Influence of the medial septal nucleus on the excitability of the commissural path-CA1 pyramidal cell synapse in the hippocampus of freely moving mice.

abstract：:While B2 receptors mediate pain and hyperalgesia induced by bradykinin, in normal rats, recent reports indicate that, in the setting of inflammation, B1 receptors also mediate pain and hyperalgesia. Since bradykinin-induced hyperalgesia in normal rats is mediated by prostaglandins released from the postganglionic symp...

journal_title：Neuroscience

authors： Khasar SG,Miao FJ,Levine JD

更新日期：1995-11-01 00:00:00

abstract：:Ciliary neurotrophic factor is known to exert both survival and differentiative actions on a number of neuronal populations of the peripheral and central nervous systems. In this study we have compared the trophic effects of ciliary neurotrophic factor and nerve growth factor on developing septal neurons of the rat in...

journal_title：Neuroscience

authors： Kew JN,Sofroniew MV

更新日期：1995-06-01 00:00:00

abstract：:In the brain of young (two weeks old) rats, angiotensin II receptors (AT2 receptors) are found in brain nuclei which receive and integrate direct visual input from the retina, the suprachiasmatic nuclei (containing only AT1 receptors), the lateral geniculate nuclei (containing AT2 receptors) and the superior colliculu...

journal_title：Neuroscience

authors： Michels KM,Heemskerk FM,Saavedra JM

更新日期：1994-02-01 00:00:00

abstract：:Amyloid beta peptide (Aβ) is implicated in the development of pathological reactions associated with Alzheimer's disease (AD), such as oxidative stress, neuro-inflammation and death of brain cells. Current pharmacological approaches to treat AD are not able to control the deposition of Aβ and suppression of Aβ-induced...

journal_title：Neuroscience

authors： Tsoy A,Saliev T,Abzhanova E,Turgambayeva A,Kaiyrlykyzy A,Akishev M,Saparbayev S,Umbayev B,Askarova S

更新日期：2019-06-01 00:00:00

abstract：:The investigation on neurotransmission function during normal and pathologic development is a pivotal component needed to understand the basic mechanisms underlying neurodevelopmental pathologies. To study these diseases, many animal models have been generated which allowed to face the limited availability of human ti...

journal_title：Neuroscience

authors： Ruffolo G,Cifelli P,Miranda-Lourenço C,De Felice E,Limatola C,Sebastião AM,Diógenes MJ,Aronica E,Palma E

更新日期：2020-07-15 00:00:00

abstract：:Earlier studies have implicated brain-derived neurotrophic factor in stress and in the mechanism of action of antidepressants. It has been shown that antidepressants upregulate, whereas corticosterone downregulates, brain-derived neurotrophic factor expression in rat brain. Whether various classes of antidepressants r...

journal_title：Neuroscience

authors： Dwivedi Y,Rizavi HS,Pandey GN

更新日期：2006-01-01 00:00:00

abstract：:Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that affects upper and lower motor neurons and leads to death a few years after symptom onset. Despite its high morbidity and mortality, its underlying pathogenic mechanisms still remain poorly understood. Although there is increasing evidence for sign...

journal_title：Neuroscience

authors： Konsolaki E,Koropouli E,Tsape E,Pothakos K,Zagoraiou L

更新日期：2020-12-01 00:00:00

abstract：:Novel approaches are required in the clinical management of peripheral nerve injuries because current surgical techniques result in deficient sensory recovery. Microsurgery alone fails to address extensive cell death in the dorsal root ganglia (DRG), in addition to poor axonal regeneration. Incorporation of cultured c...

journal_title：Neuroscience

authors： Reid AJ,Sun M,Wiberg M,Downes S,Terenghi G,Kingham PJ

更新日期：2011-12-29 00:00:00

abstract：:The spinal cord is innervated by brainstem serotonergic neurons, some of which contain substance P and/or thyrotropin-releasing hormone in addition to serotonin. These neurons project at least three types of axons to the spinal cord: those containing both substance P and thyrotropin-releasing hormone, those containing...

journal_title：Neuroscience

authors： Wu W,Elde R,Wessendorf MW

更新日期：1993-07-01 00:00:00

abstract：:We have observed that in rat caudate-putamen nuclei, neurons immunolabeled for choline acetyltransferase were sometimes in direct apposition to unlabeled perikarya and dendrites [Pickel V. M. and Chan J. (1990) J. Neurosci. Res. 25, 263-280]. Similar juxtapositions between plasmalemmas of nerve cells each receiving in...

