Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo.

abstract：:Recurring patterns of neural activity, a potential substrate of both information transfer and transformation in cortical networks, have been observed in the intact brain and in brain slices. Do these patterns require the inherent cortical microcircuitry of such preparations or are they a general property of self-organ...

journal_title：Neuroscience

authors： Rolston JD,Wagenaar DA,Potter SM

更新日期：2007-08-10 00:00:00

abstract：:We studied the distribution and cellular localization of Na(+)-coupled neutral amino acid transporter 2, a member of the system A family of amino acid transporters, in the rat and human cerebral cortex using immunocytochemical methods. Na(+)-coupled neutral amino acid transporter 2-positive neurons were pyramidal and ...

journal_title：Neuroscience

authors： Melone M,Varoqui H,Erickson JD,Conti F

更新日期：2006-06-19 00:00:00

abstract：:Laminar organization is a fundamental cytoarchitecture in mammalian CNS and a striking feature of the neocortex. ER81, a transcription factor, has recently been utilized as a marker of cells in the layer 5 of the neocortex. We further pursued the distribution of ER81 to investigate the identity of the ER81-expressing ...

journal_title：Neuroscience

authors： Yoneshima H,Yamasaki S,Voelker CC,Molnár Z,Christophe E,Audinat E,Takemoto M,Nishiwaki M,Tsuji S,Fujita I,Yamamoto N

更新日期：2006-01-01 00:00:00

abstract：:The clinical differential diagnosis between the Parkinson variant of multiple system atrophy (MSA-P) and Parkinson's disease (PD) is difficult in early stages. To identify objective markers for differential diagnosis, we combined the novel tract-based spatial statistics (TBSS) and region of interest (ROI) analyses for...

journal_title：Neuroscience

authors： Ji L,Wang Y,Zhu D,Liu W,Shi J

更新日期：2015-10-01 00:00:00

abstract：:Intracellular recordings were performed from projection cells of the cat dorsal lateral geniculate nucleus in vitro to investigate the properties and origin of optic tract evoked inhibitory postsynaptic potentials mediated by GABAB receptors and their relationship to the physiologically different cell classes present ...

journal_title：Neuroscience

authors： Soltesz I,Lightowler S,Leresche N,Crunelli V

更新日期：1989-01-01 00:00:00

abstract：:There is considerable evidence that on the anterior surface of the heart (which is usually supplied by the left anterior descending and the proximal part of the left circumflex coronary arteries), sympathetic efferent reflexes characterized by tachycardia and/or hypertension predominate following experimental or patho...

journal_title：Neuroscience

authors： Meller ST,Gebhart GF

更新日期：1992-01-01 00:00:00

abstract：:Amyloid deposits in Alzheimer's disease, Down's syndrome and aged brain are composed largely of A beta protein, which is generated by proteolytic processing of beta-amyloid precursor protein. Proteases responsible for liberating the A beta protein from the precursor have not yet been identified. Here, we examined the ...

journal_title：Neuroscience

authors： Savage MJ,Iqbal M,Loh T,Trusko SP,Scott R,Siman R

更新日期：1994-06-01 00:00:00

abstract：:The glomeruli are the first synaptic relay on the olfactory pathway and play a basic role in smell perception. Glomerular degeneration occurs in humans with age and in Alzheimer's disease (AD). The glomeruli heavily express β-amyloid precursor protein (APP), β-secretase (BACE1) and γ-secretase complex. However, extrac...

journal_title：Neuroscience

authors： Cai Y,Xue ZQ,Zhang XM,Li MB,Wang H,Luo XG,Cai H,Yan XX

更新日期：2012-07-26 00:00:00

abstract：:Immunoreactive nerve cell bodies and fibres in the intestine have been examined using three antibody preparations raised against 5-hydroxytryptamine. Cross reactivity studies indicate that the substance localized was an hydroxylated indoleamine. In the guinea-pig small intestine, nerve cell bodies were located in the ...

journal_title：Neuroscience

authors： Costa M,Furness JB,Cuello AC,Verhofstad AA,Steinbusch HW,Elde RP

更新日期：1982-02-01 00:00:00

abstract：:Chronic, but not acute, exposure to minimal electroconvulsive shock (ECS) has been shown to decrease vulnerability to neuronal cell death, without itself causing neuronal damage. One potential mechanism for the neuroprotective effect of ECS is the increase in fibroblast growth factor-2 (FGF-2) which occurs after chron...

