Kainate Receptors, Homeostatic Gatekeepers of Synaptic Plasticity.

abstract：:Acetylcholinesterase is released from both axon terminals and dendrites of nigrostriatal neurons. The relationship of this phenomenon to: (1) activation of receptors, and (2) firing rate, has been examined. In the first series of experiments, apomorphine or acetylcholine were infused into substantiae nigrae of urethan...

journal_title：Neuroscience

authors： Weston J,Greenfield SA

更新日期：1986-04-01 00:00:00

abstract：:Few studies have investigated whether neuronal function in the amygdaloid complex is necessary for the occurrence of the cardiovascular response to natural (unconditioned) environmental threats. In the present investigation in conscious unrestrained Sprague-Dawley rats we inactivated neuronal function in the amygdaloi...

journal_title：Neuroscience

authors： Mohammed M,Kulasekara K,De Menezes RC,Ootsuka Y,Blessing WW

更新日期：2013-01-03 00:00:00

abstract：:Interleukin-1beta is a relatively small and abundant polypeptide that plays diverse roles in the central nervous system. In the present study, patterns of interleukin-1beta expression were observed in the olfactory bulbs of rats that had either undergone unilateral closure of the external naris or sham surgery on post...

journal_title：Neuroscience

authors： Lim JH,Brunjes PC

更新日期：1999-01-01 00:00:00

abstract：:Developmental changes in ganglioside levels and patterns were investigated in neuronal cells dissociated from 17-day-old fetal rat hemispheres for up to 7 days of culture. Increases in ganglioside contents and the onset of GM3 synthesis, which is associated with proliferation of glial cells, were observed as the neuro...

journal_title：Neuroscience

authors： Ogiso M,Ohta M,Harada Y,Kubo H,Hirano S

更新日期：1991-01-01 00:00:00

abstract：:l-3,4-Dihydroxyphenylalanine (l-DOPA) is the therapeutic gold standard in Parkinson's disease. However, most patients develop debilitating abnormal involuntary movements termed l-DOPA-induced dyskinesia (LID) as therapy-complicating side effects. The underlying mechanisms of LID pathogenesis are still not fully unders...

journal_title：Neuroscience

authors： Klietz M,Keber U,Carlsson T,Chiu WH,Höglinger GU,Weihe E,Schäfer MK,Depboylu C

更新日期：2016-09-07 00:00:00

abstract：:In vitro autoradiography was used to examine the N-methyl-D-aspartate receptor in the brain of a baboon species, Papio anubis, and compared to that of Papio papio which exhibits a photosensitive epilepsy. The epilepsy originates in the frontal cortex and is accompanied by an enhanced sensitivity to N-methyl-D-aspartat...

journal_title：Neuroscience

authors： Geddes JW,Cooper SM,Cotman CW,Patel S,Meldrum BS

更新日期：1989-01-01 00:00:00

abstract：:We examined the immunohistochemical regional distribution of calcineurin (Ca2+/calmodulin-dependent protein phosphatase) in the adult rat hippocampus, following various regional destruction. In the normal adult rat hippocampus, the calcineurin immunoreactivity showed a characteristic pattern. This protein phosphatase ...

journal_title：Neuroscience

authors： Morioka M,Nagahiro S,Fukunaga K,Miyamoto E,Ushio Y

更新日期：1997-06-01 00:00:00

abstract：:Distributions of somata and neurites of cholinergic neurons were studied after seeding dissociated cells onto organotypic slice cultures. Slice cultures were made from hippocampal formation and adjacent cortical regions from rats or mice. Dissociated cell suspensions of basal forebrain tissue from rat or mouse fetuses...

journal_title：Neuroscience

authors： Tsai ES,Haraldson SJ,Baratta J,Lander AD,Yu J,Robertson RT

更新日期：2002-01-01 00:00:00

abstract：:Cocaine- and amphetamine-regulated transcript (CART) and nesfatin-1/nucleobindin 2 (NUCB2) are assumed to play a role in feeding and adaptation to stress. Both peptides are highly expressed in the midbrain non-preganglionic Edinger-Westphal nucleus (npEW), a center implicated in the regulation of stress adaptation and...

journal_title：Neuroscience

authors： Xu L,Bloem B,Gaszner B,Roubos EW,Kozicz T

更新日期：2010-10-13 00:00:00

abstract：:Fifteen percent to 35% of the United States population experiences tinnitus, a subjective "ringing in the ears". Up to 10% of those afflicted report severe and disabling symptoms. Tinnitus was induced in rats using unilateral, 1 h, 17 kHz-centered octave-band noise (116 dB SPL) and assessed using a gap-startle method....

