Abstract：
:A significant number of postmenopausal women report increased anxiety and vulnerability to stress, which has been linked to decreased secretion of ovarian steroids. Communication between the serotonin system and the corticotropin releasing factor (CRF) system determines stress sensitivity or resilience. This study examines the effects of the ovarian steroids, estradiol (E) and progesterone (P) on the CRF system components that impact serotonin neurons in the midbrain of nonhuman primates. Ovariectomized rhesus macaques were treated with placebo, E alone for 1 month, or E supplemented with P for the last 2 weeks. Quantitative (q)RT-PCR and immunocytochemistry were employed. E±P treatment decreased CRF-R1 and increased CRF-R2 gene expression in hemi-midbrain blocks and in laser captured serotonin neurons. Also in hemi-midbrains, E treatment increased urocortin 1 (UCN1) and CRFBP gene expression, but supplemental P treatment reversed these effects. E±P decreased CRF fiber density in the dorsal, interfascicular and median raphe nuclei and decreased CRF-R1 immunostaining in the dorsal raphe. E increased CRF-R2 immunostaining in the dorsal and median raphe. E±P increased UCN1 immunostaining in the cell bodies and increased UCN1 fiber density in the caudal linear nucleus. Estrogen receptor beta (ERβ), but not ERα was detected in the nucleus of UCN1-positive neurons. While the mechanism of ovarian hormone regulation of the midbrain CRF system requires further investigation, these studies clearly demonstrate another pathway by which ovarian hormones may have positive effects on anxiety and mood regulation.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Sanchez RL,Reddy AP,Bethea CLdoi
10.1016/j.neuroscience.2010.08.059subject
Has Abstractpub_date
2010-12-15 00:00:00pages
893-909issue
3eissn
0306-4522issn
1873-7544pii
S0306-4522(10)01209-1journal_volume
171pub_type
杂志文章相关文献
NEUROSCIENCE文献大全abstract：:Exposure of mice to the anesthetic gas nitrous oxide (N(2)O) produces a marked antinociceptive effect. Protein kinase C is a key regulatory enzyme that may be targeted by general anesthetics. However, a relationship between N(2)O-induced antinociception and protein kinase C has yet to be established. The present study...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2006.02.001
更新日期：2006-06-19 00:00:00
abstract：:The blocking action of recently synthesized benzothiazolamine derivative R56865 was compared with that of dihydropyridine (nimodipine) and diphenylalkylamine (flunarizine) on low-voltage-activated and non-inactivating high-voltage-activated Ca2+ currents. The experiments were carried out on freshly isolated Purkinje n...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(93)90230-d
更新日期：1993-06-01 00:00:00
abstract：:Basic fibroblast growth factor is a potent trophic factor with a wide spectrum of activity at various stages of neuronal development. In our studies on the effects of select lesions on the expression of growth factors, we observed that neurons of layer VIb of the rat cerebral cortex developed immunoreactivity for basi...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(92)90355-6
更新日期：1992-08-01 00:00:00
abstract：:Previous research indicates that distinct subregions of the cerebellum are involved in the processing of different primary emotions. How this is achieved in terms of connectional specificity with other brain areas still needs to be elucidated. We employed functional magnetic resonance imaging in order to investigate c...
