Maternal choline supplementation in a mouse model of Down syndrome: Effects on attention and nucleus basalis/substantia innominata neuron morphology in adult offspring.

abstract：:The rodent whisker-barrel system is characterized by its patterned somatotopic mapping between the sensory periphery and multiple regions of the brain. While somatotopy in the whisker system is established, we know far less about how preferences for stimulus orientation or other features are organized. Mouse somatosen...

journal_title：Neuroscience

authors： Kwon SE,Tsytsarev V,Erzurumlu RS,O'Connor DH

更新日期：2018-01-01 00:00:00

abstract：:The functional changes of astrocytes are deeply involved in neurodegenerating processes of various CNS diseases. ATP is released during various neuronal damages such as brain ischemia and may control astrocyte functions. We examined the effect of ATP on the production of nitric oxide in the cultured astrocytes from ra...

journal_title：Neuroscience

authors： Murakami K,Nakamura Y,Yoneda Y

更新日期：2003-01-01 00:00:00

abstract：:Nickel (Ni(2+)) is a toxic metal that affects the function of several ionic channels. In the N-methyl-d-aspartate (NMDA) subtype of glutamate receptor (NR), it causes activity enhancement of the channels containing the NR2B subunit and voltage-independent inhibition of those containing NR2A. Thus, it may represent a f...

journal_title：Neuroscience

authors： Gavazzo P,Tedesco M,Chiappalone M,Zanardi I,Marchetti C

更新日期：2011-03-17 00:00:00

abstract：:When adult dorsal root ganglion cells are dissociated and maintained in vitro, both the small dark and the large light neurons show increases in the growth-associated protein GAP-43, a membrane phosphoprotein associated with neuronal development and plasticity. Immunoreactivity for GAP-43 appears in the cytoplasm of t...

journal_title：Neuroscience

authors： Woolf CJ,Reynolds ML,Molander C,O'Brien C,Lindsay RM,Benowitz LI

更新日期：1990-01-01 00:00:00

abstract：:It has been half a century since brain volume enlargement was first reported in animals reared in an enriched environment (EE). As EE animals show improved memory task performance, exposure to EE has been a useful model system for studying the effects of experience on brain plasticity. We review EE-induced neural chan...

journal_title：Neuroscience

authors： Hirase H,Shinohara Y

更新日期：2014-11-07 00:00:00

abstract：:Delivering effective commands in the nervous systems require a temporal integration of neural activities such as synchronous firing. Although sympathetic nerve discharges are characterized by synchronous firing, its temporal structures and how it is modulated are largely unknown. This study used a collagenase-dissocia...

journal_title：Neuroscience

authors： Su CK

更新日期：2016-01-15 00:00:00

abstract：:Exposure of male Syrian hamsters to a short daylength of 8L:16D leads to gonadal regression. This effect of photoperiod was prevented by pinealectomy or chronic exposure of the brain to exogenous melatonin delivered from in-dwelling cannulae. However, the effect of melatonin was dependent on the neural site of applica...

journal_title：Neuroscience

authors： Hastings MH,Walker AP,Roberts AC,Herbert J

更新日期：1988-03-01 00:00:00

abstract：:Hypoxia evokes a regulated decrease in the body core temperature, which response is mediated, at least in part, by noradrenaline (NA) and nitric oxide (NO) in the rostromedial preoptic area (POA) of the hypothalamus. In the accompanying paper, it was shown that glutamatergic activation of the lateral POA also evokes h...

journal_title：Neuroscience

authors： Osaka T

更新日期：2012-12-13 00:00:00

abstract：:In this study, we performed in situ hybridization analysis of the expression pattern of two growth-associated proteins, stathmin and SCG10, in the hippocampus after unilateral lesion of the perforant pathway, the main excitatory input from the entorhinal cortex to the hippocampus. Stathmin is one of the major neural-e...

journal_title：Neuroscience

authors： Bräuer AU,Savaskan NE,Plaschke M,Ninnemann O,Nitsch R

更新日期：2001-01-01 00:00:00

abstract：:Immunohistochemistry for the somatostatin sst2A receptor was performed on the rat trigeminal ganglion to know its function in the trigeminal nervous system. The immunoreactivity was detected in 9.4% of primary sensory neurons in the ganglion. These neurons were small to medium-sized (range=106.5-1123.2 microm(2); mean...