journal_title：Neuroscience

authors： Pickel VM,Chan J

更新日期：1991-01-01 00:00:00

abstract：:Axonal release of serotonin (5-hydroxytryptamine, 5-HT) in the CNS is typically regulated by presynaptic 5-HT autoreceptors. Release of 5-HT in substantia nigra pars reticulata (SNr), a principal output from the basal ganglia, has seemed an interesting exception to this rule. The SNr receives one of the highest densit...

journal_title：Neuroscience

authors： Threlfell S,Greenfield SA,Cragg SJ

更新日期：2010-01-13 00:00:00

abstract：:Auditory-visual (AV) events often involve a leading visual cue (e.g. auditory-visual speech) that allows the perceiver to generate predictions about the upcoming auditory event. Electrophysiological evidence suggests that when an auditory event is predicted, processing is sped up, i.e., the N1 component of the ERP occ...

journal_title：Neuroscience

authors： Paris T,Kim J,Davis C

更新日期：2017-02-20 00:00:00

abstract：:Previous studies have shown that pretreatment with neurotrophins can potentiate the vulnerability of cultured neurons to excitotoxic and free radical-induced necrosis, in contrast to their well known neuroprotective effects against apoptosis. Here we tested the hypothesis that this unexpected injury-potentiating effec...

journal_title：Neuroscience

authors： Mcdonald JW,Stefovska VG,Liu XZ,Shin H,Liu S,Choi DW

更新日期：2002-01-01 00:00:00

abstract：:To examine changes in corticostriatal synaptic transmission in rats with ethanol withdrawal syndrome, intracellular and extracellular responses to subcortical white matter stimulation were recorded in neostriatal slice preparations. The resting membrane potential, input resistance and depolarizing postsynaptic potenti...

journal_title：Neuroscience

authors： Yamamoto Y,Nakanishi H,Takai N,Shimazoe T,Watanabe S,Kita H

更新日期：1999-01-01 00:00:00

abstract：:Drinking alcohol in moderation is often considered a health-conscious behavior, associated with improved cardiovascular and brain health. However, "moderate" amounts of alcohol include drinking 3-4 alcohol beverages in a day, which is closer to binge drinking and may do more harm than good. Here we examined how daily ...

journal_title：Neuroscience

authors： Anderson ML,Nokia MS,Govindaraju KP,Shors TJ

更新日期：2012-11-08 00:00:00

abstract：:Ascending projections from the several nuclei of the medullary reticular formation were examined using the autoradiographic method. The majority of fibers labeled after injections of [3H]leucine into nucleus gigantocellularis ascended within Forel's tractus fasciculorum tegmenti which is located ventrolateral to the m...

journal_title：Neuroscience

authors： Vertes RP,Martin GF,Waltzer R

更新日期：1986-11-01 00:00:00

abstract：:This study investigated amphetamine-induced striatal dopamine release after intraventricular unilateral fetal mesencephalic grafts in otherwise intact rats. Dopamine was monitored in vivo by differential pulse voltammetry. In grafted animals, amphetamine-induced dopamine release was decreased compared to sham-grafted,...

journal_title：Neuroscience

authors： Marburger A,Reum T,Drandarevski N,Morgenstern R

更新日期：1997-12-01 00:00:00

abstract：:The hippocampus plays an important role in the formation of new memories and spatial navigation. Recently, growing evidence supports the view that it is also involved in addiction to opiates and other drugs. Theoretical and experimental studies suggest that hippocampal neural-network oscillations at specific frequenci...

journal_title：Neuroscience

authors： Liu F,Jiang H,Zhong W,Wu X,Luo J

更新日期：2010-12-15 00:00:00

abstract：:It has been suggested that the brain adopts a simplified strategy to coordinate a large number of degrees of freedom in motor control. Synergies have been proposed as a strategy to produce movements by recruitment of a small number of fixed modular patterns. However, there is no direct support for a synergistic organi...

journal_title：Neuroscience

authors： Hao Y,Zhang S,Zhang Q,Li G,Chen W,Zheng X

更新日期：2017-08-15 00:00:00

abstract：:Emerging evidence indicates that the expression of trophic factors in the brain is regulated in an activity-dependent manner, which suggests an involvement of trophic factors in events controlled by input activity. We have investigated the possibility that visual sensory input impacts the expression of basic fibroblas...

