Dietary cholesterol increases ventricular volume and narrows cerebrovascular diameter in a rabbit model of Alzheimer's disease.

abstract：:In the present study plastic neural responses to N-methyl-D-aspartate-induced excitotoxic lesions and the neuroprotective effects of the L-type voltage-dependent Ca(2+) channel antagonist nimodipine were investigated in the rat magnocellular nucleus basalis. Assessment of spontaneous behaviour in the elevated plus maz...

journal_title：Neuroscience

authors： Harkany T,Dijkstra IM,Oosterink BJ,Horvath KM,Abrahám I,Keijser J,Van der Zee EA,Luiten PG

更新日期：2000-01-01 00:00:00

abstract：:GABAA-receptors in the brain display a striking structural heterogeneity, which is based on a multiplicity of diverse subunits. The allocation of GABAA-receptor subtypes to identified neurons is essential for an analysis of the functional significance of receptor heterogeneity. Among GABA-receptive neurons, well-chara...

journal_title：Neuroscience

authors： Gao B,Fritschy JM,Benke D,Mohler H

更新日期：1993-06-01 00:00:00

abstract：:Endocannabinoids and somatostatin (SST) play critical roles in several pathophysiological conditions via binding to different receptor subtypes. Cannabinoid receptor 1 (CB1R) and somatostatin receptors (SSTRs) are expressed in several brain regions and share overlapping functions. Whether these two prominent members o...

journal_title：Neuroscience

authors： Zou S,Somvanshi RK,Kumar U

更新日期：2017-01-06 00:00:00

abstract：:Intraspecific confrontation has been used to study effect of depleting central serotonin on the adaptation of male rats to repeated social stress (social defeat). Four groups of adult male rats were used (serotonin depletion/sham: stressed; serotonin depletion/sham: non-stressed). Central serotonin was reduced (by 59-...

journal_title：Neuroscience

authors： Chung KK,Martinez M,Herbert J

更新日期：1999-01-01 00:00:00

abstract：:In order to develop a rodent model displaying a progressive degeneration of the dopamine neurons of the substantia nigra, we bilaterally injected the tracer substance FluoroGold into the terminal field of the nigrostriatal projection, i.e. the striatum. One week later, rats received unilateral injections of 20 microgr...

journal_title：Neuroscience

authors： Sauer H,Oertel WH

更新日期：1994-03-01 00:00:00

abstract：:Increasing evidence indicates that both the ATP P2X receptors and adrenergic systems play a very important role in the development of nociception. However, there is little information concerning the interactions between these two systems in the dorsal root ganglia (DRG). In the present study, we examined the effects o...

journal_title：Neuroscience

authors： Tan Y,Sun L,Zhang Q

更新日期：2011-03-10 00:00:00

abstract：:Previous studies have shown that amphetamine (AMPH) markedly activates dopaminergic projection areas, together with some important limbic nuclei. However, a global picture of the brain areas activated is lacking and the contribution of the dose of the drug and individual differences to this global brain activation is ...

journal_title：Neuroscience

authors： Rotllant D,Márquez C,Nadal R,Armario A

更新日期：2010-07-14 00:00:00

abstract：:The mesolimbic dopaminergic system, originating from the ventral tegmental area (VTA) is implicated in the rewarding properties of ethanol. VTA dopaminergic neurons are under the tonic control of GABAergic innervations. Application of GABAergic agents changes ethanol consumption. However, it is unclear how acute ethan...

journal_title：Neuroscience

authors： Xiao C,Ye JH

更新日期：2008-04-22 00:00:00

abstract：:The synaptic organization of terminals originating either from the spinal cord (spinothalamic) or from the dorsal column nuclei (lemniscal) was investigated in the ventrobasal complex of the rat thalamus. Wheatgerm agglutinin conjugated to horseradish peroxidase was used as an anterogradely transported axonal tracer, ...

journal_title：Neuroscience

authors： Ma W,Peschanski M,Ralston HJ 3rd

更新日期：1987-09-01 00:00:00

abstract：:Brain structural connectivity is known to be altered in cases of intrauterine growth restriction and premature birth, although the specific effect of maternal nutritional restriction, a common burden in human populations, has not been assessed yet. Here we analyze the effects of maternal undernutrition during pregnanc...

