alpha(2a) and alpha(2c) adrenoceptors on spinal neurons controlling penile erection.

abstract：:Whereas activation of α1-adrenoceptors (α1-ARs) modulates glutamatergic transmission, the roles of α1-ARs in GABAergic transmission in the medial prefrontal cortex (mPFC) are elusive. Here, we examined the effects of the α1-AR agonist phenylephrine (Phe) on GABAergic transmission onto pyramidal neurons in the deep lay...

journal_title：Neuroscience

authors： Luo F,Tang H,Cheng ZY

更新日期：2015-08-06 00:00:00

abstract：:Anatomical and electrophysiological evidence has contributed to the hypothesis that microzones in the mammalian flocculus are organized to reflect control of eye movements in the planes of semicircular canals. Adult male Long-Evans rats received iontophoretic injections of FluoroGold and/or tetramethylrhodamine dextra...

journal_title：Neuroscience

authors： Balaban CD,Schuerger RJ,Porter JD

更新日期：2000-01-01 00:00:00

abstract：:The present study was designed to elucidate the distribution, time-course and mechanism(s) of status epilepticus-induced neuronal damage in the rat amygdaloid complex. Status epilepticus was induced with kainate (9 mg/kg, i.p.), and the behavioral and electrographic seizure activity of each rat was monitored via corti...

journal_title：Neuroscience

authors： Tuunanen J,Lukasiuk K,Halonen T,Pitkänen A

更新日期：1999-01-01 00:00:00

abstract：:Lamina I of the spinal dorsal horn contains a diverse mixture of neurons. Among these, a group of giant neurons (Waldeyer cells) has long been recognized. In this study we have used immunocytochemistry to characterize a population of Waldeyer cells which were identified by the presence of high levels of the glycine re...

journal_title：Neuroscience

authors： Puskár Z,Polgár E,Todd AJ

更新日期：2001-01-01 00:00:00

abstract：:Brain connectivity studies have reported that functional networks change with older age. We aim to (1) investigate whether electroencephalography (EEG) data can be used to distinguish between individual functional networks of young and old adults; and (2) identify the functional connections that contribute to this cla...

journal_title：Neuroscience

authors： Moezzi B,Pratti LM,Hordacre B,Graetz L,Berryman C,Lavrencic LM,Ridding MC,Keage HAD,McDonnell MD,Goldsworthy MR

更新日期：2019-12-01 00:00:00

abstract：:Monoamine oxidase, monoamine oxidase-A, and monoamine oxidase-B activities were compared in free moving, rapid eye movement sleep-deprived, recovered, and control rat brains. The activities were estimated in the whole brain, cerebrum, cerebellum, whole brainstem, medulla, pons, and midbrain. The flowerpot method was u...

journal_title：Neuroscience

authors： Thakkar M,Mallick BN

更新日期：1993-08-01 00:00:00

abstract：:Alzheimer's disease (AD), the most prominent form of dementia in elderly, is a yet incurable degenerative neurological illness characterized by memory loss. Here, we used an AD rat model to investigate the in vivo efficacy of caprospinol, a disease-modifying steroid developed on the concept that reduced synthesis of 2...

journal_title：Neuroscience

authors： Lecanu L,Rammouz G,McCourty A,Sidahmed EK,Greeson J,Papadopoulos V

更新日期：2010-01-20 00:00:00

abstract：:The alpha- and beta-stereoisomers of kainate correspond sterically to the L- and D-isomers of glutamate. Alpha-Kainate is a potent excitant at a specific membrane receptor site (kainate receptor). Beta-Kainate has been proposed as a functional N-methyl-D-aspartate antagonist in vivo. Because of the structural similari...

journal_title：Neuroscience

authors： Turski L,Klockgether T,Schwarz M,Sontag KH,Meldrum BS

更新日期：1987-01-01 00:00:00

abstract：:Light and electron microscopic immunocytochemical methods were used to study the distribution and the morphology of substance P-positive fibers and axon terminals in the dorsal column nuclei of rats and cats, and to determine whether they are part of an ascending input to these nuclei. In rats, substance P-positive fi...

journal_title：Neuroscience

authors： Conti F,De Biasi S,Giuffrida R,Rustioni A

更新日期：1990-01-01 00:00:00

abstract：:Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide that has been implicated in energy homeostasis. Pharmacological studies with MCH and its receptor antagonists have suggested additional behavioral roles for the neuropeptide in the control of mood and vigilance states. These suggestions have been suppo...