journal_title：Neuroscience

authors： Kondratyev A,Ved R,Gale K

更新日期：2002-01-01 00:00:00

abstract：:The responses in T3-4, T10-11 and L2-3 white rami to stimulation of different zones of the bulbar ventrolateral surface were maximal when the region of about 4 mm laterally to the midline was stimulated. A weak surface stimulation of all these zones elicited only a long latency response consisting of three waves. A sh...

journal_title：Neuroscience

authors： Lebedev VP,Krasyukov AV,Nikitin SA

更新日期：1986-01-01 00:00:00

abstract：:Few studies have investigated whether neuronal function in the amygdaloid complex is necessary for the occurrence of the cardiovascular response to natural (unconditioned) environmental threats. In the present investigation in conscious unrestrained Sprague-Dawley rats we inactivated neuronal function in the amygdaloi...

journal_title：Neuroscience

authors： Mohammed M,Kulasekara K,De Menezes RC,Ootsuka Y,Blessing WW

更新日期：2013-01-03 00:00:00

abstract：:The zona incerta (ZI), first described over a century ago by Auguste Forel as a "region of which nothing certain can be said," forms a collection of cells that derives from the diencephalon. To this day, we are still not certain of the precise function of this "zone of uncertainty" although many have been proposed, fr...

journal_title：Neuroscience

authors： Mitrofanis J

更新日期：2005-01-01 00:00:00

abstract：:The identification of leptin and a range of novel anorectic and orexigenic peptides has focussed attention on the neural circuitry involved in the genesis of food intake and the reflex control of thermogenesis. Here, the neurotropic virus pseudorabies has been utilised in conjunction with the immunocytochemical locali...

journal_title：Neuroscience

authors： Oldfield BJ,Giles ME,Watson A,Anderson C,Colvill LM,McKinley MJ

更新日期：2002-01-01 00:00:00

abstract：:Miniature endplate potentials were recorded from edge muscle fibers of frog sartorius muscles during high frequencies induced with K-propionate and during recovery. The identified neuromuscular junctions were studied with the electron microscope and their ultrastructure was correlated with amplitude and numbers of min...

journal_title：Neuroscience

authors： Florey E,Kriebel ME

更新日期：1988-12-01 00:00:00

abstract：:Principal cells of the ventral cochlear nucleus (VCN) differ in the magnitudes of low-voltage-activated potassium (gKL) and hyperpolarization-activated (gh) conductances that determine the time course of signaling. Octopus cells in mice have large gKL (500 nS) and gh (150 nS), bushy cells have smaller gKL (80 nS) and ...

journal_title：Neuroscience

authors： Oertel D,Shatadal S,Cao XJ

更新日期：2008-06-12 00:00:00

abstract：:In an attempt to evaluate the cellular organization and efferent projections of the nucleus tegmenti pedunculopontinus pars compacta, several experiments were performed in the rat. From measurements of neurons in the nucleus tegmenti pedunculopontinus pars compacta in Nissl-stained sections, the nucleus was observed t...

journal_title：Neuroscience

authors： Sugimoto T,Hattori T

更新日期：1984-04-01 00:00:00

abstract：:The circadian pacemaker of the suprachiasmatic nuclei is a complex multioscillator system, which controls circadian and seasonal rhythmicity. A number of clock genes have been identified that play a key role in the generation of circadian rhythms. These clock genes are expressed in a circadian manner as has been shown...

journal_title：Neuroscience

authors： Schaap J,Albus H,Eilers PH,Détári L,Meijer JH

更新日期：2001-01-01 00:00:00

abstract：:Modulation of soluble guanylate cyclase (sGC) by nitric oxide (NO) is altered in brain from cirrhotic patients. The aim of this work was to assess whether an animal model of cirrhosis, bile duct ligation, alone or combined with diet-induced hyperammonemia for 7-10 days reproduces the alterations in NO modulation of sG...

journal_title：Neuroscience

authors： Rodrigo R,Jover R,Candela A,Compañ A,Sáez-Valero J,Erceg S,Felipo V

更新日期：2005-01-01 00:00:00

abstract：:Behavioral studies on gene-manipulated mice have started to elucidate the neurobiological functions of the alpha(2C)-adrenoceptor (AR) subtype. In this study, we applied quantitative receptor autoradiography to investigate the potential anatomical correlates of the observed functional effects of altered alpha(2C)-AR e...

