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The negative cell cycle regulator, Tob (transducer of ErbB-2), is a multifunctional protein involved in hippocampus-dependent learning and memory.

Abstract：

:Tob (transducer of ErbB2) is a negative cell cycle regulator with anti-proliferative activity in the periphery. Using a behavioral screening paradigm to look for novel gene functions in the brain, we identified Tob as a brain-expressed protein involved in learning and memory. Behavioral training of fear-conditioning triggered a transient elevation of Tob protein, which preceded the formation of long-term memory. Functional perturbation of Tob by intra-CA1 infusion of antisense oligonucleotides in rats impaired spatial learning and memory in the Morris water maze and long-term memory for contextual fear conditioning, two behavioral paradigms that require the hippocampus. Furthermore, long-term potentiation was suppressed by Tob antisense infusion into the CA1 region. Together, these results indicate that the negative cell cycle regulator Tob is a multifunctional protein involved in hippocampus-dependent learning and memory.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Jin M,Wang XM,Tu Y,Zhang XH,Gao X,Guo N,Xie Z,Zhao G,Jing N,Li BM,Yu L

doi

10.1016/j.neuroscience.2004.10.044

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

647-59

issue

3

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(04)00951-0

journal_volume

131

pub_type

杂志文章

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