journal_title：Neuroscience

authors： Wang H,Brozoski TJ,Turner JG,Ling L,Parrish JL,Hughes LF,Caspary DM

更新日期：2009-12-01 00:00:00

abstract：:The mechanism of neuropeptide secretion induced by bradykinin from capsaicin-sensitive afferents was studied in guinea-pig atria. Both the inotropic response induced by bradykinin (0.1 microM) in the electrically driven isolated guinea-pig left atria and the bradykinin (10 microM)-induced release of calcitonin gene-re...

journal_title：Neuroscience

authors： Geppetti P,Tramontana M,Santicioli P,Del Bianco E,Giuliani S,Maggi CA

更新日期：1990-01-01 00:00:00

abstract：:Progestins mediate the onset and duration of lordosis, the mating posture of female rodents, through actions in the hypothalamus and ventral tegmental area. In the hypothalamus, progesterone has traditional, "genomic" actions via intracellular progestin receptors. In the ventral tegmental area, 3alpha-hydroxy-5alpha-p...

journal_title：Neuroscience

authors： Frye CA,Rhodes ME,Petralia SM,Walf AA,Sumida K,Edinger KL

更新日期：2006-01-01 00:00:00

abstract：:The 2-deoxyglucose metabolic mapping technique has been used to investigate the neural mechanisms which underlie the symptoms of Parkinsonism in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine primate model of Parkinson's disease. In six cynomolgus monkeys, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine was either (a) ...

journal_title：Neuroscience

authors： Mitchell IJ,Clarke CE,Boyce S,Robertson RG,Peggs D,Sambrook MA,Crossman AR

更新日期：1989-01-01 00:00:00

abstract：:Cell surface glycoconjugates are thought to mediate cell-cell recognition and play roles in neuronal development and functions. We demonstrated here that exposure of neuronal cells to nanomolar levels of gangliosides Neu5Acalpha 8Neu5Acalpha 3Galbeta 4GlcCer, Galbeta 3GalNAcbeta 4(Neu5Acalpha 8Neu5Acalpha 3)Galbeta 4G...

journal_title：Neuroscience

authors： Chen N,Furuya S,Doi H,Hashimoto Y,Kudo Y,Higashi H

更新日期：2003-01-01 00:00:00

abstract：:Non-invasive criteria determining the progress of brain healing are especially important in aging, providing a case-specific therapeutic strategy in populations with dysregulated neurorepair mechanisms. We hypothesized that temporal evolution of magnetic resonance imaging (MRI) of T2 tissue relaxation values correlate...

journal_title：Neuroscience

authors： Titova EM,Ghosh N,Valadez ZG,Zhang JH,Bellinger DL,Obenaus A

更新日期：2014-12-26 00:00:00

abstract：:The distribution, structural organization and state of phosphorylation of neurofilaments have been examined in chromaffin cells from adult bovine adrenal medulla cultured under various conditions using a series of monoclonal antibodies directed against phosphorylated and nonphosphorylated epitopes of the 200,000 mol. ...

journal_title：Neuroscience

authors： Grant NJ,Demeneix B,Aunis D,Langley OK

更新日期：1988-11-01 00:00:00

abstract：:Protection of substantia nigra (SN) dopaminergic (DA) neurons by neurotrophic factors (NTFs) is one of the promising strategies in Parkinson's disease (PD) therapy. A major clinical challenge for NTF-based therapy is that NTFs need to be delivered into the brain via invasive means, which often shows limited delivery e...

journal_title：Neuroscience

authors： Pang Y,Lin S,Wright C,Shen J,Carter K,Bhatt A,Fan LW

更新日期：2016-03-24 00:00:00

abstract：:Hippocampal cell firing in awake, behaving rats is often spatially selective, and such cells have been called place cells. Similar spatial correlates have also been described for neurons in the medial entorhinal and perirhinal cortices. All three regions receive sensory associational input from postrhinal cortex, whic...

journal_title：Neuroscience

authors： Burwell RD,Hafeman DM

更新日期：2003-01-01 00:00:00

abstract：:Localization of luteotrophic hormone-releasing hormone (LHRH) was examined by immunocytochemistry in untreated male rats and rats that received an anterior hypothalamic deafferentation. Gonadotrophic function was assessed by examining testicular weight and morphology. All of the antisera used in this study were able t...

journal_title：Neuroscience

authors： Hoffman GE,Gibbs FP

更新日期：1982-01-01 00:00:00

abstract：:Dephosphin/dynamin is a 94,000/96,000 mol. wt protein kinase C substrate from rat brain that is phosphorylated in nerve terminals and dephosphorylated upon stimulation of exocytosis and synaptic vesicle recycling. Phosphorylation activates an intrinsic GTPase activity and dephosphin may play a role in endocytosis [Rob...