journal_title：Neuroscience

authors： Ichikawa H,Schulz S,Höllt V,Sugimoto T

更新日期：2003-01-01 00:00:00

abstract：:The dorsal pallidal complex is made up of the external and internal segments of the globus pallidus (GPe and GPi respectively). It is part of the main axis of the basal ganglia (BG) that connects the thalamo-cortical networks to the BG input stages (striatum and subthalamic nucleus) and continues directly, and indirec...

journal_title：Neuroscience

authors： Goldberg JA,Bergman H

更新日期：2011-12-15 00:00:00

abstract：:As seizure propagation within limbic structures is mediated in part by a small area of deep prepiriform cortex (area tempestas), we investigated the role of area tempestas in modulating hippocampal injury induced by systemic kainate administration. Injury was quantitated by counting the numbers of neurons that stained...

journal_title：Neuroscience

authors： Shimosaka S,So YT,Simon RP

更新日期：1994-08-01 00:00:00

abstract：:Tau hyperphosphorylation leads to formation of paired helical filament/neurofibrillary tangles, the hallmark lesion seen in Alzheimer's disease (AD) brain. An imbalanced regulation in protein kinases and protein phosphatases in the affected neurons is proposed to be a reasonable causative factor to the disease process...

journal_title：Neuroscience

authors： Sun L,Liu SY,Zhou XW,Wang XC,Liu R,Wang Q,Wang JZ

更新日期：2003-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the selective degeneration and death of motoneurons in the spinal cord, brainstem and motor cortex which causes progressive muscle weakness and paralysis. Although the molecular mechanisms causing the disease remain unknown, excitotoxi...

journal_title：Neuroscience

authors： Tolosa L,Mir M,Olmos G,Lladó J

更新日期：2009-02-18 00:00:00

abstract：:The enzyme choline-O-acetyltransferase catalyses the biosynthesis of acetylcholine from acetyl coenzyme A and choline and is considered as one of the best markers for cholinergic nerve endings. The distribution of this enzymatic activity was analysed during the purification of plasma membranes of purely cholinergic ne...

journal_title：Neuroscience

authors： Eder-Colli L,Amato S

更新日期：1985-06-01 00:00:00

abstract：:The prolonged maintenance of hippocampal long-term potentiation (LTP) seems to require heterosynaptic events during its induction. We have previously shown that stimulation of the basolateral nucleus of the amygdala (BLA) within a distinct time window can reinforce a transient early-LTP into a long-lasting late-LTP in...

journal_title：Neuroscience

authors： Frey S,Bergado JA,Frey JU

更新日期：2003-01-01 00:00:00

abstract：:The protective effect of diphenyliodonium, known as an inhibitor of flavin enzymes including nitric oxide synthases, was examined against the neurotoxicity of excitatory amino acids on cultured spinal neurons of the rat. Diphenyliodonium reduced the neuronal damage induced by 15-min exposure to glutamate or N-methyl-D...

journal_title：Neuroscience

authors： Nakamura Y,Tsuji K,Shuto M,Ogita K,Yoneda Y,Shimamoto K,Shibata T,Kataoka K

更新日期：1997-01-01 00:00:00

abstract：:A qualitative and quantitative immunohistochemical study of cholinergic systems in the human hippocampal formation was performed with an antibody against choline acetyltransferase. Four control subjects and six patients with Alzheimer's disease, matched for age and post-mortem delay, were examined. Immunoreactive nerv...

journal_title：Neuroscience

authors： Ransmayr G,Cervera P,Hirsch E,Ruberg M,Hersh LB,Duyckaerts C,Hauw JJ,Delumeau C,Agid Y

更新日期：1989-01-01 00:00:00

abstract：:Ascending projections from the several nuclei of the medullary reticular formation were examined using the autoradiographic method. The majority of fibers labeled after injections of [3H]leucine into nucleus gigantocellularis ascended within Forel's tractus fasciculorum tegmenti which is located ventrolateral to the m...

journal_title：Neuroscience

authors： Vertes RP,Martin GF,Waltzer R

更新日期：1986-11-01 00:00:00

abstract：:Social play is a motivated and rewarding behavior that is displayed by nearly all mammals and peaks in the juvenile period. Moreover, social play is essential for the development of social skills and is impaired in social disorders like autism. We recently showed that the lateral septum (LS) is involved in the regulat...

journal_title：Neuroscience

authors： Bredewold R,Schiavo JK,van der Hart M,Verreij M,Veenema AH

更新日期：2015-10-29 00:00:00

abstract：:GABA immunoreactivity was studied in the optic tectum of the frog, Rana esculenta, by postembedding immunohistochemical methods at the light and electron microscopic levels. Nearly one-third of the total population of tectal cells appeared to be GABA-immunoreactive. The proportion of stained neurons was highest in lay...

