Abstract:
:Throughout his scientific career, Tom Jessell pioneered the spinal cord as a model system to study the molecular programs of neural specification, axon guidance, and connection specificity. His contributions to these fields and more broadly to that of developmental neuroscience will continue to inspire and define many generations of researchers. It is challenging to capture all of Tom's findings in one essay, and therefore, here we wish to briefly highlight his contributions to the problem of connection specificity, with a focus on the spinal sensory-motor reflex circuit. In particular, emphasis will be placed on discoveries from his laboratory that revealed a significant role of positional strategies in establishing selective sensory-motor connections. This work introduced novel principles of neuronal connectivity that may apply to how precise circuit wiring occurs throughout the nervous system.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Balaskas N,Ng D,Zampieri Ndoi
10.1016/j.neuroscience.2020.04.038subject
Has Abstractpub_date
2020-12-01 00:00:00pages
142-150eissn
0306-4522issn
1873-7544pii
S0306-4522(20)30271-2journal_volume
450pub_type
杂志文章,评审相关文献
NEUROSCIENCE文献大全abstract::Neuronal nitric oxide synthase and haem oxygenase-2 are postulated to be important enzymes involved in neuronal transmission and modulation of free radical levels in neurons. Hippocampal and cortical neuronal nitric oxide synthase and haem oxygenase-2 expressions were compared in young adult (6 months) and aged (24-26...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(00)00316-x
更新日期:2000-01-01 00:00:00
abstract::Reflex response of fusimotoneurons to sinusoidal muscle stretching were investigated in decerebrated cats. Nerve impulses of single fusimotoneurons were recorded from thin filaments dissected from otherwise intact nerves to triceps surae muscles. Amplitude of the sinusoidal stretching of these muscles was 3 mm peak-to...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(90)90020-5
更新日期:1990-01-01 00:00:00
abstract::Synapsins are a family of synaptic vesicle (SV)-associated phosphoproteins that have been identified in several vertebrates and invertebrates. We report here the cloning and expression of synapsin family genes in the zebrafish Danio rerio. We identified the complete coding sequence of synapsin 3, which is not present ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2014.09.015
更新日期:2014-11-07 00:00:00
abstract::Several studies reveal that the beneficial effects of exercise interventions are dependent on the progression of Alzheimer's disease (AD). We have previously shown that long-term treadmill exercise begun before the onset of β-amyloid (Aβ) pathology prevents the deficits of cognition and long-term potentiation (LTP) in...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2015.04.038
更新日期:2015-07-09 00:00:00
abstract::Saffron, the dried stigmata of Crocus sativus L., is used in traditional medicine for a wide range of indications including cramps, asthma, and depression. To investigate the influence of hydro-ethanolic saffron extract (CSE) and trans-crocetin on synaptic transmission, postsynaptic potentials (PSPs) were elicited by ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2011.02.037
更新日期:2011-04-28 00:00:00
abstract::The radioligands [3H]SCH 23390 and [3H]spiroperidol were used to label dopamine D1 and D2 receptors, respectively, in rat brain slices. Striatal sections were incubated in one of various concentrations of radioligand in the presence or absence of (+)-butaclamol and the resulting labeling was determined by liquid scint...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90226-e
更新日期:1991-01-01 00:00:00
abstract::We have previously demonstrated that progesterone significantly increases the rate of myelination in organotypic slice cultures of 7-day-old rat and mouse cerebellum. Here, we show that progesterone (20microM) stimulates the proliferation of oligodendrocyte precursors in cultured cerebellar slices of 7-day-old rats. T...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2005.05.023
更新日期:2005-01-01 00:00:00
abstract::The distribution and origin of nerves with calcitonin gene-related peptide, substance P or neurokinin A immunoreactivity in the walls of the cerebral arteries were investigated in three microchiropteran species. The supply of nerves immunoreactive for substance P and neurokinin A to the bat cerebral arteries is confin...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(90)90002-5
更新日期:1990-01-01 00:00:00
