Differential roles for Akt and mTORC1 in the hypertrophy of Pten mutant neurons, a cellular model of brain overgrowth disorders.

abstract：:On mating with a stud male, virgin female mice from an olfactory memory to this male which is essential to their reproductive success. Failure to form this memory results in the stud male being treated as strange, and hence, his pheromones block pregnancy. This study investigates the duration of the olfactory memory, ...

journal_title：Neuroscience

authors： Kaba H,Rosser AE,Keverne EB

更新日期：1988-01-01 00:00:00

abstract：:Six-day-old neuronal cultures derived from 14-day-old embryonic rat cerebral hemispheres were highly enriched in GABAergic neurons, as was demonstrated by immunocytochemistry using an anti-glutamate decarboxylase antiserum. They contained about 64% glutamate decarboxylase-positive neurons. About 8% of these neurons pr...

journal_title：Neuroscience

authors： Deloulme JC,Gensburger C,Sarhan S,Seiler N,Sensenbrenner M

更新日期：1991-01-01 00:00:00

abstract：:High frequency stimulation (HFS) is applied to many brain regions to treat a variety of neurological disorders/diseases, yet the mechanism(s) underlying its effects remains unclear. While some studies showed that HFS inhibits the stimulated nucleus, others report excitation. In this in vitro study, we stimulated the r...

journal_title：Neuroscience

authors： Shin DS,Samoilova M,Cotic M,Zhang L,Brotchie JM,Carlen PL

更新日期：2007-10-12 00:00:00

abstract：:Extensive evidence suggests that the reinforcing effects of cocaine involve inhibition of dopamine transporters (DAT) and subsequent increases in dopamine (DA) levels in the striatum. We have previously reported that cocaine inhibits the DAT within 4-5 s of i.v. injection, matching the temporal profile of the behavior...

journal_title：Neuroscience

authors： Yorgason JT,Jones SR,España RA

更新日期：2011-05-19 00:00:00

abstract：:Cognitive flexibility, the ability to adjust behavior in response to new and unexpected conditions in the environment, is essential for adaptation to new challenges and survival. The cholinergic system is an important modulator of this complex behavior however, the exact cholinergic circuits involved in this modulatio...

journal_title：Neuroscience

authors： Prado VF,Janickova H,Al-Onaizi MA,Prado MA

更新日期：2017-03-14 00:00:00

abstract：:The finding that endogenous tetrahydroisoquinolines may be involved in the etiology of Parkinson's disease suggests that their administration may cause changes resembling those observed in parkinsonian brain. We tested, using a high-performance liquid chromatography method, how single and chronic administration of 1,2...

journal_title：Neuroscience

authors： Antkiewicz-Michaluk L,Romañska I,Papla I,Michaluk J,Bakalarz M,Vetulani J,Krygowska-Wajs A,Szczudlik A

更新日期：2000-01-01 00:00:00

abstract：:Long-term changes in synaptic transmission between neurons in the brain are considered the cellular basis of learning and memory. Over the last few decades, many studies have revealed that the precise order and timing of activity between pre- and post-synaptic cells ("spike-timing-dependent plasticity; STDP") is cruci...

journal_title：Neuroscience

authors： Fuenzalida M,Chiu CQ,Chávez AE

更新日期：2020-08-20 00:00:00

abstract：:The effects of steady iontophoretic applications of serotonin on the spontaneous discharge and on the excitatory responses induced in deep cerebellar nuclei neurons by iontophoretic pulse applications of L-glutamate, L-aspartate, N-methyl-D,L-aspartate and quisqualate were studied in rat cerebellar slices maintained i...

journal_title：Neuroscience

authors： Gardette R,Krupa M,Crepel F

更新日期：1987-11-01 00:00:00

abstract：:Humans perform object recognition effortlessly and accurately. However, it is unknown how the visual system copes with variations in objects' appearance and the environmental conditions. Previous studies have suggested that affine variations such as size and position are compensated for in the feed-forward sweep of vi...

journal_title：Neuroscience

authors： Karimi-Rouzbahani H,Bagheri N,Ebrahimpour R

更新日期：2017-05-04 00:00:00

abstract：:Arousal enhances the readiness to process sensory information and respond to it. Rapid increment of arousal, referred to as arousal reaction or startle, increases the level of attention and the chance of survival. Arousal reaction is known to originate from the brainstem ascending reticular activating system and to mo...

