Effects of letrozole on hippocampal and cortical catecholaminergic neurotransmitter levels, neural cell adhesion molecule expression and spatial learning and memory in female rats.

abstract：:Neurotrophic factors, including basic fibroblast growth factor (FGF-2) and brain-derived neurotrophic factor (BDNF) are known to be affected by exposure to stressful experiences. Here, we examine the effects of behaviorally controllable (escapable tailshock, ES) or uncontrollable (inescapable tailshock, IS) stress on ...

journal_title：Neuroscience

authors： Bland ST,Tamlyn JP,Barrientos RM,Greenwood BN,Watkins LR,Campeau S,Day HE,Maier SF

更新日期：2007-02-23 00:00:00

abstract：:Pituitary adenylate-cyclase activating polypeptide (PACAP) has been implicated in the (patho)physiology of stress-adaptation. PACAP deficient (PACAP(-/-)) mice show altered anxiety levels and depression-like behavior, but little is known about the underlying mechanisms in stress-related brain areas. Therefore, we aime...

journal_title：Neuroscience

authors： Gaszner B,Kormos V,Kozicz T,Hashimoto H,Reglodi D,Helyes Z

更新日期：2012-01-27 00:00:00

abstract：:The present paper is the first immunocytochemical demonstration of kappa-opioid receptors in neurons isolated from seven-day-old chick embryonic forebrains and cultivated for one to seven days. The monoclonal antibody KA8 (IgG1-k) [Maderspach et al. (1991) J. Neurochem. 56, 1897-1904] was raised against the frog brain...

journal_title：Neuroscience

authors： Maderspach K,Németh K

更新日期：1993-11-01 00:00:00

abstract：:Apart from its role in regulating calcium there is growing evidence that vitamin D is a neuroactive steroid capable of regulating multiple pathways important for both brain development and mature brain function. Vitamin D induces its genomic effects through its nuclear receptor the vitamin D receptor (VDR). Although t...

journal_title：Neuroscience

authors： Eyles DW,Liu PY,Josh P,Cui X

更新日期：2014-05-30 00:00:00

abstract：:Transient outward rectifying conductances or A-like conductances in sympathetic preganglionic neurons (SPN) are prolonged, lasting for hundreds of milliseconds to seconds and are thought to play a key role in the regulation of SPN firing frequency. Here, a multidisciplinary electrophysiological, pharmacological and mo...

journal_title：Neuroscience

authors： Whyment AD,Coderre E,Wilson JM,Renaud LP,O'Hare E,Spanswick D

更新日期：2011-03-31 00:00:00

abstract：:In the present study, we first investigated the effect of single homocysteine administration on consolidation of short- and long-term memories of inhibitory avoidance task in Wistar rats. We also measured brain-derived neurotrophic factor levels in the hippocampus and parietal cortex of rats. The influence of pretreat...

journal_title：Neuroscience

authors： Matté C,Pereira LO,Dos Santos TM,Mackedanz V,Cunha AA,Netto CA,Wyse AT

更新日期：2009-11-10 00:00:00

abstract：:Differences in the uptake of tracers from radioactive 2-deoxyglucose ([1,2-3H] and [2,6-3H]), and glucose ([1-3H], [3-3H]) into hippocampal regions were investigated by freeze-mount microautoradiography after 45 min for 2-deoxyglucose, and after 15 and 45 min for glucose. Silver grains were assessed quantitatively by ...

journal_title：Neuroscience

authors： Shimada M,Shimono R,Ozaki HS

更新日期：1989-01-01 00:00:00

abstract：:Prolyl oligopeptidase (POP) is an endopeptidase which cleaves short proline-containing neuropeptides, and it is involved in memory and learning. POP also has an intercellular function mediated through the inositol pathway, and has been involved in cell death. POP has been early considered as a housekeeping enzyme, but...

journal_title：Neuroscience

authors： Moreno-Baylach MJ,Felipo V,Männistö PT,García-Horsman JA

更新日期：2008-10-15 00:00:00

abstract：:Hypocretin/orexin (Hcrt/Orx) and melanin concentrating hormone (MCH) are peptides contained in overlapping cell groups of the lateral hypothalamus and commonly involved in regulating sleep-wake states and energy balance, though likely in different ways. To see if these neurons are similarly or differentially modulated...

journal_title：Neuroscience

authors： Bayer L,Eggermann E,Serafin M,Grivel J,Machard D,Muhlethaler M,Jones BE

更新日期：2005-01-01 00:00:00

abstract：:Although serotonin has been shown to play an important role in peripheral pain mechanisms, the specific subtypes of serotonin receptors involved in pain and hyperalgesia remain poorly understood. To date, no previous study has attempted to determine the presence of any serotonin receptor subtype in human dorsal root g...