abstract::Cellular distribution of creatine kinase BB-isoenzyme and tubulin was investigated immunohistochemically with tissue sections from various areas of the gerbil brain. Both the reaction for creatine kinase BB-isoenzyme and tubulin visualized nerve cell bodies, dendrites and axons. While the reaction for tubulin was simi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(84)90183-0
更新日期:1984-07-01 00:00:00
abstract::An antisense oligonucleotide probe was used to examine the expression of gene encoding the obligatory NMDAR1 subunit of the N-methyl-D-aspartate receptor in the hippocampus and adjacent cortical areas (entorhinal and perirhinal cortices) of seven Alzheimer patients and in the same brain regions of seven control indivi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(97)00023-7
更新日期:1997-08-01 00:00:00
abstract::The effects of hypothermia on ischemia-reperfusion injury of the cochlea were studied in gerbils. Hearing was assessed by sequentially recording compound action potentials before, during and after the ischemia. The degree of hair cell loss in the organ of Corti was evaluated in specimens stained with rhodamine-phalloi...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(00)00510-8
更新日期:2001-01-01 00:00:00
abstract::The gp130 cytokines leukemia inhibitory factor and interleukin-6 are neuroactive cytokines associated with peripheral nerve injury. Here we show that exogenous administration of these factors selectively regulates neuropeptide phenotype in intact sensory neurons in a manner consistent with their role as injury-induced...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(97)00553-8
更新日期:1998-06-01 00:00:00
abstract::In the present study the effect of cocaine on thymidine, uridine and leucine incorporation was assessed in primary cortical glial and C6 glioma cells. Cocaine exposure for 24 h inhibited thymidine and uridine incorporation in cortical glial and C6 glioma cells. However, the effect of cocaine on uridine incorporation w...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(93)90079-u
更新日期:1993-11-01 00:00:00
abstract::The main objective of the study was to investigate the effects of age and sex differences on locomotor activity, learning and memory in rats. Another objective was to investigate whether repeated elevated plus maze tests induce anxiety in rats. Eighty Wistar rats were divided into eight groups according to their sex, ...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2012.09.036
更新日期:2012-12-27 00:00:00
abstract::Intracellular and extracellular recording techniques and in vitro preparation were used to examine the effect of [Met]enkephalin on the rat periaqueductal neurons. In the 20 cells that were recorded intracellularly, [Met]enkephalin caused an increase in the resting membrane conductance, hyperpolarization of the cell m...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(90)90035-3
更新日期:1990-01-01 00:00:00
abstract::During postnatal development, clusters of cells associated with the mononuclear phagocytic system appear within the white matter of rodents and cats. We studied the distribution and morphology of these cells in the hamster's brain during the first 2 weeks after birth. In animals of different ages, horseradish peroxida...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(85)90263-5
更新日期:1985-08-01 00:00:00
abstract::Androgens are known to affect cognitive and mnemonic aspects of spatial processing. The cholinergic system is thought to play an important role in cognition and memory, but little is known about the interaction between androgen and cholinergic neurons. The present study focused on the effects of testosterone on the ch...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/s0306-4522(01)00513-9
更新日期:2002-01-01 00:00:00
abstract::Many behavioral functions-including sensorimotor, attentional, memory, and emotional processes-have been associated with hippocampal processes and with dopamine transmission in the medial prefrontal cortex (mPFC). This suggests a functional interaction between hippocampus and prefrontal dopamine. The anatomical substr...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2004.12.016
更新日期:2005-01-01 00:00:00
abstract::Increasing evidence indicates that both the ATP P2X receptors and adrenergic systems play a very important role in the development of nociception. However, there is little information concerning the interactions between these two systems in the dorsal root ganglia (DRG). In the present study, we examined the effects o...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2010.12.048
更新日期:2011-03-10 00:00:00
