Abstract：
:Pannexins (Panx) constitute a new family of gap junction type proteins. Functional expression in paired Xenopus oocytes indicated that pannexins are capable of forming communicating junctions but also proved to be active in forming of unopposed hemichannels. In the vertebrate brain pannexins have been found in neurons. However, the subcellular cerebral localization of pannexin proteins which could gain first clues on their putative function is essentially unknown. Here we demonstrate by light and electron microscopical immunohistochemistry that Panx1 reveals postsynaptic localization in rodent hippocampal and cortical principal neurons accumulating at postsynaptic densities. The postsynaptic localization was corroborated by co-localization of Panx1 with postsynaptic density protein 95 (PSD-95), a prominent postsynaptic scaffolding protein, in hippocampal neurons expressing tagged versions of these proteins. The asymmetric synaptic distribution of Panx1 suggests that it may function in neurons as non-junctional channels (pannexons) at postsynaptic sites and comprises a novel component of the postsynaptic protein complex.
journal_name
Neurosciencejournal_title
Neuroscienceauthors
Zoidl G,Petrasch-Parwez E,Ray A,Meier C,Bunse S,Habbes HW,Dahl G,Dermietzel Rdoi
10.1016/j.neuroscience.2007.01.061subject
Has Abstractpub_date
2007-04-25 00:00:00pages
9-16issue
1eissn
0306-4522issn
1873-7544pii
S0306-4522(07)00093-0journal_volume
146pub_type
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