journal_title：Neuroscience

authors： Willie JT,Sinton CM,Maratos-Flier E,Yanagisawa M

更新日期：2008-10-28 00:00:00

abstract：:Human Dopamine- and cAMP-regulated phosphoprotein of molecular weight 32kDa (DARPP-32, also known as PPP1R1B) gene codes for different transcripts that are mainly translated into two DARPP-32 protein isoforms, full length (fl)-DARPP-32 and truncated (t)-DARPP. The t-DARPP lacks the first 36 residues at the N-terminal,...

journal_title：Neuroscience

authors： Straccia M,Carrere J,Rosser AE,Canals JM

更新日期：2016-10-01 00:00:00

abstract：:The electrical activity of locus coeruleus neurons was investigated during cortical spreading depression in urethane-anaesthetized rats. Cortical spreading depression was induced by a direct application of 1-3 M KCl solution to the surface of the cerebral cortex. The occurrence of cortical spreading depression was ass...

journal_title：Neuroscience

authors： Arakawa S,Nakamura S,Kawashima N,Nishiike S,Fujii Y

更新日期：1997-06-01 00:00:00

abstract：:We had previously shown that in rat spinal cord motoneurons urotensin II (UII) precursor mRNA was down-regulated by androgens. Very recently, a gene encoding the precursor of a UII analog, termed UII-related peptide (URP), has been identified. Using in situ hybridization, we studied the localization of UII and URP pre...

journal_title：Neuroscience

authors： Pelletier G,Lihrmann I,Dubessy C,Luu-The V,Vaudry H,Labrie F

更新日期：2005-01-01 00:00:00

abstract：:Activation of microglia is regulated by controlling both its population size (through modulation of proliferation/death) and the production of inflammatory mediators. Retinoids control cellular proliferation, differentiation, and death. Natural retinoids have been shown to exhibit anti-inflammatory actions against act...

journal_title：Neuroscience

authors： Farso MC,Krantic S,Rubio M,Sarfati M,Quirion R

更新日期：2011-09-29 00:00:00

abstract：:Prostaglandin E2 (PGE2) produced in the medial preoptic region (MPO) in response to immune signals is generally accepted to play a major role in triggering the illness response, a complex of physiological and behavioral changes induced by infection or injury. Hyperalgesia is now thought to be an important component of...

journal_title：Neuroscience

authors： Heinricher MM,Neubert MJ,Martenson ME,Gonçalves L

更新日期：2004-01-01 00:00:00

abstract：:Brainstem projections to hypoglossal motoneurons innervating the intrinsic and extrinsic muscles of the tongue were determined using the transneuronal transfer of Herpes simplex virus-1. Injections of Herpes simplex virus-1 into the intrinsic muscles of the anterior tongue, the geniohyoid and styloglossus muscles each...

journal_title：Neuroscience

authors： Travers JB,Montgomery N,Sheridan J

更新日期：1995-10-01 00:00:00

abstract：:We investigated the role of cyclic-AMP response element binding protein signaling in the induction of the immediate-early gene c-fos by baroreceptor activation in neurons of the nucleus tractus solitarii of anesthetized rats. Activation of the arterial baroreceptors with sustained hypertension significantly increased ...

journal_title：Neuroscience

authors： Chan JY,Chen WC,Lee HY,Chang TJ,Chan SH

更新日期：1999-01-01 00:00:00

abstract：:Field and intracellular potentials were recorded from CA1 pyramidal stratum in submerged slices (at 33 degrees). During "normal" oxygenation (95% O2 + 5% CO2), tonic depression of population spikes and field excitatory postsynaptic potentials by endogenous adenosine was demonstrated by (i) the marked enhancement by th...

journal_title：Neuroscience

authors： Zhu PJ,Krnjević K

更新日期：1994-11-01 00:00:00

abstract：:Intrauterine growth restriction is a risk factor for neurological and behavioural deficits in children although the precise underlying biological correlate for this is unclear. The present study shows that animals with intrauterine growth restriction, induced by a period of reduced placental blood flow during the seco...

journal_title：Neuroscience

authors： Mallard C,Loeliger M,Copolov D,Rees S

更新日期：2000-01-01 00:00:00

abstract：:On mating with a stud male, virgin female mice from an olfactory memory to this male which is essential to their reproductive success. Failure to form this memory results in the stud male being treated as strange, and hence, his pheromones block pregnancy. This study investigates the duration of the olfactory memory, ...

