当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Sex differences in social interaction behaviors in rats are mediated by extracellular signal-regulated kinase 2 expression in the medial prefrontal cortex.

Sex differences in social interaction behaviors in rats are mediated by extracellular signal-regulated kinase 2 expression in the medial prefrontal cortex.

Abstract：

:Considerable sex differences occur in the incidence and prevalence of anxiety disorders where women are more anxious than men, particularly in situations where social interaction is required. In preclinical studies, the social interaction test represents a valid animal model to study sex differences in social anxiety. Indeed, female rats engage less in conspecific interactions than their male counterparts, which are behaviors indicative of higher social anxiety in female rats. In this work, we implicated extracellular signal-regulated kinase 2 (ERK2) in the medial prefrontal cortex (mPFC) in mediating social interaction. Indeed, female rats' had lower ERK2 expression compared to male rats, and overexpression of ERK2 in the mPFC increases their social interaction to the level seen in their male counterparts. These data indicate that the sexually dimorphic expression of ERK2 mediates social anxiety-like behaviors.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Carrier N,Kabbaj M

doi

10.1016/j.neuroscience.2012.03.041

subject

Has Abstract

pub_date

2012-06-14 00:00:00

pages

86-92

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(12)00308-9

journal_volume

212

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • The organization and hypothalamic projections of the tuberomammillary nucleus in the rat: an immunohistochemical study of adenosine deaminase-positive neurons and fibers.

    abstract：:The intense immunohistochemical reaction for the enzyme adenosine deaminase displayed by neurons in the tuberomammillary nucleus in the rat was used to study the distribution and morphology of cells comprising this nucleus, their fiber fields within the posterior hypothalamus and their projection pathways from the hyp...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(87)90077-7

    authors： Staines WA,Daddona PE,Nagy JI

    更新日期：1987-11-01 00:00:00

  • Stress and the developing adolescent brain.

    abstract：:Adolescence is a time of continued brain maturation, particularly in limbic and cortical regions, which undoubtedly plays a role in the physiological and emotional changes coincident with adolescence. An emerging line of research has indicated that stressors experienced during this crucial developmental stage may affe...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2012.10.048

    authors： Eiland L,Romeo RD

    更新日期：2013-09-26 00:00:00

  • Properties of postganglionic sympathetic neurons with axons in the right thoracic vagus.

    abstract：:The resting and reflex-evoked activities of single postganglionic sympathetic neurons with axons in the right thoracic vagus were tested in chloralose-anaesthetized cats. The properties of a majority of neurons were found to be similar. Cardiac- and inspiration-related rhythmicities were present in the resting activit...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(92)90346-4

    authors： Bałkowiec A,Szulczyk P

    更新日期：1992-01-01 00:00:00

  • Properties of inward and outward potassium currents in cultured mouse motoneurons.

    abstract：:Inward rectifier potassium currents and calcium-dependent potassium currents have been studied in cultured embryonic mouse motoneurons. Sustained unitary inward rectifier potassium currents were recorded from cell-attached patches and the channel conductance was dependent on external K+ concentration with a value of 2...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)90396-o

    authors： McLarnon JG,Kim SU,Michikawa M,Xu R

    更新日期：1995-01-01 00:00:00

  • Expression of nerve growth factor in astrocytes of the hippocampal CA1 area following transient forebrain ischemia.

    abstract：:We have examined by immunoassay and immunohistochemistry, the expression of nerve growth factor in the rat hippocampus, one to 28 days after transient forebrain ischemia. In the CA1 area, the overall level of nerve growth factor expression remained constant over the first three days of reperfusion while it increased b...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00612-5

    authors： Gottlieb M,Matute C

    更新日期：1999-01-01 00:00:00

  • Isoflurane preconditioning improves short-term and long-term neurological outcome after focal brain ischemia in adult rats.

    abstract：:Isoflurane preconditioning improved short-term neurological outcome after focal brain ischemia in adult rats. It is not known whether desflurane induces a delayed phase of preconditioning in the brain and whether isoflurane preconditioning-induced neuroprotection is long-lasting. Two months-old Sprague-Dawley male rat...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.08.011

    authors： Li L,Zuo Z

    更新日期：2009-12-01 00:00:00

  • Electrophysiological characteristics of inhibitory neurons of the prepositus hypoglossi nucleus as analyzed in Venus-expressing transgenic rats.

