction. Understanding the time course of TBI-induced pathology is essential to effective treatment outcomes. We induced TBI in rats using an impact acceleration method...

journal_title：Neuroscience

authors： Allitt BJ,Iva P,Yan EB,Rajan R

更新日期：2016-10-15 00:00:00

abstract：:Glucocorticoid hormones exert crucial effects on the brain in relation to physiology, endocrine regulation, mood and cognition. Their two receptor types, glucocorticoid and mineralocorticoid receptors (GR and MR), are members of the nuclear receptor superfamily and act in large measure as transcription factors. The ou...

journal_title：Neuroscience

authors： Zalachoras I,Houtman R,Meijer OC

更新日期：2013-07-09 00:00:00

abstract：:This study aimed to clarify changes in the spatial expressions of types 1, 2 and 3 ryanodine receptors (RyR1, RyR2 and RyR3) in the cerebellum of a Ca(2+) channel alpha(1A) subunit mutant, rolling mouse Nagoya. Semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) revealed that the mRNA signal lev...

journal_title：Neuroscience

authors： Sawada K,Hosoi E,Bando M,Sakata-Haga H,Lee NS,Jeong YG,Fukui Y

更新日期：2008-03-27 00:00:00

abstract：:In the present study we examined the effects of normal aging in the hippocampus and cerebellum, as well as behaviors associated with these substrates. A total of 67 CB6F1 hybrid mice were tested at one of five ages (4, 8, 12, 18 or 25 months) on the context pre-exposure facilitation effect (CPFE) modification of fear ...

journal_title：Neuroscience

authors： Kennard JA,Brown KL,Woodruff-Pak DS

更新日期：2013-09-05 00:00:00

abstract：:Miniature endplate potentials were recorded from the isolated pectoralis cutaneous muscle of the frog during very stable recording conditions and low noise levels. Two to 5 x 10(3) miniature endplate potentials were filmed at eight unstressed junctions that met rigorous experimental criteria for analysis. Seven juncti...

journal_title：Neuroscience

authors： Kriebel ME,Motelica-Heino I

更新日期：1987-11-01 00:00:00

abstract：:Production of tissue inhibitors of matrix metalloproteinases (TIMPs), a family of secreted proteins with inhibitory actions on matrix metalloproteinases (MMPs), is up-regulated following nerve injuries and is suggested to have protective effects against MMP-mediated tissue damages. To clarify the extracellular signals...

journal_title：Neuroscience

authors： Koyama Y,Baba A,Matsuda T

更新日期：2007-07-13 00:00:00

abstract：:Isoflurane preconditioning improved short-term neurological outcome after focal brain ischemia in adult rats. It is not known whether desflurane induces a delayed phase of preconditioning in the brain and whether isoflurane preconditioning-induced neuroprotection is long-lasting. Two months-old Sprague-Dawley male rat...

journal_title：Neuroscience

authors： Li L,Zuo Z

更新日期：2009-12-01 00:00:00

abstract：:The postnatal development of GABAB binding sites in rat brain was studied by quantitative receptor autoradiography using [3H]GABA under selective conditions. Binding levels peak at regionally specific times during the first three weeks of life and then decline to adult levels. GABAB binding peaked in the globus pallid...

journal_title：Neuroscience

authors： Turgeon SM,Albin RL

更新日期：1994-09-01 00:00:00

abstract：:We have recently shown that isolated neuronal growth cones from developing rat forebrain possess an appreciable activity of adenylate cyclase, producing cyclic adenosine monophosphate, which can be stimulated by various neurotransmitter receptor agonists and by forskolin [Lockerbie R. O., Hervé D., Blanc G., Tassin J....

journal_title：Neuroscience

authors： Lockerbie RO,Autillo-Touati A,Araud D,Seite R,Chneiweiss H,Glowinski J,Prochiantz A

更新日期：1989-01-01 00:00:00

abstract：:In adult females many of the effects of the neuropeptide oxytocin are steroid, and especially estrogen dependent. Here we demonstrate for the first time that neonatal manipulation of oxytocin can affect the expression of estrogen receptor alpha. On the first day of postnatal life male and female prairie voles (Microtu...

journal_title：Neuroscience

authors： Yamamoto Y,Carter CS,Cushing BS

更新日期：2006-01-01 00:00:00

abstract：:To investigate whether acetylcholine is released in a similar fashion in different regions of the cortex, in vivo microdialysis was used to measure acetylcholine efflux simultaneously in the medial prefrontal and the frontoparietal cortex, under both basal conditions and following tactile stimulation. Additionally, th...

journal_title：Neuroscience

authors： Himmelheber AM,Fadel J,Sarter M,Bruno JP

更新日期：1998-10-01 00:00:00

abstract：:Some studies have demonstrated that aging is associated with impaired vestibular reflexes, especially otolithic reflexes, resulting in postural instability. However, the neurochemical basis of these age-related changes is still poorly understood. The l-arginine metabolic system has been implicated in changes in the br...

journal_title：Neuroscience

authors： Liu P,Gupta N,Jing Y,Collie ND,Zhang H,Smith PF

更新日期：2017-04-21 00:00:00

abstract：:Neural activity varies continually from moment to moment. Such temporal variability (TV) has been highlighted as a functionally specific brain property playing a fundamental role in cognition. We sought to investigate the mechanisms involved in TV changes between two basic behavioral states, namely having the eyes ope...

journal_title：Neuroscience

authors： Qin P,Duncan NW,Chen DY,Chen CJ,Huang LK,Huang Z,Lin CE,Wiebking C,Yang CM,Northoff G,Lane TJ

更新日期：2018-05-21 00:00:00

abstract：:Hydrogen peroxide (H2O2) is one of the reactive oxygen species (ROS), endogenously produced during metabolism, which acts as a second messenger. In skeletal muscles, hypoxia- or hyperthermia-induced increase in H2O2 might affect synaptic transmission by targeting the most redox-sensitive presynaptic compartment (Ginia...

journal_title：Neuroscience

authors： Giniatullin A,Petrov A,Giniatullin R

更新日期：2019-02-10 00:00:00

abstract：:Carbon monoxide (CO), like other gaseous neuromodulators, has a dual nature as both a toxic gas and a physiologically relevant signaling molecule. In the nervous system, high concentrations of CO can lead to neuronal injury while lower concentrations are found to be neuroprotective. The number of cellular targets affe...

journal_title：Neuroscience

authors： Estes S,Zhong LR,Artinian L,Rehder V

更新日期：2015-12-17 00:00:00