journal_title：Neuroscience

authors： Powell KA,Robinson PJ

更新日期：1995-02-01 00:00:00

abstract：:The noradrenergic nerve terminals and their vesicle populations have been subject to much ultrastructural research which has served to support and extend data from biochemical analysis and pharmacological-physiological experiments. Although a great deal of information has been collected, there are still many problems ...

journal_title：Neuroscience

authors： Thureson-Klein A

更新日期：1983-10-01 00:00:00

abstract：:The effect of pairing two vibrissa stimulations on unit responses of the barrel field of the somatosensory cortex were studied in partially restrained but awake and undrugged rats. Before pairing, one of the stimulations (S2) evoked a stable, short-latency and excitatory response from the recorded unit. Depending on t...

journal_title：Neuroscience

authors： Delacour J,Houcine O,Talbi B

更新日期：1987-10-01 00:00:00

abstract：:The electrical activity of locus coeruleus neurons was investigated during cortical spreading depression in urethane-anaesthetized rats. Cortical spreading depression was induced by a direct application of 1-3 M KCl solution to the surface of the cerebral cortex. The occurrence of cortical spreading depression was ass...

journal_title：Neuroscience

authors： Arakawa S,Nakamura S,Kawashima N,Nishiike S,Fujii Y

更新日期：1997-06-01 00:00:00

abstract：:Probenecid has been used for decades to treat gout, and recent studies have revealed it is also a specific inhibitor of the pannexin-1 channel. It has been reported that the pannexin-1 channel is involved in ischemic injury. Here, we investigated the neuroprotective effect and the possible mechanisms of action of prob...

journal_title：Neuroscience

authors： Wei R,Wang J,Xu Y,Yin B,He F,Du Y,Peng G,Luo B

更新日期：2015-08-20 00:00:00

abstract：:Most patients with temporal lobe epilepsy (TLE), the most common type of epilepsy, show pronounced loss of neurons in limbic brain regions, including the hippocampus. The massive neurodegeneration in the hippocampus is known as hippocampal sclerosis, and is considered one of the hallmarks of this type of difficult-to-...

journal_title：Neuroscience

authors： Brandt C,Potschka H,Löscher W,Ebert U

更新日期：2003-01-01 00:00:00

abstract：:The intracochlear infusion of neurotrophic factors via a mini-osmotic pump has been shown to prevent deafness-induced spiral ganglion neuron (SGN) degeneration; however, the use of pumps may increase the incidence of infection within the cochlea, making this technique unsuitable for neurotrophin administration in a cl...

journal_title：Neuroscience

authors： Pettingill LN,Minter RL,Shepherd RK

更新日期：2008-03-27 00:00:00

abstract：:Temporal lobe epilepsy (TLE) is the most common form of focal epilepsies in adults. It is often initiated by an insult or brain injury which triggers a series of alterations which ultimately lead to seizures (epilepsy). In 50-70% of people with TLE the condition cannot be adequately treated by the present antiepilepti...

journal_title：Neuroscience

authors： van Vliet EA,Aronica E,Gorter JA

更新日期：2014-09-26 00:00:00

abstract：:The hippocampal CA1 region receives cortical information via two main inputs: directly via the perforant (temporoammonic) path (pp-CA1 synapse) and indirectly via the tri-synaptic pathway. Although synaptic plasticity has been reported at the pp-CA1 synapse of freely behaving animals, the mechanisms underlying this ph...

journal_title：Neuroscience

authors： Aksoy-Aksel A,Manahan-Vaughan D

更新日期：2015-11-19 00:00:00

abstract：:The consequences of epileptiform discharge on the expression of glutamate and GABA receptors were examined by in situ hybridization histochemistry after treatment of rat hippocampal slice cultures with convulsants. Application of 500 microM picrotoxin for two days led to decreases in the messenger RNA levels for the N...

journal_title：Neuroscience

authors： Gerfin-Moser A,Grogg F,Rietschin L,Thompson SM,Streit P

更新日期：1995-08-01 00:00:00

abstract：:We reported previously that sensory neurons isolated from mice with a heterozygous mutation of the Nf1 gene (Nf1+/-) exhibited greater excitability and increased sodium current densities compared with wildtype mice. This raises the question as to whether the increased current density resulted from post-translational m...

journal_title：Neuroscience

authors： Hodgdon KE,Hingtgen CM,Nicol GD

更新日期：2012-03-29 00:00:00