Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid.

abstract：:Following intracerebral hemorrhage (ICH), high-mobility group box 1 protein (HMGB1) may promote vascular remodeling. Whether HMGB1 supports angiogenesis after ICH is unclear, as are the receptors and downstream signaling pathway(s) involved. We used the rat model of collagenase-induced ICH to determine whether HMGB1 a...

journal_title：Neuroscience

authors： Lei C,Zhang S,Cao T,Tao W,Liu M,Wu B

更新日期：2015-06-04 00:00:00

abstract：:The effect of systemic administration of domoic acid, a potent structural analogue of kainic acid, on the mouse hippocampus has been studied using light and electron microscopic techniques. Intraperitoneal injections of either domoic acid (4 mg/kg) or kainic acid (32 mg/kg) produced a series of behavioural changes inc...

journal_title：Neuroscience

authors： Strain SM,Tasker RA

更新日期：1991-01-01 00:00:00

abstract：:Early gestation is a neurodevelopmental period that is especially vulnerable to environmental insult and one in which neurogenesis features prominently. Prenatal perturbation during early gestation has been linked to neuropsychiatric illnesses such as autism and schizophrenia, and severe environmental insult during th...

journal_title：Neuroscience

authors： Selemon LD,Begovic A

更新日期：2020-08-21 00:00:00

abstract：:The effects of electrical stimulation of the hypothalamus paraventricular nucleus on the spontaneous firing of mitral and granule cells in the main olfactory bulb were examined in ovariectomized female rats under urethane anaesthesia. High-frequency stimulation (0.5-1.0 mA, 10-20 pulses at 100 Hz) of the paraventricul...

journal_title：Neuroscience

authors： Yu GZ,Kaba H,Okutani F,Takahashi S,Higuchi T,Seto K

更新日期：1996-06-01 00:00:00

abstract：:In rats under continuous stress (CS) there is decreased hypothalamic dopaminergic innervation to the intermediate lobe (IL) of the pituitary gland, which causes hyperactivation and subsequent degeneration of melanotrophs in the IL. In this study, we investigated the molecular basis for the changes that occur in melano...

journal_title：Neuroscience

authors： Konishi H,Ogawa T,Nakagomi S,Inoue K,Tohyama M,Kiyama H

更新日期：2010-09-15 00:00:00

abstract：:Forebrain neuronal circuits containing hypocretin-1 (hcrt-1) and norepinephrine (NE) are important components of central arousal-related processes. Recently, these two systems have been shown to have an overlapping distribution within the bed nucleus of the stria terminalis (BST), a limbic structure activated by stres...

journal_title：Neuroscience

authors： Ciriello J,Caverson MM,Li Z

更新日期：2013-01-01 00:00:00

abstract：:The role of GABA(A) receptors in the mediodorsal thalamus (mdT) in turning behaviour of rats was studied. Neither the GABA(A) receptor agonist muscimol (50 ng) nor the antagonist bicuculline (200 ng) unilaterally injected into the mdT elicited any behavioural change. Unilateral injection of the acetylcholine receptor ...

journal_title：Neuroscience

authors： Ikeda H,Kotani A,Lee J,Koshikawa N,Cools AR

更新日期：2009-04-10 00:00:00

abstract：:The distribution of axons according to diameter has been examined in the optic nerve of old world monkeys. Axon diameters were measured from electron micrographs, and histograms were constructed at regular intervals across a section through the optic nerve to reveal the local axon diameter distribution. The total axon...

journal_title：Neuroscience

authors： Reese BE,Ho KY

更新日期：1988-10-01 00:00:00

abstract：:Oxytocin and vasopressin binding sites were localized and characterized by quantitative autoradiography on consecutive sections of Long-Evans rat forebrains and pituitary glands, incubated in the presence of 5 nM [3H]oxytocin or 5 nM [3H]vasopressin. In the forebrain, two types of neurohypophysial hormone binding site...

journal_title：Neuroscience

authors： Freund-Mercier MJ,Stoeckel ME,Dietl MM,Palacios JM,Richard P

更新日期：1988-07-01 00:00:00

abstract：:Acetylcholinesterase is released from both axon terminals and dendrites of nigrostriatal neurons. The relationship of this phenomenon to: (1) activation of receptors, and (2) firing rate, has been examined. In the first series of experiments, apomorphine or acetylcholine were infused into substantiae nigrae of urethan...

