当前位置： SCI文献检索 > NEUROSCIENCE期刊下所有文献 > Congruence of zebrin II expression and functional zones defined by climbing fiber topography in the flocculus.

Congruence of zebrin II expression and functional zones defined by climbing fiber topography in the flocculus.

Abstract：

:The cerebellum is organized into parasagittal zones with respect to the topography of climbing fiber (CF) afferents and the expression of molecular markers such as zebrin II. Zebrin is expressed by a subset of Purkinje cells that are distributed as a parasagittal array of immunopositive and immunonegative stripes. Several studies in rodents suggest that, in general, CFs to the zebrin negative stripes convey somatosensory information, whereas CFs to the zebrin positive stripes convey information from visual and other sensory systems. The pigeon flocculus consists of four pairs of zebrin+/- stripes (P4 +/- through P7 +/-), however the CF input consists entirely of visual inputs. Thus, because the correspondence of zebrin expression and CF information must be different from that proposed for rodents, we investigated this relationship in the pigeon flocculus. Floccular Purkinje cells respond to patterns of optic flow resulting from self-rotation about one of two axes: either the vertical axis (zones 0 and 2), or a horizontal axis (zones 1 and 3). Visual CF afferents projecting to the flocculus arise from the medial column of the inferior olive (mcIO). Zones 0 and 2 receive input from the caudal mcIO, whereas zones 1 and 3 receive input from the rostral mcIO. We injected a fluorescent anterograde tracer into the rostral and/or caudal mcIO and visualized zebrin expression. There was a strict concordance between CF organization and zebrin labeling: caudal mcIO injections resulted in CFs in zebrin bands P4 +/- and P6 +/-, whereas rostral mcIO injections resulted in CFs in zebrin bands P5 +/- and P7 +/-. Thus, zebrin stripes P4 +/- and P6 +/- correspond to the vertical axis zones 0 and 2, whereas P5 +/- and P7 +/- correspond to the horizontal axis zones 1 and 3. This is the first explicit demonstration that a series of zebrin stripes corresponds with functional zones in the cerebellum.

journal_name

Neuroscience

journal_title

Neuroscience

authors

Pakan JM,Wylie DR

doi

10.1016/j.neuroscience.2008.08.062

subject

Has Abstract

pub_date

2008-11-11 00:00:00

pages

57-69

issue

1

eissn

0306-4522

issn

1873-7544

pii

S0306-4522(08)01286-4

journal_volume

157

pub_type

杂志文章

相关文献

NEUROSCIENCE文献大全
  • Glycogen synthase kinase 3-specific inhibitor AR-A014418 decreases neuropathic pain in mice: evidence for the mechanisms of action.

    abstract：:The present study examined the antihyperalgesic effect of a specific inhibitor of Glycogen Synthase Kinase 3 (GSK3), AR-A014418, on the partial ligation of the sciatic nerve (PSNL), a neuropathic pain model in mice and investigated some mechanisms of action. AR-A014418 (0.01-1 mg/kg) administered by intraperitoneal ro...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2012.09.020

    authors： Mazzardo-Martins L,Martins DF,Stramosk J,Cidral-Filho FJ,Santos AR

    更新日期：2012-12-13 00:00:00

  • Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities.

    abstract：:The postsynaptic density is a highly dynamic structure, which is reorganized in an activity-dependent manner. An animal model for temporal lobe epilepsy, i.e. kainate-induced limbic seizures in rats, was used to study changes in postsynaptic density composition after extensive synaptic activity. Six hours after kainat...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(00)00469-3

    authors： Wyneken U,Smalla KH,Marengo JJ,Soto D,de la Cerda A,Tischmeyer W,Grimm R,Boeckers TM,Wolf G,Orrego F,Gundelfinger ED

    更新日期：2001-01-01 00:00:00

  • Neuronal depolarization modifies motor protein mobility.