journal_title：Neuroscience

authors： Pierce PA,Xie GX,Meuser T,Peroutka SJ

更新日期：1997-12-01 00:00:00

abstract：:Changes in the distribution of 5-hydroxytryptamine-like immunoreactivity have been examined in enteric neurons at various times after microsurgical lesions of the enteric plexuses. In the myenteric plexus, varicose immunoreactive nerve fibres disappeared or were reduced in number in ganglia anal to an interruption of ...

journal_title：Neuroscience

authors： Furness JB,Costa M

更新日期：1982-02-01 00:00:00

abstract：:Remyelination is common under physiological conditions and usually occurs as a response to a pathological demyelinating event. Its potentiation is an important goal for the development of therapies against pathologies such as multiple sclerosis and white matter injury. Visualization and quantification in vivo of demye...

journal_title：Neuroscience

authors： Cisneros-Mejorado AJ,Garay E,Ortiz-Retana J,Concha L,Moctezuma JP,Romero S,Arellano RO

更新日期：2020-07-15 00:00:00

abstract：:Cholecystokinin-like immunoreactivity was investigated with an indirect immunoperoxidase technique in the whole spinal cord with the light microscope and in the dorsal horn with the electron microscope. Intraparenchymal injections of colchicine were performed to allow the detection of cholecystokinin-like immunoreacti...

journal_title：Neuroscience

authors： Conrath-Verrier M,Dietl M,Tramu G

更新日期：1984-11-01 00:00:00

abstract：:The present study was undertaken to investigate the possible effects of Spantide [D-Arg1, D-Trp7,9 Leu11]-substance P, a substance P antagonist, and of somatostatin on spinal cord blood flow. The experiments were performed with the laser-doppler technique on the L1 spinal cord segment exposed by laminectomy. The effec...

journal_title：Neuroscience

authors： Freedman J,Post C,Kåhrström J,Ohlen A,Mollenholt P,Owman C,Alari L,Hökfelt T

更新日期：1988-10-01 00:00:00

abstract：:L-arginine, a semi-essential amino acid, can be metabolized to form a number of bioactive molecules. Nitric oxide (NO), generated by NO synthase (NOS) from L-arginine, has been strongly implicated in the aging process. Agmatine, decarboxylated arginine, regulates the production of NO and other metabolites of L-arginin...

journal_title：Neuroscience

authors： Rushaidhi M,Collie ND,Zhang H,Liu P

更新日期：2012-08-30 00:00:00

abstract：:Arc (also termed activity-regulated cytoskeleton-associated protein or Arg3.1), is an effector immediate early gene whose upregulation has been demonstrated during events of synaptic plasticity. In the present study, the possibility that Arc would be specifically upregulated in rats during the acquisition of a quickly...

journal_title：Neuroscience

authors： Kelly MP,Deadwyler SA

更新日期：2002-01-01 00:00:00

abstract：:Examination of spontaneous miniature endplate potentials (MEPPs) in murine skeletal muscle has revealed that in conditions such as botulinum poisoning, during nerve terminal regeneration or in the presence of the drug 4-aminoquinoline, two types of acetylcholine release are responsible for the MEPPs. In addition to th...

journal_title：Neuroscience

authors： Thesleff S,Molgó J

更新日期：1983-05-01 00:00:00

abstract：:Several lines of clinical evidence support the idea that fragile X syndrome (FXS) may involve a dysregulation of hypothalamic-pituitary-adrenal axis function [Wisbeck et al. (2000) J Dev Behav Pediatr 21:278-282; Hessl et al. (2002) Psychoneuroendocrinology 27:855-872]. We had tested this idea in a mouse model of FXS ...

journal_title：Neuroscience

authors： Qin M,Xia Z,Huang T,Smith CB

更新日期：2011-10-27 00:00:00

abstract：:Mitochondrial defects including reduction of a key mitochondrial tricarboxylic acid cycle enzyme alpha-ketoglutarate-dehydrogenase complex (KGDHC) are characteristic of many neurodegenerative diseases. KGDHC consists of alpha-ketoglutarate dehydrogenase, dihydrolipoyl succinyltransferase (E2k), and dihydrolipoamide de...

journal_title：Neuroscience

authors： Calingasan NY,Ho DJ,Wille EJ,Campagna MV,Ruan J,Dumont M,Yang L,Shi Q,Gibson GE,Beal MF

更新日期：2008-06-02 00:00:00

abstract：:Rapid eye movement (REM) sleep deprivation elevates noradrenaline level, which upon acting on alpha1-adrenoceptors increases Na-K-ATPase activity; however, the detailed intracellular mechanism of action was unknown. Since membrane integrity is crucial for maintaining Na-K-ATPase activity as well as ionic exchange and ...

