当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Effect of excitatory amino acids on Purkinje cell dendrites in cerebellar slices from normal and staggerer mice.

Effect of excitatory amino acids on Purkinje cell dendrites in cerebellar slices from normal and staggerer mice.

Abstract：

:The sensitivity of Purkinje cells to short pulse applications of L-aspartate, L-glutamate and related derivatives in their dendritic fields was tested in normal and staggerer mutant mice using cerebellar slices maintained in vitro. In normal mice, the response of Purkinje cells to L-aspartate and L-glutamate consisted of a transient and dose-dependent increase of their firing of simple spikes. The potency of L-aspartate in exciting Purkinje cells was lower than that of L-glutamate when the two drugs were released from adjacent barrels of the same iontophoretic electrode. Quisqualate was an even more potent excitant of these cells than L-aspartate and L-glutamate, whereas N-methyl-DL-aspartate had little or no effect. In staggerer mutant mice, the sensitivity of Purkinje cells to L-aspartate, L-glutamate and quisqualate was not significantly altered. On the contrary, N-methyl-DL-aspartate had a much stronger potency than normal in exciting Purkinje cells although this was still smaller than that of the other agonists tested. These results suggest that the sensitivity of Purkinje cells to L-aspartate and L-glutamate, i.e. the putative neurotransmitters of the climbing and parallel fibers respectively, remains largely normal in staggerer mice. In contrast, in the mutant, N-methyl-D-aspartate receptors are likely to be much more developed than normal.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Dupont JL,Fournier E,Gardette R,Crepel F

doi

10.1016/0306-4522(84)90076-9

subject

Has Abstract

pub_date

1984-06-01 00:00:00

pages

613-9

issue

2

eissn

0306-4522

issn

1873-7544

pii

0306-4522(84)90076-9

journal_volume

12

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • PTEN inhibition prevents rat cortical neuron injury after hypoxia-ischemia.

    abstract：:Alterations in axon-dendrite polarity impair functional recovery in the developing CNS after hypoxia-ischemia (HI) injury. PTEN (phosphatase and tensin homolog deleted on chromosome 10) signaling pathway mediates the formation of neuronal polarity. However, its role in cerebral HI injury is not fully understood. In th...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.02.046

    authors： Zhao J,Qu Y,Wu J,Cao M,Ferriero DM,Zhang L,Mu D

    更新日期：2013-05-15 00:00:00

  • Fibroblast growth factor and endothelin-1 receptors mediate the response of human striatal precursor cells to hypoxia.

    abstract：:Fetal striatal transplantation has emerged as a new therapeutic strategy in Huntington's disease (HD). Hypoxia is one of the microenvironmental stress conditions to which fetal tissue is exposed as soon as it is isolated and transplanted into the diseased host brain. Mechanisms that support neuroblast survival and rep...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.12.073

    authors： Ambrosini S,Sarchielli E,Comeglio P,Porfirio B,Gallina P,Morelli A,Vannelli GB

    更新日期：2015-03-19 00:00:00

  • Differential vulnerability in the hindbrain neurons and local cerebral blood flow during bilateral vertebral occlusion in gerbils.

    abstract：:Differential vulnerability in the hindbrain neurons was examined immunohistochemically during hindbrain ischemia in the gerbil. Hindbrain ischemia was produced by extracranial occlusion of the bilateral vertebral arteries just before their entry into the transverse foramen of the cervical vertebra. Local cerebral bloo...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90343-e

    authors： Hata R,Matsumoto M,Hatakeyama T,Ohtsuki T,Handa N,Niinobe M,Mikoshiba K,Sakaki S,Nishimura T,Yanagihara T

    更新日期：1993-09-01 00:00:00

  • GABA mechanisms and sleep.

    abstract：:GABA is the main inhibitory neurotransmitter of the CNS. It is well established that activation of GABA(A) receptors favors sleep. Three generations of hypnotics are based on these GABA(A) receptor-mediated inhibitory processes. The first and second generation of hypnotics (barbiturates and benzodiazepines respectivel...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/s0306-4522(02)00034-9

    authors： Gottesmann C

    更新日期：2002-01-01 00:00:00

  • Regulation of 1,4,5-IP3, 1,3,4,5-IP4 and IP6 binding sites following entorhinal cortex lesions in rat brain.

    abstract：:A lesion of the entorhinal cortex produces a loss of more than 80% of the synapses in the outer molecular layer of the hippocampus in the rat. However, this synaptic loss is transient. Beginning a few days after denervation, new synapses are formed, virtually replacing the lost inputs within two months. Synaptic remod...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)90434-0

    authors： Parent A,Poirier J,Baccichet A,Quirion R

    更新日期：1994-08-01 00:00:00

  • Cerebral blood flow-based evidence for mechanisms of low- versus high-frequency transcutaneous electric acupoint stimulation analgesia: a perfusion fMRI study in humans.

