1H-MRS can monitor metabolites changes of lateral intraventricular BDNF infusion into a mouse model of Alzheimer's disease in vivo.

Abstract:

:Proton magnetic resonance spectroscopy (1H-MRS) can provide noninvasive detection of brain metabolite changes in vivo in Alzheimer's disease (AD). AD is a prevalent neurodegenerative disorder characterized by deposition of β-amyloid peptides (Aβ) in multiple brain regions. Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor whose level has been shown to be decreased in AD. BDNF supplementation can offer improvement in AD. However, the means of evaluation are still relatively limited. In the present study, 1H-MRS was applied to evaluate the therapeutic effects of bilateral intraventricular BDNF infusion into APP+PS1 (amyloid precursor protein+presenilin 1) transgenic mice. For comparison to the 1H-MRS changes in the prefrontal cortex, Morris water maze (MWM) test, Fluoro-Jade B staining and immunofluorescence for Aβ, glial fibrillary acidic protein and tropomyosin-related kinase B (TrkB) were also performed. Our results showed that N-acetylaspartate (NAA) levels increased and myo-inositol levels decreased in Tg-BDNF mice compared with Tg-PBS mice. But NAA level in Tg-BDNF mice was still lower than that in wild-type mice at 6weeks after infusion. These changes correlated with increased immunoreactivity of TrkB, reduced compact Aβ peptide and FJB+ neurons in Tg-BDNF mice compared to Tg-PBS mice. However, Tg-BDNF mice did not present obvious changes in behavior in the MWM. Taken together, we suggest that 1H-MRS may be a sensitive means of evaluating metabolic changes in response to therapeutic strategies in AD. Moreover, BDNF, may be a viable means of offering trophic support during disease.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Zhang W,Wang PJ,Li MH,Gao XL,Gu GJ,Shao ZH

doi

10.1016/j.neuroscience.2013.04.015

subject

Has Abstract

pub_date

2013-08-15 00:00:00

pages

40-9

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(13)00333-3

journal_volume

245

pub_type

杂志文章,收录出版
  • A cholinoceptive desynchronized sleep induction zone in the anterodorsal pontine tegmentum: locus of the sensitive region.

    abstract::Carbachol, a long-acting cholinergic agonist, was microinjected (4 micrograms/250 nl per 90 s) into 90 sites within the anterodorsal pontine tegmentum of four cats and the time to onset and percentage of time spent in a desynchronized sleep-like state during 40 min postinjection were calculated. Compared with more pos...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(90)90267-8

    authors: Yamamoto K,Mamelak AN,Quattrochi JJ,Hobson JA

    更新日期:1990-01-01 00:00:00

  • Schizophrenia affects speech-induced functional connectivity of the superior temporal gyrus under cocktail-party listening conditions.

    abstract::The superior temporal gyrus (STG) is involved in speech recognition against informational masking under cocktail-party-listening conditions. Compared to healthy listeners, people with schizophrenia perform worse in speech recognition under informational speech-on-speech masking conditions. It is not clear whether the ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2017.06.043

    authors: Li J,Wu C,Zheng Y,Li R,Li X,She S,Wu H,Peng H,Ning Y,Li L

    更新日期:2017-09-17 00:00:00

  • Depolarizing afterpotentials in myelinated axons of mammalian spinal cord.

    abstract::Microelectrode recordings were made from 5-10 micron dia axons of adult rat spinal cord in vitro. Action potentials in response to electrical stimulation were recorded intracellularly and electrical characteristics of the axons were examined by injecting current pulses through a bridge circuit. All action potentials l...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(85)90118-6

    authors: Blight AR,Someya S

    更新日期:1985-05-01 00:00:00

  • Neurocircuitry of two types of neurotensin-containing amacrine cells in the turtle retina.