    abstract：:Active neuronal transport along microtubules participates in the targeting of mRNAs, proteins and organelles to their sites of action. Cytoplasmic dynein represents a minus-end-directed microtubule-dependent motor protein. Due to the polarity of microtubules in axonal and distal dendritic compartments, with microtubul...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.02.034

    authors： Lardong K,Maas C,Kneussel M

    更新日期：2009-04-21 00:00:00

  • Regional differences in desensitization of c-Fos expression following repeated self-stimulation of the medial forebrain bundle in the rat.

    abstract：:The acute self-stimulation of the medial forebrain bundle was reported to induce the expression of c-Fos, the protein product of c-fos, an immediate early gene, in the central nervous system. In the present study, we examined regional changes in c-Fos expression in several reward-related areas of rat brain in response...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00510-7

    authors： Nakahara D,Ishida Y,Nakamura M,Kuwahara I,Todaka K,Nishimori T

    更新日期：1999-03-01 00:00:00

  • Serotonergic potentiation of photic phase shifts: examination of receptor contributions and early biochemical/molecular events.

    abstract：:The 5-HT mixed agonist/antagonist 1-(2-methoxyphenyl)4-[4-(phthalimido)butyl]-piperazine hydrobromide (NAN-190) has been shown to greatly potentiate photic phase shifts in hamsters. The mechanism of this potentiation has yet to be determined. NAN-190 is believed to act primarily through the 5-HT(1A) receptor, but also...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2009.09.068

    authors： Smith VM,Hagel K,Antle MC

    更新日期：2010-01-13 00:00:00

  • Correlations between immediate early gene induction and the persistence of long-term potentiation.

    abstract：:The duration of long-term potentiation in the dentate gyrus of awake rats was examined following systematic manipulation of the number of stimulus trains delivered. This was correlated with the induction of immediate early genes in separate groups of animals given identical stimulus regimes. Following 10 trains of sti...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90369-q

    authors： Abraham WC,Mason SE,Demmer J,Williams JM,Richardson CL,Tate WP,Lawlor PA,Dragunow M

    更新日期：1993-10-01 00:00:00

  • Blockade of N-methyl-D-aspartate receptors in the insular cortex disrupts taste aversion and spatial memory formation.

    abstract：:The present experiments examined the effects of direct intracortical microinjections of the N-methyl-D-aspartate receptor antagonist 2-amino-5-phosphonovaleric acid directly into the insular cortex of rats, before or immediately after training of conditioned taste aversion and the water maze spatial learning task. In ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00360-1

    authors： Gutiérrez H,Hernández-Echeagaray E,Ramírez-Amaya V,Bermúdez-Rattoni F

    更新日期：1999-03-01 00:00:00

  • Distinct development of the glycinergic terminals in the ventral and dorsal horns of the mouse cervical spinal cord.

    abstract：:In the spinal cord, glycine and γ-amino butyric acid (GABA) are inhibitory neurotransmitters. However, the ontogeny of the glycinergic network remains unclear. To address this point, we examined the developmental formation of glycinergic terminals by immunohistochemistry for glycine transporter 2 (GlyT2), a marker of ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.12.032

    authors： Sunagawa M,Shimizu-Okabe C,Kim J,Kobayashi S,Kosaka Y,Yanagawa Y,Matsushita M,Okabe A,Takayama C

    更新日期：2017-02-20 00:00:00

  • The organochlorine pesticides gamma-hexachlorocyclohexane (lindane), alpha-endosulfan and dieldrin differentially interact with GABA(A) and glycine-gated chloride channels in primary cultures of cerebellar granule cells.

    abstract：:The neurotoxic organochlorine pesticides gamma-hexachlorocyclohexane, alpha-endosulfan and dieldrin induce in mammals a hyperexcitability syndrome accompanied by convulsions. They reduce the GABA-induced Cl(-) flux. The strychnine-sensitive glycine receptor also regulates Cl(-)-flux inhibitory responses. We studied th...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00875-8

    authors： Vale C,Fonfría E,Bujons J,Messeguer A,Rodríguez-Farré E,Suñol C

    更新日期：2003-01-01 00:00:00

  • Avian influenza H5N1 virus induces cytopathy and proinflammatory cytokine responses in human astrocytic and neuronal cell lines.

