Changes in interneuronal phenotypes regulated by estradiol in the adult rat hippocampus: a potential role for neuropeptide Y.

abstract：:Acoustic trauma is the major cause of hearing loss in industrialised nations. We show in guinea-pigs that sound exposure (6 kHz, 120 dB sound pressure level for 30 min) leads to sensory cell death and subsequent permanent hearing loss. Ultrastructural analysis reveals that degeneration of the noise-damaged hair cells ...

journal_title：Neuroscience

authors： Wang J,Dib M,Lenoir M,Vago P,Eybalin M,Hameg A,Pujol R,Puel JL

更新日期：2002-01-01 00:00:00

abstract：:Extracellular single-unit recording methods were used to study the activity of neurons within a restricted portion of the dorsolateral mesopontine reticular formation, an area which includes the parabrachial, pedunculopontine tegmental and cuneiform nuclei. Recordings were obtained during presentations of unfamiliar a...

journal_title：Neuroscience

authors： Pascoe JP,Kapp BS

更新日期：1993-06-01 00:00:00

abstract：:Novel approaches are required in the clinical management of peripheral nerve injuries because current surgical techniques result in deficient sensory recovery. Microsurgery alone fails to address extensive cell death in the dorsal root ganglia (DRG), in addition to poor axonal regeneration. Incorporation of cultured c...

journal_title：Neuroscience

authors： Reid AJ,Sun M,Wiberg M,Downes S,Terenghi G,Kingham PJ

更新日期：2011-12-29 00:00:00

abstract：:A variety of neurological diseases are characterized by disturbances of the blood-brain barrier (BBB) and its transporters. We recently introduced fibroblast growth factor treated cortical organotypic slice cultures of mice as a model for in vitro studies of the blood-brain barrier and have now further characterized t...

journal_title：Neuroscience

authors： Camenzind RS,Chip S,Gutmann H,Kapfhammer JP,Nitsch C,Bendfeldt K

更新日期：2010-09-29 00:00:00

abstract：:Cytoplasmic pH (pH1) of crayfish lateral giant axons was monitored using antimony microelectrodes placed near septate junctions and variations of internal pH was induced by short applications of ammonium sulfate in the perfusing bath of the preparation. This treatment produced a rapid cell alkalinization followed, aft...

journal_title：Neuroscience

authors： Giaume C,Korn H

更新日期：1982-07-01 00:00:00

abstract：:Incubation of the rat sensory neuron-derived cell line ND7 in serum-free medium results in the arrest of mitosis and the appearance of numerous neuronal processes. During this differentiation event, secretory granule components such as chromogranins, neuropeptide Y and the C-flanking peptide of pro-neuropeptide Y move...

journal_title：Neuroscience

authors： Wheatley SC,Suburo AM,Horn DA,Vucicevic V,Terenghi G,Polak JM,Latchman DS

更新日期：1992-12-01 00:00:00

abstract：:Pseudoephedrine (PSE) salts (hydrochloride and sulfate) are commonly used as nasal and paranasal decongestants by scuba divers. Anecdotal reports from the Divers Alert Network suggest that taking PSE prior to diving while breathing pure O₂ increases the risk for CNS oxygen toxicity (CNS-OT), which manifests as seizure...

journal_title：Neuroscience

authors： Pilla R,Held HE,Landon CS,Dean JB

更新日期：2013-08-29 00:00:00

abstract：:The entorhinal cortex and other hippocampal and parahippocampal cortices are interconnected by a small number of GABAergic nonpyramidal neurons in addition to glutamatergic pyramidal cells. Since the cortical and basolateral amygdalar nuclei have cortex-like cell types and have robust projections to the entorhinal cor...

journal_title：Neuroscience

authors： McDonald AJ,Zaric V

更新日期：2015-04-02 00:00:00

abstract：:The synaptic strength between primary afferent Adelta-fibers, many of which convey pain-related information, and second order neurons in the spinal dorsal horn can be depressed for prolonged periods of time in a use- and N-methyl-D-aspartate receptor-dependent fashion. Here, we have used a transverse spinal cord slice...

journal_title：Neuroscience

authors： Chen J,Sandkühler J

更新日期：2000-01-01 00:00:00

abstract：:A satisfactory management to ensure a full restoration of peripheral nerve after trauma is not yet available. Using an experimental protocol, in which crush injury was applied 1 cm above the bifurcation of the rat sciatic nerve for 20 s, we here demonstrate that the levels of neuroactive steroids, such as pregnenolone...

journal_title：Neuroscience

authors： Roglio I,Bianchi R,Gotti S,Scurati S,Giatti S,Pesaresi M,Caruso D,Panzica GC,Melcangi RC