    abstract::The ultrastructural features and synaptic contacts of two types of neurotensin-containing amacrine cells in turtle retina were examined by electron immunocytochemistry, and the retinal peptides were characterized using radioimmunoassay and high-pressure liquid chromatography. The two types of cell were distinguished o...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(87)90146-1

    authors: Eldred WD,Carraway RE

    更新日期:1987-05-01 00:00:00

  • Muscarinic receptor stimulation increases the spontaneous [3H]GABA release in the rat substantia nigra through muscarinic receptors localized on striatonigral terminals.

    abstract::The effect of muscarinic agonists on the spontaneous release of [3H]GABA was investigated in vitro on rat substantia nigra slices. Acetylcholine (5 x 10(-5) M) in the presence of eserine (5 x 10(-5) M) induced a 12.3% increase of the spontaneous release of [3H]GABA. Similarly, carbachol (5 x 10(-4) M) enhanced by 9% t...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(94)90567-3

    authors: Kayadjanian N,Gioanni H,Ménetrey A,Besson MJ

    更新日期:1994-12-01 00:00:00

  • Icariside II, a novel phosphodiesterase-5 inhibitor, attenuates streptozotocin-induced cognitive deficits in rats.

    abstract::Beta-amyloid (Aβ) deposition and neuroinflammation are involved in Alzheimer's disease (AD)-type neurodegeneration with cognitive deficits. Phosphodiesterase-5 (PDE5) inhibitors have recently been studied as a potential target for cognitive enhancement by reducing inflammatory responses and Aβ levels. The present stud...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2016.04.022

    authors: Yin C,Deng Y,Gao J,Li X,Liu Y,Gong Q

    更新日期:2016-07-22 00:00:00

  • Maternal Consumption of High-fat Diet in Mice Alters Hypothalamic Notch Pathway, NPY Cell Population and Food Intake in Offspring.

    abstract::Studies show that maternal consumption of a high-fat diet (HFD) can impair the formation of hypothalamic neuronal circuits in mouse offspring. This damage can be mediated by Notch1/Hes5 signaling activation, leading to repression of proneural factors such as Mash1 and Ngn2/3, which are essential for neuronal different...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2017.11.043

    authors: Lemes SF,de Souza ACP,Payolla TB,Versutti MD,de Fátima da Silva Ramalho A,Mendes-da-Silva C,Souza CM,Milanski M,Torsoni AS,Torsoni MA

    更新日期:2018-02-10 00:00:00

  • Transient receptor potential vanilloid 1, vanilloid 2 and melastatin 8 immunoreactive nerve fibers in human skin from individuals with and without Norrbottnian congenital insensitivity to pain.

    abstract::Transient receptor potential vanilloid 1 (TRPV1), vanilloid 2 (TRPV2) and melastatin 8 (TRPM8) are thermosensitive cation channels expressed on primary sensory neurons. In contrast to TRPV1, which is present on nociceptive primary afferents and keratinocytes in human skin, less is known about the distribution of TRPV2...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2009.05.052

    authors: Axelsson HE,Minde JK,Sonesson A,Toolanen G,Högestätt ED,Zygmunt PM

    更新日期:2009-09-15 00:00:00

  • Immunolocalization of ecto-nucleoside triphosphate diphosphohydrolase 3 in rat brain: implications for modulation of multiple homeostatic systems including feeding and sleep-wake behaviors.

    abstract::Three anti-peptide antisera were raised against three distinct amino acid sequences of ecto-nucleoside triphosphate diphosphohydrolase 3 (NTPDase3), characterized by Western blot analyses, and used to determine the distribution of NTPDase3 protein in adult rat brain. The three antisera all yielded similar immunolocali...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2005.08.086

    authors: Belcher SM,Zsarnovszky A,Crawford PA,Hemani H,Spurling L,Kirley TL

    更新日期:2006-01-01 00:00:00

  • Neonatal inhibition of brain estrogen synthesis alters adult neural Fos responses to mating and pheromonal stimulation in the male rat.

