The nociceptin receptor antagonist [Nphe1,Arg14,Lys15]nociceptin/orphanin FQ-NH2 blocks the stimulatory effects of nociceptin/orphanin FQ on the HPA axis in rats.

abstract：:Ultrastructural degeneration studies were carried out on the cat trochlear nucleus following lesion of the vestibulo-trochlear pathway in order to characterize the location and type of presynaptic endings involved in this pathway. Four types of boutons are found in the normal trochlear nucleus. Types I and II are larg...

journal_title：Neuroscience

authors： Bak IJ,Baker R,Choi WB,Precht W

更新日期：1976-12-01 00:00:00

abstract：:Fragile X mental retardation protein (FMRP), an important RNA-binding protein responsible for fragile X syndrome, is involved in posttranscriptional control of gene expression that links with brain development and synaptic functions. Here, we reveal a novel role of FMRP in pre-mRNA alternative splicing, a general even...

journal_title：Neuroscience

authors： Zhou LT,Ye SH,Yang HX,Zhou YT,Zhao QH,Sun WW,Gao MM,Yi YH,Long YS

更新日期：2017-05-04 00:00:00

abstract：:Development and differentiation of basal forebrain-derived cholinergic neurons were studied using a new technique that combines dissociated cell cultures with organotypic slice cultures. Slices of cerebral cortex or entire forebrain hemispheres were taken from early postnatal rat pups and maintained as organotypic cul...

journal_title：Neuroscience

authors： Robertson RT,Baratta J,Kageyama GH,Ha DH,Yu J

更新日期：1997-10-01 00:00:00

abstract：:The central nervous system expresses its function in natural frames of reference. A most conspicuous feature of such frames is their non-orthogonality. Gaze stabilization and, in particular, the sensorimotor transformations performed by the vestibulo-ocular reflex, are prime examples of such general coordinate transfo...

journal_title：Neuroscience

authors： Ostriker G,Pellionisz A,Llinás R

更新日期：1985-02-01 00:00:00

abstract：:Neurons in the region of dorsomedial hypothalamus are involved in the organization of the physiological responses to emotional stress. We have recently shown that the cardiovascular response evoked by activation of dorsomedial hypothalamus neurons is largely dependent on a synaptic relay with the lateral/dorsolateral ...

journal_title：Neuroscience

authors： da Silva LG Jr,Menezes RC,Villela DC,Fontes MA

更新日期：2006-01-01 00:00:00

abstract：:The relationship of lumbar dorsal root afferents to lateral motor column motoneurons was studied using anterograde injury filling of dorsal roots and retrograde injury filling of ventral roots with horseradish peroxidase. At the light microscopic level, horseradish peroxidase labelled dorsal root axons were observed t...

journal_title：Neuroscience

authors： Liuzzi FJ,Beattie MS,Bresnahan JC

更新日期：1984-04-01 00:00:00

abstract：:Increasing evidence indicates that endothelin-1 has a role for peripheral nociceptive signaling in animals and humans. However, the mechanisms of the nociceptive effects of endothelin-1 have not been fully understood. The current study investigated the effects of endothelin-1 on the capsaicin-evoked intracellular Ca2+...

journal_title：Neuroscience

authors： Yamamoto H,Kawamata T,Ninomiya T,Omote K,Namiki A

更新日期：2006-02-01 00:00:00

abstract：:Iron may catalyse the production of reactive oxygen species during post-ischemic reoxygenation and subsequently lead to brain damage. Ferritin, an iron sequestering and storage protein, can also be a source of iron after ischemic insult. However, its role in ischemia-reperfusion has not been carefully investigated. In...

journal_title：Neuroscience

authors： Chi SI,Wang CK,Chen JJ,Chau LY,Lin TN

更新日期：2000-01-01 00:00:00

abstract：:The midbrain is essential for prepulse inhibition (PPI) of the startle reflex, but the exact neural circuits for PPI are not yet determined. Electrical stimulation of the superior colliculus (SC) or pedunculopontine tegmentum was used to characterize the neurons and pathways that mediate PPI and the activation of star...

journal_title：Neuroscience

authors： Yeomans JS,Lee J,Yeomans MH,Steidl S,Li L

更新日期：2006-11-03 00:00:00

abstract：:Response inhibition is a central aspect of cognitive control. Usually, response inhibition is examined using information from a single sensory modality. Yet, evidence suggests that conflicts between information from different modalities affect response inhibition. It is, however, crucial to consider that there are mod...