journal_title：Neuroscience

authors： Löfberg O,Julkunen P,Pääkkönen A,Karhu J

更新日期：2014-08-22 00:00:00

abstract：:The aged dog brain accumulates beta-amyloid in the form of diffuse senile plaques, which provides a potentially useful in vivo model system for studying the events surrounding the deposition of beta-amyloid. We used postembedding immunocytochemistry at the electron microscopic level to determine the subcellular distri...

journal_title：Neuroscience

authors： Torp R,Head E,Milgram NW,Hahn F,Ottersen OP,Cotman CW

更新日期：2000-01-01 00:00:00

abstract：:Several types of brain injuries have been associated with alterations in the striatal expression of neurotrophic factors, including glial cell line-derived neurotrophic factor (GDNF). However, contradictory results on the striatal expression of GDNF have been reported in different animal models of Parkinson's disease....

journal_title：Neuroscience

authors： Mertens B,Massie A,Michotte Y,Sarre S

更新日期：2009-08-04 00:00:00

abstract：:Activities of daily living require simultaneous and coordinated activation of trunk and upper-limb segments, which involves complex interlimb interaction within the central nervous system. Although many studies have reported associations between activity of trunk and limb muscles during functional tasks, evidence on c...

journal_title：Neuroscience

authors： Sasaki A,Milosevic M,Nakazawa K

更新日期：2020-12-15 00:00:00

abstract：:Inflammatory processes may play a critical role in the degeneration of basal forebrain cholinergic cells that underlies some of the cognitive impairments associated with Alzheimer's disease. In the present study, the proinflammagen lipopolysaccharide, from the cell wall of Gram-negative bacteria, was used to produce i...

journal_title：Neuroscience

authors： Willard LB,Hauss-Wegrzyniak B,Wenk GL

更新日期：1999-01-01 00:00:00

abstract：:S100A1 and S100B are members of a multigenic family of Ca(2+)-binding proteins of the EF-hand type highly abundant in astrocyte and striated muscle cells that have been implicated in the Ca(2+)-dependent regulation of several intracellular activities including the assembly and disassembly of microtubules and type III ...

journal_title：Neuroscience

authors： Sorci G,Agneletti AL,Donato R

更新日期：2000-01-01 00:00:00

abstract：:Cell surface glycoconjugates are thought to mediate cell-cell recognition and play roles in neuronal development and functions. We demonstrated here that exposure of neuronal cells to nanomolar levels of gangliosides Neu5Acalpha 8Neu5Acalpha 3Galbeta 4GlcCer, Galbeta 3GalNAcbeta 4(Neu5Acalpha 8Neu5Acalpha 3)Galbeta 4G...

journal_title：Neuroscience

authors： Chen N,Furuya S,Doi H,Hashimoto Y,Kudo Y,Higashi H

更新日期：2003-01-01 00:00:00

abstract：:Intrathecally-administered endomorphin-1 and endomorphin-2 produce antinociceptive effects which are different from each other. In order to elucidate a cellular basis for this result, we examined the effects of endomorphin-1 and endomorphin-2 on holding currents and spontaneous glutamatergic excitatory transmission in...

journal_title：Neuroscience

authors： Fujita T,Kumamoto E

更新日期：2006-01-01 00:00:00

abstract：:The alpha- and beta-stereoisomers of kainate correspond sterically to the L- and D-isomers of glutamate. Alpha-Kainate is a potent excitant at a specific membrane receptor site (kainate receptor). Beta-Kainate has been proposed as a functional N-methyl-D-aspartate antagonist in vivo. Because of the structural similari...

journal_title：Neuroscience

authors： Turski L,Klockgether T,Schwarz M,Sontag KH,Meldrum BS

更新日期：1987-01-01 00:00:00

abstract：:Repetitive transcranial magnetic stimulation (rTMS) is an established technique that can modulate excitability of the motor cortex and corticospinal tract, beyond the duration of the stimulation itself. More recently, a newer repetitive technique, known as I-wave periodicity TMS (iTMS) has been purported to show incre...

journal_title：Neuroscience

authors： Kidgell DJ,Mason J,Frazer A,Pearce AJ

更新日期：2016-05-13 00:00:00

abstract：:Multiple aspartate-specific cysteine proteases have been identified and specific members of this family have been implicated in the apoptotic death of many mammalian cell types. Caspase-3-like proteases seem to play a pivotal role in neuronal apoptosis since mice with germline inactivation of the caspase-3 gene manife...

