Origin and trajectory of the cerebello-olivary projection: an experimental study with radioactive and fluorescent tracers in the cat.

Abstract:

:It was demonstrated with autoradiographic methods that a tract of thin fibers, which is for the most part distinct from the brachium conjunctivum and its crossed descending limb, can be followed from the cerebellar nuclei to the inferior olive. Neurons from all regions of the interposed and dentate nuclei contribute to this tract. With two fluorescent tracers, Fast Blue and Diamidino Yellow Dihydrochloride, the perikarya of neurons in the cerebellar nuclei that project to the inferior olive or thalamus were identified and the possibility of collateral projections from single neurons to both regions was investigated. Numerous retrogradely labeled neurons were seen in the contralateral interposed and dentate nuclei but no double-labeled cells were ever encountered. The mean diameters of the cells projecting to the inferior olive were between 15 and 20 microns while the mean diameters for those projecting to the nucleus ventrolateralis of thalamus were between 25 and 35 microns. Differences in the morphology of the two cell populations were noted. It was also found that the fastigio-olivary projection is small, terminating mainly contralaterally, in the caudal medial accessory olive and subnucleus beta. It is concluded that cerebello-olivary fibers are not collaterals of the cerebellothalamic projection and that there are two different populations of neurons in the cerebellar nuclei that give rise to these distinct efferent projections.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Legendre A,Courville J

doi

10.1016/0306-4522(87)90044-3

subject

Has Abstract

pub_date

1987-06-01 00:00:00

pages

877-91

issue

3

eissn

0306-4522

issn

1873-7544

pii

0306-4522(87)90044-3

journal_volume

21

pub_type

杂志文章
  • Exposure to Auditory Feedback Delay while Speaking Induces Perceptual Habituation but does not Mitigate the Disruptive Effect of Delay on Speech Auditory-motor Learning.

    abstract::Perceiving the sensory consequences of our actions with a delay alters the interpretation of these afferent signals and impacts motor learning. For reaching movements, delayed visual feedback of hand position reduces the rate and extent of visuomotor adaptation, but substantial adaptation still occurs. Moreover, the d...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2020.07.041

    authors: Shiller DM,Mitsuya T,Max L

    更新日期:2020-10-15 00:00:00

  • The visual encoding of tool-object affordances.

    abstract::The perception of tool-object pairs involves understanding their action-relationships (affordances). Here, we sought to evaluate how an observer visually encodes tool-object affordances. Eye-movements were recorded as right-handed participants freely viewed static, right-handed, egocentric tool-object images across th...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2015.09.060

    authors: Natraj N,Pella YM,Borghi AM,Wheaton LA

    更新日期:2015-12-03 00:00:00

  • Variations of nucleus accumbens dopamine and serotonin following systemic interleukin-1, interleukin-2 or interleukin-6 treatment.

    abstract::The effects of systemically administered interleukin-1beta (1.0 microg), interleukin-6 (1.0 microg) and interleukin-2 (1.0 microg) on in vivo variations of monoamines were assessed in the nucleus accumbens. Administration of interleukin-1beta did not affect extracellular accumbal dopamine, provoked a modest rise of ho...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(98)00271-1

    authors: Song C,Merali Z,Anisman H

    更新日期:1999-01-01 00:00:00

  • Early deprivation, atypical brain development, and internalizing symptoms in late childhood.

    abstract::Children exposed to extreme early-life neglect such as in institutional rearing are at heightened risk for developing depression and anxiety disorders, and internalizing problems more broadly. These outcomes are believed to be due to alterations in the development of neural circuitry that supports emotion regulation. ...

    journal_title:Neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.neuroscience.2015.09.026

    authors: Bick J,Fox N,Zeanah C,Nelson CA

    更新日期:2017-02-07 00:00:00

  • Involvement of dorsal hippocampus glutamatergic and nitrergic neurotransmission in autonomic responses evoked by acute restraint stress in rats.

    abstract::The dorsal hippocampus (DH) is a structure of the limbic system that is involved in emotional, learning and memory processes. There is evidence indicating that the DH modulates cardiovascular correlates of behavioral responses to stressful stimuli. Acute restraint stress (RS) is an unavoidable stress situation that ev...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2013.11.022

    authors: Moraes-Neto TB,Scopinho AA,Biojone C,Corrêa FM,Resstel LB

    更新日期:2014-01-31 00:00:00

  • The growth-associated protein GAP-43 appears in dorsal root ganglion cells and in the dorsal horn of the rat spinal cord following peripheral nerve injury.