    abstract::Neonatal inhibition of brain estrogen formation in male rats by administration of the aromatase inhibitor, 1,4,6-androstatriene-3,17-dione (ATD), permanently changes aspects of their mating behavior and partner preference in adulthood. The medial preoptic area receives chemosensory inputs via a sexually dimorphic vome...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(96)00096-6

    authors: Bakker J,Baum MJ,Slob AK

    更新日期:1996-09-01 00:00:00

  • Large dense-core vesicle exocytosis from mouse dorsal root ganglion neurons is regulated by neuropeptide Y.

    abstract::Peptidergic dorsal root ganglion (DRG) neurons transmit sensory and nociceptive information from the periphery to the central nervous system. Their synaptic activity is profoundly affected by neuromodulatory peptides stored and released from large dense-core vesicles (LDCVs). However, the mechanism of peptide secretio...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2017.01.006

    authors: Bost A,Shaib AH,Schwarz Y,Niemeyer BA,Becherer U

    更新日期:2017-03-27 00:00:00

  • Ethanol dually modulates GABAergic synaptic transmission onto dopaminergic neurons in ventral tegmental area: role of mu-opioid receptors.

    abstract::The mesolimbic dopaminergic system, originating from the ventral tegmental area (VTA) is implicated in the rewarding properties of ethanol. VTA dopaminergic neurons are under the tonic control of GABAergic innervations. Application of GABAergic agents changes ethanol consumption. However, it is unclear how acute ethan...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2008.01.040

    authors: Xiao C,Ye JH

    更新日期:2008-04-22 00:00:00

  • Genetic deletion or antagonism of kinin B(1) and B(2) receptors improves cognitive deficits in a mouse model of Alzheimer's disease.

    abstract::Increased brain deposition of amyloid beta protein (Abeta) and cognitive deficits are classical signs of Alzheimer's disease (AD) that have been widely associated to inflammatory response. We have recently shown that a single i.c.v. injection of aggregated beta-amyloid peptide-(1-40) (Abeta(1-40)) (400 pmol/mouse) res...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2007.11.009

    authors: Prediger RD,Medeiros R,Pandolfo P,Duarte FS,Passos GF,Pesquero JB,Campos MM,Calixto JB,Takahashi RN

    更新日期:2008-02-06 00:00:00

  • Gray matter damage in multiple sclerosis: Impact on clinical symptoms.

    abstract::Traditionally, multiple sclerosis (MS) is considered to be a disease primarily affecting the white matter (WM). However, the development of some clinical symptoms such as cognitive impairment cannot be fully explained by the severity of WM pathology alone. During the past decades it became clear that gray matter (GM) ...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2015.07.006

    authors: van Munster CE,Jonkman LE,Weinstein HC,Uitdehaag BM,Geurts JJ

    更新日期:2015-09-10 00:00:00

  • Lithium suppresses excitotoxicity-induced striatal lesions in a rat model of Huntington's disease.

    abstract::Huntington's disease is a progressive, inherited neurodegenerative disorder characterized by the loss of subsets of neurons primarily in the striatum. In this study, we assessed the neuroprotective effect of lithium against striatal lesion formation in a rat model of Huntington's disease in which quinolinic acid was u...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(01)00311-6

    authors: Wei H,Qin ZH,Senatorov VV,Wei W,Wang Y,Qian Y,Chuang DM

    更新日期:2001-01-01 00:00:00

  • Dopaminergic regulation of striatal proenkephalin mRNA and prodynorphin mRNA: contrasting effects of D1 and D2 antagonists.

    abstract::In situ hybridization was used to measure the levels of proenkephalin mRNA and prodynorphin mRNA in regions of rat striatum and nucleus accumbens. Chronic administration of haloperidol (2.4 mg/kg/day for 7 days) increased the levels of proenkephalin mRNA in both striatum and nucleus accumbens. In contrast, the levels ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(88)90256-4

    authors: Morris BJ,Höllt V,Herz A

    更新日期:1988-05-01 00:00:00

  • Neurogenesis in adolescent brain is potently inhibited by ethanol.