    abstract：:Brain activities in response to acupuncture have been investigated in multiple studies; however, the neuromechanisms of low- and high-frequency transcutaneous electric acupoint stimulation (TEAS) analgesia are unclear. This work aimed to investigate how brain activity and the analgesic effect changed across 30-min low...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2014.03.019

    authors： Jiang Y,Liu J,Liu J,Han J,Wang X,Cui C

    更新日期：2014-05-30 00:00:00

  • Loss of Sodium-Activated Potassium Channel Slack and FMRP Differentially Affect Social Behavior in Mice.

    abstract：:The sodium-activated potassium channel Slack (Slo2.2) is widely expressed in central and peripheral neurons where it is supposed to shape firing properties important for neuronal excitability. Slack activity is enhanced by interaction with the Fragile-X-Mental-Retardation-Protein (FMRP) and loss of FMRP leads to decre...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2018.05.040

    authors： Bausch AE,Ehinger R,Straubinger J,Zerfass P,Nann Y,Lukowski R

    更新日期：2018-08-01 00:00:00

  • Ipsilateral versus contralateral spontaneous post-stroke neuroplastic changes: involvement of BDNF?

    abstract：:Stroke is a leading cause of death and disability in industrialized countries. Although surviving patients exhibit a certain degree of restoration of function attributable to brain plasticity, the majority of stroke survivors has to struggle with persisting deficits. In order to potentiate post-stroke recovery, severa...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.11.054

    authors： Madinier A,Bertrand N,Rodier M,Quirié A,Mossiat C,Prigent-Tessier A,Marie C,Garnier P

    更新日期：2013-02-12 00:00:00

  • Topography of centrifugal acetylcholinesterase-positive fibres in the olfactory bulb of the rat: evidence for original projections in atypical glomeruli.

    abstract：:An original pathway of centrifugal acetylcholinesterase-positive fibres is described in the olfactory bulb of the rat. A dense network of positive fibres spreads out superficially at the boundaries of the lateral olfactory tract and the glomerular layer. These labelled fibres converge towards atypical glomerular struc...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(87)90183-7

    authors： Zheng LM,Ravel N,Jourdan F

    更新日期：1987-12-01 00:00:00

  • Behavioral and neurochemical effects of neurotensin microinjection into the ventral tegmental area of the rat.

    abstract：:The ventral tegmental area of the rat brain has been shown to possess high densities of neurotensin- and dopamine-containing neuronal perikarya. We recently demonstrated that microinjection of neurotensin into the ventral tegmental area produces behavioral hyperactivity similar to amphetamine-induced increase in explo...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(83)90195-1

    authors： Kalivas PW,Burgess SK,Nemeroff CB,Prange AJ Jr

    更新日期：1983-03-01 00:00:00

  • N-methyl-d-aspartic acid receptor antagonist-induced frequency oscillations in mice recreate pattern of electrophysiological deficits in schizophrenia.

    abstract：INTRODUCTION:Electrophysiological responses to auditory stimuli have provided a useful means of elucidating mechanisms and evaluating treatments in psychiatric disorders. Deficits in gating during paired-click tasks and lack of mismatch negativity following deviant stimuli have been well characterized in patients with ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.10.031

    authors： Ehrlichman RS,Gandal MJ,Maxwell CR,Lazarewicz MT,Finkel LH,Contreras D,Turetsky BI,Siegel SJ

    更新日期：2009-01-23 00:00:00

  • Tyrosine hydroxylase- and dopamine-beta-hydroxylase-positive neurons and fibres in the developing human cerebellum--an immunohistochemical study.

    abstract：:Six human fetuses of gestational ages 16-28 weeks were employed. The immunocytochemical avidin-biotin-peroxidase complex method combined with the silver Bodian technique was used to evaluate the presence of tyrosine hydroxylase and dopamine-beta-hydroxylase neurons and afferent and efferent fibres in the cerebellum du...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(94)00521-6

    authors： Yew DT,Luo CB,Shen WZ,Chow PH,Zheng DR,Yu MC

    更新日期：1995-03-01 00:00:00

  • Estrogen receptor α and G-protein coupled receptor 30 mediate the neuroprotective effects of 17β-estradiol in novel murine hippocampal cell models.

    abstract：:The hippocampus is a multifaceted, complex brain structure considered to be the learning center. The use of primary hippocampal cell cultures has uncovered important cellular mechanisms involved in overall physiological function. Yet, the use of primary culture is inherently difficult, and the lack of immortalized cel...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.06.076

    authors： Gingerich S,Kim GL,Chalmers JA,Koletar MM,Wang X,Wang Y,Belsham DD

    更新日期：2010-09-29 00:00:00

  • Specificity of attachment and neurite outgrowth of dissociated basal forebrain cholinergic neurons seeded on to organotypic slice cultures of forebrain.