    abstract::When adult dorsal root ganglion cells are dissociated and maintained in vitro, both the small dark and the large light neurons show increases in the growth-associated protein GAP-43, a membrane phosphoprotein associated with neuronal development and plasticity. Immunoreactivity for GAP-43 appears in the cytoplasm of t...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(90)90155-w

    authors: Woolf CJ,Reynolds ML,Molander C,O'Brien C,Lindsay RM,Benowitz LI

    更新日期:1990-01-01 00:00:00

  • Microglia Do Not Take Up Soluble Amyloid-beta Peptides, But Partially Degrade Them by Secreting Insulin-degrading Enzyme.

    abstract::Microglia play important roles in the pathogenesis of Alzheimer's disease (AD), in part, by affecting the clearance of amyloid-β (Aβ) peptides. Most studies, however, used synthetic soluble Aβ (sAβ) at higher concentrations. The exact mechanisms underlying microglia-mediated clearance of physiological sAβ at very low ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2020.07.020

    authors: Fu H,Liu B,Li L,Lemere CA

    更新日期:2020-09-01 00:00:00

  • Oxytocin-induced stimulation and inhibition of bladder activity in normal, conscious rats--influence of nitric oxide synthase inhibition.

    abstract::The role of the oxytocin-containing projections to the autonomic nuclei of the spinal cord for lower urinary tract function has not been clarified. The hypothesis was tested that oxytocin acts as a mediator of bladder contraction at the spinal cord level. In conscious female rats undergoing continuous cystometry, intr...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(97)00651-9

    authors: Pandita RK,Nylén A,Andersson KE

    更新日期:1998-08-01 00:00:00

  • Increased expression of apoptosis-linked gene 2 (ALG2) in the rat brain after temporary focal cerebral ischemia.

    abstract::Calcium is an important mediator of programmed cell death induced by transient cerebral ischemia, and calcium-binding proteins have been implicated in calcium-regulated signal transduction. Apoptosis-linked gene 2 is a calcium-binding protein required for cell death induced by different apoptotic stimuli. By Western b...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(99)00531-x

    authors: Li W,Jin K,Nagayama T,He X,Chang J,Minami M,Graham SH,Simon RP,Greenberg DA

    更新日期:2000-01-01 00:00:00

  • FTY720 Improves Behavior, Increases Brain Derived Neurotrophic Factor Levels and Reduces α-Synuclein Pathology in Parkinsonian GM2+/- Mice.

    abstract::Parkinson's disease (PD) is a progressive aging disorder that affects millions worldwide, thus, disease-modifying-therapies are urgently needed. PD pathology includes α-synuclein (aSyn) accumulation as synucleinopathy. Loss of GM1 gangliosides occurs in PD brain, which is modeled in GM2 synthase transgenic mice. GM2+/...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2019.05.029

    authors: Vidal-Martinez G,Najera K,Miranda JD,Gil-Tommee C,Yang B,Vargas-Medrano J,Diaz-Pacheco V,Perez RG

    更新日期:2019-07-15 00:00:00

  • Induction of homosynaptic long-term depression at spinal synapses of sensory a delta-fibers requires activation of metabotropic glutamate receptors.

    abstract::The synaptic strength between primary afferent Adelta-fibers, many of which convey pain-related information, and second order neurons in the spinal dorsal horn can be depressed for prolonged periods of time in a use- and N-methyl-D-aspartate receptor-dependent fashion. Here, we have used a transverse spinal cord slice...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(00)00080-4

    authors: Chen J,Sandkühler J

    更新日期:2000-01-01 00:00:00

  • Distribution of somatostatin mRNA in the rat nervous system as visualized by a novel non-radioactive in situ hybridization histochemistry procedure.

    abstract::The cellular localization of preprosomatostatin mRNA in the rat brain and sensory ganglia has been examined in detail using a newly developed highly sensitive non-radioactive in situ hybridization histochemistry procedure. An alkaline phosphatase labelled anti-sense 30mer oligodeoxynucleotide probe was used for detect...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(90)90388-k

    authors: Kiyama H,Emson PC

    更新日期:1990-01-01 00:00:00

  • Protective effects of the alpha 2-adrenoceptor antagonist, dexefaroxan, against degeneration of the basalocortical cholinergic system induced by cortical devascularization in the adult rat.

    abstract::It has been hypothesized [Colpaert, F.C., 1994. In: Briley, M., Marien, M. (Eds.), Noradrenergic Mechanisms in Parkinson's Disease. CRC Press, Boca Raton, FL, pp. 225-254] that a deficiency in the noradrenergic system originating from the locus coeruleus is a decisive factor in the progression of central neurodegenera...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(02)00406-2

    authors: Debeir T,Marien M,Chopin P,Martel JC,Colpaert F,Raisman-Vozari R

    更新日期:2002-01-01 00:00:00

  • Muscle resistance to slow ramp weakly depends on activation level.