    abstract::Adolescence is a period of progressive changes in brain that likely contribute to the maturation of behavior. Human adolescents consume large amounts of ethanol. To investigate the effects of ethanol on adolescent neural progenitor cells, male rats (35-40 days old) were treated with an acute dose of ethanol (1.0, 2.5 ...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2005.08.090

    authors: Crews FT,Mdzinarishvili A,Kim D,He J,Nixon K

    更新日期:2006-01-01 00:00:00

  • Analysis of parvalbumin and calbindin D28k-immunoreactive neurons in dorsal root ganglia of rat in relation to their cytochrome oxidase and carbonic anhydrase content.

    abstract::Histochemical and immunohistochemical techniques were used to determine relationships between the parvalbumin or calbindin D28k content and the cytochrome oxidase or carbonic anhydrase activity of neurons in lumbar dorsal root ganglia in rat. Subpopulations of dorsal root ganglion neurons that displayed parvalbumin- o...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(89)90216-9

    authors: Carr PA,Yamamoto T,Karmy G,Baimbridge KG,Nagy JI

    更新日期:1989-01-01 00:00:00

  • The Selective Glucocorticoid Receptor Modulator Cort 113176 Reduces Neurodegeneration and Neuroinflammation in Wobbler Mice Spinal Cord.

    abstract::Wobbler mice are experimental models for amyotrophic lateral sclerosis. As such they show motoneuron degeneration, motor deficits, and astrogliosis and microgliosis of the spinal cord. Additionally, Wobbler mice show increased plasma, spinal cord and brain corticosterone levels and focal adrenocortical hyperplasia, su...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2018.05.042

    authors: Meyer M,Lara A,Hunt H,Belanoff J,de Kloet ER,Gonzalez Deniselle MC,De Nicola AF

    更新日期:2018-08-01 00:00:00

  • Altered adrenergic receptor signaling following traumatic brain injury contributes to working memory dysfunction.

    abstract::The prefrontal cortex is highly vulnerable to traumatic brain injury (TBI) and its structural and/or functional alterations as a result of TBI can give rise to persistent working memory (WM) dysfunction. Using a rodent model of TBI, we have described profound WM deficits following TBI that are associated with increase...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2010.10.048

    authors: Kobori N,Hu B,Dash PK

    更新日期:2011-01-13 00:00:00

  • The effect of selective serotonergic neurotoxin treatment on tachykinin levels in the rat ventral spinal cord.

    abstract::The levels of 5-hydroxytryptamine and tachykinin neuropeptides substance P, neurokinin A, neurokinin B and neuropeptide K were measured in the spinal cord of rats treated by intraventricular injection of the selective serotonergic neurotoxin 5,7-dihydroxytryptamine. The spinal cord levels of 5-hydroxytryptamine as mea...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(91)90231-c

    authors: Franck J,Brodin E,Fried K,Rosén A,Yamamoto Y,Fried G

    更新日期:1991-01-01 00:00:00

  • Maintaining stable memory engrams: new roles for Nogo-A in the CNS.

    abstract::Nogo-A interaction with its different receptors (Nogo receptor 1 (NgR1), S1P receptor 2 (S1PR2), paired immunoglobulin-like receptor B (PirB)) restricts plasticity and growth-dependent processes leading, via the activation of different signaling pathway to the stabilization of the neuronal networks (either development...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuroscience.2014.08.030

    authors: Zagrebelsky M,Korte M

    更新日期:2014-12-26 00:00:00

  • Functional development of the vagal and glossopharyngeal nerve-related nuclei in the embryonic rat brainstem: optical mapping with a voltage-sensitive dye.

    abstract::We investigated functional organization of the vagus nerve (N. X)- and glossopharyngeal nerve (N. IX)-related nuclei in the embryonic rat brainstem and compared their development and spatial distribution patterns, using multiple-site optical recording with a fast voltage-sensitive dye, NK2761. Intact brainstem prepara...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2011.06.019

    authors: Momose-Sato Y,Nakamori T,Sato K

    更新日期:2011-09-29 00:00:00

  • Neuronal plasticity in the hedgehog supraoptic nucleus during hibernation.