    abstract：:Development and differentiation of basal forebrain-derived cholinergic neurons were studied using a new technique that combines dissociated cell cultures with organotypic slice cultures. Slices of cerebral cortex or entire forebrain hemispheres were taken from early postnatal rat pups and maintained as organotypic cul...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(97)00067-5

    authors： Robertson RT,Baratta J,Kageyama GH,Ha DH,Yu J

    更新日期：1997-10-01 00:00:00

  • Acetylcholinesterase in the rat neurohypophysis is decreased after dehydration and released by stimulation of the pituitary stalk.

    abstract：:Specific acetylcholinesterase and non-specific cholinesterases are present in all three lobes of the rat pituitary gland. This paper describes two new observations on hypophyseal acetylcholinesterase. Firstly, a prolonged increase of neurohormone secretion evoked by dehydration and sodium loading was accompanied by a ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(87)90132-1

    authors： Alexandrova M,Holzbauer M,Racke K,Sharman DF

    更新日期：1987-05-01 00:00:00

  • Role of myelin plasticity in oscillations and synchrony of neuronal activity.

    abstract：:Conduction time is typically ignored in computational models of neural network function. Here we consider the effects of conduction delays on the synchrony of neuronal activity and neural oscillators, and evaluate the consequences of allowing conduction velocity (CV) to be regulated adaptively. We propose that CV vari...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.11.007

    authors： Pajevic S,Basser PJ,Fields RD

    更新日期：2014-09-12 00:00:00

  • Chitinase1 contributed to a potential protection via microglia polarization and Aβ oligomer reduction in D-galactose and aluminum-induced rat model with cognitive impairments.

    abstract：:Chitinase activity is increased in Alzheimer's disease (AD). However, the role of chitinase1 in AD is unknown. We investigated the effects of chitinase1 on Alzheimer's pathology and microglia function. Artificial chitinase1 and chitinase inhibitor (chitinase-IN-2) were used to determine the effects of chitinase1 on in...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2017.04.050

    authors： Xiao Q,Yu W,Tian Q,Fu X,Wang X,Gu M,Lü Y

    更新日期：2017-07-04 00:00:00

  • Effects of estradiol on the stimulation of dopamine turnover in mesolimbic and nigrostriatal systems by cocaine- and amphetamine-regulated transcript peptide in female rats.

    abstract：:The present studies aimed to determine whether estradiol (E(2)) modulates the stimulation of cocaine- and amphetamine-regulated transcript (CART) peptide in the mesolimbic and nigrostriatal dopaminergic systems. I.c.v. administration of the CART peptide (55-102, 1 microg/3 microl) increased dopamine turnover (3,4-dihy...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.01.086

    authors： Shieh KR,Yang SC

    更新日期：2008-07-17 00:00:00

  • Postweaning Enriched Environment Enhances Cognitive Function and Brain-Derived Neurotrophic Factor Signaling in the Hippocampus in Maternally Separated Rats.

    abstract：:Adverse environments during early life may lead to different neurophysiological and behavioral consequences, including depression and learning and memory deficits that persist into adulthood. Previously, we demonstrated that exposure to an enriched environment during adolescence mitigates the cognitive impairment obse...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.09.058

    authors： Cordier JM,Aguggia JP,Danelon V,Mir FR,Rivarola MA,Mascó D

    更新日期：2021-01-15 00:00:00

  • Brainstem auditory evoked potentials during brainstem ischemia and reperfusion in gerbils.

    abstract：:To evaluate the reversibility of neural function in the brainstem following ischemia, we investigated the effect of transient brainstem ischemia on the brainstem auditory evoked potential in gerbils. Brainstem ischemia was produced by bilateral extracranial occlusion of vertebral arteries. Local cerebral blood flow wa...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(97)00364-3

    authors： Hata R,Matsumoto M,Matsuyama T,Yamamoto K,Hatakeyama T,Kubo T,Mikoshiba K,Sakaki S,Sugita M,Yanagihara T

    更新日期：1998-03-01 00:00:00

  • Functional development of the vagal and glossopharyngeal nerve-related nuclei in the embryonic rat brainstem: optical mapping with a voltage-sensitive dye.

    abstract：:We investigated functional organization of the vagus nerve (N. X)- and glossopharyngeal nerve (N. IX)-related nuclei in the embryonic rat brainstem and compared their development and spatial distribution patterns, using multiple-site optical recording with a fast voltage-sensitive dye, NK2761. Intact brainstem prepara...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.06.019

    authors： Momose-Sato Y,Nakamori T,Sato K

    更新日期：2011-09-29 00:00:00

  • Impaired release of beta-endorphin in response to serotonin in a rat model of depression.

