Abstract:
:The origin of the corticothalamic projections to the contralateral mediodorsal nucleus, the collateralization of cortical fibers and their synaptic organization in the ipsi- and contralateral mediodorsal nuclei were investigated in adult rats with double retrograde fluorescent and anterograde tracing. After tracer injections in the mediodorsal nuclei on either side, neurons were retrogradely labeled in all the areas of the contralateral prefrontal cortex in which ipsilateral labeling was also observed. Contralateral corticothalamic cells accounted for 15% of the labeled neurons in the orbital and agranular insular areas, while their proportion was lower (3%) in the anterior cingulate cortex. Up to 70% of the contralateral cortical neurons were double labeled by bilateral injections in the mediodorsal nuclei. At the electron microscopic level, unilateral injections of biotinylated dextran-amine in the orbitofrontal cortex resulted in anterograde labeling of small terminals and a few large boutons in the ipsilateral mediodorsal nucleus, while only small boutons were identified contralaterally. The diameter of postsynaptic dendritic profiles contacted by labeled small cortical endings was significantly larger in the ipsilateral mediodorsal nucleus than contralaterally. These findings demonstrate that dense contralateral cortical projections to the mediodorsal nucleus derive from the orbital and agranular insular areas, and that crossed corticothalamic afferents are mostly formed by collaterals of the ipsilateral connections. Our observations also point out the heterogeneity of corticothalamic boutons in the rat mediodorsal nucleus and morphological differences in the synaptic organization of prefrontal fibers innervating the two sides, indicating that ipsilateral cortical afferents may be more proximally distributed than crossed cortical fibers on dendrites of mediodorsal neurons.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Négyessy L,Hámori J,Bentivoglio Mdoi
10.1016/s0306-4522(97)00559-9subject
Has Abstractpub_date
1998-06-01 00:00:00pages
741-53issue
3eissn
0306-4522issn
1873-7544pii
S0306-4522(97)00559-9journal_volume
84pub_type
杂志文章相关文献
NEUROSCIENCE文献大全abstract::In neuronal cultures it has been demonstrated that neurotrophins can elicit neuronal death through the p75 neurotrophic receptor (p75ntr) in the absence of concomitant Trk signaling. However, it was suggested that p75ntr induces neuronal death after status epilepticus (SE) in neuronal populations that express relative...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2008.04.038
更新日期:2008-06-26 00:00:00
abstract::Clozapine, an atypical antipsychotic agent important for the treatment of schizophrenia, has marked inhibitory effects on sympathetic outflow to the thermoregulatory cutaneous circulation. In rabbits clozapine reverses ear pinna vasoconstriction induced either by administration of MDMA (3,4-methylenedioxymethamphetami...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2006.05.050
更新日期:2006-09-15 00:00:00
abstract::Subjects with Parkinson's disease exhibit abnormally short compensatory steps in response to external postural perturbations. We examined whether: (1) Parkinson's disease subjects exhibit short compensatory steps due to abnormal central proprioceptive-motor integration, (2) this proprioceptive-motor deficit can be ove...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2006.04.014
更新日期:2006-08-25 00:00:00
abstract::The nucleus retroambiguus in the cat has been shown to receive strong projections from the periaqueductal gray and to send fibres to distinct motoneuronal cell groups in brainstem and spinal cord. The nucleus retroambiguus plays a role in the production of vocalization and possibly copulatory (lordosis and mounting) b...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(97)00061-4
更新日期:1997-09-01 00:00:00
abstract::Multiple sclerosis (MS) is a disease of the CNS in which inflammation, demyelination and neurodegeneration contribute to its initiation and progression. A frequently employed model of MS is experimental autoimmune encephalomyelitis (EAE). Here, to gain new insights into the disease process, an analysis of proteins in ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2007.04.051
更新日期:2007-07-13 00:00:00
abstract::Ubiquitination is a post-translational modification that can dynamically alter the function, degradation and transport of a protein, as well as its interaction with other proteins, and activity of an enzyme. Dysfunctional ubiquitination is detrimental to normal cellular functions, and can result in severe diseases. Ov...