journal_title：Neuroscience

authors： Gómez-Pinilla F,Choi J,Ryba EA

更新日期：1999-01-01 00:00:00

abstract：:To evaluate the potential for lipofectin-mediated central nervous system gene transfer, the plasmid coding for cholecystokinin was administered intracerebroventricularly to rats, which have congenital audiogenic seizures and high responses to peripheral electric stimulation-induced analgesia. Previous studies had show...

journal_title：Neuroscience

authors： Zhang LX,Li XL,Smith MA,Post RM,Han JS

更新日期：1997-03-01 00:00:00

abstract：:Microtubule-associated protein 1B is a major constituent of the neuronal cytoskeleton during the early stages of development. This protein and its phosphorylated isoform, microtubule-associated protein 1B-P, defined by the monoclonal antibody 1B-P [Boyne L. J. et al. (1995) J. Neurosci. Res. 40, 439-450], are present ...

journal_title：Neuroscience

authors： Ma D,Connors T,Nothias F,Fischer I

更新日期：2000-01-01 00:00:00

abstract：:Synapse or dendritic spine loss is the strongest correlate of cognitive decline in Alzheimer's disease (AD), and neurofibrillary tangles (NFTs), but not amyloid-β plaques, associate more closely with transition to mild cognitive impairment. Yet, how dendritic spine architecture is affected by hyperphosphorylated tau i...

journal_title：Neuroscience

authors： Walker CK,Greathouse KM,Boros BD,Poovey EH,Clearman KR,Ramdas R,Muhammad HM,Herskowitz JH

更新日期：2020-12-17 00:00:00

abstract：:The capacity of neural stem cells (NSC) to generate different types of neurons and glia depends on the action of intrinsic determinants and extracellular signals. Here, we isolated adult olfactory bulb stem cells (aOBSC) that express nestin, RC2 and Sox2, and that have the capacity to generate neurons possessing matur...

journal_title：Neuroscience

authors： Vergaño-Vera E,Méndez-Gómez HR,Hurtado-Chong A,Cigudosa JC,Vicario-Abejón C

更新日期：2009-08-04 00:00:00

abstract：:Classic neurotransmitter phenotypes are generally predetermined and develop as a consequence of target-independent lineage decisions. A unique mode of target-dependent phenotype instruction is the acquisition of the cholinergic phenotype in the peripheral sympathetic nervous system. A body of work suggests that the sw...

journal_title：Neuroscience

authors： Schütz B,von Engelhardt J,Gördes M,Schäfer MK,Eiden LE,Monyer H,Weihe E

更新日期：2008-10-02 00:00:00

abstract：:The possible roles of G-protein coupled metabotropic glutamate receptors in central nervous function are currently the focus of intensive investigation. The complexity of effects produced by agonists at these receptors probably reflects the activity of a range of sub-types. The metabotropic glutamate receptors first d...

journal_title：Neuroscience

authors： Birse EF,Eaton SA,Jane DE,Jones PL,Porter RH,Pook PC,Sunter DC,Udvarhelyi PM,Wharton B,Roberts PJ

更新日期：1993-02-01 00:00:00

abstract：:Aging occurs due to a combination of several factors, such as telomere attrition, cellular senescence, and stem cell exhaustion. The telomere attrition-dependent cellular senescence is regulated by increased levels of SMAD specific E3 ubiquitin protein ligase 2 (smurf2). With age smurf2 expression increases and Smurf2...

journal_title：Neuroscience

authors： Sasik MUT,Eravsar ETK,Kinali M,Ergul AA,Adams MM

更新日期：2020-06-01 00:00:00

abstract：:A variety of N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonists, and the antiepileptic drug lamotrigine, were examined for their ability to restore locomotion and other behaviours when injected stereotaxically via indwelling cannulae into the striatum or substantia n...

journal_title：Neuroscience

authors： Kaur S,Starr MS

更新日期：1997-01-01 00:00:00

abstract：:It was demonstrated with autoradiographic methods that a tract of thin fibers, which is for the most part distinct from the brachium conjunctivum and its crossed descending limb, can be followed from the cerebellar nuclei to the inferior olive. Neurons from all regions of the interposed and dentate nuclei contribute t...

journal_title：Neuroscience

authors： Legendre A,Courville J

更新日期：1987-06-01 00:00:00

abstract：:Previous studies from our laboratory and others have shown that there are major age-related differences in brainstem neuronal function. Since GABAA receptors are major targets for GABA-mediated inhibitory modulation and play a key role in regulating cardiorespiratory function, especially during O2 deprivation, we exam...

journal_title：Neuroscience

authors： Xia Y,Haddad GG

更新日期：1992-08-01 00:00:00