Abstract：
:Extracellular single-unit recording methods were used to study the activity of neurons within a restricted portion of the dorsolateral mesopontine reticular formation, an area which includes the parabrachial, pedunculopontine tegmental and cuneiform nuclei. Recordings were obtained during presentations of unfamiliar and familiar sensory stimuli, during Pavlovian differential conditioning procedures that elicited conditioned bradycardia, and while stimulating the amygdaloid central nucleus to identify neurons that projected to, or received projections from, the amygdaloid central nucleus. Activity in most dorsolateral mesopontine reticular neurons was altered during sensory stimulation, and the convergence of auditory and somatic inputs onto single neurons was common. Moreover, neural responses were often of a different magnitude and/or direction to auditory stimuli that were unfamiliar vs familiar vs reinforced (paired with pinna stimulation), and many of these differentially responsive neurons were activated orthodromically by stimulation of the amygdaloid central nucleus. In contrast, neurons activated antidromically by stimulation of the amygdaloid central nucleus were relatively quiescent during all phases of the experiment. Results are discussed in relation to current hypotheses concerning the functional significance of various neuronal subpopulations within the dorsolateral mesopontine reticular formation during Pavlovian conditioning.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Pascoe JP,Kapp BSdoi
10.1016/0306-4522(93)90245-bsubject
Has Abstractpub_date
1993-06-01 00:00:00pages
753-72issue
3eissn
0306-4522issn
1873-7544pii
0306-4522(93)90245-Bjournal_volume
54pub_type
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