Abstract：
:Transparent larval zebrafish offer the opportunity to unravel genetic and neuronal networks underlying behavior in a developing system. In this study, we developed a choice chamber paradigm to measure reward-associated behavior in larval zebrafish. In the chamber where larval zebrafish have a choice of spending their time in either a water- or morphine-containing compartment, larvae that have previously experienced morphine spend significantly more time in the compartment containing morphine. This behavior can be attentuated by pre-treatment with antagonists of the opioid receptor or the dopamine receptor, and furthermore, is impaired in the too few mutant, which has a genetic deficiency in the production of specific groups of dopaminergic and serotonergic neurons in the ventral forebrain. These results uncover a choice behavior for an addictive substance in larval zebrafish that is mediated through central opioid and monoaminergic neurotransmitter systems.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Bretaud S,Li Q,Lockwood BL,Kobayashi K,Lin E,Guo Sdoi
10.1016/j.neuroscience.2006.12.073subject
Has Abstractpub_date
2007-05-25 00:00:00pages
1109-16issue
3eissn
0306-4522issn
1873-7544pii
S0306-4522(06)01679-4journal_volume
146pub_type
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