更新日期：2008-08-26 00:00:00

abstract：:Serotonin (5-HT) and norepinephrine (NE) have been implicated in the mediation of endogenous analgesic mechanisms via the descending inhibitory pain pathway in the brain, and dysfunction in both the 5-HT and NE systems has been suggested as an etiology of fibromyalgia (FM). Given that 5-HT reuptake inhibition in the b...

journal_title：Neuroscience

authors： Murai N,Fushiki H,Honda S,Murakami Y,Iwashita A,Irie M,Tamura S,Nagakura Y,Aoki T

更新日期：2015-03-19 00:00:00

abstract：:Calcium is an important mediator of programmed cell death induced by transient cerebral ischemia, and calcium-binding proteins have been implicated in calcium-regulated signal transduction. Apoptosis-linked gene 2 is a calcium-binding protein required for cell death induced by different apoptotic stimuli. By Western b...

journal_title：Neuroscience

authors： Li W,Jin K,Nagayama T,He X,Chang J,Minami M,Graham SH,Simon RP,Greenberg DA

更新日期：2000-01-01 00:00:00

abstract：:The hypocretin/orexin system regulates, among other things, sleep and energy homeostasis. The system is likely regulated by both homeostatic and circadian mechanisms. Little is known about local differences in the regulation of hypocretin activity. The aim of this study was to establish an optimized peptide quantifica...

journal_title：Neuroscience

authors： Justinussen JL,Holm A,Kornum BR

更新日期：2015-12-03 00:00:00

abstract：:Ubiquitination is a post-translational modification that can dynamically alter the function, degradation and transport of a protein, as well as its interaction with other proteins, and activity of an enzyme. Dysfunctional ubiquitination is detrimental to normal cellular functions, and can result in severe diseases. Ov...

journal_title：Neuroscience

authors： Zhu J,Tsai NP

更新日期：2020-01-21 00:00:00

abstract：:The concentrations of fourteen neurochemicals associated with metabolism, neurotransmission, antioxidant capacity, and cellular structure were measured noninvasively from two distinct brain regions using 1H magnetic resonance spectroscopy. Seventeen young adults (age 19-22years) and sixteen cognitively normal older ad...

journal_title：Neuroscience

authors： Marjańska M,McCarten JR,Hodges J,Hemmy LS,Grant A,Deelchand DK,Terpstra M

更新日期：2017-06-23 00:00:00

abstract：:Pathological forms of the microtubule-associated protein tau are involved in a large group of neurodegenerative diseases named tauopathies, including frontotemporal lobar degeneration (FTLD-tau). K369I mutant tau transgenic mice (K3 mice) recapitulate neural and behavioural symptoms of FTLD, including tau aggregates i...

journal_title：Neuroscience

authors： Mo M,Jönsson ME,Mathews MA,Johnstone D,Ke YD,Ittner LM,Balleine BW,Furlong TM,Camp AJ

更新日期：2020-11-21 00:00:00

abstract：:The release of chemical transmitter from nerve terminals is critically dependent on a transient increase in intracellular Ca2+. The increase in Ca2+ may be due to influx of Ca2+ from the extracellular fluid or release of Ca2+ from intracellular stores such as mitochondria. Whether Ca2+ utilized in transmitter release ...

journal_title：Neuroscience

authors： Brailoiu E,Miyamoto MD

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:depression is characterized by a stable negative bias toward emotional stimuli. This bias is associated with abnormal activities in emotion-processing regions (such as the amygdala) and cognitive-control regions (such as the dorsolateral prefrontal cortex [DLPFC]). However, it remains unclear whether the emo...

journal_title：Neuroscience

authors： Liao C,Feng Z,Zhou D,Dai Q,Xie B,Ji B,Wang X,Wang X

更新日期：2012-01-10 00:00:00

abstract：:Depression is a chronic disease that affects nearly twice as many women as men, and symptoms can differ by sex. Preclinical models disproportionately use male subjects and test a single behavioral endpoint immediately at the cessation of stress. We conducted variable stress in male and female mice for 6, 28, and 56 da...

journal_title：Neuroscience

authors： Johnson A,Rainville JR,Rivero-Ballon GN,Dhimitri K,Hodes GE

更新日期：2021-02-01 00:00:00

abstract：:GABA release was recorded in vivo by push-pull perfusion from the globus pallidus and substantia nigra of control rats, rats with unilateral ibotenic acid lesions of the neostriatum, and rats with embryonic striatal tissue grafts implanted in the lesioned striatum. The lesions reduced baseline levels of GABA release t...

journal_title：Neuroscience

authors： Sirinathsinghji DJ,Dunnett SB,Isacson O,Clarke DJ,Kendrick K,Björklund A

