Synaptic Functions of Type-1 Cannabinoid Receptors in Inhibitory Circuits of the Anterior Piriform Cortex.

abstract：:The first Kavli Prize in Neuroscience recognizes a confluence of career achievements that together provide a fundamental understanding of how brain and spinal cord circuits are assembled during development and function in the adult. The members of the Kavli Neuroscience Prize Committee have decided to reward three sci...

journal_title：Neuroscience

authors： Glover JC

更新日期：2009-11-10 00:00:00

abstract：:The axonal development of serotonin (5-HT)-, noradrenaline (NA)-, or tyrosine hydroxylase (TH)-containing monoaminergic neurons is affected by rearing conditions during the juvenile period. Impaired monoaminergic axonal development is implicated in the pathophysiology of emotional and cognitive dysfunction. On the oth...

journal_title：Neuroscience

authors： Ishikawa J,Ishikawa A

更新日期：2013-01-29 00:00:00

abstract：:One class of spinal interneurons, the Renshaw cells, is able to discharge at very high frequencies in adult mammals. Neuronal firing at such high frequencies requires voltage-gated potassium channels to rapidly repolarize the membrane potential after each action potential. We sought to establish the pattern of express...

journal_title：Neuroscience

authors： Song ZM,Hu J,Rudy B,Redman SJ

更新日期：2006-05-12 00:00:00

abstract：:The impact of treating astrocytes with the astrocytic toxin l-alpha amino adipic acid (L-AAA) on neuronal outgrowth, complexity and synapse formation was assessed, using a model of astrocyte-neuronal interaction. Treatment of rat primary cortical neurons with conditioned media (CM) derived from astrocytes treated with...

journal_title：Neuroscience

authors： David J,O'Toole E,O'Reilly K,Thuery G,Assmann N,Finlay D,Harkin A

更新日期：2018-11-10 00:00:00

abstract：:We investigated the effects of the cholinergic agonist carbachol (25 microM) on the synaptic potentials recorded extracellularly and intracellularly from the CA3 area of immature hippocampal slices of the rat (postnatal days 10-20). In control conditions, carbachol reduced the amplitude of evoked synaptic responses (n...

journal_title：Neuroscience

authors： Psarropoulou C,Dallaire F

更新日期：1998-02-01 00:00:00

abstract：:Considerable sex differences occur in the incidence and prevalence of anxiety disorders where women are more anxious than men, particularly in situations where social interaction is required. In preclinical studies, the social interaction test represents a valid animal model to study sex differences in social anxiety....

journal_title：Neuroscience

authors： Carrier N,Kabbaj M

更新日期：2012-06-14 00:00:00

abstract：:Beta-amyloid (Aβ) deposition and neuroinflammation are involved in Alzheimer's disease (AD)-type neurodegeneration with cognitive deficits. Phosphodiesterase-5 (PDE5) inhibitors have recently been studied as a potential target for cognitive enhancement by reducing inflammatory responses and Aβ levels. The present stud...

journal_title：Neuroscience

authors： Yin C,Deng Y,Gao J,Li X,Liu Y,Gong Q

更新日期：2016-07-22 00:00:00

abstract：:We have used several anatomical tracing techniques to study the organization of the lateral ventromedial thalamic nucleus in the rat, a region that is selectively activated by cutaneous nociceptive inputs from any part of the body. The lateral ventromedial thalamic projections are organized as a widespread dense band ...

journal_title：Neuroscience

authors： Desbois C,Villanueva L

更新日期：2001-01-01 00:00:00

abstract：:Previous studies have demonstrated that human astrocytes express mRNA and receptor protein for group I and II metabotropic glutamate receptors (mGluRs). Whether these receptors can influence the inflammatory and immune response and can modulate the capacity of astrocytes to produce inflammatory cytokines is still uncl...

journal_title：Neuroscience

authors： Aronica E,Gorter JA,Rozemuller AJ,Yankaya B,Troost D

更新日期：2005-01-01 00:00:00

abstract：:The recognition molecule myelin-associated glycoprotein is expressed by oligodendrocytes, the myelinating cells of the central nervous system. The myelin-associated glycoprotein gene gives rise to two alternatively spliced transcript variants ("early" and "late" message) which are developmentally regulated. In this st...

journal_title：Neuroscience

authors： Kirchhoff F,Ohlemeyer C,Kettenmann H

更新日期：1997-05-01 00:00:00

abstract：:In the present study, in vivo voltammetry was used to monitor changes in dopamine levels in the left and right medial prefrontal cortex of rats exposed to mild physical and psychological stress. These were 2 min of tail-pinch and 15 min exposure to cat odour, respectively. Fourteen male Long Evans rats with bilateral ...