journal_title：Neuroscience

authors： Weston J,Greenfield SA

更新日期：1986-04-01 00:00:00

abstract：:Neural injury triggers changes in the expression of a large number of gene families. Particularly interesting are those encoding proteins involved in the generation, propagation or restoration of electric potentials. The expression of the Na+, K+-ATPase subunit isoforms (alpha, beta and gamma) was studied in dorsal ro...

journal_title：Neuroscience

authors： Arteaga MF,Gutiérrez R,Avila J,Mobasheri A,Díaz-Flores L,Martín-Vasallo P

更新日期：2004-01-01 00:00:00

abstract：:Transparent larval zebrafish offer the opportunity to unravel genetic and neuronal networks underlying behavior in a developing system. In this study, we developed a choice chamber paradigm to measure reward-associated behavior in larval zebrafish. In the chamber where larval zebrafish have a choice of spending their ...

journal_title：Neuroscience

authors： Bretaud S,Li Q,Lockwood BL,Kobayashi K,Lin E,Guo S

更新日期：2007-05-25 00:00:00

abstract：:It was demonstrated with autoradiographic methods that a tract of thin fibers, which is for the most part distinct from the brachium conjunctivum and its crossed descending limb, can be followed from the cerebellar nuclei to the inferior olive. Neurons from all regions of the interposed and dentate nuclei contribute t...

journal_title：Neuroscience

authors： Legendre A,Courville J

更新日期：1987-06-01 00:00:00

abstract：:Endomorphin 2 (EM2) plays essential roles in regulating nociceptive transmission within the spinal dorsal horn, where EM2-immunopositive (EM2-IP) fibers and terminals are densely encountered. However, the origins of these EM2-IP structures are still obscure. Unilateral primary sensory afferents disruption (lumbar 3-6 ...

journal_title：Neuroscience

authors： Hui R,Wang W,Chen T,Lü BC,Li H,Zhang T,Wu SX,Li YQ

更新日期：2010-08-11 00:00:00

abstract：:Recently evidence has accumulated that schizophrenia can arise from primary synaptic defects involving structural proteins particularly, microtubule associated proteins. Previous experiments have demonstrated that a STOP (stable tubule only peptide) gene deletion in mice leads to a phenotype mimicking some aspects of ...

journal_title：Neuroscience

authors： Bégou M,Volle J,Bertrand JB,Brun P,Job D,Schweitzer A,Saoud M,D'Amato T,Andrieux A,Suaud-Chagny MF

更新日期：2008-11-11 00:00:00

abstract：:In vertebrates, locomotion is associated with changes in respiratory activity, but the neural mechanisms by which this occurs remain unknown. We began examining this in lampreys using a semi-intact preparation of young adult Petromyzon marinus, in which respiratory and locomotor behaviors can be recorded simultaneousl...

journal_title：Neuroscience

authors： Gravel J,Brocard F,Gariépy JF,Lund JP,Dubuc R

更新日期：2007-02-09 00:00:00

abstract：:With the six convulsants studied (Soman, intrahippocampal penicillin, bicuculline, pentylenetetrazol, picrotoxin and strychnine), the anatomical distribution of changes in local cerebral glucose utilization was related to the type of seizure observed. Strychnine induced a few very intense motor convulsions during the ...

journal_title：Neuroscience

authors： Pazdernik TL,Cross RS,Giesler M,Samson FE,Nelson SR

更新日期：1985-03-01 00:00:00

abstract：:Previous studies have shown oxidative damage resulting from amyloid Abeta exposure to cultured cells and in murine models. A target of oxidation is 14-3-3 which comprises a group of proteins involved in kinase activation and chaperone activity. The present study shows glycoxidative damage, as revealed with mono and bi...

journal_title：Neuroscience

authors： Santpere G,Puig B,Ferrer I

更新日期：2007-06-08 00:00:00

abstract：:Developmental or degenerative damage of the neuronal architecture in the entorhinal cortex may disintegrate a functional part of hippocampal input since the entorhinal cortex provides a major source of neocortical and subcortical input to the hippocampus. These alterations, such as seen in Alzheimer's disease, schizop...

journal_title：Neuroscience

authors： Falkenberg T,Metsis M,Timmusk T,Lindefors N

更新日期：1993-12-01 00:00:00

abstract：:Spinocerebellar tract neurons are inhibited by various sources of input via pathways activated by descending tracts as well as peripheral afferents. Inhibition may be used to modulate transmission of excitatory information forwarded to the cerebellum. However it may also provide information on the degree of inhibition...

journal_title：Neuroscience

authors： Shakya Shrestha S,Bannatyne BA,Jankowska E,Hammar I,Nilsson E,Maxwell DJ