journal_title：Neuroscience

authors： Barbeito-Andrés J,Gleiser PM,Bernal V,Hallgrímsson B,Gonzalez PN

更新日期：2018-06-01 00:00:00

abstract：:Light and electron microscopic immunocytochemical methods were used to study the distribution and the morphology of substance P-positive fibers and axon terminals in the dorsal column nuclei of rats and cats, and to determine whether they are part of an ascending input to these nuclei. In rats, substance P-positive fi...

journal_title：Neuroscience

authors： Conti F,De Biasi S,Giuffrida R,Rustioni A

更新日期：1990-01-01 00:00:00

abstract：:The hippocampal CA1 region receives cortical information via two main inputs: directly via the perforant (temporoammonic) path (pp-CA1 synapse) and indirectly via the tri-synaptic pathway. Although synaptic plasticity has been reported at the pp-CA1 synapse of freely behaving animals, the mechanisms underlying this ph...

journal_title：Neuroscience

authors： Aksoy-Aksel A,Manahan-Vaughan D

更新日期：2015-11-19 00:00:00

abstract：:Exposure to severe stress leads to development of neuropsychiatric disorders, including depression and Post-Traumatic Stress Disorder (PTSD) in at-risk individuals. Neuropeptide Y (NPY) is associated with resilience or improved recovery. Therefore exogenous administration to the brain has therapeutic potential althoug...

journal_title：Neuroscience

authors： Serova LI,Tillinger A,Alaluf LG,Laukova M,Keegan K,Sabban EL

更新日期：2013-04-16 00:00:00

abstract：:Previous studies show that most short thoracic propriospinal (TPS; T5-T7) and long descending propriospinal tract (LDPT; C4-C6) neurons are lost following low-thoracic spinal cord contusion injury (cSCI), as assessed by retrograde labeling with fluorogold (FG). Gene microarray and terminal deoxynucleotidyl transferase...

journal_title：Neuroscience

authors： Conta Steencken AC,Smirnov I,Stelzner DJ

更新日期：2011-10-27 00:00:00

abstract：:Nuclear factor-kappa B (NF-κB) is a ubiquitous transcription factor that regulates immune and cell-survival signaling pathways. NF-κB has been reported to be present in neurons wherein it reportedly responds to immune and toxic stimuli, glutamate, and synaptic activity. However, because the brain contains many cell ty...

journal_title：Neuroscience

authors： Listwak SJ,Rathore P,Herkenham M

更新日期：2013-10-10 00:00:00

abstract：:Efr3a has been found to be involved in the functional maintenance and structural degeneration of sensory and motor nervous tissues. Our previous data have suggested that Efr3a may be associated with the initiation of the degeneration of spiral ganglion neurons (SGNs). In this study, we used Efr3a knockdown (Efr3a KD) ...

journal_title：Neuroscience

authors： Hu H,Ma Y,Ye B,Wang Q,Yang T,Lv J,Shi J,Wu H,Xiang M

更新日期：2017-01-26 00:00:00

abstract：:Substantial human and animal data suggest a correlation between hypertension and memory impairment that may appear prior to overt manifestations of cerebrovascular pathology. It is unclear, however, whether hypertension plays a causal role in these memory deficits, whether hypertension and cognitive impairment are eac...

journal_title：Neuroscience

authors： Terry AV Jr,Hernandez CM,Buccafusco JJ

更新日期：2001-01-01 00:00:00

abstract：:Administration of kainic acid induces acute seizures that result in the loss of neurons, gliosis and reorganization of mossy fiber pathways in the hippocampus resembling those observed in human temporal lobe epilepsy. Although these structural changes have been well characterized, the mechanisms underlying the degener...

journal_title：Neuroscience

authors： Banerjee M,Sasse VA,Wang Y,Maulik M,Kar S

更新日期：2015-01-22 00:00:00

abstract：:The effect of a transient increase in extracellular calcium concentration on the Schaffer collateral-commissural evoked excitatory postsynaptic potential and population spike responses of CAI pyramidal neurons was investigated using the rat in vitro hippocampal slice preparation. Brief exposure of slices (5-10 min) to...

journal_title：Neuroscience

authors： Turner RW,Baimbridge KG,Miller JJ

更新日期：1982-06-01 00:00:00

abstract：:A new mammalian neuromuscular preparation is introduced for physiology and microscopy of all sorts: the intrinsic muscle of the mouse ear. The great utility of this preparation is demonstrated by illustrating how it has permitted us to develop a wholly new technique for staining muscle T-tubules, the critical conducti...