    abstract：:Involvement of both the serotonergic and the endogenous opioid systems in the onset of depressive behavior has been suggested. Previously we showed that serotonin (5-hydroxytryptamine) facilitates beta-endorphin release in the nucleus accumbens (NAcc). Herein, the microdialysis method was used to assess in vivo the ef...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(01)00612-1

    authors： Zangen A,Nakash R,Roth-Deri I,Overstreet DH,Yadid G

    更新日期：2002-01-01 00:00:00

  • Nuclear Factor [Erythroid-derived 2]-like 2 and Mitochondrial Transcription Factor A Contribute to Moderate-intensity Swimming Effectiveness against Memory Impairment in Young Mice Induced by Concomitant Exposure to a High-calorie Diet during the Early Li

    abstract：:Increased energy food consumption during early-life has been associated with memory impairment. Swimming training has been reported to improve memory processes in rodent models. This study aimed to evaluate whether moderate-intensity swimming training counteracts learning and memory impairment in young mice fed a high...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.11.023

    authors： Jardim NS,Müller SG,Pase FM,Nogueira CW

    更新日期：2021-01-01 00:00:00

  • Dynamic interactions of evoked potentials in a polysensory cortex of the cat.

    abstract：:Interactions of acoustic and somatosensory evoked potentials were studied in the anterior suprasylvian gyrus of the cat. Two kinds of interaction could be observed: occlusion or facilitation. In most cases occlusion was observed. The interactions showed dynamic changes and were susceptible to different kinds of influe...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(84)90084-8

    authors： Toldi J,Fehér O,Feuer L

    更新日期：1984-11-01 00:00:00

  • Differential signaling of glial cell line-derived neurothrophic factor and brain-derived neurotrophic factor in cultured ventral mesencephalic neurons.

    abstract：:In the ventral mesencephalon, two neurotrophic factors, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor, have been shown previously to have similar effects on the survival of dopaminergic neurons. Here, we compared the signaling mechanisms for brain-derived neurotrophic factor and gli...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(99)00129-3

    authors： Feng L,Wang CY,Jiang H,Oho C,Dugich-Djordjevic M,Mei L,Lu B

    更新日期：1999-01-01 00:00:00

  • Changes in excitability of corticomotor inputs to the trunk muscles during experimentally-induced acute low back pain.

    abstract：:Acute low back pain (LBP) is associated with differential changes in motor coordination of deep and superficial trunk muscles. Whether this is related to differential changes in excitability of descending corticomotor inputs remains unclear and was investigated in nine healthy individuals. Fine-wire i.m. electrodes we...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.02.033

    authors： Tsao H,Tucker KJ,Hodges PW

    更新日期：2011-05-05 00:00:00

  • Adenosine A(2A) receptor facilitation of hippocampal synaptic transmission is dependent on tonic A(1) receptor inhibition.

    abstract：:Adenosine tonically inhibits synaptic transmission through actions at A(1) receptors. It also facilitates synaptic transmission, but it is unclear if this facilitation results from pre- and/or postsynaptic A(2A) receptor activation or from indirect control of inhibitory GABAergic transmission. The A(2A) receptor agoni...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00080-5

    authors： Lopes LV,Cunha RA,Kull B,Fredholm BB,Ribeiro JA

    更新日期：2002-01-01 00:00:00

  • Bilateral lesions of the central but not anterior or posterior parts of the piriform cortex retard amygdala kindling in rats.

    abstract：:The piriform cortex is thought to be involved in temporal lobe seizure propagation, such as that occurring during kindling of the amygdala or hippocampus. A number of observations suggested that the circuits of the piriform cortex might act as a critical pathway for limbic seizure discharges to assess motor systems, b...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(00)00407-3

    authors： Schwabe K,Ebert U,Löscher W

    更新日期：2000-01-01 00:00:00

  • Regulation of the expression and phosphorylation of microtubule-associated protein 1B during regeneration of adult dorsal root ganglion neurons.

    abstract：:Microtubule-associated protein 1B is a major constituent of the neuronal cytoskeleton during the early stages of development. This protein and its phosphorylated isoform, microtubule-associated protein 1B-P, defined by the monoclonal antibody 1B-P [Boyne L. J. et al. (1995) J. Neurosci. Res. 40, 439-450], are present ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(00)00141-x

    authors： Ma D,Connors T,Nothias F,Fischer I

    更新日期：2000-01-01 00:00:00

  • Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons.

    abstract：:Morphine induces profound analgesic tolerance in vivo despite inducing little internalization of the mu opioid receptor (muOR). Previously proposed explanations suggest that this lack of internalization could either lead to prolonged signaling and associated compensatory changes in downstream signaling systems, or tha...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.06.021

    authors： Walwyn WM,Wei W,Xie CW,Chiu K,Kieffer BL,Evans CJ,Maidment NT

    更新日期：2006-10-13 00:00:00