    abstract::The mechanical response of human m. flexor pollicis longus to slow (3.2 degrees/s) linear stretch by 5.5 degrees was measured during sustained (45-60 s, 9-13.5 p.p.s.) unfused tetanus evoked by electrical stimulation. The stiffness increased during unfused tetanus. At the late phase of unfused tetanus it was 1.8 +/- 0...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(97)00130-9

    authors: Gurfinkel VS,Ivanenko YP,Levik YS

    更新日期:1997-09-01 00:00:00

  • 3,4-Methylenedioxymethamphetamine (MDMA) Alters Synaptic Dopamine Release in the Dorsal Striatum Through Nicotinic Receptors and DAT Inhibition.

    abstract::An increase of extracellular dopamine (DA) has been implicated in the psychostimulant properties of 3,4-methylenedioxymethamphetamine (MDMA). Although this drug has been reported to affect the DA uptake transporter (DAT), it might activate other mechanisms to regulate the outflow of DA in the brain. Our aim was to exa...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2018.02.037

    authors: Rizzo FR,Federici M,Mercuri NB

    更新日期:2018-05-01 00:00:00

  • Dendritic arborization and axon trajectory of neurons in the hypothalamic arcuate nucleus of the rat--updated.

    abstract::Neurons in the hypothalamic arcuate nucleus (arcuate neurons) were traced on Golgi-impregnated sections. Dendrites of arcuate neurons showed characteristic orientation patterns. Dendrites along the lateral side follow the convex border of the nucleus by running parallel to the tanycyte processes. Neurons located in th...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(85)90005-3

    authors: Réthelyi M

    更新日期:1985-10-01 00:00:00

  • Amyloid-like inclusions in Huntington's disease.

    abstract::Huntington's disease is a progressive, autosomal dominantly inherited, neurodegenerative disease that is characterized by involuntary movements (chorea), cognitive decline and psychiatric manifestations. This is one of a number of late-onset neurodegenerative disorders caused by expanded glutamine repeats, with a like...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(00)00391-2

    authors: McGowan DP,van Roon-Mom W,Holloway H,Bates GP,Mangiarini L,Cooper GJ,Faull RL,Snell RG

    更新日期:2000-01-01 00:00:00

  • Thyroid hormone distribution in the mouse brain: the role of transthyretin.

    abstract::Transthyretin is the major thyroxine-binding protein in the plasma of rodents, and the main thyroxine-binding protein in the cerebrospinal fluid of both rodents and humans. The choroid plexus synthesizes transthyretin and secretes it to the cerebrospinal fluid. Although it was suggested that transthyretin might play a...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(02)00228-2

    authors: Palha JA,Nissanov J,Fernandes R,Sousa JC,Bertrand L,Dratman MB,Morreale de Escobar G,Gottesman M,Saraiva MJ

    更新日期:2002-01-01 00:00:00

  • Localization of VGLUT3, the vesicular glutamate transporter type 3, in the rat brain.

    abstract::We have recently identified a third subtype of glutamate vesicular transporter (VGLUT) named VGLUT3. In the present study, we provide a detailed account of the regional and cellular distributions of VGLUT3 in the rat brain, using specific nucleotide probes and antisera. The distribution of VGLUT3 protein was compared ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2003.10.039

    authors: Herzog E,Gilchrist J,Gras C,Muzerelle A,Ravassard P,Giros B,Gaspar P,El Mestikawy S

    更新日期:2004-01-01 00:00:00

  • Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid.

    abstract::Lysophosphatidic acid receptor (LPA(1)) signaling initiates neuropathic pain and several pathological events in a partial sciatic nerve injury model. Recently, we reported that lysophosphatidic acid (LPA) induces neuropathic pain as well as demyelination and pain-related protein expression changes via LPA(1) receptor ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2007.12.041

    authors: Inoue M,Xie W,Matsushita Y,Chun J,Aoki J,Ueda H

    更新日期:2008-03-18 00:00:00

  • The immunohistochemical localization of nine peptides in the sacral parasympathetic nucleus and the dorsal gray commissure in rat spinal cord.

    abstract::The sixth lumbar and first sacral spinal cord segments in the rat contain parasympathetic preganglionic neurons which innervate the pelvic viscera. There have been few studies, however, which have specifically considered the distribution of putative peptide neurotransmitters in these cord segments. The present paper d...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(84)90175-1

    authors: Sasek CA,Seybold VS,Elde RP

    更新日期:1984-07-01 00:00:00

  • Oxytocin and Stress: Neural Mechanisms, Stress-Related Disorders, and Therapeutic Approaches.