    abstract：:It has previously been reported that the avian H5N1 type of influenza A virus can be detected in neurons and astrocytes of human brains in autopsy cases. However, the underlying neuropathogenicity remains unexplored. In this study, we used differentiated human astrocytic and neuronal cell lines as models to examine th...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2010.04.013

    authors： Ng YP,Lee SM,Cheung TK,Nicholls JM,Peiris JS,Ip NY

    更新日期：2010-07-14 00:00:00

  • When a line is a number: color yields magnitude information in a digit-color synesthete.

    abstract：:The phenomenon of synesthesia has received a great deal of interest recently in the scientific literature. Many previous studies stressed the unidirectional nature of this phenomenon. For example, color-grapheme synesthetes automatically perceive achromatic numbers as colored (e.g. 7 is turquoise). Conversely, colors ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2005.08.057

    authors： Cohen Kadosh R,Henik A

    更新日期：2006-01-01 00:00:00

  • Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo.

    abstract：:The tight junctions found between cerebral vascular endothelial cells form the basis of the blood-brain barrier. Breakdown of the blood-brain barrier is a feature of a variety of CNS pathologies that are characterized by extensive leucocyte recruitment, such as multiple sclerosis and stroke. The molecular mechanisms a...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(98)00058-x

    authors： Bolton SJ,Anthony DC,Perry VH

    更新日期：1998-10-01 00:00:00

  • Improved survival of young donor age dopamine grafts in a rat model of Parkinson's disease.

    abstract：:In an attempt to improve the survival of implanted dopamine cells, we have readdressed the optimal embryonic donor age for dopamine grafts. In a rat model of Parkinson's disease, animals with unilateral 6-hydroxydopamine lesions of the median forebrain bundle received dopamine-rich ventral mesencephalic grafts derived...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2007.03.037

    authors： Torres EM,Monville C,Gates MA,Bagga V,Dunnett SB

    更新日期：2007-06-08 00:00:00

  • Input-specific effects of acetylcholine on sensory and intracortical evoked responses in the "barrel cortex" in vivo.

    abstract：:The somatosensory neocortex processes extrinsic information from the thalamus and intrinsic information from local circuits. We compared the effects of acetylcholine (Ach) on neocortical field potential responses evoked by stimulation of the whiskers and by local electrical stimulation in the upper layers of the neoco...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(02)00663-2

    authors： Oldford E,Castro-Alamancos MA

    更新日期：2003-01-01 00:00:00

  • A stable brain from unstable components: Emerging concepts and implications for neural computation.

    abstract：:Neuroscientists have often described the adult brain in similar terms to an electronic circuit board- dependent on fixed, precise connectivity. However, with the advent of technologies allowing chronic measurements of neural structure and function, the emerging picture is that neural networks undergo significant remod...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2017.06.005

    authors： Chambers AR,Rumpel S

    更新日期：2017-08-15 00:00:00

  • Effects of serotonin on dorsal horn dorsal spinocerebellar tract neurons.

    abstract：:Effects of ionophoretic application of serotonin and of one of its agonists were tested on responses of dorsal horn dorsal spinocerebellar tract neurons evoked by electrical stimulation of peripheral nerves. Both drugs depressed monosynaptically evoked actions of group II muscle afferents; they decreased the number an...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(95)00060-v

    authors： Jankowska E,Krutki P,Läckberg ZS,Hammar I

    更新日期：1995-07-01 00:00:00

  • Cigarette smoke-induced airway oedema due to activation of capsaicin-sensitive vagal afferents and substance P release.

