gp130 cytokines, leukemia inhibitory factor and interleukin-6, induce neuropeptide expression in intact adult rat sensory neurons in vivo: time-course, specificity and comparison with sciatic nerve axotomy.

Abstract:

:The gp130 cytokines leukemia inhibitory factor and interleukin-6 are neuroactive cytokines associated with peripheral nerve injury. Here we show that exogenous administration of these factors selectively regulates neuropeptide phenotype in intact sensory neurons in a manner consistent with their role as injury-induced factors. Intraneural injection of leukemia inhibitory factor into the intact sciatic nerve of adult rats induces a significant increase in the percentage of neuronal profiles immunoreactive for galanin in the L4 and L5 dorsal root ganglia without altering the percentage profiles immunoreactive for vasoactive intestinal polypeptide or neuropeptide Y. Galanin-immunoreactivity was predominantly confined to those neurons which retrogradely transported and accumulated leukemia inhibitory factor. The up-regulation of galanin-immunoreactivity observed in L4 and L5 dorsal root ganglia following unilateral axotomy of the sciatic nerve was significantly reduced following continuous treatment for two weeks with a monoclonal antibody against the gp130 receptor motif. Intraneural injection of interleukin-6 into the intact sciatic nerve also significantly increased the percentage of neuronal profiles which displayed galanin-immunoreactivity but not vasoactive intestinal polypeptide or neuropeptide Y-immunoreactivity. Our results indicate that cytokines which interact with the gp130 receptor at the site of peripheral nerve injury contribute to the cell body response to axotomy. Changes in the levels of such cytokines however are insufficient to account for the complete repertoire of neuropeptide phenotypic changes associated with peripheral nerve injury.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Thompson SW,Priestley JV,Southall A

doi

10.1016/s0306-4522(97)00553-8

subject

Has Abstract

pub_date

1998-06-01 00:00:00

pages

1247-55

issue

4

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(97)00553-8

journal_volume

84

pub_type

杂志文章
  • Chemically defined feedback connections from infragranular layers of sensory association cortices in the rat.

    abstract::The primary visual (V1), auditory (AI), and somatosensory (SI) cortices are reciprocally connected with their respective sensory association cortices. In the rat, we have previously demonstrated that some of the connections arising from the secondary somatosensory (SII) and parietal insular (PA) cortices and terminati...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2003.08.056

    authors: Bai WZ,Ishida M,Arimatsu Y

    更新日期:2004-01-01 00:00:00

  • Reconstruction of the defective cerebellar circuitry in adult Purkinje cell degeneration mutant mice by Purkinje cell replacement through transplantation of solid embryonic implants.

    abstract::Solid pieces of cerebellar primordia taken from 12-day-old C57BL embryos were implanted into the cerebellar parenchyma of 3- to 4-month-old "Purkinje cell degeneration" mutant mice and analysed 2-3 months later. Purkinje cell replacement was followed by means of immunocytochemistry with antisera against either cyclic ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(87)90002-9

    authors: Sotelo C,Alvarado-Mallart RM

    更新日期:1987-01-01 00:00:00

  • The effect of neocortical lesions on the number of cells in neonatal or adult feline caudate nucleus: comparison to fetal lesions.

    abstract::After a unilateral resection of the frontal cortex in fetal cats the volume of the caudate nucleus increases while the packing density of neuronal and glial cells does not change. In the present report we address the questions of whether a similar lesion sustained neonatally or a more extensive neodecortication sustai...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(96)00457-5

    authors: Loopuijt LD,Villablanca JR,Hovda DA,Huang E,Mancuso S

    更新日期:1997-03-01 00:00:00

  • Cigarette smoke-induced airway oedema due to activation of capsaicin-sensitive vagal afferents and substance P release.

    abstract::Exposure of rats to smoke from one cigarette caused local oedema due to a marked increased in vascular permeability from the epiglottis down to bronchioli, as indicated by extravasation of Evans blue in the airway mucosa. The cigarette smoke-induced extravasation of Evans blue was still present after removal of the ta...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(83)90117-3

    authors: Lundberg JM,Martling CR,Saria A,Folkers K,Rosell S

    更新日期:1983-12-01 00:00:00

  • Changes in interneuronal phenotypes regulated by estradiol in the adult rat hippocampus: a potential role for neuropeptide Y.

    abstract::Ovarian hormones regulate pyramidal cell synapse formation and excitability and interneuronal GABAergic tone in the CA1 region of the adult female rat hippocampus. The role of 17beta-estradiol in these effects is complex and appears to involve a subset of hippocampal interneurons, which express different calcium-bindi...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2005.07.056

    authors: Nakamura NH,McEwen BS

    更新日期:2005-01-01 00:00:00

  • Role of lateral and feedback connections in primary visual cortex in the processing of spatiotemporal regularity - a TMS study.

