当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Differential responsiveness of dopamine transmission to food-stimuli in nucleus accumbens shell/core compartments.

Differential responsiveness of dopamine transmission to food-stimuli in nucleus accumbens shell/core compartments.

Abstract：

:The nucleus accumbens septi is the major target of mesolimbic dopamine neurons originating in the ventral tegmental area of the mesencephalon. Studies involving experimental manipulation of dopamine transmission by drugs and by lesions, as well as in vivo monitoring of extracellular dopamine concentrations, have provided evidence that the dopamine transmission of the nucleus accumbens plays an important role in behaviour motivated by conventional (e.g., food, sex) and drug reinforcers. Motivated behaviour is distinguished into an appetitive (preparatory/anticipatory) phase consisting of flexible response patterns intended to search and approach the reward itself, and a consummatory phase, consisting of fixed response patterns (eating, drinking, copulating, etc.) finalized to the utilization of the biological resources of the reward (caloric, metabolic, genetic, etc.). While some studies reported a stimulation of dopamine transmission in the nucleus accumbens in relation to appetitive as well as consummatory behaviour, other studies reported a relationship exclusively with consummatory behaviour. Therefore, the precise relationship between dopamine transmission in the nucleus accumbens and specific phases of motivated behaviour is debated. On the basis of topographical, histochemical and connectional evidence, the nucleus accumbens has been subdivided into two compartments, a medioventral "shell" and a laterodorsal "core". This heterogeneity may be relevant to the current debate over the role of nucleus accumbens dopamine in behaviour. Thus, one might hypothesize that, depending on the specific compartment of the nucleus accumbens where dopamine transmission is monitored, a different relationship with specific stimuli which motivate behaviour is obtained. In order to verify this possibility we monitored by microdialysis the changes in dopamine transmission in the nucleus accumbens shell and core during appetitive and consummatory phases of behaviour motivated by food. As food we utilized a palatable snack food (Fonzies) whose consumption has been shown in previous studies from our laboratory to release dopamine in the nucleus accumbens shell and in the medial prefrontal cortex. Unpredicted consumption of Fonzies preferentially stimulated dopamine transmission in the shell as compared to the core. Appetitive food stimuli (perforated Fonzies-filled boxes) phasically stimulated dopamine transmission in the core but not in the shell and sensitized the dopamine response to feeding in the core but inhibited that in the shell. These clear-cut differences between nucleus accumbens shell and core suggest that phasic dopamine transmission in each compartment of the nucleus accumbens subserves different roles in motivated behaviour.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Bassareo V,Di Chiara G

doi

10.1016/s0306-4522(98)00583-1

keywords:

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

637-41

issue

3

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(98)00583-1

journal_volume

89

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Fibroblast growth factor-2 increases the expression of neurogenic genes and promotes the migration and differentiation of neurons derived from transplanted neural stem/progenitor cells.

    abstract：:The capacity of neural stem cells (NSC) to generate different types of neurons and glia depends on the action of intrinsic determinants and extracellular signals. Here, we isolated adult olfactory bulb stem cells (aOBSC) that express nestin, RC2 and Sox2, and that have the capacity to generate neurons possessing matur...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.03.033

    authors： Vergaño-Vera E,Méndez-Gómez HR,Hurtado-Chong A,Cigudosa JC,Vicario-Abejón C

    更新日期：2009-08-04 00:00:00

  • Effects of local cholinesterase inhibition on acetylcholine release assessed simultaneously in prefrontal and frontoparietal cortex.

    abstract：:To investigate whether acetylcholine is released in a similar fashion in different regions of the cortex, in vivo microdialysis was used to measure acetylcholine efflux simultaneously in the medial prefrontal and the frontoparietal cortex, under both basal conditions and following tactile stimulation. Additionally, th...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00097-9

    authors： Himmelheber AM,Fadel J,Sarter M,Bruno JP

    更新日期：1998-10-01 00:00:00

  • Differential emotional experience induces elevated spine densities on basal dendrites of pyramidal neurons in the anterior cingulate cortex of Octodon degus.