    abstract：:Exposure of rats to smoke from one cigarette caused local oedema due to a marked increased in vascular permeability from the epiglottis down to bronchioli, as indicated by extravasation of Evans blue in the airway mucosa. The cigarette smoke-induced extravasation of Evans blue was still present after removal of the ta...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(83)90117-3

    authors： Lundberg JM,Martling CR,Saria A,Folkers K,Rosell S

    更新日期：1983-12-01 00:00:00

  • Cerebrospinal fluid derived from progressive multiple sclerosis patients promotes neuronal and oligodendroglial differentiation of human neural precursor cells in vitro.

    abstract：:In the adult CNS, tissue-specific germinal niches, such as the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus of the hippocampus, contain multipotent neural precursor cells (NPCs) with the capacity to self-renew and differentiate into functional brain cells (i.e. neurons, a...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2013.07.022

    authors： Cristofanilli M,Cymring B,Lu A,Rosenthal H,Sadiq SA

    更新日期：2013-10-10 00:00:00

  • Effects of acoustic startle stimuli on interceptive action.

    abstract：:In reaction time (RT) tasks, presentation of a startling acoustic stimulus (SAS) together with a visual imperative stimulus can dramatically reduce RT while leaving response execution unchanged. It has been suggested that a prepared motor response program is triggered early by the SAS but is not otherwise affected. Mo...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.06.029

    authors： Tresilian JR,Plooy AM

    更新日期：2006-10-13 00:00:00

  • gamma-Aminobutyric acid and 5-hydroxytryptamine interrelationship in the rat nucleus raphe dorsalis: combination of radioautographic and immunocytochemical techniques at light and electron microscopy levels.

    abstract：:Serotonin and gamma-aminobutyric acid (GABA) neurons in the nucleus raphe dorsalis were identified by immunocytochemistry using antibodies to 5-hydroxytryptamine or GABA. The pattern of the 5-hydroxytryptamine and GABA immunostaining presented similar features: 5-hydroxytryptamine or GABA immunoreactive somata were fu...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(87)90336-8

    authors： Harandi M,Aguera M,Gamrani H,Didier M,Maitre M,Calas A,Belin MF

    更新日期：1987-04-01 00:00:00

  • Strand-specific RNA-sequencing analysis of multiple system atrophy brain transcriptome.

    abstract：:Multiple system atrophy (MSA) is a sporadic neurodegenerative disease. The major pathological hallmark of MSA is the accumulation of α-synuclein in oligodendrocytes. In contrast to Parkinson's disease no definitive familial etiology for MSA has been determined. Yet, there is a growing body of evidence that perturbatio...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2016.02.042

    authors： Mills JD,Ward M,Kim WS,Halliday GM,Janitz M

    更新日期：2016-05-13 00:00:00

  • The PDZ-binding domain is essential for the dendritic targeting of 5-HT2A serotonin receptors in cortical pyramidal neurons in vitro.

    abstract：:The 5-HT(2A) serotonin receptor represents an important molecular target for atypical antipsychotic drugs and for most hallucinogens. In the mammalian cerebral cortex, 5-HT(2A) receptors are enriched in pyramidal neurons, within which 5-HT(2A) receptors are preferentially sorted to the apical dendrites. In primary cor...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(03)00589-x

    authors： Xia Z,Hufeisen SJ,Gray JA,Roth BL

    更新日期：2003-01-01 00:00:00

  • Astrocytes in Memory Function: Pioneering Findings and Future Directions.

    abstract：:Astrocytes have been generally believed to perform mainly homeostatic and supportive functions for neurons in the central nervous system. Recently, a growing body of evidence suggests previously unrecognized and surprising functions for astrocytes, including regulation of synaptic formation, transmission and plasticit...

    journal_title：Neuroscience

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuroscience.2017.05.033

    authors： Adamsky A,Goshen I

    更新日期：2018-02-01 00:00:00

  • Regulation of the expression and phosphorylation of microtubule-associated protein 1B during regeneration of adult dorsal root ganglion neurons.

