Abstract:
:Population-based studies have demonstrated that children with a history of febrile seizure (FS) perform better than age-matched controls at hippocampus-dependent memory tasks. Here, we report that FSs induce two distinct structural reorganizations in the hippocampus and bidirectionally modify future learning abilities in an age-dependent manner. Compared with age-matched controls, adult mice that had experienced experimental FSs induced by hyperthermia (HT) on postnatal day 14 (P14-HT) performed better in a cognitive task that requires dentate granule cells (DGCs). The enhanced memory performance correlated with an FS-induced persistent increase in the density of large mossy fiber terminals (LMTs) of the DGCs. The memory enhancement was not observed in mice that had experienced HT-induced seizures at P11 which exhibited abnormally located DGCs in addition to the increased LMT density. The ectopic DGCs of the P11-HT mice were abolished by the diuretic bumetanide, and this pharmacological treatment unveiled the masked memory enhancement. Thus, this work provides a novel basis for age-dependent structural plasticity in which FSs influence future brain function.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Tao K,Ichikawa J,Matsuki N,Ikegaya Y,Koyama Rdoi
10.1016/j.neuroscience.2016.01.011subject
Has Abstractpub_date
2016-03-24 00:00:00pages
34-44eissn
0306-4522issn
1873-7544pii
S0306-4522(16)00030-0journal_volume
318pub_type
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