    abstract::Clinical reports show that oxytocin (OT) is related to stress-related disorders such as depression, anxiety disorder, and post-traumatic stress disorder. Two key structures in the brain should be paid special attention with regard to stress regulation, namely, the hypothalamus and the hippocampus. The former is the re...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2019.07.046

    authors: Matsushita H,Latt HM,Koga Y,Nishiki T,Matsui H

    更新日期:2019-10-01 00:00:00

  • Immunocytochemical visualization of kappa-opioid receptors on chick embryonic neurons differentiating in vitro.

    abstract::The present paper is the first immunocytochemical demonstration of kappa-opioid receptors in neurons isolated from seven-day-old chick embryonic forebrains and cultivated for one to seven days. The monoclonal antibody KA8 (IgG1-k) [Maderspach et al. (1991) J. Neurochem. 56, 1897-1904] was raised against the frog brain...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(93)90078-t

    authors: Maderspach K,Németh K

    更新日期:1993-11-01 00:00:00

  • Correlation between seizure intensity and stress protein expression after limbic epilepsy in the rat brain.

    abstract::Induction of heat shock/stress proteins is a key feature of a universal mechanism of cellular defence to injury known as the "stress response". The present study investigated whether heat shock protein expression correlates with the extent of neuronal injury inflicted by increasingly intense seizure activity. Limbic e...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(95)92049-p

    authors: Gass P,Prior P,Kiessling M

    更新日期:1995-03-01 00:00:00

  • Internalization of mu-opioid receptors produced by etorphine in the rat locus coeruleus.

    abstract::Chronic administration of mu-opioid receptor agonists is known to produce adaptive changes within noradrenergic neurons of the locus coeruleus. Although mu-opioid receptors are densely expressed by locus coeruleus neurons, the effects of acute and chronic administration of agonists on the subcellular distribution of m...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(01)00426-2

    authors: Van Bockstaele EJ,Commons KG

    更新日期:2001-01-01 00:00:00

  • Acute and chronic noradrenergic regulation of neurotrophin messenger RNA expression in rat hippocampus: evidence from lesions and organotypic cultures.

    abstract::Noradrenergic neurons from the locus coeruleus innervate several brain regions, such as hippocampus and cortex. The hippocampus exhibits the highest concentration of the neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 in the brain. To study the role of the noradrenergic system i...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(95)00346-k

    authors: Hutter P,Johansson M,Saria A,Humpel C

    更新日期:1996-01-01 00:00:00

  • Thyroid hormone regulates excitability in central neurons from postnatal rats.

    abstract::A lack of thyroid hormone in the postnatal period causes an irreversible mental retardation, characterized by a slowing of thoughts and movements accompanied by prolonged latencies of several evoked potentials and slowed electroencephalographic rhythms. Here we show that in cultured hippocampal and cortical neurons fr...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2004.01.047

    authors: Hoffmann G,Dietzel ID

    更新日期:2004-01-01 00:00:00

  • Analgesic Efficacy of α2 Adrenergic Receptor Agonists Depends on the Chronic State of Neuropathic Pain: Role of Regulator of G Protein Signaling 4.

    abstract::The analgesic effect of alpha-2 adrenergic receptor (α2AR) agonists, which relieve chronic neuropathic pain, is highly variable among individuals. Here, we used a mouse model of spared nerve injury (SNI) to show that treatment time after the establishment of neuropathic pain was important for the variability in the an...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2020.12.021

    authors: Yoon SY,Roh DH,Yeo JH,Woo J,Han SH,Kim KS

    更新日期:2020-12-25 00:00:00

  • Electrophysiological study of sympathoexcitatory structures of the bulbar ventrolateral surface as related to vasomotor regulation.

    abstract::The responses in T3-4, T10-11 and L2-3 white rami to stimulation of different zones of the bulbar ventrolateral surface were maximal when the region of about 4 mm laterally to the midline was stimulated. A weak surface stimulation of all these zones elicited only a long latency response consisting of three waves. A sh...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(86)90236-8

    authors: Lebedev VP,Krasyukov AV,Nikitin SA

    更新日期:1986-01-01 00:00:00

  • Zic1 levels regulate mossy fiber neuron position and axon laterality choice in the ventral brain stem.

    abstract::Pontine gray neurons of the brain stem are a major source of mossy fiber (MF) afferents to granule cells of the cerebellum. Achieving this connectivity involves an early regionalization of pontine gray neuron cell bodies within the brainstem pontine nuclei, as well as establishing the proper ratio of crossed versus un...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2009.02.082

    authors: Dipietrantonio HJ,Dymecki SM

    更新日期:2009-09-01 00:00:00