    abstract::The purpose of the present study was to identify processes of plasticity in the receptive field of neurosecretory neurons of the supraoptic nucleus during hibernation in the hedgehog, in order to correlate them with the increased neurosecretory activity observed in this nucleus during this annual period. Using the Rap...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(89)90396-5

    authors: Sanchez-Toscano F,Caminero AA,Machin C,Abella G

    更新日期:1989-01-01 00:00:00

  • GABA mechanisms and sleep.

    abstract::GABA is the main inhibitory neurotransmitter of the CNS. It is well established that activation of GABA(A) receptors favors sleep. Three generations of hypnotics are based on these GABA(A) receptor-mediated inhibitory processes. The first and second generation of hypnotics (barbiturates and benzodiazepines respectivel...

    journal_title:Neuroscience

    pub_type: 杂志文章,评审

    doi:10.1016/s0306-4522(02)00034-9

    authors: Gottesmann C

    更新日期:2002-01-01 00:00:00

  • Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11alpha protein up-regulation in Alzheimer's disease.

    abstract::Besides formation of neurofibrillary tangles and neuron loss, the Alzheimer's disease brain is characterized by neuritic plaques consisting of beta-amyloid peptide deposits and impaired neurotransmission. The proteins Munc18a, Munc18-interacting protein 1 and Munc18-interacting protein 2 mediate exocytosis and decreas...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/j.neuroscience.2005.11.017

    authors: Jacobs EH,Williams RJ,Francis PT

    更新日期:2006-01-01 00:00:00

  • Opiate receptors modulate estrogen-induced cholecystokinin and tachykinin but not enkephalin messenger RNA levels in the limbic system and hypothalamus.

    abstract::Cholecystokinin, substance P and methionine enkephalin all regulate the display of reproductive behaviour. Their expression is exquisitely regulated by estrogen in the limbic-hypothalamic circuit, a circuit that regulates the display of estrogen-sensitive female reproductive behavior. Relatively little is known, howev...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(97)00072-9

    authors: Eckersell CB,Micevych PE

    更新日期:1997-09-01 00:00:00

  • Increased level of neurokinin-1 tachykinin receptor gene expression during early postnatal development of rat brain.

    abstract::Substance P is known to elicit diverse actions via activating multiple subtypes of tachykinin receptors, and these actions appear to be involved not only in synaptic transmission but also in synaptic plasticity during development of the mammalian central nervous system. The availability of sensitive quantitation of in...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(96)00198-4

    authors: Taoka M,Song SY,Kubota M,Minegishi A,Yamakuni T,Konishi S

    更新日期:1996-10-01 00:00:00

  • Dye coupling among immunocytochemically identified neurons in the supraoptic nucleus: increased incidence in lactating rats.

    abstract::The hypothesis that electrotonic spread among oxytocinergic neurons contributes to synchronized bursting in the lactating rat leads to the prediction that coupling among oxytocinergic neurons would be stronger and more abundant in lactating than in non-lactating animals. We tested this prediction using, as an index of...

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/0306-4522(87)90047-9

    authors: Hatton GI,Yang QZ,Cobbett P

    更新日期:1987-06-01 00:00:00

  • The electroreceptor organ of the catfish, Ictalurus melas, as a model for cisplatin-induced ototoxicity.

    abstract::The ototoxic side-effects of the anti-cancer drug cisplatin (cis-diaminedichloroplatinum) have been widely investigated. However, the exact site of action remains unclear. In this study, the electroreceptor organ of the freshwater catfish Ictalurus melas is used as a model for examining the acute effects of cisplatin....

    journal_title:Neuroscience

    pub_type: 杂志文章

    doi:10.1016/s0306-4522(98)00658-7

    authors: Peters RC,Mommersteeg PM,Heijmen PS

    更新日期:1999-01-01 00:00:00