Effects of aging on the electrophysiological properties of layer 5 pyramidal cells in the monkey prefrontal cortex.

abstract：:We have examined the relationship between brain-derived neurotrophic factor gene expression in the hippocampus and memory retention as well as long-term potentiation of rats. One-way inhibitory avoidance learning was adopted as the behavioural paradigm. Results revealed that brain-derived neurotrophic factor messenger...

journal_title：Neuroscience

authors： Ma YL,Wang HL,Wu HC,Wei CL,Lee EH

更新日期：1998-02-01 00:00:00

abstract：:The protective effect of diphenyliodonium, known as an inhibitor of flavin enzymes including nitric oxide synthases, was examined against the neurotoxicity of excitatory amino acids on cultured spinal neurons of the rat. Diphenyliodonium reduced the neuronal damage induced by 15-min exposure to glutamate or N-methyl-D...

journal_title：Neuroscience

authors： Nakamura Y,Tsuji K,Shuto M,Ogita K,Yoneda Y,Shimamoto K,Shibata T,Kataoka K

更新日期：1997-01-01 00:00:00

abstract：:The aim of this study was to test a possible role of A5 neurons in the expression of the pressor and tachycardic responses to conditioned fear and restraint, two forms of psychological stress. Previous Fos studies have shown that the C1 adrenergic neurons and spinally projecting neurons in the vasopressor region of th...

journal_title：Neuroscience

authors： Vianna DM,Carrive P

更新日期：2010-04-14 00:00:00

abstract：:Exposure of rats to smoke from one cigarette caused local oedema due to a marked increased in vascular permeability from the epiglottis down to bronchioli, as indicated by extravasation of Evans blue in the airway mucosa. The cigarette smoke-induced extravasation of Evans blue was still present after removal of the ta...

journal_title：Neuroscience

authors： Lundberg JM,Martling CR,Saria A,Folkers K,Rosell S

更新日期：1983-12-01 00:00:00

abstract：:Using structural magnetic resonance imaging in a clinical scanner at 3.0T, we describe results showing that following 12weeks on a diet of 2% cholesterol, rabbits experience a significant increase in the volume of the third ventricle compared to rabbits on a diet of 0% cholesterol. Using time-of-flight magnetic resona...

journal_title：Neuroscience

authors： Schreurs BG,Smith-Bell CA,Lemieux SK

更新日期：2013-12-19 00:00:00

abstract：:Neurotrophin gene expression in adult brain varies according to physiological activity and following brain injury, suggesting a role in neuronal maintenance and plasticity. However, the exact roles and mechanisms of action of neurotrophins in the adult brain are still poorly understood. We have recently demonstrated t...

journal_title：Neuroscience

authors： Guilhem D,Dreyfus PA,Makiura Y,Suzuki F,Onteniente B

更新日期：1996-06-01 00:00:00

abstract：:It has been suggested that the enzymatic pathway of 5-lipoxygenase (5-LOX) influences brain functioning and pathobiology. The mRNAs for both the enzyme 5-LOX and its activating protein FLAP have been found in the cerebellum. In this work, we investigated the cellular expression of 5-LOX in the adult mouse cerebellar c...

journal_title：Neuroscience

authors： Chen H,Dzitoyeva S,Manev H

更新日期：2010-12-01 00:00:00

abstract：:The amygdala is a temporal lobe region that is implicated in emotional information processing. The amygdala also is associated with the processing and modulation of pain sensation. Recently, we demonstrated that in nonhuman primates, the amygdala is necessary for the full expression of cannabinoid-induced antinocicept...

journal_title：Neuroscience

authors： Manning BH,Martin WJ,Meng ID

更新日期：2003-01-01 00:00:00

abstract：:Since the early 90s, the subthalamic nucleus (STN) has started to be the subject of an increasing interest not only in the community of the basal ganglia scientists but also for neurosurgeons and neurologists, thanks to the development of the surgical treatment for Parkinson's disease. The involvement of the STN in co...

journal_title：Neuroscience

authors： Baunez C,Yelnik J,Mallet L

更新日期：2011-12-15 00:00:00

abstract：:In the ventral mesencephalon, two neurotrophic factors, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor, have been shown previously to have similar effects on the survival of dopaminergic neurons. Here, we compared the signaling mechanisms for brain-derived neurotrophic factor and gli...

