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Intrauterine Growth Restriction Modifies the Accumbal Dopaminergic Response to Palatable Food Intake.

Abstract：

:Intrauterine growth restriction (IUGR) associates with increased preference for palatable foods and altered insulin sensitivity. Insulin modulates the central dopaminergic response and changes behavioral responses to reward. We measured the release of dopamine in the accumbens during palatable food intake in IUGR rats both at baseline and in response to insulin. From pregnancy day 10 until birth, gestating Sprague-Dawley rats received either an ad libitum (Control), or a 50% food restricted (FR) diet. In adulthood, palatable food consumption and feeding behavior entropy was assessed using an electronic food intake monitor (BioDAQ®), and dopamine response to palatable food was measured by chronoamperometry recordings in the nucleus accumbens (NAcc). FR rats eat more palatable foods during the dark phase, and their eating pattern has a higher entropy compared to control rats. There was a delayed dopamine release in the FR group in response to palatable food and insulin administration reverted this delayed effect. Western blot showed a decrease in suppressor of cytokine signaling 3 protein (SOCS3) in the ventral tegmental area (VTA) and an increase in the ratio of phospho-tyrosine hydroxylase to tyrosine hydroxylase (pTH/TH) in the NAcc of FR rats. Administration of insulin also abolished this latter effect in FR rats. FR rats showed metabolic alterations and a delay in the dopaminergic response to palatable foods. This could explain the increased palatable food intake and behavioral entropy found in FR rats. IUGR may lead to binge eating, obesity and its metabolic consequences by modifying the central dopaminergic response to sweet food.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Laureano DP,Alves MB,Miguel PM,Machado TD,Reis AR,Mucellini AB,Cunha FS,Lampert C,Salvador APA,Dalle Molle R,Mosca PR,Pokhvisneva I,Desai M,Ross MG,Silveira PP

doi

10.1016/j.neuroscience.2018.12.036

subject

Has Abstract

pub_date

2019-02-21 00:00:00

pages

184-195

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(18)30854-6

journal_volume

400

pub_type

杂志文章

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