journal_title：Neuroscience

authors： Das G,Gopalakrishnan A,Faisal M,Mallick BN

更新日期：2008-07-31 00:00:00

abstract：:Semi-quantitative immunocytochemistry was used to investigate the levels of cyclase response element-binding protein, phosphorylated cyclase response element-binding protein, Fos and Fos-related antigen immunoreactivity in the striatum of rats after acute or repeated amphetamine administration. Rats were perfused 20 m...

journal_title：Neuroscience

authors： Simpson JN,Wang JQ,McGinty JF

更新日期：1995-11-01 00:00:00

abstract：:Diabetes type 1 is a common autoimmune disease manifesting by insulin deficiency and hyperglycemia, which can lead to dementia-like brain dysfunctions. The factors triggering the pathological processes in hyperglycemic brain remain unknown. We reported in this study that brain areas with different susceptibility to di...

journal_title：Neuroscience

authors： Fiedorowicz A,Prokopiuk S,Zendzian-Piotrowska M,Chabowski A,Car H

更新日期：2014-01-03 00:00:00

abstract：:In an earlier study we have shown that local application of capsaicin directly to one sciatic nerve induces a decrease of substance P and cholecystokinin octapeptide (CCK8)-like peptide from the dorsal spinal cord using immunocytochemical analysis. Here the effect of locally applied capsaicin on seven peptides known t...

journal_title：Neuroscience

authors： Gibson SJ,McGregor G,Bloom SR,Polak JM,Wall PD

更新日期：1982-01-01 00:00:00

abstract：:Specific high-affinity neurotensin binding sites were labeled in sections of the rat caudal brainstem using a monoiodinated ligand, and their distribution was examined by light microscopic radioautography after fixation with glutaraldehyde. In the medulla, labeled binding sites were mainly concentrated within the dors...

journal_title：Neuroscience

authors： Kessler JP,Moyse E,Kitabgi P,Vincent JP,Beaudet A

更新日期：1987-10-01 00:00:00

abstract：:Lamina I of the spinal dorsal horn contains a diverse mixture of neurons. Among these, a group of giant neurons (Waldeyer cells) has long been recognized. In this study we have used immunocytochemistry to characterize a population of Waldeyer cells which were identified by the presence of high levels of the glycine re...

journal_title：Neuroscience

authors： Puskár Z,Polgár E,Todd AJ

更新日期：2001-01-01 00:00:00

abstract：:Neurosteroids are synthesized de novo in the brain and the cerebellar Purkinje cell is a major site for neurosteroid formation. We have demonstrated that the rat Purkinje cell actively produces progesterone de novo from cholesterol only during neonatal life and progesterone promotes dendritic growth, spinogenesis and ...

journal_title：Neuroscience

authors： Sakamoto H,Ukena K,Takemori H,Okamoto M,Kawata M,Tsutsui K

更新日期：2004-01-01 00:00:00

abstract：:Our sensory receptors are faced with an onslaught of different environmental inputs. Each sensory event or encounter with an object involves a distinct combination of physical energy sources impinging upon receptors. In the rodent whisker system, each primary afferent neuron located in the trigeminal ganglion innervat...

journal_title：Neuroscience

authors： Bale MR,Maravall M

更新日期：2018-01-01 00:00:00

abstract：:Intracellular recordings were performed in a pontine slice preparation of the rat brain containing the locus coeruleus. The enzymatically stable P2-purinoceptor agonist alpha,beta-methylene ATP increased the firing rate without altering the amplitude or shape of action potentials; the afterhyperpolarization following ...

journal_title：Neuroscience

authors： Harms L,Finta EP,Tschöpl M,Illes P

更新日期：1992-06-01 00:00:00

abstract：:Exposure to severe stress leads to development of neuropsychiatric disorders, including depression and Post-Traumatic Stress Disorder (PTSD) in at-risk individuals. Neuropeptide Y (NPY) is associated with resilience or improved recovery. Therefore exogenous administration to the brain has therapeutic potential althoug...

journal_title：Neuroscience

authors： Serova LI,Tillinger A,Alaluf LG,Laukova M,Keegan K,Sabban EL

更新日期：2013-04-16 00:00:00

abstract：:The cellular localization of preprosomatostatin mRNA in the rat brain and sensory ganglia has been examined in detail using a newly developed highly sensitive non-radioactive in situ hybridization histochemistry procedure. An alkaline phosphatase labelled anti-sense 30mer oligodeoxynucleotide probe was used for detect...

journal_title：Neuroscience

authors： Kiyama H,Emson PC

更新日期：1990-01-01 00:00:00