journal_title：Neuroscience

authors： Sullivan RM,Gratton A

更新日期：1998-03-01 00:00:00

abstract：:PSD-95/SAP90, a molecular scaffold protein, attaches the N-methyl-D-aspartate receptor to cellular signaling pathways through PSD-95/DLG/Z0-1 domain interactions at neuronal synapses.(5,9) This suggests that PSD-95/SAP90 might be involved in many physiological and pathophysiological actions triggered via the N-methyl-...

journal_title：Neuroscience

authors： Tao YX,Huang YZ,Mei L,Johns RA

更新日期：2000-01-01 00:00:00

abstract：:The response to iontophoretic application of acetylcholine in the mouse neuroblastoma cell line N1E-115 was composed of three phases. The initial fast depolarizing phase was blocked by 10 microM d-tubocurarine, but not by 0.1 microM atropine. This phase was followed by a transient hyperpolarization which in turn was f...

journal_title：Neuroscience

authors： Kato E,Anwyl R,Quandt FN,Narahashi T

更新日期：1983-03-01 00:00:00

abstract：:The mechanisms underlying antiepileptic or antiepileptogenic effects of repeated transcranial magnetic stimulation (rTMS) are poorly understood. In this study, we investigated the effect of rTMS applied during rapid amygdala kindling on some electrophysiological properties of hippocampal CA1 pyramidal neurons. Male Wi...

journal_title：Neuroscience

authors： Shojaei A,Semnanian S,Janahmadi M,Moradi-Chameh H,Firoozabadi SM,Mirnajafi-Zadeh J

更新日期：2014-11-07 00:00:00

abstract：:Excessive expression of vascular endothelial growth factor (VEGF) is a common cause of blood-brain barrier (BBB) breakdown that triggers severe complications following traumatic brain injury (TBI). It has been shown that inhibition of VEGF activities may attenuate cerebral edema in pathological conditions. Vascular en...

journal_title：Neuroscience

authors： Zhou Z,Gao S,Li Y,Peng R,Zheng Z,Wei W,Zhao Z,Liu X,Li L,Zhang J

更新日期：2020-07-01 00:00:00

abstract：:Despite high levels of use, the mechanism of action of effective pharmacotherapies in attention deficit hyperactivity disorder (ADHD) is unknown. It has recently been hypothesized that one site of therapeutic action is the midbrain superior colliculus, a structure traditionally associated with visual processing, but a...

journal_title：Neuroscience

authors： Dommett EJ,Overton PG,Greenfield SA

更新日期：2009-12-15 00:00:00

abstract：:Oxytocin (OT) levels in plasma increase during sexual response and are significantly lower in patients with depression. A drug for the treatment of sexual dysfunction, sildenafil, enhances the electrically evoked release of OT from the posterior pituitary. In this study, we showed that sildenafil had an antidepressant...

journal_title：Neuroscience

authors： Matsushita H,Matsuzaki M,Han XJ,Nishiki TI,Ohmori I,Michiue H,Matsui H,Tomizawa K

更新日期：2012-01-03 00:00:00

abstract：:Three anti-peptide antisera were raised against three distinct amino acid sequences of ecto-nucleoside triphosphate diphosphohydrolase 3 (NTPDase3), characterized by Western blot analyses, and used to determine the distribution of NTPDase3 protein in adult rat brain. The three antisera all yielded similar immunolocali...

journal_title：Neuroscience

authors： Belcher SM,Zsarnovszky A,Crawford PA,Hemani H,Spurling L,Kirley TL

更新日期：2006-01-01 00:00:00

abstract：:This study compared the pharmacology of adrenergic agents that influence plasma extravasation in normal animals with those agents that influence tissue injury in an inflammatory disease model. Specifically we studied the effects of beta 2- and alpha 2-adrenergic receptor agonists and antagonists on bradykinin-induced ...

journal_title：Neuroscience

authors： Coderre TJ,Chan AK,Helms C,Basbaum AI,Levine JD

更新日期：1991-01-01 00:00:00

abstract：:Synapse specific differences in NR2 subunit expression exist in several systems within the mammalian CNS. Here we have studied such differences on motoneurons in the neonatal rat cord using ifenprodil known to inhibit voltage-, use- and glycine-independent responses mediated by NR2B-containing N-methyl-d-aspartate rec...