    abstract::Our human visual system exploits spatiotemporal regularity to interpret incoming visual signals. With a dynamic stimulus sequence of four collinear bars (predictors) appearing consecutively toward the fovea, followed by a target bar with varying contrasts, we have previously found that this predictable spatiotemporal ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2014.01.027

    authors: Roebuck H,Bourke P,Guo K

    更新日期:2014-03-28 00:00:00

  • Nitric oxide in the afferent synaptic transmission of the axolotl vestibular system.

    abstract::This study was performed using intracellular and multiunit extracellular recording techniques in order to characterize the role of nitric oxide in the afferent synaptic transmission of the vestibular system of the axolotl (Ambystoma tigrinum). Bath application of nitric oxide synthase inhibitors N(G)-nitro-L-arginine ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(00)00587-x

    authors: Flores A,Soto E,Vega R

    更新日期:2001-01-01 00:00:00

  • Concerted enhancement of calcium influx, neurotransmitter release and protein phosphorylation by a phorbol ester in cultured brain neurons.

    abstract::We have recently shown that the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate enhances the depolarization induced, calcium dependent release of [3H]dopamine from cultured brain neurons in the rat. In the present study the effects of 12-O-tetradecanoyl-phorbol-13-acetate on the kinetic parameters of depolarizatio...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(86)90140-5

    authors: Zurgil N,Yarom M,Zisapel N

    更新日期:1986-12-01 00:00:00

  • Dopaminergic activation excites rat lateral habenular neurons in vivo.

    abstract::The lateral habenular complex (LHb) of the epithalamus is part of a dorsal diencephalic conduction system connecting basal forebrain with regulatory midbrain nuclei. The LHb has been implicated in the regulation of ascending monoaminergic transmission, particularly midbrain dopaminergic neuronal activity. Here, we hav...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2009.04.026

    authors: Kowski AB,Veh RW,Weiss T

    更新日期:2009-07-21 00:00:00

  • Description of the sub-miniature endplate potential distribution, determination of subunit size and number of subunits in the adult frog neuromuscular bell-miniature endplate potential.

    abstract::Miniature endplate potentials were recorded from the isolated pectoralis cutaneous muscle of the frog during very stable recording conditions and low noise levels. Two to 5 x 10(3) miniature endplate potentials were filmed at eight unstressed junctions that met rigorous experimental criteria for analysis. Seven juncti...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(87)90093-5

    authors: Kriebel ME,Motelica-Heino I

    更新日期:1987-11-01 00:00:00

  • Rat odontoblasts may use glutamate to signal dentin injury.

    abstract::Accumulating evidence indicates that odontoblasts act as sensor cells, capable of triggering action potentials in adjacent pulpal nociceptive axons, suggesting a paracrine signaling via a currently unknown mediator. Since glutamate can mediate signaling by non-neuronal cells, and peripheral axons may express glutamate...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2016.08.029

    authors: Cho YS,Ryu CH,Won JH,Vang H,Oh SB,Ro JY,Bae YC

    更新日期:2016-10-29 00:00:00

  • Role of the substantia nigra in the expression of dopamine D1 receptor-mediated and D2 receptor-mediated behaviours.

    abstract::This study examines the proposal that striatonigral pathways support circling mediated by dopamine D1 receptors, but not D2 receptors, in unilaterally 6-hydroxydopamine-treated rats. In this model the D1/D2 agonist apomorphine, the D1 agonist 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine hydrochloride and...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(87)90175-8

    authors: Fletcher GH,Starr MS

    更新日期:1987-12-01 00:00:00

  • Quantitative autoradiographical analysis of the age-related modulation of central dopamine D1 and D2 receptors.

    abstract::Quantitative autoradiography of [3H]SCH 23390 and [3H](-)-sulpiride binding was performed in the brain of rats of various ages (3, 11 and 24 months) in order to study the changes in D1 and D2 receptor density with age. Binding of [3H]SCH 23390 in the caudate-putamen decreased progressively and markedly at rostral leve...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(90)90435-7

    authors: Morelli M,Mennini T,Cagnotto A,Toffano G,Di Chiara G

    更新日期:1990-01-01 00:00:00

  • Extremely non-orthogonal axes in a sense organ for rotation: behavioural analysis of the dipteran haltere system.