journal_title：Neuroscience

authors： Feng L,Wang CY,Jiang H,Oho C,Dugich-Djordjevic M,Mei L,Lu B

更新日期：1999-01-01 00:00:00

abstract：:S100A1 and S100B are members of a multigenic family of Ca(2+)-binding proteins of the EF-hand type highly abundant in astrocyte and striated muscle cells that have been implicated in the Ca(2+)-dependent regulation of several intracellular activities including the assembly and disassembly of microtubules and type III ...

journal_title：Neuroscience

authors： Sorci G,Agneletti AL,Donato R

更新日期：2000-01-01 00:00:00

abstract：:It is well established that women experience major depression at roughly twice the rate of men. Interestingly, accumulating clinical and experimental evidence shows that the responsiveness of males and females to antidepressant pharmacotherapy, and particularly to tricyclic antidepressants (TCAs), is sex-differentiate...

journal_title：Neuroscience

authors： Pitychoutis PM,Dalla C,Sideris AC,Tsonis PA,Papadopoulou-Daifoti Z

更新日期：2012-05-17 00:00:00

abstract：:Ubiquitination is a post-translational modification that can dynamically alter the function, degradation and transport of a protein, as well as its interaction with other proteins, and activity of an enzyme. Dysfunctional ubiquitination is detrimental to normal cellular functions, and can result in severe diseases. Ov...

journal_title：Neuroscience

authors： Zhu J,Tsai NP

更新日期：2020-01-21 00:00:00

abstract：:Tissue injury results in several changes in spinal cord neurons that contribute to hyperalgesia arising from the injured tissue. In models of unilateral hindpaw inflammation, changes in the neurochemistry and electrophysiology of dorsal horn neurons ipsilateral, and to a much lesser extent contralateral, to the inflam...

journal_title：Neuroscience

authors： Solodkin A,Traub RJ,Gebhart GF

更新日期：1992-12-01 00:00:00

abstract：:The distribution of atrial natriuretic factor-like immunoreactivity in the central nervous system of the frog Rana ridibunda was investigated by indirect immunofluorescence and the immunogold technique, using an antiserum generated in rabbits against synthetic atrial natriuretic factor (Arg 101-Tyr 126). A stereotaxic...

journal_title：Neuroscience

authors： Netchitailo P,Feuilloley M,Pelletier G,Leboulenger F,Cantin M,Gutkowska J,Vaudry H

更新日期：1987-07-01 00:00:00

abstract：:The capacity of neural stem cells (NSC) to generate different types of neurons and glia depends on the action of intrinsic determinants and extracellular signals. Here, we isolated adult olfactory bulb stem cells (aOBSC) that express nestin, RC2 and Sox2, and that have the capacity to generate neurons possessing matur...

journal_title：Neuroscience

authors： Vergaño-Vera E,Méndez-Gómez HR,Hurtado-Chong A,Cigudosa JC,Vicario-Abejón C

更新日期：2009-08-04 00:00:00

abstract：:Here, we demonstrate in a direct electrophysiological experiment that a neuron can form electrical connections to itself. An isolated identified neuron with a long axon was plated in culture and the axon was looped so that its distal end contacted the cell body. After two days in culture, the cell body and the axon we...

journal_title：Neuroscience

authors： Panchin YV,Kelmanson IV

更新日期：2000-01-01 00:00:00

abstract：:Synapsins (SynI, SynII, SynIII) are a multigene family of synaptic vesicle (SV) phosphoproteins implicated in the regulation of synaptic transmission and plasticity. Synapsin I, II, I/II and I/II/III knockout mice are epileptic and SYN1/2 genes have been identified as major epilepsy susceptibility genes in humans. We ...

journal_title：Neuroscience

authors： Boido D,Farisello P,Cesca F,Ferrea E,Valtorta F,Benfenati F,Baldelli P

更新日期：2010-11-24 00:00:00

abstract：:This study shows that in adult rat spinal motoneurons brain-derived neurotrophic factor exerts a neuroprotective effect which extends several weeks beyond the duration of treatment. In addition, brain-derived neurotrophic factor strongly enhances regeneration of avulsed motor axons across the border between the centra...

journal_title：Neuroscience

authors： Novikov L,Novikova L,Kellerth JO

更新日期：1997-08-01 00:00:00

abstract：:The effect of the availability of synaptic targets on neuronal survival was tested by explanting the cochleovestibular ganglion from embryonic day 3-1/2 chick embryos and maintaining it in the presence or absence of appropriate synaptic target tissues for 14 days in culture. The targets were the inner ear, peripherall...