    abstract：:It appears likely that, in analogy to the synaptic development of sensory and motor cortices, which critically depends on sensory or motor stimulation (Rosenzweig and Bennett, 1996), the synaptic development of limbic cortical regions are modulated by early postnatal cognitive and emotional experiences. The very first...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(01)00201-9

    authors： Helmeke C,Poeggel G,Braun K

    更新日期：2001-01-01 00:00:00

  • Differential effects of peripheral damage on vibrissa-related patterns in trigeminal nucleus principalis, subnucleus interpolaris, and subnucleus caudalis.

    abstract：:Histochemistry for cytochrome oxidase reveals a vibrissa-related pattern in trigeminal nucleus principalis, subnucleus interpolaris, and the magnocellular portion of subnucleus caudalis. This pattern is apparent in late fetal animals and is disrupted by transection of the infraorbital nerve on the day of birth. We rec...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(92)90082-d

    authors： Chiaia NL,Bennett-Clarke CA,Rhoades RW

    更新日期：1992-07-01 00:00:00

  • The Effects of Mobile Phone Radiofrequency Electromagnetic Fields on β-Amyloid-Induced Oxidative Stress in Human and Rat Primary Astrocytes.

    abstract：:Amyloid beta peptide (Aβ) is implicated in the development of pathological reactions associated with Alzheimer's disease (AD), such as oxidative stress, neuro-inflammation and death of brain cells. Current pharmacological approaches to treat AD are not able to control the deposition of Aβ and suppression of Aβ-induced...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.03.058

    authors： Tsoy A,Saliev T,Abzhanova E,Turgambayeva A,Kaiyrlykyzy A,Akishev M,Saparbayev S,Umbayev B,Askarova S

    更新日期：2019-06-01 00:00:00

  • Long-term potentiation during whole-cell recording in rat hippocampal slices.

    abstract：:Factors involved in the production of long-term potentiation in the CA1 region of rat hippocampal slices were examined using whole-cell voltage clamp recordings. The pairing of postsynaptic membrane depolarization with tetanic stimulation produced a reliable long-lasting enhancement of synaptic currents provided that ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90282-k

    authors： Kato K,Clifford DB,Zorumski CF

    更新日期：1993-03-01 00:00:00

  • Volumes of hippocampus, amygdala and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes.

    abstract：:An increased frequency of apolipoprotein E E4 allele has been reported in patients with late onset Alzheimer's disease. Apolipoprotein E participates in the transport of cholesterol and other lipids and interferes with the growth and regeneration of both peripheral and central nervous system tissues during development...

    journal_title：Neuroscience

    pub_type： 临床试验,杂志文章

    doi：10.1016/0306-4522(95)00014-a

    authors： Lehtovirta M,Laakso MP,Soininen H,Helisalmi S,Mannermaa A,Helkala EL,Partanen K,Ryynänen M,Vainio P,Hartikainen P

    更新日期：1995-07-01 00:00:00

  • Non-Invasive Assays of Cochlear Synaptopathy - Candidates and Considerations.

    abstract：:Studies in multiple species, including in post-mortem human tissue, have shown that normal aging and/or acoustic overexposure can lead to a significant loss of afferent synapses innervating the cochlea. Hypothetically, this cochlear synaptopathy can lead to perceptual deficits in challenging environments and can contr...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2019.02.031

    authors： Bharadwaj HM,Mai AR,Simpson JM,Choi I,Heinz MG,Shinn-Cunningham BG

    更新日期：2019-05-21 00:00:00

  • Mesolimbic alpha-, but not beta-adrenoceptors control the accumbal release of dopamine that is derived from reserpine-sensitive storage vesicles.