    abstract::Flies acquire information about self-rotation via Coriolis forces detected by their moving halteres. Information processing in the haltere system was analysed by exploiting the method of simulating rotational stimuli by vibrating the fly's body and simultaneously observing compensatory head and wing reactions. Althoug...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(94)90068-x

    authors: Nalbach G

    更新日期:1994-07-01 00:00:00

  • Transneuronal labeling in hamster brainstem following lingual injections with herpes simplex virus-1.

    abstract::Brainstem projections to hypoglossal motoneurons innervating the intrinsic and extrinsic muscles of the tongue were determined using the transneuronal transfer of Herpes simplex virus-1. Injections of Herpes simplex virus-1 into the intrinsic muscles of the anterior tongue, the geniohyoid and styloglossus muscles each...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(95)00203-u

    authors: Travers JB,Montgomery N,Sheridan J

    更新日期:1995-10-01 00:00:00

  • Erythropoietin neuroprotection is enhanced by direct cortical application following subdural blood evacuation in a rat model of acute subdural hematoma.

    abstract::Recombinant human erythropoietin (EPO) has been successfully tested as neuroprotectant in brain injury models. The first large clinical trial with stroke patients, however, revealed negative results. Reasons are manifold and may include side-effects such as thrombotic complications or interactions with other medicatio...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2013.01.067

    authors: Rahimi Nedjat M,Wähmann M,Bächli H,Güresir E,Vatter H,Raabe A,Heimann A,Kempski O,Alessandri B

    更新日期:2013-05-15 00:00:00

  • Examination of the role of the pedunculopontine tegmental nucleus in radial maze tasks with or without a delay.

    abstract::Two radial maze tasks, random foraging and delayed spatial win-shift, have been used to investigate, in rats, the functions and inter-relationships of structures connected through the corticostriatal loops, such as the prelimbic cortex, nucleus accumbens, ventral pallidum and mediodorsal thalamus. The random foraging ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(02)00108-2

    authors: Keating GL,Winn P

    更新日期:2002-01-01 00:00:00

  • The organization of lateral ventromedial thalamic connections in the rat: a link for the distribution of nociceptive signals to widespread cortical regions.

    abstract::We have used several anatomical tracing techniques to study the organization of the lateral ventromedial thalamic nucleus in the rat, a region that is selectively activated by cutaneous nociceptive inputs from any part of the body. The lateral ventromedial thalamic projections are organized as a widespread dense band ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(00)00537-6

    authors: Desbois C,Villanueva L

    更新日期:2001-01-01 00:00:00

  • Increased matrix-metalloproteinase-2 and matrix-metalloproteinase-9 expression in the brain of dystrophic mdx mouse.

    abstract::Brain edema and severe alterations of the glial and endothelial cells have recently been demonstrated in the dystrophin-deficient mdx mouse, an experimental model of Duchenne muscular dystrophy, and an increase in microvessel density in patients affected by Duchenne muscular dystrophy has also been shown. In order to ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2006.02.077

    authors: Nico B,Corsi P,Ria R,Crivellato E,Vacca A,Roccaro AM,Mangieri D,Ribatti D,Roncali L

    更新日期:2006-07-07 00:00:00

  • Neuroprotective effects of a ligand of translocator protein-18 kDa (Ro5-4864) in experimental diabetic neuropathy.

    abstract::Peripheral neuropathy represents an important complication of diabetes involving a spectrum of structural, functional and biochemical alterations in peripheral nerves. Recent observations obtained in our laboratory have shown that the levels of neuroactive steroids present in the sciatic nerve of rat raised diabetic b...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2009.08.005

    authors: Giatti S,Pesaresi M,Cavaletti G,Bianchi R,Carozzi V,Lombardi R,Maschi O,Lauria G,Garcia-Segura LM,Caruso D,Melcangi RC

    更新日期:2009-12-01 00:00:00

  • Substantia nigra and ventral tegmental area projections to cortex: topography and collateralization.

    abstract::The substantia nigra and ventral tegmental area of the rat were examined by retrograde transport methods to determine the topography and collateralization patterns of projections to cortex and certain subcortical sites. The topographical relationships between cells and their terminal fields were confirmed and clarifie...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(84)90034-4

    authors: Loughlin SE,Fallon JH

    更新日期:1984-02-01 00:00:00

  • Different populations of prostaglandin EP3 receptor-expressing preoptic neurons project to two fever-mediating sympathoexcitatory brain regions.

    abstract::The central mechanism of fever induction is triggered by an action of prostaglandin E(2) (PGE(2)) on neurons in the preoptic area (POA) through the EP3 subtype of prostaglandin E receptor. EP3 receptor (EP3R)-expressing POA neurons project directly to the dorsomedial hypothalamus (DMH) and to the rostral raphe pallidu...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2009.03.041

    authors: Nakamura Y,Nakamura K,Morrison SF

    更新日期:2009-06-30 00:00:00

  • Tract-based analysis of white matter degeneration in Alzheimer's disease.

    abstract::Although much prior work has focused on the known cortical pathology that defines Alzheimer's disease (AD) histologically, recent work has additionally demonstrated substantial damage to the cerebral white matter in this condition. While there is large evidence of diffuse damage to the white matter in AD, it is unclea...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2015.05.049

    authors: Lee SH,Coutu JP,Wilkens P,Yendiki A,Rosas HD,Salat DH,Alzheimer’s disease Neuroimaging Initiative (ADNI).