journal_title：Neuroscience

authors： Antal M

更新日期：1991-01-01 00:00:00

abstract：:There is evidence of structural and functional deterioration in the brain, including the prefrontal cortex (PFC) and hippocampus, during the normal aging process in animals and humans. Extracellular matrix-associated glycoproteins, such as chondroitin sulfate proteoglycans (CSPGs), are involved in not only maintaining...

journal_title：Neuroscience

authors： Tanaka Y,Mizoguchi K

更新日期：2009-12-15 00:00:00

abstract：:The transforming growth factor beta-activated kinase 1 (TAK1), a member of the Mitogen-activated protein kinase kinase kinase family, is characterized as a key regulator in inflammatory and apoptosis signaling pathways. The aim of the present study was to evaluate the role of the TAK1 pathway in experimental traumatic...

journal_title：Neuroscience

authors： Zhang D,Hu Y,Sun Q,Zhao J,Cong Z,Liu H,Zhou M,Li K,Hang C

更新日期：2013-05-15 00:00:00

abstract：:The deep cerebellar nuclei (DCN) are the final integrative units of the cerebellar network. The strongest single afferent to the DCN is formed by GABAergic Purkinje neuron axons whose synapses constitute the majority of all synapses in the DCN, with their action strongly regulating the intrinsic activity of their targ...

journal_title：Neuroscience

authors： Uusisaari M,Knöpfel T

更新日期：2008-10-15 00:00:00

abstract：:How obesity exacerbates migraine and other pain disorders remains unknown. Trigeminal nociceptive processing, crucial in migraine pathophysiology, is abnormal in mice with diet induced obesity. However, it is not known if this is also true in genetic models of obesity. We hypothesized that obese mice, regardless of th...

journal_title：Neuroscience

authors： Rossi HL,Raj NR,Marquez de Prado B,Kuburas A,Luu AKS,Barr GA,Recober A

更新日期：2019-09-01 00:00:00

abstract：:Cholinergic interneurons, which provide the main source of acetylcholine (ACh) in the striatum, control the striatal local circuits and deeply involve in the pathogenesis of neurodegenerative diseases. Glycogen synthase kinase-3 (GSK-3) is a crucial kinase with diverse fundamental functions and accepted that deregulat...

journal_title：Neuroscience

authors： Zhao L,Chu CB,Li JF,Yang YT,Niu SQ,Qin W,Hao YG,Dong Q,Guan R,Hu WL,Wang Y

更新日期：2013-01-01 00:00:00

abstract：:The sec6/8 (exocyst) complex is implicated in targeting of vesicles for regulated exocytosis in various cell types and is believed to play a role in synaptogenesis and brain development. We show that the subunits sec6 and sec8 are present at significant levels in neurons of adult rat brain, and that immunoreactivity f...

journal_title：Neuroscience

authors： Vik-Mo EO,Oltedal L,Hoivik EA,Kleivdal H,Eidet J,Davanger S

更新日期：2003-01-01 00:00:00

abstract：:Population-based studies have demonstrated that children with a history of febrile seizure (FS) perform better than age-matched controls at hippocampus-dependent memory tasks. Here, we report that FSs induce two distinct structural reorganizations in the hippocampus and bidirectionally modify future learning abilities...

journal_title：Neuroscience

authors： Tao K,Ichikawa J,Matsuki N,Ikegaya Y,Koyama R

更新日期：2016-03-24 00:00:00

abstract：:The entorhinal cortex and other hippocampal and parahippocampal cortices are interconnected by a small number of GABAergic nonpyramidal neurons in addition to glutamatergic pyramidal cells. Since the cortical and basolateral amygdalar nuclei have cortex-like cell types and have robust projections to the entorhinal cor...

journal_title：Neuroscience

authors： McDonald AJ,Zaric V

更新日期：2015-04-02 00:00:00

abstract：:Eider duck (Somateria mollissima) cerebellar neurons are highly tolerant toward hypoxia in vitro, which in part is due to a hypoxia-induced depression of their spontaneous activity. We have studied whether this response involves ATP-sensitive potassium (KATP) channels, which are known to be involved in the hypoxic/isc...

journal_title：Neuroscience

authors： Geiseler SJ,Ludvigsen S,Folkow LP

更新日期：2015-01-22 00:00:00