journal_title：Neuroscience

authors： Shanthanelson M,Mendell LM

更新日期：2010-03-17 00:00:00

abstract：:We employed simultaneous field potential recordings from CA3, subiculum and entorhinal cortex in an in vitro brain slice preparation to understand the involvement of these limbic areas in the generation of the field potential oscillations that are induced by bath application of the muscarinic receptor agonist carbacho...

journal_title：Neuroscience

authors： Lévesque M,Cataldi M,Chen LY,Hamidi S,Avoli M

更新日期：2017-04-21 00:00:00

abstract：:A lack of thyroid hormone in the postnatal period causes an irreversible mental retardation, characterized by a slowing of thoughts and movements accompanied by prolonged latencies of several evoked potentials and slowed electroencephalographic rhythms. Here we show that in cultured hippocampal and cortical neurons fr...

journal_title：Neuroscience

authors： Hoffmann G,Dietzel ID

更新日期：2004-01-01 00:00:00

abstract：:There are two different proposals regarding the role of the cerebellar flocculus in the adaptation of the vestibulo-ocular reflex: that the flocculus is the site for both the induction and retention of the adaptation, or that the flocculus plays an important role in the induction, but the vestibular nuclei to which th...

journal_title：Neuroscience

authors： Nagao S,Kitazawa H

更新日期：2003-01-01 00:00:00

abstract：:The distribution of [125I]omega-conotoxin GVIA binding sites, the putative voltage-sensitive calcium channels, was studied by an autoradiographic method in the rat brain. The toxin binding sites were distributed throughout the brain in a highly heterogeneous manner. The highest density of the binding sites was observe...

journal_title：Neuroscience

authors： Takemura M,Kiyama H,Fukui H,Tohyama M,Wada H

更新日期：1989-01-01 00:00:00

abstract：:Traditionally, multiple sclerosis (MS) is considered to be a disease primarily affecting the white matter (WM). However, the development of some clinical symptoms such as cognitive impairment cannot be fully explained by the severity of WM pathology alone. During the past decades it became clear that gray matter (GM) ...

journal_title：Neuroscience

authors： van Munster CE,Jonkman LE,Weinstein HC,Uitdehaag BM,Geurts JJ

更新日期：2015-09-10 00:00:00

abstract：:In brainstem motor networks, hypoglossal motoneurons (HMs) play the physiological role of driving tongue contraction, an activity critical for inspiration, phonation, chewing and swallowing. HMs are an early target of neurodegenerative diseases like amyotrophic lateral sclerosis that, in its bulbar form, is manifested...

journal_title：Neuroscience

authors： Ghezzi F,Monni L,Corsini S,Rauti R,Nistri A

更新日期：2017-12-26 00:00:00

abstract：:To be highly reliable, synaptic transmission needs postsynaptic receptors (Rs) in precise apposition to the presynaptic release sites. At inhibitory synapses, the postsynaptic protein gephyrin self-assembles to form a scaffold that anchors glycine and GABAARs to the cytoskeleton, thus ensuring the accurate accumulatio...

journal_title：Neuroscience

authors： Pizzarelli R,Griguoli M,Zacchi P,Petrini EM,Barberis A,Cattaneo A,Cherubini E

更新日期：2020-07-15 00:00:00

abstract：:In the present study, we analysed the distribution and cellular localization of metabotropic glutamate receptors (1alpha, 2/3, 5) in parabrachial and Kölliker-Fuse nuclei using subtype-specific antisera. Immunolabelling revealed that different nuclei express different sets of metabotropic glutamate receptors. Metabotr...

journal_title：Neuroscience

authors： Guthmann A,Herbert H

更新日期：1999-03-01 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune disease in which more than 70% of patients experience visual disturbance as the earliest symptoms. Lysolecithin (LPC)-induced focal demyelination model has been developed to evaluate the effects of different therapies on myelin repair improvement. In this study, the effects of ...

journal_title：Neuroscience

authors： Daneshdoust D,Khalili-Fomeshi M,Ghasemi-Kasman M,Ghorbanian D,Hashemian M,Gholami M,Moghadamnia A,Shojaei A

更新日期：2017-03-06 00:00:00

abstract：:Migraine attacks are typically described as unilateral, throbbing pain that is usually accompanied by nausea, vomiting, and exaggerated sensitivities to light, noise and smell. The headache phase of a migraine attack is mediated by activation of the trigeminovascular pathway; a nociceptive pathway that originates in t...

journal_title：Neuroscience

authors： Kagan R,Kainz V,Burstein R,Noseda R

更新日期：2013-09-17 00:00:00