    更新日期:2015-08-20 00:00:00

  • Older Adults Differentially Modulate Transcranial Magnetic Stimulation-Electroencephalography Measures of Cortical Inhibition during Maximal Single-joint Exercise.

    abstract::The effects of muscle fatigue are known to be altered in older adults, and age-related changes in the brain are likely to be a contributing factor. However, the neural mechanisms underlying these changes are not known. The aim of the current study was to use transcranial magnetic stimulation combined with electroencep...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2019.11.022

    authors: Opie GM,Otieno LA,Pourmajidian M,Semmler JG,Sidhu SK

    更新日期:2020-01-15 00:00:00

  • Central cholinergic functions in human amyloid precursor protein knock-in/presenilin-1 transgenic mice.

    abstract::Alzheimer's disease is characterized by amyloid peptide formation and deposition, neurofibrillary tangles, central cholinergic dysfunction, and dementia; however, the relationship between these parameters is not well understood. We studied the effect of amyloid peptide formation and deposition on central cholinergic f...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2004.02.038

    authors: Hartmann J,Erb C,Ebert U,Baumann KH,Popp A,König G,Klein J

    更新日期:2004-01-01 00:00:00

  • Amphetamine up-regulates activator of G-protein signaling 1 mRNA and protein levels in rat frontal cortex: the role of dopamine and glucocorticoid receptors.

    abstract::Acute and chronic exposure to psychostimulants results in altered function of G-protein-coupled receptors in the forebrain. It is believed that neuroadaptations in G-protein signaling contribute to behavioral sensitivity to psychostimulants that persists over a prolonged drug-free period. Proteins termed activators of...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2010.03.013

    authors: Schwendt M,McGinty JF

    更新日期:2010-06-16 00:00:00

  • Regulation of electrical activity and neuronal excitability in Helisoma trivolvis by carbon monoxide.

    abstract::Carbon monoxide (CO), like other gaseous neuromodulators, has a dual nature as both a toxic gas and a physiologically relevant signaling molecule. In the nervous system, high concentrations of CO can lead to neuronal injury while lower concentrations are found to be neuroprotective. The number of cellular targets affe...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2015.10.056

    authors: Estes S,Zhong LR,Artinian L,Rehder V

    更新日期:2015-12-17 00:00:00

  • Neurotensin-containing projections from the retrosplenial cortex to the anterior ventral thalamic nucleus in the rat.

    abstract::The neurotensin-containing projections from the retrosplenial cortex to the anterior ventral thalamus were demonstrated by electrolytic lesion studies and fluorescent retrograde tracing combined with immunocytochemistry. Three-to-five-day-old rats were used, because the immunoreactivity of neurotensin fibers in anteri...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(88)90102-9

    authors: Fukami K,Kiyama H,Shiotani Y,Tohyama M

    更新日期:1988-09-01 00:00:00

  • Vitamin E inhibits activated chaperone-mediated autophagy in rats with status epilepticus.

    abstract::Seizures and status epilepticus induce an excessive production of reactive oxygen species leading to oxidative stress. Vitamin E, a classic antioxidant, has a neuroprotective effect on rats with seizures by regulating reactive oxygen species production. The activity of chaperone-mediated autophagy, a selective pathway...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2009.02.059

    authors: Cao L,Chen R,Xu J,Lin Y,Wang R,Chi Z

    更新日期:2009-06-16 00:00:00

  • Tipepidine activates VTA dopamine neuron via inhibiting dopamine D₂ receptor-mediated inward rectifying K⁺ current.

    abstract::We previously reported that the novel antidepressant-like effect of tipepidine may be produced at least partly through the activation of mesolimbic dopamine (DA) neurons via inhibiting G protein-coupled inwardly rectifying potassium (GIRK) channels. In this study, we investigated the action of tipepidine on DA D2 rece...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2013.07.044

    authors: Hamasaki R,Shirasaki T,Soeda F,Takahama K

    更新日期:2013-11-12 00:00:00