journal_title：Neuroscience

authors： Ard MD,Morest DK,Hauger SH

更新日期：1985-09-01 00:00:00

abstract：:The glycine transporter GLYT2 is present in axonal boutons throughout the spinal cord, and its laminar distribution matches that of glycine-enriched axons, which are presumed to be glycinergic. In order to determine whether boutons which possess GLYT2 are glycine-enriched, we have carried out pre-embedding immunocytoc...

journal_title：Neuroscience

authors： Spike RC,Watt C,Zafra F,Todd AJ

更新日期：1997-03-01 00:00:00

abstract：:The cerebellum is thought to have a variety of functions because it developed with the evolution of the cerebrum and connects with different areas in the frontoparietal cortices. Like neurons in the cerebral cortex, those in the cerebellum also exhibit strong activity during planning in addition to the execution of mo...

journal_title：Neuroscience

authors： Tanaka M,Kunimatsu J,Suzuki TW,Kameda M,Ohmae S,Uematsu A,Takeya R

更新日期：2020-04-30 00:00:00

abstract：:Undifferentiated PC12 cells undergo apoptosis, via a calcium-induced calcium release mechanism, when the calcium-binding protein purified from bovine brain (native S100) is present in micromolar concentration in the medium. This process begins when S100 binds to specific membrane binding sites and involves up to 50% o...

journal_title：Neuroscience

authors： Fulle S,Mariggiò MA,Belia S,Petrelli C,Ballarini P,Guarnieri S,Fanò G

更新日期：1999-03-01 00:00:00

abstract：:The topographical organization of the subnuclear projections towards the thalamus was studied with autographic methods in adult Wistar rats. The four cerebellar deep nuclei give rise to projections to the ventral region of the rostral thalamus. Most of the fibers end contralaterally, according to a topographical patte...

journal_title：Neuroscience

authors： Angaut P,Cicirata F,Serapide F

更新日期：1985-06-01 00:00:00

abstract：:Since functional imaging of whole body movements is not feasible with functional magnetic resonance imaging (fMRI), the present study presents in vivo functional near-infrared spectroscopy (fNIRS) as a suitable technique to measure body movement effects on fronto-temporo-parietal cortical activation in single- and dua...

journal_title：Neuroscience

authors： Metzger FG,Ehlis AC,Haeussinger FB,Schneeweiss P,Hudak J,Fallgatter AJ,Schneider S

更新日期：2017-02-20 00:00:00

abstract：:Neurotrophic factors are known to promote neuronal survival during development and after acute brain injury. Recent data suggest that some neuropeptides also exhibit neurotrophic activities, as shown for the pituitary adenylate cyclase activating polypeptide, which increases the survival of various neuronal population...

journal_title：Neuroscience

authors： Skoglösa Y,Lewén A,Takei N,Hillered L,Lindholm D

更新日期：1999-04-01 00:00:00

abstract：:In the present study the effect of cocaine on thymidine, uridine and leucine incorporation was assessed in primary cortical glial and C6 glioma cells. Cocaine exposure for 24 h inhibited thymidine and uridine incorporation in cortical glial and C6 glioma cells. However, the effect of cocaine on uridine incorporation w...

journal_title：Neuroscience

authors： Garg UC,Turndorf H,Bansinath M

更新日期：1993-11-01 00:00:00

abstract：:The sympathetic nervous system plays a role in carcinogenesis wherein locally released sympathetic neurotransmitters affect proliferation, angiogenesis, vessel permeability, lymphocyte traffic and cytokine production. The present in vivo study was designed to investigate whether surgical sympathectomy, both unilateral...

journal_title：Neuroscience

authors： Raju B,Haug SR,Ibrahim SO,Heyeraas KJ

更新日期：2007-11-09 00:00:00

abstract：:Tob (transducer of ErbB2) is a negative cell cycle regulator with anti-proliferative activity in the periphery. Using a behavioral screening paradigm to look for novel gene functions in the brain, we identified Tob as a brain-expressed protein involved in learning and memory. Behavioral training of fear-conditioning t...

journal_title：Neuroscience

authors： Jin M,Wang XM,Tu Y,Zhang XH,Gao X,Guo N,Xie Z,Zhao G,Jing N,Li BM,Yu L

更新日期：2005-01-01 00:00:00

abstract：:Individuals continuously confronted with various stresses in modern life generate high levels of cortisol (corticosterone in rodents), the major glucocorticoid secreted by adrenal gland when hypothalamic-pituitary-adrenal axis is activated. Chronic stress can induce constant release of glucocorticoid and cause many se...

journal_title：Neuroscience

authors： Jiang Y,Botchway BOA,Hu Z,Fang M

更新日期：2019-07-15 00:00:00