abstract::4-Aminopyridine (4-AP) is suggested to improve symptomatology of spinal injury patients because it may facilitate neuromuscular transmission, spinal impulse flow and the operation of the locomotor central pattern generator (CPG). Since 4-AP can also induce repetitive discharges from dorsal root afferents, this phenome...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2005.02.012
更新日期:2005-01-01 00:00:00
abstract::In an attempt to evaluate the cellular organization and efferent projections of the nucleus tegmenti pedunculopontinus pars compacta, several experiments were performed in the rat. From measurements of neurons in the nucleus tegmenti pedunculopontinus pars compacta in Nissl-stained sections, the nucleus was observed t...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(84)90204-5
更新日期:1984-04-01 00:00:00
abstract::Hindbrain-derived stimuli restrain the gonadotropin-releasing hormone (GnRH)-pituitary luteinizing hormone (LH) reproductive neuroendocrine axis during energy insufficiency. Interruption of food intake, planned or unplanned, is emblematic of modern life. This study investigated the premise that the hindbrain energy se...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2018.04.040
更新日期:2018-07-15 00:00:00
abstract::We report the cloning and molecular characterization of the zfPDYN. The complete open reading frame for this propeptide is comprised in two exons that are localized on chromosome 23. zfPDYN cDNA codes for a polypeptide of 252 amino acids that contains the consensus sequences for four opioid peptides: an Ile-enkephalin...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2006.09.028
更新日期:2007-01-19 00:00:00
abstract::A major input to the substantia nigra is from the 5-hydroxytryptamine-containing neurons in the dorsal raphe nucleus. In order to examine the morphology and distribution of this projection, rats were given injections of the anterograde tracers, Phaseolus vulgaris-leucoagglutinin or biocytin, in the dorsal raphe nucleu...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(93)90510-m
更新日期:1993-07-01 00:00:00
abstract::Effects of glutamate agonists and their selective antagonists on the Ca(2+)-dependent release of [3H]GABA from rat hippocampal slices were studied in a superfusion system. The release was enhanced by glutamate, kainate, quisqualate, N-methyl-D-aspartate and glycine in a concentration-dependent manner. In general, (+)-...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(93)90623-n
更新日期:1993-04-01 00:00:00
abstract::Extracellular nucleotides exert their actions via two subfamilies of purinoceptors: P2X and P2Y. Eight mammalian P2Y receptor subtypes (P2Y(1,2,4,6,11,12,13,14)) have been identified. In this work, the localization of P2Y(6) was studied in rat retina using double immunofluorescence labeling and confocal scanning micro...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2012.06.032
更新日期:2012-09-18 00:00:00
abstract::Mature neurons contain two distinct regulated secretory pathways, characterized electron microscopically by so-called large dense core vesicles and small synaptic vesicles, respectively. Each vesicle type is characterized by vesicle-specific proteins, such as the granins (chromogranins/secretogranins) for the matrix o...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(92)90044-3
更新日期:1992-01-01 00:00:00
abstract::The distributions of the alpha 1-adrenoceptor and its subtypes (alpha 1A and alpha 1B) in human and rat hippocampus are analysed by quantitative receptor autoradiography. alpha 1-Adrenoceptors are labelled by [3H]prazosin. The alpha 1A subtype is visualized by [3H]prazosin after irreversible blockade of alpha 1B adren...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/0306-4522(91)90122-5
更新日期:1991-01-01 00:00:00
abstract::Although extensively investigated in socio-cognitive neuroscience, empathy is difficult to study. The first difficulty originates in its multifaceted nature. According to the multidimensional model, empathy combines emotional, automatic (simulation), cognitive (mentalizing) and regulatory (executive functions) process...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2014.02.024
更新日期:2014-05-16 00:00:00
abstract::Neurodegeneration in fetal development of Down syndrome (DS) patients is proposed to result in apparent neuropathological abnormalities and to contribute to the phenotypic characteristics of mental retardation and premature development of Alzheimer disease. In order to identify the aberrant and specific genes involved...
journal_title:Neuroscience
pub_type: 杂志文章
doi:10.1016/j.neuroscience.2004.06.081
更新日期:2004-01-01 00:00:00