    abstract：:Microtubule-associated protein 1B is a major constituent of the neuronal cytoskeleton during the early stages of development. This protein and its phosphorylated isoform, microtubule-associated protein 1B-P, defined by the monoclonal antibody 1B-P [Boyne L. J. et al. (1995) J. Neurosci. Res. 40, 439-450], are present ...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(00)00141-x

    authors： Ma D,Connors T,Nothias F,Fischer I

    更新日期：2000-01-01 00:00:00

  • Entorhinal axons project to dentate gyrus in organotypic slice co-culture.

    abstract：:We have demonstrated the formation of entorhinodentate projections by axons arising from explants of embryonic mouse entorhinal cortex or slices of postnatal rat entorhinal area co-cultured in contact with slices of postnatal rat hippocampus in roller tube and static culture. Species-specific markers (Thy-1 alleles an...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/0306-4522(93)90530-s

    authors： Li D,Field PM,Starega U,Li Y,Raisman G

    更新日期：1993-02-01 00:00:00

  • Adenosine inhibits basal forebrain cholinergic and noncholinergic neurons in vitro.

    abstract：:Adenosine has been proposed as a homeostatic "sleep factor" that promotes the transition from waking to sleep by affecting several sleep-wake regulatory systems. In the basal forebrain, adenosine accumulates during wakefulness and, when locally applied, suppresses neuronal activity and promotes sleep. However, the neu...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2006.02.010

    authors： Arrigoni E,Chamberlin NL,Saper CB,McCarley RW

    更新日期：2006-06-30 00:00:00

  • Sleep and circadian abnormalities in a transgenic mouse model of Alzheimer's disease: a role for cholinergic transmission.

    abstract：:The Tg2576 mouse model of Alzheimer's disease (AD) exhibits age-dependent amyloid beta (Abeta) deposition in the brain. We studied electroencephalographically defined sleep and the circadian regulation of waking activities in Tg2576 mice to determine whether these animals exhibit sleep abnormalities akin to those in A...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2004.11.018

    authors： Wisor JP,Edgar DM,Yesavage J,Ryan HS,McCormick CM,Lapustea N,Murphy GM Jr

    更新日期：2005-01-01 00:00:00

  • Desynchronisation of spontaneously recurrent experimental seizures proceeds with a single rhythm.

    abstract：:Here we investigate the temporal properties of recurrent seizure-like events (SLEs) in a low-[Mg(2+)] model of experimental epilepsy. Simultaneous intra- and extracellular electric signals were recorded in the CA3 region of rat hippocampal slices whereby cytosolic [Ca(2+)] transients were imaged by fluorescence detect...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(03)00559-1

    authors： Nyikos L,Lasztóczi B,Antal K,Kovács R,Kardos J

    更新日期：2003-01-01 00:00:00

  • Cholinergic excitation from the pedunculopontine tegmental nucleus to the dentate nucleus in the rat.

    abstract：:In spite of the existence of pedunculopontine tegmental nucleus (PPTg) projections to cerebellar nuclei, their nature and functional role is unknown. These fibers may play a crucial role in postural control and may be involved in the beneficial effects induced by deep-brain stimulation (DBS) of brainstem structures in...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/j.neuroscience.2015.12.055

    authors： Vitale F,Mattei C,Capozzo A,Pietrantoni I,Mazzone P,Scarnati E

    更新日期：2016-03-11 00:00:00

  • A microdialysis study of striatal dopamine release in the circling rat, a genetic animal model with spontaneous lateralized rotational behavior.

    abstract：:The circling rat is an autosomal recessive mutant (homozygous ci2/ci2) that displays lateralized circling behavior, locomotor hyperactivity, hyperexcitability, ataxia, and stereotypic head-movement. These abnormal behaviors are induced or intensified by stress. Heterozygous (ci2/+) littermates display normal spontaneo...

    journal_title：Neuroscience

    pub_type： 杂志文章

    doi：10.1016/s0306-4522(00)00040-3

    authors： Fedrowitz M,Potschka H,Richter A,Löscher W

    更新日期：2000-01-01 00:00:00