journal_title:Neuroscience
pub_type: 杂志文章,评审
doi:10.1016/j.neuroscience.2019.12.030
更新日期:2020-01-21 00:00:00
abstract::The non-human primate models of Parkinson's disease which have been developed using the neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine) have proven to be either unstable or variable, or to display only a limited subset of parkinsonian features. The present study examined a new two-stage lesion approach ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(93)90176-g
更新日期:1993-01-01 00:00:00
abstract::Throughout his scientific career, Tom Jessell pioneered the spinal cord as a model system to study the molecular programs of neural specification, axon guidance, and connection specificity. His contributions to these fields and more broadly to that of developmental neuroscience will continue to inspire and define many...
journal_title:Neuroscience
pub_type: 杂志文章,评审
doi:10.1016/j.neuroscience.2020.04.038
更新日期:2020-12-01 00:00:00
abstract::Antagonists acting at the 5-hydroxytryptamine3 receptor are potent anti-emetic agents in cases of cytotoxic- and radiation-induced vomiting, and binding sites for these compounds have been described in brainstem areas known to be involved in mediation of nausea and vomiting. We have used autoradiography to examine the...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(90)90060-h
更新日期:1990-01-01 00:00:00
abstract::Repeated nonreinforced preexposure to a stimulus interferes with the establishment of conditioned responding to this stimulus when it is subsequently paired with reinforcement. This stimulus-preexposure effect is known as latent inhibition (LI). Rather remarkably, LI appears to be resistant to the effects of numerous ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2004.06.020
更新日期:2004-01-01 00:00:00
abstract::In two experiments, we combined a semantic blocked naming paradigm with anodal transcranial direct current stimulation (tDCS) to shed light on the neural correlates of the semantic interference (SI) effect. In particular, prior to the naming task, anodal tDCS was applied over the left superior temporal gyrus (STG, Exp...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2012.07.046
更新日期:2012-10-25 00:00:00
abstract::The effect of exogenously applied cholinergic agents upon mitral-granule cell complex activity of the olfactory bulb was studied in anesthetized rats. Output neurons were activated by electrical paired-pulse stimulation (40-80 ms time interval) applied either to the olfactory nerve (orthodromic stimulation) or to the ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90278-v
更新日期:1991-01-01 00:00:00
abstract::We have shown that synaptosomal membrane Na+, K+-ATPase activity is stimulated or inhibited by norepinephrine according to the presence or absence of a brain soluble fraction. Gel filtration of such soluble fraction has allowed the separation of two fractions, peaks I and II, able to stimulate and inhibit Na+, K+-ATPa...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(98)00421-7
更新日期:1999-05-01 00:00:00
abstract::During early embryonic development, the olfactory placode is the source of different cell types migrating toward the telencephalic vesicle. Among these cell types are the ensheathing cells, the luteinizing hormone-releasing hormone-producing cells and the olfactory marker protein-immunoreactive cells. We have identifi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(95)00199-s
更新日期:1995-10-01 00:00:00
abstract::Cognitive aging affects episodic memory and executive functions, and these vulnerable domains are postulated to be modulated by endogenous and exogenous estrogen exposures. In midlife and late-life women without dementia, estrogen effects on cognition can be examined through associations with concentrations of serum e...