journal_title：Neuroscience

authors： Dodel RC,Du Y,Bales KR,Ling ZD,Carvey PM,Paul SM

更新日期：1998-10-01 00:00:00

abstract：:To investigate whether the ageing process might affect neuron-target interactions which influence the phenotype of septal cholinergic neurons, we compared the response of these neurons to partial loss of target tissue in young adult and aged animals. Groups of young adult (four to six months) or aged (24-33 months) ma...

journal_title：Neuroscience

authors： Cooper JD,Sofroniew MV

更新日期：1996-11-01 00:00:00

abstract：:Active neuronal transport along microtubules participates in the targeting of mRNAs, proteins and organelles to their sites of action. Cytoplasmic dynein represents a minus-end-directed microtubule-dependent motor protein. Due to the polarity of microtubules in axonal and distal dendritic compartments, with microtubul...

journal_title：Neuroscience

authors： Lardong K,Maas C,Kneussel M

更新日期：2009-04-21 00:00:00

abstract：:Experiments that demonstrated a role for the substantia nigra in eye movements have played an important role in our understanding of the function of the basal ganglia in behavior more broadly. In this review we explore more recent experiments that extend the role of the substantia nigra pars reticulata from a simple g...

journal_title：Neuroscience

authors： Basso MA,Sommer MA

更新日期：2011-12-15 00:00:00

abstract：:In the brain of young (two weeks old) rats, angiotensin II receptors (AT2 receptors) are found in brain nuclei which receive and integrate direct visual input from the retina, the suprachiasmatic nuclei (containing only AT1 receptors), the lateral geniculate nuclei (containing AT2 receptors) and the superior colliculu...

journal_title：Neuroscience

authors： Michels KM,Heemskerk FM,Saavedra JM

更新日期：1994-02-01 00:00:00

abstract：:We have examined the effects of low pH and the selectivity of the capsaicin antagonist capsazepine on single sensory fibres innervating the guinea-pig trachea in vitro, and on the whole isolated vagus nerve. Application of a pH 5 solution for 1 min to the exposed receptive fields of single fibres caused excitation of ...

journal_title：Neuroscience

authors： Fox AJ,Urban L,Barnes PJ,Dray A

更新日期：1995-08-01 00:00:00

abstract：:The midbrain periaqueductal gray matter has been identified as a reflex centre located uppermost in the central organization of diverse defensive reactions. We recently found that when activated, the caudal third of the lateral periaqueductal gray was also capable of provoking a marked increase in cortical blood flow....

journal_title：Neuroscience

authors： Nakai M,Ogata J,Fukui K,Nakai Y,Maeda M

更新日期：1997-07-01 00:00:00

abstract：:The afferent inputs to the rostral pole of the anterior pretectal nucleus have been examined by utilizing the retrograde axonal transport of a fluorescent dye, Fast Blue. After unilateral injection of the dye into the rostral anterior prectectal nucleus, large numbers of labelled neuronal somata were found in the soma...

journal_title：Neuroscience

authors： Foster GA,Sizer AR,Rees H,Roberts MH

更新日期：1989-01-01 00:00:00

abstract：:The duration of long-term potentiation in the dentate gyrus of awake rats was examined following systematic manipulation of the number of stimulus trains delivered. This was correlated with the induction of immediate early genes in separate groups of animals given identical stimulus regimes. Following 10 trains of sti...

journal_title：Neuroscience

authors： Abraham WC,Mason SE,Demmer J,Williams JM,Richardson CL,Tate WP,Lawlor PA,Dragunow M

更新日期：1993-10-01 00:00:00

abstract：:Nitric oxide synthase is the biosynthetic enzyme for the free radical neurotransmitter nitric oxide. Using an affinity-purified antiserum, nitric oxide synthase was found to be localized to peripheral ocular nerve fibers, related cranial ganglia, and the retina of the rat. In the eye, nitric oxide synthase-like immuno...

journal_title：Neuroscience

authors： Yamamoto R,Bredt DS,Snyder SH,Stone RA

更新日期：1993-05-01 00:00:00

abstract：:The basal forebrain cholinergic system is a critical component of the neurobiological substrates underlying attentional function. Orexin neurons are important for arousal and maintenance of wakefulness and are found in the area of the hypothalamus previously shown to project to the basal forebrain. We used dual-probe ...

journal_title：Neuroscience

authors： Fadel J,Pasumarthi R,Reznikov LR

更新日期：2005-01-01 00:00:00