journal_title：Neuroscience

authors： Holmberg M,Fagerholm V,Scheinin M

更新日期：2003-01-01 00:00:00

abstract：:The mesopontine tegmental anesthesia area (MPTA) is a small brainstem nucleus that, when exposed to minute quantities of GABAA receptor agonists, induces a state of general anesthesia. In addition to immobility and analgesia this state is accompanied by widespread suppression of neural activity in the cerebral cortex ...

journal_title：Neuroscience

authors： Lellouche Y,Minert A,Schreiber C,Aroch I,Vaso K,Fishman Y,Devor M

更新日期：2020-04-15 00:00:00

abstract：:Cholinergic neurons of the striatum play a crucial role in controlling output from this region. Their firing is under the control of a relatively limited glutamatergic input, deriving principally from the thalamus. Glutamate transmission is effected via three major subtypes of receptors, including those with affinity ...

journal_title：Neuroscience

authors： Bloomfield C,O'Donnell P,French SJ,Totterdell S

更新日期：2007-12-12 00:00:00

abstract：:Paired helical filaments isolated from brains of two different patients with Alzheimer's disease were extensively treated with the ionic detergent, sodium dodecyl sulphate. Filaments were solubilized at different extents, depending on the brain examined, thus suggesting the existence of two types of paired helical fil...

journal_title：Neuroscience

authors： González PJ,Correas I,Avila J

更新日期：1992-09-01 00:00:00

abstract：:Insulin-like growth factor binding protein-2 binds insulin-like growth factors I and II with high affinity and modulates the interaction of these ligands with the type I insulin-like growth factor receptor. Previously we have shown that insulin-like growth factor binding protein-2 and insulin-like growth factor-I gene...

journal_title：Neuroscience

authors： Lee WH,Michels KM,Bondy CA

更新日期：1993-03-01 00:00:00

abstract：:Serotonin (5-HT) is a key regulator of mood and sexual behaviors. 5-HT reuptake inhibitors have been used as antidepressants. Really interesting new gene (RING) finger proteins have been associated with 5-HT regulation but their role remains largely unknown. Some RING finger proteins are involved in the serotonergic s...

journal_title：Neuroscience

authors： Moriya S,Khel NB,Parhar IS

更新日期：2015-05-21 00:00:00

abstract：:The distribution and origin of nerves with calcitonin gene-related peptide, substance P or neurokinin A immunoreactivity in the walls of the cerebral arteries were investigated in three microchiropteran species. The supply of nerves immunoreactive for substance P and neurokinin A to the bat cerebral arteries is confin...

journal_title：Neuroscience

authors： Ando K,Arai S,Kawamura K

更新日期：1990-01-01 00:00:00

abstract：:Effects of L-arginine in the nervous system are often attributed to nitric oxide. Using whole-cell patch pipettes to record membrane currents in voltage-clamp from dopamine neurons in the rat midbrain slice, the present studies found that L-arginine potentiates GABA-dependent membrane currents via a nitric oxide-indep...

journal_title：Neuroscience

authors： Shen KZ,Cox BA,Johnson SW

更新日期：1997-08-01 00:00:00

abstract：:The present studies aimed to determine whether estradiol (E(2)) modulates the stimulation of cocaine- and amphetamine-regulated transcript (CART) peptide in the mesolimbic and nigrostriatal dopaminergic systems. I.c.v. administration of the CART peptide (55-102, 1 microg/3 microl) increased dopamine turnover (3,4-dihy...

journal_title：Neuroscience

authors： Shieh KR,Yang SC

更新日期：2008-07-17 00:00:00

abstract：:Synaptotagmins (Syts) constitute a multi-gene family of 15 putative membrane trafficking proteins. The expression of some of the Syts in the brain might be dopaminergically controlled and thus affected by dopamine depletion in Parkinson's disease. We used hemiparkinsonian rats to investigate the effects of chronic str...

journal_title：Neuroscience

authors： Glavan G,Zivin M

更新日期：2005-01-01 00:00:00

abstract：:The presence of the acetylcholinesterase neurons and substance P-like and enkephalin-like fibers in the various nuclear columns of the ventral horns of the spinal cords was studied in the developing human by acetylcholinesterase histochemistry and substance P and enkephalin immunohistochemistry. Acetylcholinesterase-p...

journal_title：Neuroscience

authors： Luo CB,Yew DT,Zheng DR,Liu YQ

更新日期：1992-06-01 00:00:00