    abstract：:Mesolimbic beta-, but not alpha-adrenoceptors control the accumbal release of dopamine that is derived from alpha-methyl-para-tyrosine-sensitive pools of newly synthesized neurotransmitter. The aim of this study was to investigate which of these adrenoceptors control the accumbal release of dopamine that is derived fr...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.05.034

    authors： Verheij MM,Cools AR

    更新日期：2009-09-15 00:00:00

  • Short increase of BDNF messenger RNA triggers kainic acid-induced neuronal hypertrophy in adult mice.

    abstract：:Neurotrophin gene expression in adult brain varies according to physiological activity and following brain injury, suggesting a role in neuronal maintenance and plasticity. However, the exact roles and mechanisms of action of neurotrophins in the adult brain are still poorly understood. We have recently demonstrated t...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(96)00005-x

    authors： Guilhem D,Dreyfus PA,Makiura Y,Suzuki F,Onteniente B

    更新日期：1996-06-01 00:00:00

  • The distribution of Alz-50 immunoreactivity in the normal human brain.

    abstract：:Alz-50 is a monoclonal antibody that recognizes normal tau proteins as well as phosphorylated tau proteins that are associated with paired helical filaments in Alzheimer's disease. To establish an accurate baseline for future pathological studies, we examined the distribution of Alz-50 immunoreactivity in normal human...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90567-y

    authors： Rye DB,Leverenz J,Greenberg SG,Davies P,Saper CB

    更新日期：1993-09-01 00:00:00

  • The role of estrogens in seizures and epilepsy: the bad guys or the good guys?

    abstract：:Estrogens influence neuronal activity and are important for normal brain functions. Effects of estrogens on seizures are contradictory. It is commonly accepted that estrogens may increase neuronal excitability and thus mediate proconvulsant effects. However, clinical and animal data show that estrogen may also have no...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2005.07.005

    authors： Velísková J

    更新日期：2006-01-01 00:00:00

  • GABAA receptors in the mediodorsal thalamus play a crucial role in rat shell-specific acetylcholine-mediated, but not dopamine-mediated, turning behaviour.

    abstract：:The role of GABA(A) receptors in the mediodorsal thalamus (mdT) in turning behaviour of rats was studied. Neither the GABA(A) receptor agonist muscimol (50 ng) nor the antagonist bicuculline (200 ng) unilaterally injected into the mdT elicited any behavioural change. Unilateral injection of the acetylcholine receptor ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.02.015

    authors： Ikeda H,Kotani A,Lee J,Koshikawa N,Cools AR

    更新日期：2009-04-10 00:00:00

  • The stop null mice model for schizophrenia displays [corrected] cognitive and social deficits partly alleviated by neuroleptics.

    abstract：:Recently evidence has accumulated that schizophrenia can arise from primary synaptic defects involving structural proteins particularly, microtubule associated proteins. Previous experiments have demonstrated that a STOP (stable tubule only peptide) gene deletion in mice leads to a phenotype mimicking some aspects of ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.07.080

    authors： Bégou M,Volle J,Bertrand JB,Brun P,Job D,Schweitzer A,Saoud M,D'Amato T,Andrieux A,Suaud-Chagny MF

    更新日期：2008-11-11 00:00:00

  • Focal Suppression of Epileptiform Activity in the Hippocampus by a High-frequency Magnetic Field.

    abstract：:Electric current has been used for epilepsy treatment by targeting specific neural circuitries. Despite its success, direct contact between the electrode and tissue could cause side effects including pain, inflammation, and adverse biological reactions. Magnetic stimulation overcomes these limitations by offering adva...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.02.018

    authors： Ye H,Chen VC,Helon J,Apostolopoulos N

    更新日期：2020-04-15 00:00:00

  • Increased expression of the N-methyl-D-aspartate receptor subunit, NR1, in immunohistochemically identified magnocellular hypothalamic neurons during dehydration.

