Experimental febrile seizures induce age-dependent structural plasticity and improve memory in mice.

Abstract:

:Population-based studies have demonstrated that children with a history of febrile seizure (FS) perform better than age-matched controls at hippocampus-dependent memory tasks. Here, we report that FSs induce two distinct structural reorganizations in the hippocampus and bidirectionally modify future learning abilities in an age-dependent manner. Compared with age-matched controls, adult mice that had experienced experimental FSs induced by hyperthermia (HT) on postnatal day 14 (P14-HT) performed better in a cognitive task that requires dentate granule cells (DGCs). The enhanced memory performance correlated with an FS-induced persistent increase in the density of large mossy fiber terminals (LMTs) of the DGCs. The memory enhancement was not observed in mice that had experienced HT-induced seizures at P11 which exhibited abnormally located DGCs in addition to the increased LMT density. The ectopic DGCs of the P11-HT mice were abolished by the diuretic bumetanide, and this pharmacological treatment unveiled the masked memory enhancement. Thus, this work provides a novel basis for age-dependent structural plasticity in which FSs influence future brain function.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Tao K,Ichikawa J,Matsuki N,Ikegaya Y,Koyama R

doi

10.1016/j.neuroscience.2016.01.011

subject

Has Abstract

pub_date

2016-03-24 00:00:00

pages

34-44

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(16)00030-0

journal_volume

318

pub_type

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