Development and retraction of a crossed retinal projection to the inferior colliculus in neonatal pigmented rats.

abstract：:Correlated pre- and postsynaptic activity is thought to promote maturation of excitatory synapses in the developing brain by directing AMPA receptors to pure NMDA synapses. However, this hypothesis has not been tested in vivo. Here, we have performed such test by inhibiting correlated neural activity in vivo using a s...

journal_title：Neuroscience

authors： Groc L,Gustafsson B,Hanse E

更新日期：2003-01-01 00:00:00

abstract：:3-Nitropropionic acid (3-NP), an irreversible inhibitor of succinate dehydrogenase, induced ATP depletion and both necrosis and apoptosis in human NT2-N neurons. Necrosis occurred predominantly within the first two days, and increased in a dose-dependent fashion with the concentration of 3-NP, whereas apoptosis was ob...

journal_title：Neuroscience

authors： Lee WT,Itoh T,Pleasure D

更新日期：2002-01-01 00:00:00

abstract：:Exposure to severe stress leads to development of neuropsychiatric disorders, including depression and Post-Traumatic Stress Disorder (PTSD) in at-risk individuals. Neuropeptide Y (NPY) is associated with resilience or improved recovery. Therefore exogenous administration to the brain has therapeutic potential althoug...

journal_title：Neuroscience

authors： Serova LI,Tillinger A,Alaluf LG,Laukova M,Keegan K,Sabban EL

更新日期：2013-04-16 00:00:00

abstract：:Physiological and anatomical investigations are commonly combined in experimental models. When studying the lower urinary tract (LUT), it is often of interest to perform both urodynamic studies and retrogradely labeled neurons innervating the peripheral target organs. However, it is not known whether the use of anatom...

journal_title：Neuroscience

authors： Chang HY,Havton LA

更新日期：2010-03-10 00:00:00

abstract：:Hippocampal neurogenesis in adult mammals is influenced by many factors. Lesioning of the entorhinal cortex is a standard model used to study injury and repair in the hippocampus. Here we use bromodeoxyuridine (BrdU) labeling combined with immunohistochemical identification using cell type specific markers to follow t...

journal_title：Neuroscience

authors： Gama Sosa MA,Wen PH,De Gasperi R,Perez GM,Senturk E,Friedrich VL Jr,Elder GA

更新日期：2004-01-01 00:00:00

abstract：:The role of agrin in synaptogenesis has been extensively studied. On the other hand, little is known about the function of this extracellular matrix protein during developmental processes that precede the formation of synapses. Recently, agrin was shown to regulate the rate of neurite elongation and the behavior of gr...

journal_title：Neuroscience

authors： Bergstrom RA,Sinjoanu RC,Ferreira A

更新日期：2007-11-09 00:00:00

abstract：:This good laboratory practice (GLP) study of aluminum salts in Sprague-Dawley rats was conducted according to double-blind, vehicle-controlled randomized design by exposing offspring to aluminum citrate in-utero, through lactation, and then in drinking water post-weaning. Three dose levels were used: 30, 100, 300 mg A...

journal_title：Neuroscience

authors： Poirier J,Semple H,Davies J,Lapointe R,Dziwenka M,Hiltz M,Mujibi D

更新日期：2011-10-13 00:00:00

abstract：:Neural injury triggers changes in the expression of a large number of gene families. Particularly interesting are those encoding proteins involved in the generation, propagation or restoration of electric potentials. The expression of the Na+, K+-ATPase subunit isoforms (alpha, beta and gamma) was studied in dorsal ro...

journal_title：Neuroscience

authors： Arteaga MF,Gutiérrez R,Avila J,Mobasheri A,Díaz-Flores L,Martín-Vasallo P

更新日期：2004-01-01 00:00:00

abstract：:The aim of this study was to assess the effect of blocking the axonal transport of sensory neuropeptides, by local injection of colchicine at pelvic ganglia level, on the sensory and efferent functions mediated by capsaicin-sensitive primary afferent neurons innervating the rat urinary bladder. Bilateral injection of ...

journal_title：Neuroscience

authors： Lecci A,Patacchini R,De Giorgio R,Corinaldesi R,Theodorsson E,Giuliani S,Santicioli P,Maggi CA

更新日期：1996-03-01 00:00:00

abstract：:The rat brain and spinal cord have been mapped for Type II glucocorticoid receptor-like immunoreactivity in neurons and glia, using a monoclonal antibody, BUGR2, which recognizes an epitope close to the DNA-binding domain of the rat Type II receptor. The study revealed a widespread distribution of Type II-like immunor...