    abstract：:N-Methyl-D-aspartate receptors are thought to be involved in synaptic signaling within the hypothalamo-neurohypophysial system, but the extent and nature of their involvement has not been determined. In this study, in the rat, we evaluated the effect of hyperosmotic stimulation on the N-methyl-D-aspartate receptor sub...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(96)00544-1

    authors： Decavel C,Curras MC

    更新日期：1997-05-01 00:00:00

  • Mechanisms of chlorpyrifos and diazinon induced neurotoxicity in cortical culture.

    abstract：:The main action of organophosphorous insecticides is generally believed to be the inhibition of acetylcholinesterase (AChE). However, these compounds also inhibit many other enzymes, any of which may play a role in their toxicity. We tested the neurotoxic mechanism of two organophosphorous insecticides, chlorpyrifos a...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.01.025

    authors： Rush T,Liu XQ,Hjelmhaug J,Lobner D

    更新日期：2010-03-31 00:00:00

  • Hippocampal neuroplasticity in major depressive disorder.

    abstract：:One of the most replicated findings has been that hippocampus volume is decreased in patients with major depressive disorder (MDD). Recent volumetric magnetic resonance imaging (MRI) studies suggest that localized differences in hippocampal volume may be more prominent than global differences. Preclinical and post-mor...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2015.04.047

    authors： Malykhin NV,Coupland NJ

    更新日期：2015-11-19 00:00:00

  • Reduced frontal cortex thickness and cortical volume associated with pathological narcissism.

    abstract：:Pathological narcissism is often characterized by arrogant behavior, a lack of empathy, and willingness to exploit other individuals. Generally, individuals with high levels of narcissism are more likely to suffer mental disorders. However, the brain structural basis of individual pathological narcissism trait among h...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.04.025

    authors： Mao Y,Sang N,Wang Y,Hou X,Huang H,Wei D,Zhang J,Qiu J

    更新日期：2016-07-22 00:00:00

  • Ethanol modulates mammalian circadian clock phase resetting through extrasynaptic GABA receptor activation.

    abstract：:Ethanol modulates the actions of multiple neurotransmitter systems, including GABA. However, its enhancing effects on GABA signaling typically are seen only at high concentrations. In contrast, although GABA is a prominent neurotransmitter in the circadian clock of the suprachiasmatic nucleus (SCN), we see ethanol mod...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.08.020

    authors： McElroy B,Zakaria A,Glass JD,Prosser RA

    更新日期：2009-12-01 00:00:00

  • Ascorbate modulates pentylenetetrazol-induced convulsions biphasically.

    abstract：:Ascorbate is an antioxidant vitamin that is found in high concentrations in the brain which seems to have neuroprotective properties in some experimental models of excitotoxic neurological disorders, including convulsive behavior and reactive species-related damage. In this study we tested whether ascorbate (30, 100 o...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.07.012

    authors： Schneider Oliveira M,Flávia Furian A,Freire Royes LF,Rechia Fighera M,de Carvalho Myskiw J,Gindri Fiorenza N,Mello CF

    更新日期：2004-01-01 00:00:00

  • Changes in immunoreactivity for growth associated protein-43 suggest reorganization of synapses on spinal sympathetic neurons after cord transection.

    abstract：:Cervical or high thoracic spinal cord injury often results in autonomic dysreflexia, a condition characterized by exaggerated spinal reflexes and episodic hypertension, that may be caused by reorganization of synapses on sympathetic preganglionic neurons after loss of supraspinal input. To assess remodelling of synapt...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(97)00151-6

    authors： Weaver LC,Cassam AK,Krassioukov AV,Llewellyn-Smith IJ

    更新日期：1997-11-01 00:00:00

  • Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse.

    abstract：:The striatum, which processes cortical information for behavioral output, is a key target of Huntington's disease (HD), an autosomal dominant condition characterized by cognitive decline and progressive loss of motor control. Increasing evidence implicates deficient glutamate uptake caused by a down-regulation of GLT1...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2008.02.004

    authors： Miller BR,Dorner JL,Shou M,Sari Y,Barton SJ,Sengelaub DR,Kennedy RT,Rebec GV