更新日期：2012-12-13 00:00:00

abstract：:Our previous results obtained by lesioning or stimulating the ventrolateral part of the lateral septum and the bed nuclei of the stria terminalis suggested that this area is involved in the control of milk ejection pattern in rats. The present study was undertaken with the aim of testing ventrolateral part of the late...

journal_title：Neuroscience

authors： Lambert RC,Moos FC,Ingram CD,Wakerley JB,Kremarik P,Guerné Y,Richard P

更新日期：1993-05-01 00:00:00

abstract：:This work addresses the presence, pharmacological properties, and anatomical localization of calcitonin gene-related peptide-alpha (CGRPalpha) binding sites and the receptor's accessory proteins in endplate-enriched and non-endplate muscle membrane samples from adult rat gracilis muscles. We examined the binding of (1...

journal_title：Neuroscience

authors： Fernandez HL,Chen M,Nadelhaft I,Durr JA

更新日期：2003-01-01 00:00:00

abstract：:The release of chemical transmitter from nerve terminals is critically dependent on a transient increase in intracellular Ca2+. The increase in Ca2+ may be due to influx of Ca2+ from the extracellular fluid or release of Ca2+ from intracellular stores such as mitochondria. Whether Ca2+ utilized in transmitter release ...

journal_title：Neuroscience

authors： Brailoiu E,Miyamoto MD

更新日期：2000-01-01 00:00:00

abstract：:We have generated and characterized a multi-functional polyclonal anti-brain-derived neurotrophic factor antibody. Western blot analysis, dorsal root ganglion neurite outgrowth and dorsal root ganglion neuron survival assays showed that this antibody specifically recognized brain-derived neurotrophic factor and not th...

journal_title：Neuroscience

authors： Yan Q,Rosenfeld RD,Matheson CR,Hawkins N,Lopez OT,Bennett L,Welcher AA

更新日期：1997-05-01 00:00:00

abstract：:Past studies have implicated calcium influx through the N-methyl-D-aspartate class of ionotropic glutamate receptors as a key factor in excitotoxicity. Here, primary cultures of hippocampal neurons were exposed to N-methyl-D-aspartate with or without the L-type calcium channel agonist BayK8644(+/-). Calcium influxes w...

journal_title：Neuroscience

authors： Barger SW

更新日期：1999-03-01 00:00:00

abstract：:The synaptic events underlying the excitation of neurons in the rat's dorsal nucleus of the lateral lemniscus were studied by whole-cell patch-clamp recordings in a brain slice preparation of the auditory midbrain. Both current-clamp and voltage-clamp data were obtained with the brain slice submerged in artificial cer...

journal_title：Neuroscience

authors： Fu XW,Brezden BL,Kelly JB,Wu SH

更新日期：1997-06-01 00:00:00

abstract：:The transition from multipotent neural stem cells (NSCs) to terminally differentiated neurons is a multistep process, and the transition is finely regulated by transcription factors with basic helix-loop-helix (bHLH) motifs. Melatonin is an endogenous neurohormone with profound neurotrophic and neuroprotective effects...

journal_title：Neuroscience

authors： Li X,Chen X,Zhou W,Ji S,Li X,Li G,Liu G,Wang F,Hao A

更新日期：2017-11-19 00:00:00

abstract：:Two types of GABAergic interneurone are known to express cholecystokinin-related peptides in the isocortex: basket cells, which preferentially innervate the somata and proximal dendrites of pyramidal cells; and double bouquet cells, which innervate distal dendrites and dendritic spines. In the hippocampus, cholecystok...

journal_title：Neuroscience

authors： Cope DW,Maccaferri G,Márton LF,Roberts JD,Cobden PM,Somogyi P

更新日期：2002-01-01 00:00:00

abstract：:The present study was undertaken to quantify selected neuropeptides (thyrotropin releasing hormone, substance P, methionine and leucine enkephalin) in the cervical spinal cord and other regions of the central nervous system of Wobbler mice by radioimmunoassays during several stages of the motoneuron disease compared w...

journal_title：Neuroscience

authors： Yung KK,Tang F,Fielding R,Du YH,Vacca-Galloway LL

更新日期：1992-09-01 00:00:00

abstract：:A systematic line-sampling method is described for counting and mapping myelinated axons in transverse sections of the spinal cord. Its advantages over random sampling of small areas are considered. The technique was applied to quantifying experimental weight-drop contusion injuries of cat spinal cord, from several mo...

journal_title：Neuroscience

authors： Blight AR

更新日期：1983-10-01 00:00:00