    abstract：:The identification and characterization of excitatory and inhibitory neurons are significant steps in understanding neural network functions. In this study, we investigated the intrinsic electrophysiological properties of neurons in the prepositus hypoglossi nucleus (PHN), a brainstem structure that is involved in gaz...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.09.017

    authors： Shino M,Kaneko R,Yanagawa Y,Kawaguchi Y,Saito Y

    更新日期：2011-12-01 00:00:00

  • HIF1α is necessary for exercise-induced neuroprotection while HIF2α is needed for dopaminergic neuron survival in the substantia nigra pars compacta.

    abstract：:Exercise reduces the risk of developing a number of neurological disorders and increases the efficiency of cellular energy production. However, overly strenuous exercise produces oxidative stress. Proper oxygenation is crucial for the health of all tissues, and tight regulation of cellular oxygen is critical to balanc...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.03.015

    authors： Smeyne M,Sladen P,Jiao Y,Dragatsis I,Smeyne RJ

    更新日期：2015-06-04 00:00:00

  • Charting of type II glucocorticoid receptor-like immunoreactivity in the rat central nervous system.

    abstract：:The rat brain and spinal cord have been mapped for Type II glucocorticoid receptor-like immunoreactivity in neurons and glia, using a monoclonal antibody, BUGR2, which recognizes an epitope close to the DNA-binding domain of the rat Type II receptor. The study revealed a widespread distribution of Type II-like immunor...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(90)90244-x

    authors： Ahima RS,Harlan RE

    更新日期：1990-01-01 00:00:00

  • Inhibition of long-term potentiation in the schaffer-CA1 pathway by repetitive high-intensity sound stimulation.

    abstract：:High-intensity sound can induce seizures in susceptible animals. After repeated acoustic stimuli changes in behavioural seizure repertoire and epileptic EEG activity might be seen in recruited limbic and forebrain structures, a phenomenon known as audiogenic kindling. It is postulated that audiogenic kindling can prod...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.09.040

    authors： Cunha AO,de Oliveira JA,Almeida SS,Garcia-Cairasco N,Leão RM

    更新日期：2015-12-03 00:00:00

  • Activation of nitric oxide-producing neurons in the brain stem during cardiac sympathoexcitatory reflexes in the cat.

    abstract：:Our previous studies have shown that selective inhibition of nitric oxide in the brain reduces pressor responses to activation of cardiac sympathetic afferents, thus suggesting that nitric oxide is involved in central regulation of cardiac-cardiovascular sympathoexcitatory reflexes. Central neural regions in which nit...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00707-8

    authors： Guo ZL,Longhurst JC

    更新日期：2003-01-01 00:00:00

  • Reduced frontal cortex thickness and cortical volume associated with pathological narcissism.

    abstract：:Pathological narcissism is often characterized by arrogant behavior, a lack of empathy, and willingness to exploit other individuals. Generally, individuals with high levels of narcissism are more likely to suffer mental disorders. However, the brain structural basis of individual pathological narcissism trait among h...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.04.025

    authors： Mao Y,Sang N,Wang Y,Hou X,Huang H,Wei D,Zhang J,Qiu J

    更新日期：2016-07-22 00:00:00

  • Effect of social isolation on CB1 and D2 receptor and fatty acid amide hydrolase expression in rats.

    abstract：:Rearing rats in isolation has been shown to produce behavioral and neurochemical alterations similar to those observed in psychoses such as schizophrenia. Also, a dysregulation in both the endocannabinoid and dopaminergic systems has been implicated in schizophrenia. The aim of this study was to determine if there are...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.10.043

    authors： Malone DT,Kearn CS,Chongue L,Mackie K,Taylor DA

    更新日期：2008-03-03 00:00:00

  • Developmental change in ganglioside expression in primary culture of rat neurons.

    abstract：:Developmental changes in ganglioside levels and patterns were investigated in neuronal cells dissociated from 17-day-old fetal rat hemispheres for up to 7 days of culture. Increases in ganglioside contents and the onset of GM3 synthesis, which is associated with proliferation of glial cells, were observed as the neuro...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(91)90207-5

    authors： Ogiso M,Ohta M,Harada Y,Kubo H,Hirano S

    更新日期：1991-01-01 00:00:00

  • Phenylethylidenehydrazine, a novel GABA-transaminase inhibitor, reduces epileptiform activity in rat hippocampal slices.