journal_title：Neuroscience

authors： Friedrich J,Beste C

更新日期：2019-07-01 00:00:00

abstract：:Interleukin-1 is known to exert pleiotropic effects in host defence mechanisms and in inflammation. Chronic pain, inflammation and interleukin-1 beta enhance the production of substance P. Recently, axonal transport of opiate receptors was found to increase in rat sciatic nerves in the model of Freund's adjuvant-induc...

journal_title：Neuroscience

authors： Jeanjean AP,Moussaoui SM,Maloteaux JM,Laduron PM

更新日期：1995-09-01 00:00:00

abstract：:A satisfactory management to ensure a full restoration of peripheral nerve after trauma is not yet available. Using an experimental protocol, in which crush injury was applied 1 cm above the bifurcation of the rat sciatic nerve for 20 s, we here demonstrate that the levels of neuroactive steroids, such as pregnenolone...

journal_title：Neuroscience

authors： Roglio I,Bianchi R,Gotti S,Scurati S,Giatti S,Pesaresi M,Caruso D,Panzica GC,Melcangi RC

更新日期：2008-08-26 00:00:00

abstract：:In some brain regions, previous studies reported the frequent coexistence between neuronal nitric oxide synthase (nNOS) and somatostatin (SOM). In the hippocampus, nNOS and SOM were mainly expressed in GABAergic nonprincipal neurons. Here we estimated the immunocytochemical colocalization of nNOS and SOM in the mouse ...

journal_title：Neuroscience

authors： Jinno S,Kosaka T

更新日期：2004-01-01 00:00:00

abstract：:Despite a long history of interrogation, the functional organization of motor cortex remains obscure. A major barrier has been the inability to measure and perturb activity with sufficient resolution to reveal clear functional elements within motor cortex and its associated circuits. Increasingly, the mouse has been e...

journal_title：Neuroscience

authors： Warriner CL,Fageiry SK,Carmona LM,Miri A

更新日期：2020-12-01 00:00:00

abstract：:Sucrose gap techniques recorded dorsal root potentials evoked by supramaximal dorsal root stimulation in in vitro, hemisected frog spinal cords. In 0 mM Mg2+ large (mean 13.0 mV), long lasting (mean 8.1 s) dorsal root potentials were recorded which consisted of two components: (1) an early component sensitive to picro...

journal_title：Neuroscience

authors： Hackman JC,Davidoff RA

更新日期：1991-01-01 00:00:00

abstract：:The vulnerability of different dopaminergic cell populations to damage caused by the herbicide paraquat was assessed by stereological counts of tyrosine hydroxylase-positive and calbindin-D28k-immunoreactive neurons in A9 (substantia nigra pars compacta) and A10 (ventral tegmental area and other cell groups). In salin...

journal_title：Neuroscience

authors： McCormack AL,Atienza JG,Langston JW,Di Monte DA

更新日期：2006-08-25 00:00:00

abstract：:We sought to determine the impact of 17beta-estradiol throughout the hippocampal trisynaptic pathway and to investigate the afferent fiber systems within CA1 and CA3 in detail. To achieve this objective, we utilized multielectrode arrays to simultaneously record the field excitatory postsynaptic potentials from the CA...

journal_title：Neuroscience

authors： Kim MT,Soussou W,Gholmieh G,Ahuja A,Tanguay A,Berger TW,Brinton RD

更新日期：2006-08-11 00:00:00

abstract：:Previous studies have raised the possibility that a decrease in voltage-gated K+ currents may contribute to hyperexcitability of injured dorsal root ganglion (DRG) neurons and the emergence of neuropathic pain. We examined the effects of axotomy on mRNA levels for various Kv1 family subunits and voltage-gated K+ curre...

journal_title：Neuroscience

authors： Yang EK,Takimoto K,Hayashi Y,de Groat WC,Yoshimura N

更新日期：2004-01-01 00:00:00

abstract：:We have demonstrated the formation of entorhinodentate projections by axons arising from explants of embryonic mouse entorhinal cortex or slices of postnatal rat entorhinal area co-cultured in contact with slices of postnatal rat hippocampus in roller tube and static culture. Species-specific markers (Thy-1 alleles an...

journal_title：Neuroscience

authors： Li D,Field PM,Starega U,Li Y,Raisman G

更新日期：1993-02-01 00:00:00

abstract：:In unanesthetized cats it has been found that pyramidal volleys elicited upon medullary pyramidal tract stimulation were capable of modifying the discharge of 41% of intracerebellar nuclear cells, via pontocerebellar systems impinging predominantly on the lateral cerebellar cortex. The incidence of responsive cells wa...