journal_title：Neuroscience

authors： Heuser JE,Tenkova TI

更新日期：2020-07-15 00:00:00

abstract：:Studies in rats and mice have shown several sex-dependent functional and structural differences in the hippocampal region, a brain structure playing a key role in learning and memory. The aim of the present study was to establish whether sex differences exist prior to puberty in the stereological parameters of the den...

journal_title：Neuroscience

authors： Severi S,Guidi S,Ciani E,Bartesaghi R

更新日期：2005-01-01 00:00:00

abstract：:Acute osmolar loading of cerebrospinal fluid within one lateral ventricle of dogs was examined as a cause of water extraction from the bloodstream and an increase in intracranial pressure. We have shown that a certain amount of (3)H₂O from the bloodstream enters osmotically loaded cerebrospinal fluid significantly fas...

journal_title：Neuroscience

authors： Klarica M,Miše B,Vladić A,Radoš M,Orešković D

更新日期：2013-09-17 00:00:00

abstract：:We investigated immunohistochemically the cellular localization of multifunctional type II Ca2+/calmodulin-dependent protein kinase in the rat basal ganglia and intrastriatal grafts derived from fetal striatal primordia, in comparison with that of calcineurin, a reliable marker for striatal medium-sized spinous neuron...

journal_title：Neuroscience

authors： Goto S,Yamada K,Oyama T,Korematsu K,Nagahiro S,Ushio Y,Fukunaga K,Miyamoto E,Hofer W

更新日期：1994-10-01 00:00:00

abstract：:We have re-examined in the rat the nuclear localization of the medullary catecholamine-containing cell groups (A1 and A2) and their relation to the vagal motor nuclei using a double labeling method. The vagal nuclei were defined by the retrograde transport of horseradish peroxidase applied to the cervical vagus, and n...

journal_title：Neuroscience

authors： Ritchie TC,Westlund KN,Bowker RM,Coulter JD,Leonard RB

更新日期：1982-06-01 00:00:00

abstract：:In some brain regions, previous studies reported the frequent coexistence between neuronal nitric oxide synthase (nNOS) and somatostatin (SOM). In the hippocampus, nNOS and SOM were mainly expressed in GABAergic nonprincipal neurons. Here we estimated the immunocytochemical colocalization of nNOS and SOM in the mouse ...

journal_title：Neuroscience

authors： Jinno S,Kosaka T

更新日期：2004-01-01 00:00:00

abstract：:Lamina I of the spinal dorsal horn contains a diverse mixture of neurons. Among these, a group of giant neurons (Waldeyer cells) has long been recognized. In this study we have used immunocytochemistry to characterize a population of Waldeyer cells which were identified by the presence of high levels of the glycine re...

journal_title：Neuroscience

authors： Puskár Z,Polgár E,Todd AJ

更新日期：2001-01-01 00:00:00

abstract：:Further cytochemical studies on the ultrastructural localization of 5'-nucleotidase in the rat retina have revealed activity to be associated with the complex synapses formed by the rod spherules of the receptors and the bipolar and horizontal cell processes. Activity was also seen on the axolemma of receptor fibers. ...

journal_title：Neuroscience

authors： Kreutzberg GW,Hussain ST

更新日期：1984-04-01 00:00:00

abstract：:Resident microglia are involved in immune responses of the central nervous system and may contribute to neuronal degeneration and death. Here, we tested in adult rats whether injection of bacterial lipopolysaccharide (which causes inflammation and microglial activation) just above the substantia nigra, results in the ...

journal_title：Neuroscience

authors： Lu X,Bing G,Hagg T

更新日期：2000-01-01 00:00:00

abstract：:We have previously observed that migraine attacks impervious to triptan therapy were readily terminated by subsequent i.v. administration of the non-steroidal anti-inflammatory drug (NSAID) ketorolac. Since such attacks were associated with periorbital allodynia--a symptom of central sensitization--we examined whether...

journal_title：Neuroscience

authors： Jakubowski M,Levy D,Kainz V,Zhang XC,Kosaras B,Burstein R

更新日期：2007-08-24 00:00:00

abstract：:Depolarization-induced transmitter release in synaptosomes prepared from the hippocampus of aged rats is decreased compared with release from young animals. Although the underlying cause of this deficit is not known, some evidence suggests that increased membrane rigidity may contribute to these age-related synaptic c...

journal_title：Neuroscience

authors： McGahon BM,Martin DS,Horrobin DF,Lynch MA

更新日期：1999-01-01 00:00:00