journal_title：Neuroscience
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.neuroscience.2013.04.048
更新日期：2013-08-29 00:00:00
abstract：:Healthy aging is accompanied by neurobiological changes that affect the brain's functional organization and the individual's cognitive abilities. The aim of this study was to investigate the effect of global age-related differences in the cortical white and gray matter on neural activity in three key large-scale netwo...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2015.01.049
更新日期：2015-04-02 00:00:00
abstract：:The electrophysiological, biochemical and behavioral responses produced by administration of haloperidol were studied in intact rats and in rats with 6-hydroxydopamine-induced partial lesions of the nigrostriatal dopamine pathway. In both control rats and rates tested four to 10 days postlesion, the electrophysiologic...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(92)90168-2
更新日期：1992-01-01 00:00:00
abstract：:Effects of ionophoretic application of serotonin and of one of its agonists were tested on responses of dorsal horn dorsal spinocerebellar tract neurons evoked by electrical stimulation of peripheral nerves. Both drugs depressed monosynaptically evoked actions of group II muscle afferents; they decreased the number an...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(95)00060-v
更新日期：1995-07-01 00:00:00
abstract：:Contraversive turning movements of the head were elicited in alert cats by unilateral electrical stimulation of the entopeduncular nucleus. To determine the relative functional importance of ascending and descending pathways activated by the stimulation, the animals were submitted to thalamocortical or midbrain lesion...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(83)90090-8
更新日期：1983-09-01 00:00:00
abstract：:The perception of tool-object pairs involves understanding their action-relationships (affordances). Here, we sought to evaluate how an observer visually encodes tool-object affordances. Eye-movements were recorded as right-handed participants freely viewed static, right-handed, egocentric tool-object images across th...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2015.09.060
更新日期：2015-12-03 00:00:00
abstract：:Nerve injury often leads to chronic, sometimes excruciating, pain. The mechanisms contributing to this syndrome include neurochemical plasticity in neurons involved in the earliest stages of pain transmission. Endomorphin-2 (Tyr-Pro-Phe-Phe-NH(2)) is an endogenous morphine-like substance that binds to the mu-opioid re...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(01)00228-7
更新日期：2001-01-01 00:00:00
abstract：:The distribution of axoplasmic organelles at consecutive nodes of Ranvier was investigated light- and electronmicroscopically in horseradish peroxidase-transporting muscle nerve fibres of the adult cat. Three main and apparently temporally interrelated distribution patterns were noted. These patterns were referred to ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(86)90148-x
更新日期：1986-12-01 00:00:00
abstract：:The hypothesis that electrotonic spread among oxytocinergic neurons contributes to synchronized bursting in the lactating rat leads to the prediction that coupling among oxytocinergic neurons would be stronger and more abundant in lactating than in non-lactating animals. We tested this prediction using, as an index of...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(87)90047-9
更新日期：1987-06-01 00:00:00
abstract：:The presence of mRNAs in synaptic terminals and their regulated translation are important factors in neuronal communication and plasticity. Heterogeneous nuclear ribonucleoprotein (hnRNP) complexes are involved in the translocation, stability, and subcellular localization of mRNA and the regulation of its translation....
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2015.05.040
更新日期：2015-08-06 00:00:00
abstract：:Multiple aspartate-specific cysteine proteases have been identified and specific members of this family have been implicated in the apoptotic death of many mammalian cell types. Caspase-3-like proteases seem to play a pivotal role in neuronal apoptosis since mice with germline inactivation of the caspase-3 gene manife...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(98)00154-7
更新日期：1998-10-01 00:00:00
abstract：:We have recently shown that isolated neuronal growth cones from developing rat forebrain possess an appreciable activity of adenylate cyclase, producing cyclic adenosine monophosphate, which can be stimulated by various neurotransmitter receptor agonists and by forskolin [Lockerbie R. O., Hervé D., Blanc G., Tassin J....
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(89)90191-7
更新日期：1989-01-01 00:00:00
abstract：:Neuronal nitric oxide synthase and haem oxygenase-2 are postulated to be important enzymes involved in neuronal transmission and modulation of free radical levels in neurons. Hippocampal and cortical neuronal nitric oxide synthase and haem oxygenase-2 expressions were compared in young adult (6 months) and aged (24-26...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(00)00316-x
更新日期：2000-01-01 00:00:00
abstract：:A role has been suggested for hypothalamic alpha1 adrenoceptors in the acute stress-induced activation of the hypothalamic-pituitary-adrenal axis. Using a polyclonal antiserum against the rat alpha1B adrenergic receptor protein, we have demonstrated alpha1B receptor immunoreactivity in neurons and especially in puncta...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(96)00351-x