更新日期：1988-03-01 00:00:00

abstract：:Extracellular nucleotides exert their actions via two subfamilies of purinoceptors: P2X and P2Y. Eight mammalian P2Y receptor subtypes (P2Y(1,2,4,6,11,12,13,14)) have been identified. In this work, the localization of P2Y(6) was studied in rat retina using double immunofluorescence labeling and confocal scanning micro...

journal_title：Neuroscience

authors： Zhang PP,Yang XL,Zhong YM

更新日期：2012-09-18 00:00:00

abstract：:Some studies have demonstrated that aging is associated with impaired vestibular reflexes, especially otolithic reflexes, resulting in postural instability. However, the neurochemical basis of these age-related changes is still poorly understood. The l-arginine metabolic system has been implicated in changes in the br...

journal_title：Neuroscience

authors： Liu P,Gupta N,Jing Y,Collie ND,Zhang H,Smith PF

更新日期：2017-04-21 00:00:00

abstract：:The present study was designed to assess the possibility that sub-total ventral hippocampal lesions might leave intact a mechanism for only highly accurate navigation, whereas sub-total dorsal hippocampal lesions might leave intact a mechanism only for less precise navigation. Animals with selective dorsal, ventral or...

journal_title：Neuroscience

authors： Zhang WN,Pothuizen HH,Feldon J,Rawlins JN

更新日期：2004-01-01 00:00:00

abstract：:Synaptic vesicle protein 2 is an integral synaptic vesicle membrane glycoprotein which is present in all synapses for which it has been examined. We used an anti-synaptic vesicle protein 2 monoclonal antibody to examine synaptic vesicle protein 2 localization in the developing hamster retinofugal pathway. From postnat...

journal_title：Neuroscience

authors： Confaloni A,Lyckman AW,Moya KL

更新日期：1997-04-01 00:00:00

abstract：:The trigeminal ganglia (TG) subserving the head and the dorsal root ganglia (DRG) subserving the rest of the body are homologous handling sensory neurons. Differences exist, as a number of signaling substances cause headache but no pain in the rest of the body. To date, very few genes involved in this difference have ...

journal_title：Neuroscience

authors： Kogelman LJA,Christensen RE,Pedersen SH,Bertalan M,Hansen TF,Jansen-Olesen I,Olesen J

更新日期：2017-05-14 00:00:00

abstract：BACKGROUND:Spasticity and rigidity are serious complications associated with spinal traumatic or ischemic injury. Clinical studies show that tizanidine (Tiz) is an effective antispasticity agent; however, the mechanism of this effect is still not clear. Tiz binds not only to α2-adrenoreceptors (AR) but also to imidazol...

journal_title：Neuroscience

authors： Fuchigami T,Kakinohana O,Hefferan MP,Lukacova N,Marsala S,Platoshyn O,Sugahara K,Yaksh TL,Marsala M

更新日期：2011-10-27 00:00:00

abstract：:Cerebellar Purkinje neurons have intracellular regulatory systems including Ca2+-binding proteins, intracellular Ca2+ stores, Ca2+-ATPase and Na+-Ca2+ exchanger (NCX) that keep intracellular Ca2+ concentration ([Ca2+]i) in physiological range. Among these, NCX interacts with AMPA receptors, activation of which induces...

journal_title：Neuroscience

authors： Kim YT,Namkung YL,Kwak J,Suh CK

更新日期：2007-04-25 00:00:00

abstract：:The midbrain periaqueductal gray (PAG) is the area promoting emotional motor responses, reproductive behaviors and analgesia. Recent studies suggest that neurons in the PAG may be crucial for regulating the micturition reflex in both experimental animals and humans. We examined single neuronal activities in the PAG an...

journal_title：Neuroscience

authors： Liu Z,Sakakibara R,Nakazawa K,Uchiyama T,Yamamoto T,Ito T,Hattori T

更新日期：2004-01-01 00:00:00

abstract：:In anaesthetized adult rats, facial nerve injury causes a disinhibition of the interhemispheric connections between homotopic representation fields in the primary motor cortex with a latency of 4 min (Toldi et al., 1996, Neurosci Lett. 203, 179-182). One possible explanation for the induction of such rapid changes is ...

journal_title：Neuroscience

authors： Farkas T,Kis Z,Toldi J,Wolff JR

更新日期：1999-05-01 00:00:00

abstract：:Chronic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to baboons was shown previously to result in a motor syndrome and a pattern of striatal dopaminergic fibre loss similar to those observed in idiopathic Parkinson's disease. In the present study, tyrosine hydroxylase-immunoreactive neurons we...

journal_title：Neuroscience

authors： Varastet M,Riche D,Maziere M,Hantraye P

更新日期：1994-11-01 00:00:00