journal_title：Neuroscience

authors： Ahima RS,Harlan RE

更新日期：1990-01-01 00:00:00

abstract：:Sexually experienced male rats infused bilaterally into the amygdala with 60 pmol beta-endorphin show decreased rate of precopulatory investigation of the female and delayed intromission latency, but copulation is left unaltered. Such males are still able to discriminate between the odours of bedding from receptive an...

journal_title：Neuroscience

authors： McGregor A,Herbert J

更新日期：1992-01-01 00:00:00

abstract：:Apart from its role in regulating calcium there is growing evidence that vitamin D is a neuroactive steroid capable of regulating multiple pathways important for both brain development and mature brain function. Vitamin D induces its genomic effects through its nuclear receptor the vitamin D receptor (VDR). Although t...

journal_title：Neuroscience

authors： Eyles DW,Liu PY,Josh P,Cui X

更新日期：2014-05-30 00:00:00

abstract：:Amyloid-β (Aβ) production and clearance in the brain is a crucial focus of investigations into the pathogenesis of Alzheimer disease. Imbalance between production and clearance leads to accumulation of Aβ. The important Aβ-degrading enzymes in the brain are neprilysin (NEP) and insulin-degrading enzyme (IDE), and defe...

journal_title：Neuroscience

authors： Yamamoto N,Shibata M,Ishikuro R,Tanida M,Taniguchi Y,Ikeda-Matsuo Y,Sobue K

更新日期：2017-10-24 00:00:00

abstract：:Experiment 1 investigated the effects of catecholaminergic deafferentation or cell body lesions of the amygdala on fear conditioning to explicit and contextual cues. Bilateral infusions of quinolinic acid mainly damaged neurons within the basolateral region of the amygdala. 6-Hydroxydopamine infusions at the same coor...

journal_title：Neuroscience

authors： Selden NR,Everitt BJ,Jarrard LE,Robbins TW

更新日期：1991-01-01 00:00:00

abstract：:Considerable evidence suggests that dynorphin participates in the regulation of energy balance. In this study, we have used immunohistochemistry to investigate in detail the cellular localization of pro-dynorphin (DYN) immunoreactive cell bodies in the mediobasal hypothalamus with special reference to neurons producin...

journal_title：Neuroscience

authors： Maolood N,Meister B

更新日期：2008-06-26 00:00:00

abstract：:The development of chronic pain is associated with activity-dependent plastic changes in neuronal structures in the peripheral and central nervous system. In order to investigate the time-dependent processing of afferent noxious stimuli in the spinal cord we employed the quantitative autoradiographic 2-deoxyglucose te...

journal_title：Neuroscience

authors： Schadrack J,Neto FL,Ableitner A,Castro-Lopes JM,Willoch F,Bartenstein P,Zieglgänsberger W,Tölle TR

更新日期：1999-01-01 00:00:00

abstract：:Adenosine tonically inhibits synaptic transmission through actions at A(1) receptors. It also facilitates synaptic transmission, but it is unclear if this facilitation results from pre- and/or postsynaptic A(2A) receptor activation or from indirect control of inhibitory GABAergic transmission. The A(2A) receptor agoni...

journal_title：Neuroscience

authors： Lopes LV,Cunha RA,Kull B,Fredholm BB,Ribeiro JA

更新日期：2002-01-01 00:00:00

abstract：:A mechanomyographic response of the hind foot to passive straightening and bending, as well as an electromyographic activity of the gastrocnemius and tibialis anterior muscles were recorded in old (35-44-month-old) and young female rats. In old rats, spontaneous, tonic electromyographic activity patterns were concurre...

journal_title：Neuroscience

authors： Ossowska K,Schulze G,Wolfarth S,Coper H,Kaminska A,Hausmanowa-Petrusewicz I

更新日期：1992-11-01 00:00:00

abstract：:The role of the cerebral cortex in maintaining human standing balance remains unclear. Beta corticomuscular coherence (CMC) provides a measure of communication between the sensory-motor cortex and muscle, but past literature has not demonstrated significant beta CMC during human stance. This study evaluated the effect...

journal_title：Neuroscience

authors： Jacobs JV,Wu G,Kelly KM

更新日期：2015-07-09 00:00:00

abstract：:The present study characterized fetal sulcation patterns and gyrification in the cerebrum of the New World monkey group, common marmosets, using a 3D T2-weighted high-resolution anatomical magnetic resonance imaging (MRI) sequence from the fixed brain at 7-tesla ex vivo. Fetal sulcation in the marmoset cerebrum began ...