journal_title：Neuroscience

authors： Kaba H,Rosser AE,Keverne EB

更新日期：1988-01-01 00:00:00

abstract：:Adenosine trisphosphate-sensitive potassium (K-ATP) channels in the substantia nigra pars reticulata were studied in rat brain slices using whole-cell patch clamp recording. Substantia nigra pars reticula neurons were identified as such by their spontaneous action potential firing at mean rate of 15.3 Hz1 virtual abse...

journal_title：Neuroscience

authors： Stanford IM,Lacey MG

更新日期：1996-09-01 00:00:00

abstract：:The effects of tetanus toxin and its light and heavy chain subunits on vasopressin release were investigated in digitonin-permeabilized neurosecretory nerve terminals isolated from the neural lobe of the rat pituitary gland. Exocytosis was induced by challenging the permeabilized nerve endings with micromolar calcium ...

journal_title：Neuroscience

authors： Dayanithi G,Weller U,Ahnert-Hilger G,Link H,Nordmann JJ,Gratzl M

更新日期：1992-01-01 00:00:00

abstract：:Secretion of neurotrophins is critical for the delivery of neurotrophic support. Brain-derived neurotrophic factor is targeted to a regulated secretory pathway in neurons as well as the neurosecretory AtT-20 cells. Here, we show that pertussis toxin, which inactivates Gi and Go G proteins, inhibits up to 50% of the re...

journal_title：Neuroscience

authors： Gunther EC,von Bartheld CS,Goodman LJ,Johnson JE,Bothwell M

更新日期：2000-01-01 00:00:00

abstract：:In some brain regions, previous studies reported the frequent coexistence between neuronal nitric oxide synthase (nNOS) and somatostatin (SOM). In the hippocampus, nNOS and SOM were mainly expressed in GABAergic nonprincipal neurons. Here we estimated the immunocytochemical colocalization of nNOS and SOM in the mouse ...

journal_title：Neuroscience

authors： Jinno S,Kosaka T

更新日期：2004-01-01 00:00:00

abstract：:S100A1 and S100B are members of a multigenic family of Ca(2+)-binding proteins of the EF-hand type highly abundant in astrocyte and striated muscle cells that have been implicated in the Ca(2+)-dependent regulation of several intracellular activities including the assembly and disassembly of microtubules and type III ...

journal_title：Neuroscience

authors： Sorci G,Agneletti AL,Donato R

更新日期：2000-01-01 00:00:00

abstract：:Biochemical and immunocytochemical analyses were performed to resolve how glutamate and glutamine are handled in rat cerebellar cortex in acute hypoosmotic stress. Rats were subjected to a 15-20% reduction in plasma osmolality by intraperitoneal injection of distilled water and then perfusion fixed after 4 or 8 h surv...

journal_title：Neuroscience

authors： Nagelhus EA,Lehmann A,Ottersen OP

更新日期：1996-06-01 00:00:00

abstract：:It has been suggested that not only mesostriatal but also mesolimbic pathways are involved in the degeneration of dopaminergic neurons in Parkinson's disease. Using quantitative ligand autoradiography we have investigated dopamine transporter sites in basal ganglia of patients affected by Huntington's chorea, Parkinso...

journal_title：Neuroscience

authors： Chinaglia G,Alvarez FJ,Probst A,Palacios JM

更新日期：1992-07-01 00:00:00

abstract：:Our aim was to evaluate continuous theta burst stimulation (cTBS) as a tool to induce temporary impairment (virtual lesion) in semantic processing. Four groups with 20 subjects each were stimulated. In the three experimental groups the stimulation site was the left superior temporal cortex. Stimulation was either 1Hz ...

journal_title：Neuroscience

authors： Brückner S,Kiefer M,Kammer T

更新日期：2013-03-13 00:00:00

abstract：:We report the cloning and molecular characterization of the zfPDYN. The complete open reading frame for this propeptide is comprised in two exons that are localized on chromosome 23. zfPDYN cDNA codes for a polypeptide of 252 amino acids that contains the consensus sequences for four opioid peptides: an Ile-enkephalin...

journal_title：Neuroscience

authors： Gonzalez-Nuñez V,Marrón Fernández de Velasco E,Arsequell G,Valencia G,Rodríguez RE

更新日期：2007-01-19 00:00:00

abstract：:In rats under continuous stress (CS) there is decreased hypothalamic dopaminergic innervation to the intermediate lobe (IL) of the pituitary gland, which causes hyperactivation and subsequent degeneration of melanotrophs in the IL. In this study, we investigated the molecular basis for the changes that occur in melano...

journal_title：Neuroscience

authors： Konishi H,Ogawa T,Nakagomi S,Inoue K,Tohyama M,Kiyama H

更新日期：2010-09-15 00:00:00