更新日期：1997-02-01 00:00:00
abstract：:Our light and electron microscopic studies (Seress L., Nitsch R. and Leranth C. (1993) Neuroscience 55, 775-796.) indicated that in the hippocampus of the African Green monkey, calretinin is exclusively present in non-pyramidal cells. Calretinin-positive axons formed a prominent band at the border of the dentate molec...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(93)90442-i
更新日期：1993-08-01 00:00:00
abstract：:The beta-amyloid precursor protein is the precursor of the main component of senile plaques (the beta-amyloid peptide or beta/A4) found in the brain of aged humans and, in higher amounts, in the brain of Alzheimer's disease and Down's syndrome subjects. Four different forms of beta-amyloid precursor protein messenger ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(93)90304-x
更新日期：1993-03-01 00:00:00
abstract：:Plethodontid salamanders display intricate courtship behaviors. Proteinaceous courtship pheromones were recently discovered in the submandibular (mental) gland of the male Plethodon shermani, the red-legged salamander. Behavioral studies showed that these male pheromones are delivered by direct contact to the female s...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2007.11.006
更新日期：2008-01-24 00:00:00
abstract：:We have observed that in rat caudate-putamen nuclei, neurons immunolabeled for choline acetyltransferase were sometimes in direct apposition to unlabeled perikarya and dendrites [Pickel V. M. and Chan J. (1990) J. Neurosci. Res. 25, 263-280]. Similar juxtapositions between plasmalemmas of nerve cells each receiving in...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(91)90341-k
更新日期：1991-01-01 00:00:00
abstract：:Epigenetic modulation participates in the mechanism of multiple types of pathological pain, so targeting the involved regulators may be a promising strategy for pain treatment. Our previous research identified the analgesic effect of the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) on mechanical hyperalge...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2018.02.026
更新日期：2018-05-01 00:00:00
abstract：:A significant decline in executive system function mediated by the prefrontal cortex (PFC) often occurs with normal aging. In vitro slice studies have shown that layer 2/3 pyramidal cells in the monkey PFC exhibit increased action potential (AP) firing rates which may, in part, contribute to this decline. Given that l...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2007.09.042
更新日期：2007-12-12 00:00:00
abstract：:Oligodendrocyte-derived myelin retards the ability of CNS axons to regenerate following transection. The intrinsic response of CNS axons to an axotomy insult may be vastly different in the absence of myelin. However, the paucity of adequate experimental models has limited detailed investigation of cellular behaviour f...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2010.12.053
更新日期：2011-03-17 00:00:00
abstract：:Using the indirect immunofluorescence method, the distribution of substance P-like-immunoreactivity was studied in spinal cord and dorsal root ganglia of 25 human foetuses ranging from 12 to 29 weeks of gestational age. The spinal cord and dorsal root ganglia of three infants (1 day-, 2 and 4 month-old) were also inve...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(83)90079-9
更新日期：1983-09-01 00:00:00
abstract：:The thoracolumbar and lumbosacral spinal cord contain respectively sympathetic and parasympathetic preganglionic neurons that supply the organs of the pelvis including the penis. These neurons are influenced by supraspinal information and receive aminergic projections from the brainstem. The presence of the alpha(1)- ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/s0306-4522(02)00367-6
更新日期：2002-01-01 00:00:00
abstract：:Nociceptin/orphanin FQ (N/OFQ) is an opioid-related peptide that stimulates corticosterone release after i.c.v. administration in non-stressed rats. We employed in situ hybridization histochemistry to investigate N/OFQ-stimulated activation of the HPA axis at the hypothalamic and pituitary level. We have demonstrated ...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2006.05.036
更新日期：2006-09-15 00:00:00
abstract：:Increased levels of preproenkephalin mRNA in spinal cord neurons induced by peripheral tissue inflammation were examined using in situ hybridization histochemistry. In addition, in situ hybridization histochemistry was combined with immunocytochemistry to determine whether increases in preproenkephalin mRNA were co-lo...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/0306-4522(92)90144-q
更新日期：1992-01-01 00:00:00
abstract：:Aversive experiences in early life are thought to dispose to psychopathologies such as mood or anxiety disorders. In a two-hit stress model, we assessed the effects of juvenile and/or adult stress on the 5-HT-mediated modulation of synaptic inhibition of ventral dentate gyrus granule cells. Combined but not single str...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2015.02.050
更新日期：2015-05-07 00:00:00
abstract：:In several neurological disorders including hyperhomocysteinemia, homocysteine (Hcy) accumulates in the brain, and acts as a potent neurotoxin. However, the molecular mechanisms induced by increased levels of Hcy in brain are not well understood. Here we show an activation of the extracellular signal-regulated kinases...
journal_title：Neuroscience
pub_type： 杂志文章
doi：10.1016/j.neuroscience.2005.03.034
更新日期：2005-01-01 00:00:00