journal_title：Neuroscience

authors： Giuffrida R,Licata F,Li Volsi G,Perciavalle V,Urbano A

更新日期：1983-06-01 00:00:00

abstract：:Ovarian hormones regulate pyramidal cell synapse formation and excitability and interneuronal GABAergic tone in the CA1 region of the adult female rat hippocampus. The role of 17beta-estradiol in these effects is complex and appears to involve a subset of hippocampal interneurons, which express different calcium-bindi...

journal_title：Neuroscience

authors： Nakamura NH,McEwen BS

更新日期：2005-01-01 00:00:00

abstract：:Experiments in a variety of preparations have indicated that excessive activation of receptors for the excitatory amino acids glutamate and aspartate may mediate irreversible anoxic neuronal injury. We investigated this hypothesis in the in vitro hippocampal slice. Rat hippocampal slices perfused for 40 min with buffe...

journal_title：Neuroscience

authors： Clark GD,Rothman SM

更新日期：1987-06-01 00:00:00

abstract：:Dopamine (DA), released from the lateral olivocochlear (LOC) efferent terminals, the efferent arm of the short-loop feedback in the cochlea, is considered as a protective factor in the inner ear since it inhibits auditory nerve dendrite firing in ischemia- or noise-induced excitotoxicity leading to sensorineural heari...

journal_title：Neuroscience

authors： Halmos G,Doleviczényi Z,Répássy G,Kittel A,Vizi ES,Lendvai B,Zelles T

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Psychiatric illness and anxiety disorders have strong neurodevelopmental components. Environmental insults such as prenatal exposure to stress and genetic differences in stress responses may affect brain development. METHODS:A rat model of random variable prenatal stress was used to study the expression and...

journal_title：Neuroscience

authors： Neeley EW,Berger R,Koenig JI,Leonard S

更新日期：2011-07-28 00:00:00

abstract：:Constraints involving the delivery method of glial cell line-derived neurotrophic factor (GDNF) have hampered its efficacy as a neuroprotectant in Parkinson's disease. Ex vivo gene therapy, in which suitable cells, such as bone marrow-derived mesenchymal stem cells (MSCs), are genetically engineered to overexpress GDN...

journal_title：Neuroscience

authors： Hoban DB,Howard L,Dowd E

更新日期：2015-09-10 00:00:00

abstract：:Rats received bilateral lesions of the nucleus basalis magnocellularis by infusion of ibotenic acid. Fourteen days later, osmotic minipumps releasing human recombinant nerve growth factor (0.3 micrograms/day) were implanted subcutaneously. Starting one month after the lesion, spatial learning of the animals was tested...

journal_title：Neuroscience

authors： Dekker AJ,Gage FH,Thal LJ

更新日期：1992-01-01 00:00:00

abstract：:Somatosensory information from the limbs reaches the contralateral Primary Sensory Cortex (S1) with a delay of 23ms for finger, and 40ms for leg (somatosensory N20/N40). Upon arrival of this input in the cortex, motor evoked potentials (MEPs) elicited by Transcranial Magnetic Stimulation (TMS) are momentarily inhibite...

journal_title：Neuroscience

authors： Ruddy KL,Jaspers E,Keller M,Wenderoth N

更新日期：2016-10-01 00:00:00

abstract：:The goal of this research was to examine the effect of preconception paternal stress (PPS) on the subsequent neurodevelopment and behavior of male and female offspring. Prenatal (gestational) stress has been shown to alter brain morphology in the developing brain, and is presumed to be a factor in the development of s...

journal_title：Neuroscience

authors： Harker A,Raza S,Williamson K,Kolb B,Gibb R

更新日期：2015-09-10 00:00:00

abstract：:Two types of GABAergic interneurone are known to express cholecystokinin-related peptides in the isocortex: basket cells, which preferentially innervate the somata and proximal dendrites of pyramidal cells; and double bouquet cells, which innervate distal dendrites and dendritic spines. In the hippocampus, cholecystok...

journal_title：Neuroscience

authors： Cope DW,Maccaferri G,Márton LF,Roberts JD,Cobden PM,Somogyi P

更新日期：2002-01-01 00:00:00

abstract：:Migration of neurons is a key step in the formation of the central nervous system, and an increase in internal Ca(2+) concentration has been shown to increase the rate of migration of granule cells along radial glial processes in slices of postnatal cerebellum. In embryonic spinal cord, the non-radial migration of aut...

journal_title：Neuroscience

authors： Wetts R,Vaughn JE

更新日期：2000-01-01 00:00:00