    更新日期：2008-04-22 00:00:00

  • Length summation of complex cells in cat striate cortex: a reappraisal of the "special/standard" classification.

    abstract：:A reappraisal of the relationship between length summation and receptive field length assessed by the minimum response field method, was made in complex cells recorded from the lightly anaesthetized feline striate cortex. This relationship has previously been proposed by Gilbert [(1977) J. Physiol., Lond. 268, 391-421...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(85)90065-x

    authors： Hammond P,Ahmed B

    更新日期：1985-07-01 00:00:00

  • Contribution of astrocyte glycogen stores to progression of spreading depression and related events in hippocampal slices.

    abstract：:Spreading depression (SD) is a wave of coordinated cellular depolarization that propagates slowly throughout brain tissue. SD has been associated with migraine aura, and related events have been implicated in the enlargement of some brain injuries. Selective disruption of astrocyte oxidative metabolism has previously ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2011.05.006

    authors： Seidel JL,Shuttleworth CW

    更新日期：2011-09-29 00:00:00

  • Kainic acid induced seizures: changes in somatostatin, substance P and neurotensin.

    abstract：:The neuropeptides somatostatin, neurotensin and substance P were investigated in rats during and after limbic seizures induced by systemic injection of kainic acid (10 mg/kg, i.p.). Three hours after injection of the toxin, pronounced decreases (40-50%) in somatostatin-like immunoreactivity in frontal cortex, striatum...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(86)90081-3

    authors： Sperk G,Wieser R,Widmann R,Singer EA

    更新日期：1986-04-01 00:00:00

  • Neurogenic and non-neurogenic mechanisms of plasma extravasation in the rat.

    abstract：:We describe two distinct mechanisms for the enhancement of plasma extravasation in the knee joint of the rat. One is activated by bradykinin and is neurogenic; the other is activated by platelet-activating factor and is non-neurogenic. Bradykinin-induced synovial plasma extravasation is known to be dependent on the sy...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90422-c

    authors： Green PG,Luo J,Heller PH,Levine JD

    更新日期：1993-02-01 00:00:00

  • Neural Representation in Visual Word Form Area during Word Reading.

    abstract：:The visual word form area (VWFA) has been consistently identified as a crucial structure in visual word processing. Nevertheless, it is controversial whether the VWFA represents external visual information (e.g., case information) of visual words. To address that question, we functionally localized VWFA at the group l...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2020.10.040

    authors： Lu C,Li H,Fu R,Qu J,Yue Q,Mei L

    更新日期：2021-01-01 00:00:00

  • Calcium-dependent inactivation of neuronal calcium channel currents is independent of calcineurin.

    abstract：:Dephosphorylation by the Ca2+/calmodulin-dependent phosphatase calcineurin has been suggested as an important mechanism of Ca2+-dependent inactivation of voltage-gated Ca2+ channels. We have tested whether calcineurin plays a role in the inactivation process of two types of high-voltage-activated Ca2+ channels (L and ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(99)00434-0

    authors： Zeilhofer HU,Blank NM,Neuhuber WL,Swandulla D

    更新日期：2000-01-01 00:00:00

  • Selective effects of neonatal handling on rat brain N-methyl-D-aspartate receptors.

    abstract：:Neonatal handling, an experimental model of early life experiences, is known to affect the hypothalamic-pituitary-adrenal axis function thus increasing adaptability, coping with stress, cognitive abilities and in general brain plasticity-related processes. A molecule that plays a most critical role in such processes i...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.09.032

    authors： Stamatakis A,Toutountzi E,Fragioudaki K,Kouvelas ED,Stylianopoulou F,Mitsacos A

    更新日期：2009-12-29 00:00:00