journal_title：Neuroscience

authors： Sawada K,Hikishima K,Murayama AY,Okano HJ,Sasaki E,Okano H

更新日期：2014-01-17 00:00:00

abstract：:During periods of high-frequency stimulation the maintenance of synaptic transmission depends on a continued supply of synaptic vesicles. Local recycling in the terminals ensures synaptic vesicle replenishment, but the intermediate steps are still a matter of debate. We analyzed changes in synaptic vesicle pools and e...

journal_title：Neuroscience

authors： Leenders AG,Scholten G,de Lange RP,Lopes da Silva FH,Ghijsen WE

更新日期：2002-01-01 00:00:00

abstract：:Pannexins (Panx) constitute a new family of gap junction type proteins. Functional expression in paired Xenopus oocytes indicated that pannexins are capable of forming communicating junctions but also proved to be active in forming of unopposed hemichannels. In the vertebrate brain pannexins have been found in neurons...

journal_title：Neuroscience

authors： Zoidl G,Petrasch-Parwez E,Ray A,Meier C,Bunse S,Habbes HW,Dahl G,Dermietzel R

更新日期：2007-04-25 00:00:00

abstract：:γ-Hydroxybutyrate (GHB) has a complex array of neural actions that include effects on its own high-affinity GHB receptor, the release of neuroactive steroids, and agonist actions at GABAA and GABAB receptors. We previously reported partial overlap in the c-Fos expression patterns produced by GHB and the GABAB agonist,...

journal_title：Neuroscience

authors： van Nieuwenhuijzen PS,McGregor IS,Chebib M,Hunt GE

更新日期：2014-09-26 00:00:00

abstract：:Synaptic plasticity involves remodeling of extracellular matrix. This is mediated, in part, by enzymes of the matrix metalloproteinase (MMP) family, in particular by gelatinase MMP-9. Accordingly, there is a need of developing methods to visualize gelatinolytic activity at the level of individual synapses, especially ...

journal_title：Neuroscience

authors： Gawlak M,Górkiewicz T,Gorlewicz A,Konopacki FA,Kaczmarek L,Wilczynski GM

更新日期：2009-01-12 00:00:00

abstract：:Several types of brain injuries have been associated with alterations in the striatal expression of neurotrophic factors, including glial cell line-derived neurotrophic factor (GDNF). However, contradictory results on the striatal expression of GDNF have been reported in different animal models of Parkinson's disease....

journal_title：Neuroscience

authors： Mertens B,Massie A,Michotte Y,Sarre S

更新日期：2009-08-04 00:00:00

abstract：:The concentration of intracellular Ca(2+) ([Ca(2+)](i)) influences neuronal properties ranging from excitability to neurotransmitter release. Persistent inflammation is associated with changes in the properties of primary afferent neurons ranging from excitability to transmitter release. The purpose of the present stu...

journal_title：Neuroscience

authors： Lu SG,Gold MS

更新日期：2008-04-22 00:00:00

abstract：:Hindbrain-derived stimuli restrain the gonadotropin-releasing hormone (GnRH)-pituitary luteinizing hormone (LH) reproductive neuroendocrine axis during energy insufficiency. Interruption of food intake, planned or unplanned, is emblematic of modern life. This study investigated the premise that the hindbrain energy se...

journal_title：Neuroscience

authors： Shakya M,Shrestha PK,Briski KP

更新日期：2018-07-15 00:00:00

abstract：:Increasing evidence indicates that both the ATP P2X receptors and adrenergic systems play a very important role in the development of nociception. However, there is little information concerning the interactions between these two systems in the dorsal root ganglia (DRG). In the present study, we examined the effects o...

journal_title：Neuroscience

authors： Tan Y,Sun L,Zhang Q

更新日期：2011-03-10 00:00:00

abstract：:Previous studies from our laboratory and others have shown that there are major age-related differences in brainstem neuronal function. Since GABAA receptors are major targets for GABA-mediated inhibitory modulation and play a key role in regulating cardiorespiratory function, especially during O2 deprivation, we exam...

journal_title：Neuroscience

authors： Xia Y,Haddad GG

更新日期：1992-08-01 00:00:00

abstract：:The transmembrane isoform of agrin (Tm-agrin) is the predominant form expressed in the brain but its putative roles in brain development are not well understood. Recent reports have implicated Tm-agrin in the formation and stabilization of filopodia on neurites of immature central and peripheral neurons in culture. In...

journal_title：Neuroscience

authors： McCroskery S,Bailey A,Lin L,Daniels MP

更新日期：2009-09-29 00:00:00