    abstract：:Phenylethylidenehydrazine (PEH), an analog of the monoamine oxidase inhibitor, beta-phenylethylhydrazine (phenelzine), inhibits the gamma-aminobutyric acid (GABA) catabolic enzyme GABA-transaminase and increases brain levels of GABA. GABA is the predominant fast inhibitory transmitter counteracting glutamatergic excit...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.03.007

    authors： Duffy S,Nguyen PV,Baker GB

    更新日期：2004-01-01 00:00:00

  • Pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal polypeptide promote the genesis of calcium currents in differentiating mouse embryonic stem cells.

    abstract：:Identification of novel molecules that can induce neuronal differentiation of embryonic stem (ES) cells is essential for deciphering the molecular mechanisms of early development and for exploring cell therapy approaches. Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal polypeptide ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.09.062

    authors： Chafai M,Basille M,Galas L,Rostene W,Gressens P,Vaudry H,Gonzalez BJ,Louiset E

    更新日期：2011-12-29 00:00:00

  • Types of synapses contacting the soma of corticotectal cells in the visual cortex of the cat.

    abstract：:Retrograde transport of horseradish peroxidase has been used to single out a distinct functional cortical cell type for ultrastructural study. Following injection of horseradish peroxidase into the superior colliculus, labelled pyramidal cells were found in layer V of the visual cortex. Examination of the labelled cor...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(82)90127-0

    authors： Kennedy H

    更新日期：1982-01-01 00:00:00

  • Activation of metabotropic glutamate receptor 3 enhances interleukin (IL)-1beta-stimulated release of IL-6 in cultured human astrocytes.

    abstract：:Previous studies have demonstrated that human astrocytes express mRNA and receptor protein for group I and II metabotropic glutamate receptors (mGluRs). Whether these receptors can influence the inflammatory and immune response and can modulate the capacity of astrocytes to produce inflammatory cytokines is still uncl...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.10.024

    authors： Aronica E,Gorter JA,Rozemuller AJ,Yankaya B,Troost D

    更新日期：2005-01-01 00:00:00

  • Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies.

    abstract：:Calcitonin gene-related peptide (CGRP) is a potent vasodilator and a neuromodulator implicated in the pathophysiology of migraine. It binds to the extracellular domains of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein (RAMP) 1 that together form the CGRP receptor. Antagonist antibodie...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.04.046

    authors： Miller S,Liu H,Warfvinge K,Shi L,Dovlatyan M,Xu C,Edvinsson L

    更新日期：2016-07-22 00:00:00

  • Changes of inter-hemispheric functional connectivity between motor cortices after brachial plexuses injury: a resting-state fMRI study.

    abstract：OBJECT:The aim of this study is to explore the changes of inter-hemispheric functional connectivity in patients with unilateral brachial plexus injury. METHODS:Nine patients with five roots of unilateral brachial plexus avulsion injury and 11 healthy controls were recruited in this study. Resting-state functional conn...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.03.048

    authors： Liu B,Li T,Tang WJ,Zhang JH,Sun HP,Xu WD,Liu HQ,Feng XY

    更新日期：2013-07-23 00:00:00

  • Single intranasal neuropeptide Y infusion attenuates development of PTSD-like symptoms to traumatic stress in rats.

    abstract：:Exposure to severe stress leads to development of neuropsychiatric disorders, including depression and Post-Traumatic Stress Disorder (PTSD) in at-risk individuals. Neuropeptide Y (NPY) is associated with resilience or improved recovery. Therefore exogenous administration to the brain has therapeutic potential althoug...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.01.040

    authors： Serova LI,Tillinger A,Alaluf LG,Laukova M,Keegan K,Sabban EL

    更新日期：2013-04-16 00:00:00

  • Regulation of inflammatory transcription factors by heat shock protein 70 in primary cultured astrocytes exposed to oxygen-glucose deprivation.

    abstract：:Inflammation is an important event in ischemic injury. These immune responses begin with the expression of pro-inflammatory genes modulating transcription factors, such as nuclear factor-κB (NF-κB), activator protein-1 (AP-1), and signal transducers and activator of transcription-1 (STAT-1). The 70-kDa heat shock prot...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.11.057

    authors： Kim JY,Yenari MA,Lee JE

    更新日期：2015-02-12 00:00:00

  • Serotonin-induced in vitro long-term facilitation exhibits differential pattern sensitivity in cervical and thoracic inspiratory motor output.