journal_title:Neuroscience
pub_type: 杂志文章,评审
doi:10.1016/j.neuroscience.2011.05.059
更新日期:2011-09-15 00:00:00
abstract::Voltage-gated Ca2+ channels (VGCCs) play key roles in auditory perception and information processing within the inner ear and brainstem. Pharmacological inhibition of low voltage-activated (LVA) T-type Ca2+ channels is related to both age- and noise induced hearing loss in experimental animals and may represent a prom...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2019.04.024
更新日期:2019-06-15 00:00:00
abstract::NADPH-diaphorase histochemical staining demonstrated a distinct neural group that might synthesize nitric oxide in the lower brainstem of rats. The NADPH-diaphorase stain revealed a Golgi-like network in the dorsomedial spinal trigeminal nucleus oralis and rostrolateral solitary tract nucleus, whereas this network was...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(94)90436-7
更新日期:1994-08-01 00:00:00
abstract::AMPA-type glutamate receptor (GluR) channels provide fast excitatory synaptic transmission in the CNS, but mediate also cytotoxic insults. It could be shown that AMPA-type GluR channel-mediated chronic excitotoxicity leads to an increased intracellular calcium concentration and plays an important role in neurodegenera...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2006.07.034
更新日期:2006-11-03 00:00:00
abstract::Plethodontid salamanders display intricate courtship behaviors. Proteinaceous courtship pheromones were recently discovered in the submandibular (mental) gland of the male Plethodon shermani, the red-legged salamander. Behavioral studies showed that these male pheromones are delivered by direct contact to the female s...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2007.11.006
更新日期:2008-01-24 00:00:00
abstract::The sec6/8 (exocyst) complex is implicated in targeting of vesicles for regulated exocytosis in various cell types and is believed to play a role in synaptogenesis and brain development. We show that the subunits sec6 and sec8 are present at significant levels in neurons of adult rat brain, and that immunoreactivity f...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(03)00065-4
更新日期:2003-01-01 00:00:00
abstract::Basic parameters which are crucial for the survival of human embryonic striatal grafts need to be investigated before initiating clinical trials in Huntington's disease. In order to define the dissection of human striatal-donor tissue which gives rise to the largest amount of striatal neurons after intrastriatal trans...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(96)00008-5
更新日期:1996-07-01 00:00:00
abstract::The roles of the central noradrenergic and serotonergic system in the activity-dependent regulation of ocular dominance plasticity have been a contentious issue. Using c-Fos activity mapping, we have developed a new, straightforward method to measure the strength of ocular dominance plasticity: the number of c-Fos-imm...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2013.01.013
更新日期:2013-04-03 00:00:00
abstract::Noninvasive functional imaging holds great promise for the future of translational research, due to the ability to directly compare between preclinical and clinical models of psychiatric disorders. Despite this potential, concerns have been raised regarding the necessity to anesthetize rodent and monkey subjects durin...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2015.12.047
更新日期:2016-03-01 00:00:00
abstract::Bitter taste serves as an important signal for potentially poisonous compounds in foods to avoid their ingestion. Thousands of compounds are estimated to taste bitter and presumed to activate taste receptor cells expressing bitter taste receptors (Tas2rs) and coupled transduction components including gustducin, phosph...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2017.10.047
更新日期:2018-01-15 00:00:00
abstract::Seipin is a widely expressed protein but with highest levels found in the brain and testes. Seipin function is not yet completely understood, therefore the aim of this study was to evaluate the expression of BSCL2 transcripts in the central nervous system (CNS) of humans and investigate the effect of their overexpress...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2018.11.004
更新日期:2019-01-01 00:00:00
abstract::Cognitive impairment is one of the common non-motor symptoms in Parkinson's disease (PD). The hippocampus is a critical structure for learning and memory processes. The abnormal synaptic plasticity in the hippocampus is suggested to be associated with cognitive dysfunction in PD. Voltage gated sodium channels (VGSCs) ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2019.08.024
更新日期:2019-10-15 00:00:00
abstract::We have previously shown how the Frontal Pole cortex (FPC) neurons play a unique role in both the monitoring and evaluating of self-generated decisions during feedback in a visually cued strategy task. For each trial of this task, a cue instructed one of two strategies: to either stay with the previous goal or shift t...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2019.02.023
更新日期:2019-04-15 00:00:00
abstract::High densities of mRNAs for three rhythm-related genes, rPeriod1 (rPer1), rPer2, and rClock, which share high homology in Drosophila and mice, were found in the hypothalamic suprachiasmatic nucleus (SCN). The SCN, however, is not the only brain region that expresses these genes. To understand the distributions and pos...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(03)00004-6
更新日期:2003-01-01 00:00:00
abstract::Treatment of P19 embryonal carcinoma cells with retinoic acid induces their differentiation into a population of cells consisting of neurons and other cell types normally derived from neuroectoderm. We used immunohistological and histochemical techniques to identify some of the neurotransmitters in the P19-derived neu...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(94)90451-0
更新日期:1994-02-01 00:00:00
abstract::The laggard (lag) mutant mouse, characterized by hypomyelination and cerebellar ataxia, is a spontaneously occurring mutant mouse caused by mutation in the Kif14 gene. In this mutant mouse, the laminated structures such as the cerebral and cerebellar cortices and the dentate gyrus are cytoarchitecturally abnormal. Mac...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2014.06.011
更新日期:2014-09-05 00:00:00