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Changes in local cerebral glucose utilization induced by convulsants.

Abstract：

:With the six convulsants studied (Soman, intrahippocampal penicillin, bicuculline, pentylenetetrazol, picrotoxin and strychnine), the anatomical distribution of changes in local cerebral glucose utilization was related to the type of seizure observed. Strychnine induced a few very intense motor convulsions during the 2-deoxyglucose experimental period without having a major effect on brain local cerebral glucose utilization, in support of the view that its actions are predominantly in the spinal cord. Pentylenetetrazol and picrotoxin induced intermittent intense seizures and marked increases in local cerebral glucose utilization in the globus pallidus and substantia nigra. Soman, intrahippocampal penicillin and bicuculline all induced persistent status epilepticus associated with increases in local cerebral glucose utilization in many brain areas; those with striking increases in glucose use include: cortical areas, the limbic system, basal ganglia and substantia nigra. The glucose use changes produced by Soman, penicillin and bicuculline greatly exceeded those induced by pentylenetetrazol and picrotoxin. Activation of the substantia nigra and basal ganglia occurred with all centrally mediated convulsions and with status epilepticus there was also marked activation of cortical and limbic structures.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Pazdernik TL,Cross RS,Giesler M,Samson FE,Nelson SR

doi

10.1016/0306-4522(85)90146-0

subject

Has Abstract

pub_date

1985-03-01 00:00:00

pages

823-35

issue

3

eissn

0306-4522

issn

1873-7544

pii

0306-4522(85)90146-0

journal_volume

14

pub_type

杂志文章

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