    abstract：:Intermittent hypoxia induces 5-HT-dependent, pattern-sensitive long-term facilitation (LTF) of spinal respiratory motor output. We used a split-bath in vitro neonatal rat brainstem-spinal cord preparation to test whether: 1) intermittent spinal 5-HT exposure (without hypoxia) is sufficient to induce LTF in phrenic and...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.06.036

    authors： Lovett-Barr MR,Mitchell GS,Satriotomo I,Johnson SM

    更新日期：2006-10-27 00:00:00

  • Behavioural and neurochemical consequences of chronic gut microbiota depletion during adulthood in the rat.

    abstract：:Gut microbiota colonization is a key event for host physiology that occurs early in life. Disruption of this process leads to altered brain development which ultimately manifests as changes in brain function and behaviour in adulthood. Studies using germ-free (GF) mice highlight the extreme impact on brain health that...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.10.003

    authors： Hoban AE,Moloney RD,Golubeva AV,McVey Neufeld KA,O'Sullivan O,Patterson E,Stanton C,Dinan TG,Clarke G,Cryan JF

    更新日期：2016-12-17 00:00:00

  • Serotonergic pre-treatments block in vitro serotonergic phase shifts of the mouse suprachiasmatic nucleus circadian clock.

    abstract：:The suprachiasmatic nucleus (SCN) contains a circadian clock that maintains its time-generating and phase-modulating capacities in vitro. Previous studies report clear differences in the ability of serotonergic stimuli to phase-shift the SCN clock when applied directly to the SCN either in vivo or in vitro: while mice...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.06.014

    authors： Prosser RA,Lee HM,Wehner A

    更新日期：2006-10-13 00:00:00

  • Accelerated high-frequency repetitive transcranial magnetic stimulation enhances motor activity in rats.

    abstract：:High-frequency repetitive transcranial magnetic stimulation (HF-rTMS) is currently accepted as an evidence-based treatment option for treatment-resistant depression (TRD). Additionally, HF-rTMS showed beneficial effects on psychomotor retardation in patients. The classical HF-rTMS paradigms however are unlikely to rep...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.01.045

    authors： El Arfani A,Parthoens J,Demuyser T,Servaes S,De Coninck M,De Deyn PP,Van Dam D,Wyckhuys T,Baeken C,Smolders I,Staelens S

    更新日期：2017-04-07 00:00:00

  • Increased level of neurokinin-1 tachykinin receptor gene expression during early postnatal development of rat brain.

    abstract：:Substance P is known to elicit diverse actions via activating multiple subtypes of tachykinin receptors, and these actions appear to be involved not only in synaptic transmission but also in synaptic plasticity during development of the mammalian central nervous system. The availability of sensitive quantitation of in...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(96)00198-4

    authors： Taoka M,Song SY,Kubota M,Minegishi A,Yamakuni T,Konishi S

    更新日期：1996-10-01 00:00:00

  • Strand-specific RNA-sequencing analysis of multiple system atrophy brain transcriptome.

    abstract：:Multiple system atrophy (MSA) is a sporadic neurodegenerative disease. The major pathological hallmark of MSA is the accumulation of α-synuclein in oligodendrocytes. In contrast to Parkinson's disease no definitive familial etiology for MSA has been determined. Yet, there is a growing body of evidence that perturbatio...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.02.042

    authors： Mills JD,Ward M,Kim WS,Halliday GM,Janitz M

    更新日期：2016-05-13 00:00:00

  • Some inhibitory neurons in the spinal cord develop c-fos-immunoreactivity after noxious stimulation.

    abstract：:In order to determine which types of spinal neuron produce c-fos in response to noxious stimulation, we have combined pre-embedding detection of c-fos-like immunoreactivity with post-embedding immunocytochemistry using antibodies against GABA and glycine, 2 h after subcutaneous injection of formalin into a hindpaw of ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90525-8

    authors： Todd AJ,Spike RC,Brodbelt AR,Price RF,Shehab SA

    更新日期：1994-12-01 00:00:00

  • Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesia.

    abstract：:Analgesic effects of delta opioid receptor (DOR) -selective agonists are enhanced during persistent inflammation and arthritis. Although the underlying mechanisms are still unknown, membrane density of DOR was shown to be increased 72 h after induction of inflammation, an effect abolished in mu opioid receptor (MOR) -...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.09.060

    authors： Gendron L,Pintar JE,Chavkin C

    更新日期：2007-12-19 00:00:00