The Positional Logic of Sensory-Motor Reflex Circuit Assembly.

Abstract:

:Throughout his scientific career, Tom Jessell pioneered the spinal cord as a model system to study the molecular programs of neural specification, axon guidance, and connection specificity. His contributions to these fields and more broadly to that of developmental neuroscience will continue to inspire and define many generations of researchers. It is challenging to capture all of Tom's findings in one essay, and therefore, here we wish to briefly highlight his contributions to the problem of connection specificity, with a focus on the spinal sensory-motor reflex circuit. In particular, emphasis will be placed on discoveries from his laboratory that revealed a significant role of positional strategies in establishing selective sensory-motor connections. This work introduced novel principles of neuronal connectivity that may apply to how precise circuit wiring occurs throughout the nervous system.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Balaskas N,Ng D,Zampieri N

doi

10.1016/j.neuroscience.2020.04.038

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

142-150

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(20)30271-2

journal_volume

450

pub_type

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